Management Activities Research Articles

Assessment of anthropogenic disturbances on mangrove aboveground biomass in Malaysian Borneo using airborne LiDAR data

Mangroves are known for their carbon storage capacity, yet they are under immense pressure from human activities. This study assessed anthropogenic disturbances on mangroves’ aboveground biomass (AGB) in northern Borneo, Malaysia, using airborne light detection and ranging (LiDAR) data. Three global or pantropical allometries were compared in the development of an AGB estimation model by regressing LiDAR metrics against the AGB. The best model predicted AGB from Saenger and Snedaker allometry with an R2 of 0.85 and a root mean square error (RMSE) of 14.59 Mg/ha (relative RMSE: 7.24 %). The high-resolution AGB map revealed a natural AGB gradient in intact mangroves from the coast to the interior. However, only a weak correlation between the distance from shoreline and AGB in disturbed mangroves was found. The LiDAR estimated AGBs were 196.36 Mg/ha and 157.27 Mg/ha for intact mangroves and disturbed mangroves, respectively. Relatively high AGB areas were abundant in the intact mangroves but scarce in the disturbed mangroves. The LiDAR-based AGB assessment is accurate and high-resolution, supporting carbon stock conservation and sustainable management activities under climate change mitigation programs such as REDD + .

Framing water–energy–food–ecosystem (WEFE) nexus interactions in the Tana-Beles Sub-basin of Ethiopia

The water–energy–food–ecosystems (WEFE) provide vital resources that are essential to human existence. Exploring synergies and trade-offs in these systems has been of interest in recent years to increase economic gain while sustaining the environment. The Tana-Beles Sub-basin of Ethiopia is challenged by population density, climate change, and ecosystem degradation that requires a WEFE Nexus thinking. To understand the current WEFE nexus interactions in the basin, a systematic review of 102 scientific research articles published from 1991 to 2021 was undertaken. Additionally, the systematic review is complemented by spatial data analysis to identify synergies and trade-offs among the WEFE nexus indicators. The analysis revealed the dominance of food–water–ecosystem interdependencies in WEFE nexus research for the Tana-Beles Sub-basin. This dominance is driven by extensive food production activities, which lead to substantial water abstraction and hydrological alterations to meet the intensive water demands of crop cultivation. Simultaneously, the energy-ecosystem interactions are critical due to excessive biomass utilization that exceeds the biomass production potential of the area. Furthermore, the available vegetation cover of the area is very limited to supplement the growing fuel wood demands, which is exerting extreme land degradation and threatening the ecosystem in the sub-basin. This study identifies gaps in WEFE understanding, highlights specific challenges and opportunities within the basin, and calls for coordinated stakeholder action for sustainable resource management through a Nexus approach.

Disentangling drivers of annual grass invasion: Abiotic susceptibility vs. fire-induced conversion to cheatgrass dominance in the sagebrush biome

Invasive annual grasses are often facilitated by fire, yet they can become ecologically dominant in susceptible locations even in the absence of fire. We used an extensive vegetation plot database to model susceptibility to the invasive annual grass cheatgrass (Bromus tectorum L.) in the sagebrush biome as a function of climate and soil water availability variables. We built random forest models predicting cheatgrass presence or dominance (>15 % relative cover) under unburned (37,219 plots) and burned conditions (6340 plots). We mapped predicted probability of cheatgrass presence and dominance, conditional on burning. We combined predicted susceptibility with burn probability to quantify the 10-year total risk of cheatgrass dominance. Finally, we identified portions of the landscape (1) at risk of fire-induced conversion to cheatgrass dominance, (2) consistently susceptible to cheatgrass dominance, or (3) consistently resistant to cheatgrass dominance. At the scale of the sagebrush biome, we found that abiotic susceptibility to cheatgrass dominance drives total risk, regardless of fire. At local scales (i.e., individual 30 m pixels), burning increased the probability of cheatgrass dominance by a median of 14 %. Threshold-based analyses indicate that 10–31 % of the sagebrush biome was at risk of fire-induced dominance, with 55 % exhibiting abiotic resistance and 5 % exhibiting abiotic susceptibility to dominance regardless of fire. Burn probability was higher in areas predicted to be susceptible to dominance, illustrating how cheatgrass invasion can cause ecosystem conversions that are then sustained by grass-fire cycles. Disentangling the influence of abiotic conditions and fire contributes to our understanding of the mechanisms driving invasion dynamics, and modeling the probability of dominance can help anticipate where ecological transformations are at risk of occurring. Our approach can facilitate the prioritization of management actions in the sagebrush biome and be used as a framework for modeling invasion risk in other disturbance-prone ecosystems.

Avenues for Coexistence: How Perception of Costs and Benefits Shape Attitudes towards Wolves

AbstractHuman dimensions play a pivotal role in wolf management and conservation. To offer an informed basis to improve Human-Wolf coexistence, we explore how socio-demographic factors, fear, knowledge, and perceptions of costs and benefits of wolf presence drive human attitudes in the southern area of the Douro River, Portugal, a region inhabited by a small and endangered wolf population. We interviewed 220 people (175 from the general public, 13 hunters, and 32 livestock owners) through a semi-structured survey organized on a 5-point Likert scale. Public and hunter respondents exhibited neutral to positive attitudes, whereas livestock owners expressed negative to neutral attitudes and revealed a Not-In-My-Backyard sentiment. We found that positive attitudes were linked to a greater receptiveness to increased wolf numbers, particularly in areas of irregular wolf presence. Fear was a significant driver of public attitudes, while the presence of wolves influenced livestock owners’views. For both groups, attitudes were also influenced by perceived costs and benefits. Knowledge about wolves did not significantly influence attitudes, with scores being consistently low across groups, and the myth of reintroduction persisting. Thus, management actions should address the concerns and complaints of individuals directly affected by wolves, dispel common fears and myths, and emphasize the ecological and economic benefits of wolf presence in the territory. Media outlets can serve as strategic partners in engaging the neutral population through untargeted interventions. Prioritizing the input of all groups, including conservationists, is essential for establishing common ground and ensuring sustained coexistence.

IoT appropriation for crop management and productivity enhancement in South Africa

Background: While the Internet of things (IoT) has been praised for its potential to improve food security and combat climate change, it is unclear how agricultural entrepreneurs (especially farmers) in emerging contexts are harnessing this technology to leverage agricultural productivity.Objectives: Given the lack of documentation of novel-technology-supported farming approaches in relevant extant literature in emerging economies, this study sought to explore how South African farmers are harnessing the strength of IoT to leverage productivity in crop farming.Method: To address this research gap, a systematic literature review was conducted to establish how IoT was implemented in crop farming in resource-constrained contexts of South Africa. These databases, namely Google Scholar, Scopus, MDPI, IEEE Xplore, and Science Direct, were utilised to gather the relevant information.Results: The findings highlighted that IoT technology presented multiple opportunities for improving operational efficiency and connectivity and facilitating remote management of agricultural activities. Conversely, the findings suggested that the utilisation of IoT in crop farming poses serious challenges arising from software complexity, data security, lack of supporting infrastructure and technical skills.Conclusion: This article demonstrates how institutional voids, human capital and technological gaps in the South African farming industry undermine crop farming, food security in the communities and government efforts at promoting the latest technologies for leveraging agricultural productivity and the farming industry in general.Contribution: The study has contributed to filling the gap in the IoT literature in South Africa and worldwide. This study also contributed by aligning the theory to the study.

Incorporating ecological heterogeneity and intraspecific variation differentiates complex interactions between apex predators and stocked fish

Ecological heterogeneity and intraspecific variation can impact energy flow from the base of the food web to top predators. We evaluated the effect of intraspecific variation on estimates of lake trout (Salvelinus namaycush) consumption of stocked kokanee (lacustrine sockeye salmon, Oncorhynchus nerka) in a 390 ha oligotrophic lake with two distinct basins. Lake trout stomach content analyses, stable isotope niche space, and catch rates indicated high intraspecific variation in resource use across habitats and basins. Intraspecific variation and ecological heterogeneity were incorporated into two bioenergetics modeling approaches; one lake-wide model, and one partitioned model that accounted for differences in lake trout diet composition and population size across habitats. The ecologically partitioned model highlighted that lake trout consumption was primarily in the epilimnion of one basin, while the lake-wide, unpartitioned model performed similarly but failed to provide ecological context for where that consumption occurred. Incorporating ecological heterogeneity and intraspecific variation into bioenergetic models can more accurately represent top predators foraging patterns across habitats and inform management actions to mitigate impacts to stocked fish.

Understanding Local Perspectives on Climate Change and Its Impacts on Small-Scale Fishing Communities in Honda Bay, Palawan, Philippines

Climate change's adverse impacts are already evident, particularly in coastal areas. However, local perception that is essential in formulating policies for mitigating its impacts remains limited. Thus, this study evaluated the level of perception of small fishing communities on climate change and its impacts on livelihood and the environment. The data were obtained using a face-to-face survey with the aid of a structured questionnaire. They were interpreted and analyzed using the Likert point scale, descriptive statistics, and chi-square. A total of 308 male fisherfolks participated in the survey. Majority belong to age 51-60 years old (38%) and 61 years old and above (32%). Most of them (65%) finished elementary and generally (94%) rely on fishing for main source of living. As for income, 47% earned an estimated monthly income of Php 2,501-5,000 and 28% got Php 5,001-7,500. Most of the respondents are full-time fishers (89%) for more than 11 years (87%), and fishing within the municipal water (92%). Majority (90%) have an idea about climate change as reflected by their very high score in Likert Perception (24.3±2.3%). The climate change impacts perceived by the respondents include: increasing sea surface temperature (87%); fish are sensitive to changing climate (87%); and fossil fuel consumption contributes to climate change (84%). They said they got the information from TV/ Radio (99%) and social media (10%). The age (p-value < 0.0032) and source of information (p-value < 0.0348) are among the variables with significant relationship to the perception of respondents on climate change impacts. In total, it appears that majority of fishers are aware of the impacts of climates. It is suggested that effective management actions, such as emergency preparedness schemes and livelihood diversification should be explored to address the specific needs of fishing communities that are vulnerable to the impacts of climate change. Furthermore, an ecosystem-based approach that focuses on socio-economic dynamics and climate-induced changes in assessments and management is essential for the sustainable use of fisheries resources amidst the changing climate.

Managing the transformation of foreign economic activity in an unstable macroeconomic environment

In modern conditions of chaoticization of the system of international economic relations and foreign economic activity of business entities, the tasks of improving the management of foreign economic activity of enterprises by the state and the formation of its embedded mechanisms to ensure the protection of state security in the world market are actualized. The purpose of the article is to analyze the topical issues of foreign economic activity transformation in the context of global instability. According to the author, in the system of state regulation of foreign economic activity of an enterprise, the implementation of an integrated foreign economic activity management system will be timely, which will significantly offset the problems existing in subjects of foreign economic activity related to external factors. However, it is impossible to quickly adjust to dynamically changing conditions and ensure management consistency, increase the efficiency of foreign economic activity of domestic enterprises and protect state economic security. The main goal of the transformation, according to the author, is to provide the necessary transparency and flexibility in the management system of foreign economic activity both at the state level and at the level of a specific subject of foreign economic activity, which is very important in the context of growing instability of the macroeconomic environment. Priorities in the context of growing global instability are to increase the efficiency of foreign economic activity, the competitiveness of the economy and the protection of economic security.

Response of the phytoplankton community to the cessation of wastewater discharges in the urdaibai estuary (SE bay of biscay) based on PIGMENTUM analysis of HPLC pigments

Phytoplankton responds rapidly to nutrient availability variations, becoming a useful indicator for eutrophication and/or management actions to reduce it. The present study evaluated the medium-term response of the phytoplankton community of a temperate estuary (Urdaibai estuary) to the cessation of discharges from a wastewater treatment-plant (WWTP), comparing the physicochemical conditions and the phytoplankton community before (2020) and after (2022) the sewerage works. The cessation led to a decrease of ammonium and phosphate, causing decreases of phytoplankton biomass in the outer and middle estuary and increases in the surroundings of the WWTP. Community composition also changed, recording an increase of prasinoxanthin-containing algae's contribution to total biomass, and a composition shift in the inner estuary, from mainly flagellates (alloxanthin-containing and chlorophyll b-containing algae) to the increase of diatoms, which could be prompted by the change of nutrient-ratios and the nitrogen source, and might indicate the recuperation of the system.

Стратегическое планирование в птицеводстве

The article notes that nowadays strategic planning has taken its weighty place among management functions. Taking into account modern requirements, according to the quality management system, it is advisable to develop and introduce into practice a complex mechanism of enterprise activity management, including a set of economic, motivational, organizational and legal ways of purposeful interaction of economic subjects for the realization of enterprise potential to ensure its sustainable economic, financial and innovative development. The stages of development strategy of poultry enterprises on the example of a specific enterprise in Krasnodar Krai are described, three possible alternative scenario approaches of strategic development are proposed: pessimistic, traditional and optimistic, taking into account the influence of external and internal factors on the development of the enterprise at the present stage.

Effect of a 15-Week Whole Foods, Plant-Based Diet, Physical Activity, and Stress Management Intervention on Cardiometabolic Risk Factors in a Population of US Veterans: A Retrospective Analysis

Effect of a 15-Week Whole Foods, Plant-Based Diet, Physical Activity, and Stress Management Intervention on Cardiometabolic Risk Factors in a Population of US Veterans: A Retrospective Analysis

Soils after forestry management activities in spruce plantations

The carbon accumulation in forest ecosystems helps to mitigate climate changes, therefore the interest in finding strategies for adapted forest management is a major goal of our time. The artificial plantations of Norway spruce (Picea abies Karst) are part of the Bulgarian project to restore the regulatory functions of forest ecosystems. Due to their low resistance, intensive processes of deposition and degradation take place in them, which emphasizes the need to understand the condition of soils and the amount of accumulated carbon in them. This paper reports results from a study on the thinning in even-aged Norway spruce plantations (Picea abies Karst) and its effect on some soil properties. The study includes two thinned plots and an untinned control: 1) Control – an unmanaged spruce plantation, without any activities in it through the last 20 years; 2) Thinned – managed with regular felling over the years, the last of which was carried out 10 years ago with 25% intensity; and 3) Ice storm – plantation damaged from an ice storm in 2007 (when it was 33 years old), felling followed by removal of all affected trees – over 95%, and afforestation with spruce saplings. The soil was examined by layers from 10 cm to 30 cm depth. The main soil characteristics connected with the carbon stocks in soil are analyzed - bulk density, skel-eton, and carbon content. The results of the experiment show that the performed forestry activities were conducted with abidance of the requirements for habitat protection and the ecosystem’s functionality in the studied sites. No significant changes in coarse fraction content and bulk density of soils were found. There is no statistical difference between the plots in the studied depths, but there is a trend of decrease in the organic carbon content in the managed sites. The differences in the soil carbon stocks are significant for the first two soil layers between the control and the managed trough thinning plot. 

Nasal sprays and behavioural interventions compared with usual care for acute respiratory illness in primary care: a randomised, controlled, open-label, parallel-group trial

A small amount of evidence suggests that nasal sprays, or physical activity and stress management, could shorten the duration of respiratory infections. This study aimed to assess the effect of nasal sprays or a behavioural intervention promoting physical activity and stress management on respiratory illnesses, compared with usual care. This randomised, controlled, open-label, parallel-group trial was done at 332 general practitioner practices in the UK. Eligible adults (aged ≥18 years) had at least one comorbidity or risk factor increasing their risk of adverse outcomes due to respiratory illness (eg, immune compromise due to serious illness or medication; heart disease; asthma or lung disease; diabetes; mild hepatic impairment; stroke or severe neurological problem; obesity [BMI ≥30 kg/m2]; or age ≥65 years) or at least three self-reported respiratory tract infections in a normal year (ie, any year before the COVID-19 pandemic). Participants were randomly assigned (1:1:1:1) using a computerised system to: usual care (brief advice about managing illness); gel-based spray (two sprays per nostril at the first sign of an infection or after potential exposure to infection, up to 6 times per day); saline spray (two sprays per nostril at the first sign of an infection or after potential exposure to infection, up to 6 times per day); or a brief behavioural intervention in which participants were given access to a website promoting physical activity and stress management. The study was partially masked: neither investigators nor medical staff were aware of treatment allocation, and investigators who did the statistical analysis were unaware of treatment allocation. The sprays were relabelled to maintain participant masking. Outcomes were assessed using data from participants' completed monthly surveys and a survey at 6 months. The primary outcome was total number of days of illness due to self-reported respiratory tract illnesses (coughs, colds, sore throat, sinus or ear infections, influenza, or COVID-19) in the previous 6 months, assessed in the modified intention-to-treat population, which included all randomly assigned participants who had primary outcome data available. Key secondary outcomes were possible harms, including headache or facial pain, and antibiotic use, assessed in all randomly assigned participants. This trial was registered with ISRCTN, 17936080, and is closed to recruitment. Between Dec 12, 2020, and April 7, 2023, of 19 475 individuals screened for eligibility, 13 799 participants were randomly assigned to usual care (n=3451), gel-based nasal spray (n=3448), saline nasal spray (n=3450), or the digital intervention promoting physical activity and stress management (n=3450). 11 612 participants had complete data for the primary outcome and were included in the primary outcome analysis (usual care group, n=2983; gel-based spray group, n=2935; saline spray group, n=2967; behavioural website group, n=2727). Compared with participants in the usual care group, who had a mean of 8·2 (SD 16·1) days of illness, the number of days of illness was significantly lower in the gel-based spray group (mean 6·5 days [SD 12·8]; adjusted incidence rate ratio [IRR] 0·82 [99% CI 0·76-0·90]; p<0·0001) and the saline spray group (6·4 days [12·4]; 0·81 [0·74-0·88]; p<0·0001), but not in the group allocated to the behavioural website (7·4 days [14·7]; 0·97 [0·89-1·06]; p=0·46). The most common adverse event was headache or sinus pain in the gel-based group: 123 (4·8%) of 2556 participants in the usual care group; 199 (7·8%) of 2498 participants in the gel-based group (risk ratio 1·61 [95% CI 1·30-1·99]; p<0·0001); 101 (4·5%) of 2377 participants in the saline group (0·81 [0·63-1·05]; p=0·11); and 101 (4·5%) of 2091 participants in the behavioural intervention group (0·95 [0·74-1·22]; p=0·69). Compared with usual care, antibiotic use was lower for all interventions: IRR 0·65 (95% CI 0·50-0·84; p=0·001) for the gel-based spray group; 0·69 (0·45-0·88; p=0·003) for the saline spray group; and 0·74 (0·57-0·94; p=0·02) for the behavioural website group. Advice to use either nasal spray reduced illness duration and both sprays and the behavioural website reduced antibiotic use. Future research should aim to address the impact of the widespread implementation of these simple interventions. National Institute for Health and Care Research.

Design of a chatbot in a mobile application for managing payments and controlling activities in a fast school organization

The fast school (FS) educational organization, like many contemporary educational institutions, faces challenges in efficient payment management and rigorous control of activities. Technology, particularly through mobile applications, has shown to be a potential solution to these problems, allowing institutions to stay at the forefront and provide optimized services to their educational community. Therefore, this research work focuses on how a chatbot, integrated into a mobile application, can improve payment management and control of activities in the FS educational organization. Through a detailed study on current trends in educational technology, the design and development of a chatbot adapted to the specific needs of the organization is presented. This chatbot not only facilitates payment processes, offering immediate responses and managing transactions, but also allows for more efficient control of academic and extracurricular activities, improving the experience of its users. In conclusion, the integration of chatbots in mobile applications is presented as a viable and promising solution to face and overcome management challenges in modern educational environments, providing adaptive and user-centered tools that enhance the operational efficiency of institutions. This work is developed with the Scrum methodology and presents a security gateway validated by a digital token.

Robust hybrid control strategy for active power management in Kabertene wind farm within Algeria’s PIAT grid

The paper introduces a hybrid control strategy for optimised active power management in Algeria's Kabertene wind farm, crucial for the pole insalah-adrar-timimoune (PIAT) grid's stability. This strategy merges simultaneous interconnection and damping assignment (SIDA) passivity theory, passivity-based control (PBC), and multivariable proportional-integral-derivative (PID) controllers. This combined approach ensures frequency and voltage stability within the PIAT grid, which encompasses various elements like wind farms, solar plants, gas turbines, and dynamic impedance (Z), current (I), and active power (P) (D-ZIP), load model. By tailoring controllers for doubly fed induction generators (DFIGs) using SIDA-PBC principles and optimising internal parameters, the strategy achieves precise control of active power output. Additionally, particle swarm optimisation (PSO) refines power scheduling, which is especially beneficial for intermittent renewable sources like DFIGs. This comprehensive strategy offers numerous advantages: improved network stability, minimized voltage deviations, reduced frequency fluctuations, and enhanced integration of renewable energy sources. The paper emphasises practical implementation considerations, providing valuable guidance for efficient Kabertene wind farm operation and integration. This research contributes significantly to fostering cleaner and more reliable energy systems, facilitating the PIAT grid's transition towards sustainable energy generation.

The use of conceptual ecological models to identify critical data and uncertainties to support numerical modeling: The northern Gulf of Mexico eastern oyster Crassostrea virginica example

AbstractObjectiveIncreasing reliance on numerical simulation models to help inform management and restoration choices benefits from careful consideration of critical early steps in model development. Along the northern coast of the Gulf of Mexico, the eastern oyster Crassostrea virginica fulfills important ecological and economic roles. Using the eastern oyster as an example, we draw on several recent frameworks outlining best practices for model development and application for restoration, conservation, and management.MethodsWe identify priority model questions, outline a conceptual ecological model (CEM) to guide numerical model development, and use this framework to identify uncertainties and research needs.ResultThe CEM uses a nested design, identifying explicit vital rates, processes, attributes, and outcomes for the species (oysters), population, and metapopulation (i.e., network of populations) levels in response to drivers of species, population, and metapopulation changes and changing environmental factors. Most management actions related to oyster restoration and harvest affect population attributes directly, but many coastal management actions and changes (i.e., climate change and coastal and water resource engineering) impact environmental factors that alter vital rates and attributes of oysters, populations, and metapopulations.ConclusionInvestment in studies targeting individual oyster‐ and population‐level multi‐stressor responses (filtration, respiration, growth, and reproduction) and improving hydrodynamic and environmental models targeting drivers that influence metapopulation vital rates and attributes (i.e., connectivity and substrate persistence) would contribute to reducing uncertainties. Development of numerical models covering the entire oyster life cycle and connectivity of populations using hydrodynamic models of current and predicted conditions to provide key abiotic and biotic factors influencing larval movement, recruitment, and on‐reef oyster vital rates would assist in balancing the goals of conservation, restoration, and fisheries management of this foundational estuarine species.

Estimating the economic impact of comorbidities in patients with MASH and defining high-cost burden in patients with noncirrhotic MASH.

Metabolic dysfunction-associated steatohepatitis (MASH) is associated with high health care costs. This US study investigated the economic burden of MASH, particularly in patients without cirrhosis, and the impact of comorbidities on health care costs. This retrospective, observational study used data from patients diagnosed with MASH aged ≥18 years from October 2015 to March 2022 (IQVIA Ambulatory electronic medical record-US). Patients were stratified by the absence or presence of cirrhosis. Primary outcomes included baseline characteristics and annualized total health care cost after MASH diagnosis during follow-up. In addition, this study defined high costs for the MASH population and identified patient characteristics associated with increased health care costs among those without cirrhosis. Overall, 16,919 patients (14,885 without cirrhosis and 2034 with cirrhosis) were included in the analysis. The prevalence of comorbidities was high in both groups; annual total health care costs were higher in patients with cirrhosis. Patients with a high-cost burden (threshold defined using the United States national estimated annual health care expenditure of $13,555) had a higher prevalence of comorbidities and were prescribed more cardiovascular medications. MASH diagnosis was associated with an increase in cost, largely driven by inpatient costs. In patients without cirrhosis, an increase in cost following MASH diagnosis was associated with the presence and burden of comorbidities and cardiovascular medication utilization. Comorbidities, such as cardiovascular disease and type 2 diabetes, are associated with a higher cost burden and may be aggravated by MASH. Prioritization and active management may benefit patients without cirrhosis with these comorbidities. Clinical care should focus on preventing progression to cirrhosis and managing high-burden comorbidities.

Linking epidemiological and genomic data in cases of enteric fever in England to inform clinical management and public health action.

To explore the feasibility of linking data from enhanced surveillance patient questionnaires from each enteric fever case in England with genome sequencing data, including antimicrobial resistance (AMR) profiles, from the corresponding isolate of typhoidal salmonellae. After linking data we interrogated the merged dataset and assessed the utility of passive surveillance data to match and monitor antimicrobial treatment regimens in enteric fever patients with the AMR profiles of the infectious agent. A high proportion of cases were given antibiotics (n = 1230/1415; 86.9%); half of the cases stated the class of antibiotic they were given (n = 630/1239) and half were prescribed cephalosporins (n = 316/630). Reported treatment with a combination of antibiotics increased with symptom severity. Nearly half of isolates (n = 644/1415; 45.5%) had mutations conferring resistance to ciprofloxacin. Based on genome-derived AMR profiles, typhoidal salmonellae isolates inferred to be susceptible to the recommended first-line antimicrobials were twice as likely to be isolated from individuals residing in the least deprived areas compared with the most deprived (n = 26/169; 15.4% versus n = 32/442; 7.2%). Due to the high proportion of missing data obtained from patient interviews, we recommend a more transparent and systematic approach to recording the antibiotic prescription details by healthcare professionals in primary and secondary care. A more robust approach to data capture at this point in the care pathway would enable us to audit inconsistencies in the prescribing algorithms across England and ensure equitable treatment across all sections of society. Integrating prescribing data with the genome-derived AMR profiles of the causative agent at the individual patient level provides an opportunity to monitor the impact of treatment on clinical outcomes, and to promote best practice in real time.

The football world upside down: Traditional equities as an alternative for the new fan tokens? A portfolio optimization study

This study provides a comprehensive analysis of the relationship between fan tokens and equities as investment vehicles in football clubs. Using the GO-GARCH methodology to account for time-varying higher-order co-moments, we examine the risk-return characteristics of these assets in different portfolio contexts over the period November 2021-March 2023. Our results show high diversification opportunities between fan tokens and equities, especially with investments in different leagues. Portfolio analysis shows that equities generally outperform fan tokens as an investment vehicle, highlighting the importance of active portfolio management. The study also shows that equities have broader diversification potential than fan tokens when added to a portfolio. Furthermore, Turkish fan tokens have better characteristics than Italian fan tokens, possibly due to the nonfinancial benefits for investors. The results are relevant for both retail and institutional investors, regardless of their risk tolerance profiles.

Review of the Longitudinal Management of Autoimmune Encephalitis, Potential Biomarkers, and Novel Therapeutics.

Increasing awareness and earlier diagnosis of autoimmune encephalitis (AE) have led to a greater number of patients being cared for longitudinally by neurologists. Although many neurologists are now familiar with the general approach to diagnosis and acute immunosuppression, this review aims to provide neurologists with guidance related to management beyond the acute phase of disease, including long-term immunosuppression, monitoring, potential biomarkers of disease activity, outcome measures, and symptom management. Observational studies in AE have demonstrated that early diagnosis and treatment is associated with improved neurologic outcomes, particularly in AE with antibodies targeting neuronal cell surface/synaptic proteins. The literature regarding long-term management is evolving. In addition to traditional immunosuppressive approaches, there is emerging use of novel immunosuppressive therapies (ISTs) in case series, and several randomized controlled trials are planned. Novel biomarkers of disease activity and methods to measure outcomes and response to treatment are being explored. Furthermore, it is increasingly recognized that many individuals have chronic symptoms affecting quality of life including seizures, cognitive impairment, fatigue, sleep disorders, and mood disorders, and there are emerging data supporting the use of patient centered outcome measures and multidisciplinary symptom-based care. This review aims to summarize recent literature and offer a practical approach to long-term management of adult patients with AE through a multidisciplinary approach. We summarize current knowledge on ISTs, potential biomarkers of disease activity, outcome measures, and long-term sequelae. Further research is needed to answer questions regarding optimal IST, biomarker validity, and sequelae of disease.