The paper focuses on management issues in the field of sustainable functioning and development of business entities on the basis of guaranteeing their economic security. The industry specialization of entities specializing in logistics activities is taken into account. New aspects of security-oriented management of logistics entities are defined and taken into account, in particular in the languages of digitalization, which bring to the fore the issues of information and cyber security, digital communications, as well as cashless electronic payments. On this basis, the purpose of the research is to identify new accents of security-oriented management of logistics entities in the conditions of digitalization. The components of the economic security of logistics entities that require priority attention in terms of strengthening during the digital transformation of the economy and society have been determined. The toolkit of safety-oriented management under modern conditions for subjects of logistics activity is indicated. It is shown that under modern conditions, business entities specializing in logistics activities should focus on two mega aspects when forming their own security-oriented management systems. These are: (1) operational challenges caused by critical instability and the consequences of a full-scale war; (2) new opportunities, realities, as well as challenges of global and comprehensive digital transformation of economic relations. It was concluded that the new emphasis of security-oriented management of logistics entities concerns all the leading components of their economic security.