Successful Management Research Articles

Real-world experience of pegcetacoplan in paroxysmal nocturnal hemoglobinuria.

Pegcetacoplan significantly improves outcomes for patients with paroxysmal nocturnal hemoglobinuria (PNH) experiencing extravascular hemolysis (EVH) on eculizumab, leading to approval in 2021/2022 (USA/Europe). We report the first collaborative real-world evidence on pegcetacoplan use in UK and France. A total of 48 patients were either currently receiving or previously received pegcetacoplan (2019-2023). A total of 12 patients had participated in the PEGASUS clinical trial, continuing treatment after trial completion. Five patients were on combination treatment of C5 inhibition and pegcetacoplan. Mean pegcetacoplan duration was 20.2 months. Indication for pegcetacoplan was EVH on C5 inhibitors (Eculizumab, n = 29, Ravulizumab n = 16, others n = 3) with 35/48 patients requiring blood transfusion within the previous 12 months. Mean hemoglobin and reticulocyte count at pegcetacoplan commencement and after 3 months: 91 g/L and 205 × 109/L and 115.8 g/L and 107 × 109/L, respectively, resulting in mean Hb change of 22.3 g/L. Mean LDH pre- and post-pegcetacoplan was unchanged. Six patients have stopped pegcetacoplan. A total of 32 breakthrough hemolysis (BTH) events occurred in 13/48 patients. A total of 14 events were within clinical trials (reported separately). Six patients experienced 18 acute BTH events outside clinical trials, 7/18 associated with complement activating conditions. Successful clinical management included daily pegcetacoplan subcutaneously for 3 days or single eculizumab doses; these events are manageable with prompt intervention. Pegcetacoplan is effective for patients with PNH experiencing EVH. In this large patient cohort, treatment was well tolerated with improved hemoglobin and reticulocytes and maintained LDH control. Although BTH occurs, this is manageable by acute dose modification, with the majority of patients being maintained on pegcetacoplan.

Examining successful and unsuccessful time management through process data: two novel indicators of test-taking behaviors

Test-taking behavior is a potential source of construct irrelevant variance for test scores in international large-scale assessments where test-taking effort, motivation, and behaviors in general tend to be confounded with test scores. In an attempt to disentangle this relationship and gain further insight into examinees’ test-taking processes, researchers can now utilize process and timing data to obtain a more comprehensive view of test-taking behaviors, such as test-taking effort. The purpose of this study is to propose and evaluate two novel response-based, standardized indicators of test-taking behaviors that utilize a combination of examinee response and process (timing) data to better understand and describe test-taking effort in ILSAs. These indices were empirically estimated with USA data from two booklets from e-TIMSS 2019 in mathematics for grade 4. In addition, their predictive validity was examined with respect to achievement estimates. Their network of associations with other relevant variables such as motivation, interest in the subject, as well as across subjects were also examined to test their intra-individual stability in e-TIMSS.

Evaluation of the FluoroType Mycobacteria assay for identification of mycobacteria.

This study is the first clinical evaluation report of the novel FluoroType Mycobacteria assay. The assay has the potential to replace the established GenoType NTM product family in identification of culture-enriched mycobacteria. However, our research results suggest that the assay performs suboptimally and may not be feasible for use in all clinical settings.

Acromioclavicular Ganglion Cyst: A Rare Case Report

Acromioclavicular Ganglion Cyst: A Rare Case Report

Population Genetics Assessment of the Model Coral Species Stylophora pistillata from Eilat, the Red Sea

The successful management of coral reefs necessitates understanding the genetic characteristics of reefs’ populations since levels of genetic diversity play a critical role in their resilience, enabling them to withstand environmental changes with greater efficacy. To assess the genetic diversity and connectivity of the widespread Indo-Pacific coral, Stylophora pistillata, eight microsatellite loci were employed on 380 tissue samples collected from eight sites along the northern Gulf of Eilat, Red Sea. We documented deviations from the Hardy–Weinberg equilibrium and observed low heterozygosity and high values of expected heterozygosity (0.59 and 0.82, respectively). The relatively high FST values and STRUCTURE analysis results showed population fragmentation along the short coastline (<12 km). These results signify isolation by distance, low gene flow between most populations, and possible non-random mating. These results are connected to this species’ sexual reproduction traits, a brooding coral species with planulae that settle shortly upon release with limited connectivity that are most probably further exacerbated by anthropogenic impacts imposed on Eilat’s reefs. This study provides insights into the connectivity and population genetics of S. pistillata residing in an urbanized northern Red Sea reef and reinforces the need for better management of the current MPA, employing future active coral reef restoration in the area.

SERIAL CASES INTRAVITREAL TENECTEPLASE AND PNEUMATIC DISPLACEMENT OF SUBMACULAR HEMORRHAGE

Introduction : OBJECTIVE Submacular hemorrhage {SMH} is uncommon complication of choroidal or retinal vascular abnormalities, including choroidal neovascularization {CNV}, polypoidal choroidal vasculopathy {PCV} and retinal macroaneurysm of these, PCV is condition most frequency associated with large SMH {reported in 20%-63% of eyes with PCV} PURPOSE To presence successful management of submacular hemorrhage with combination injection intravitreal {IVT} Tenecteplase and gas C3F8 100%
 Case Illustration : METHODES All patient with SMH already take foto fundus and OCT pre and post IVT methalyse and gas C3F8 100%. All patients undergone IVT gas C3F8 100% 0.2 cc and take a rest for 20 second after that IVT methalyse 0.1 cc was injected. Positioning 1st 24 hours: Free Positioning, 2nd 24 hour: Positioned face down, 3rd days: Follow up.
 Discussion : RESULT The submacular hemorrhage move out from macular for all of cases. Vision improvement occourred in all cases.
 Conclusion : CONCLUTION Intravitreal Tenecteplase in conjunction with pneumatic displacement appears effective in displacing submacular blood.

Virna Glaucoma Implant (VGI) as the Management of Secondary Glaucoma following TASS : A Case Report

Introduction : Secondary glaucoma may occur in severe TASS. The inflammatory cell and debris can clog trabecular meshwork causing IOP to rise. In this case, we describe the successful management of secondary glaucoma due to TASS using Virna Glaucoma Implant (VGI).
 Case Illustration : A 66-year-old woman presented with decreased vision in the left eye one week after anterior vitrectomy and anterior segment lavage due to TASS. She had a history of phacoemulsification and intraocular lens placement with complication of PCR. On ocular examination, the visual acuity was 1/60 in the left eye with intraocular pressure (IOP) 55 mmHg. After maximum glaucoma medication using timolol, latanoprost, brinzolamide eye-drops and oral acetazolamide IOP was 22mmHg. Glaucoma Drainage Device (GDD) surgery using VGI was performed. After 2.5 weeks, IOP in the left eye was reduced to 19 mmHg without anti-glaucoma medication and visual acuity has improved to 6/60, showing a favourable outcome.
 Discussion : TASS may cause significant damage to the trabecular meshwork, which leads to secondary glaucoma. Although medical therapy is often used to control elevated IOP, surgical therapy may be required to treat refractor IOP elevation. GDD surgery has been reported to have effective outcomein secondary glaucoma and pseudophakic eyes.
 Conclusion : Secondary glaucoma is considered as one of the characteristics in the late stages of TASS, and required prompt treatment. VGI implantation is a promising choice of treatment in managing secondary glaucoma following TASS when medication is not effective.

Organisational Change as A Project Management Process, Using the PMI Approach

It can be argued (Todnem,2005) that the successful management of change is crucial to any Organisation/ project to survive, be developed and succeed in the current competitive and continuously evolving business environment. However, theories and approaches to change management currently available are often contradictory, mostly lacking empirical evidence and supported by unchallenged hypotheses concerning the nature of organisational change management. The purpose of this article is, therefore, to provide a review of some of the main theories and approaches to organisational change management as an important first step towards constructing a new framework for managing change. Having as fundamental basis the Change theories and the principle of project management compose a change process based on project management principle and steps. The purpose of this article is, therefore, to provide a review of theories and approaches currently available in a bid to encourage further research into the nature of organisational change with the aim of constructing a new and realistic framework for the management of it. This article will concentrate on the main characteristics of change the relative theories, the commons between the project management process and change and proposed a project management way facing any organisational change. The article concludes with recommendations for further research.

Analyzing the Quality of Academic Information Systems on System Success

Since the needs for academic management are always changing, the creation of academic information systems must focus on user benefits and satisfaction in order to gauge how successful academic management systems are. This research uses the Delone and McLean IS Success Model which is known as one of the system success models, so the aims to ascertain the effects of system, information, and service quality, as well as usage rate, on benefits and user satisfaction SIAKAD system. Respondents were determined using the Slovin formula and taken using proportionate stratified random sampling techniques as many as 100 people. Descriptive analysis was carried out to explain respondents' perceptions and evaluate the success of the system using Three levels of communication were used to measure the success of the system: technical, semantic, and effectiveness levels. The Delone and Mclean IS Success Model's variable relationships were investigated using SEM-PLS analysis. Hypothesis testing results indicate that User Satisfaction is significantly impacted by Information; System; and Service Quality, then Information Quality also significantly affects Usage; and Net Benefits are significantly impacted by User Usage and Satisfaction; however, neither System Quality nor Service Quality significantly affects Use or Use on User Satisfaction.

Faktor-Faktor Yang Mempengaruhi Kinerja Organisasi Bawaslu Republik Indonesia

This research examines the factors that influence the performance of Bawaslu RI, namely using organizational culture variables, change management and information system success. This research uses descriptive analysis and the Structural Equation Modeling (SEM)-Lisrel statistical method. Data was collected from questionnaires distributed and returned from 325 Bawaslu members in Indonesia as respondents. The results of the study show that organizational culture, change management and the success of information systems have a positive and significant effect on the performance of Bawaslu RI.

Effect of Stakeholder Involvement on Project Management Success in Nigeria's Fast-Moving Consumable Goods Industry

In the FMCG sector of Nigeria, the study examined the impact of stakeholder participation on project management success. The study was simplified in order to assess the degree to which stakeholder engagement, support, and involvement effect project goals for a set of fast-moving consumer products in Nigeria. The study's qualitative design involved choosing seven FMCG companies in Nigeria: Dangote Sugar Plc, Nigerian Breweries Plc, Nestle Plc, Cadbury Nig Plc, Nigerian Breweries, Guiness Nig Plc, and Unilever Nig Plc. In order to create a cross-sectional period of 70 observations, secondary data on stakeholder involvement, support, and participation as well as the accomplishment of project objectives were sourced and gathered from yearly financial statement of account and Business Source Premier from 2013–2022. The data were subjected to panel regression analysis, and the results demonstrated that among a group of selected FMCGs in Nigeria, stakeholder involvement and participation have positive and significant effects on project goals, whereas stakeholder support has a negative and insignificant impact. Thus, it is concluded that one of the elements influencing project management performance in Nigeria's FMCG business is stakeholder involvement and participation.

Success Factors in Management of IT Service Projects: Regression, Confirmatory Factor Analysis, and Structural Equation Models

Although there have been some studies on the success factors for IT software projects, there is still a lack of coherent research on the success factors for IT service projects. Therefore, this study aimed to identify and understand the factors and their relationships that contribute to the success of IT service projects. For this purpose, multivariate regressions and structural equation models (SEMs) were developed and analyzed. The regression models included six project management success criteria used as dependent variables (quality of the delivered product, scope realization and requirements, timeliness of delivery, delivery within budget, customer satisfaction, and provider satisfaction) and four independent variables (agile techniques and change management, organization and people, stakeholders and risk analysis, work environment), which had been identified through exploratory factor analysis. The results showed that not all success factors were relevant to all success criteria, and there were differences in their importance. An additional series of exploratory and confirmatory factor analyses along with appropriate statistical measures were employed to evaluate the quality of these four factors. The SEM approach was based on five latent constructs with a total of twenty components. The study suggests that investing in improving people’s knowledge and skills, using agile methodologies, creating a supportive work environment, and involving stakeholders in regular risk analysis are important for project management success. The results also suggest that the success factors for IT service projects depend on both traditional and agile approaches. The study extensively compared its findings with similar research and discussed common issues and differences in both the model structures and methodologies applied. The investigation utilized mathematical methods and techniques that are not commonly applied in the field of project management success modeling. The comprehensive methodology that was applied may be helpful to other researchers who are interested in this topic.

Modified blade: an interventional option in rigid bronchoscopy for non-resectable benign tracheal stenosis

IntroductionBenign tracheobronchial stenosis is a abnormal tracheal lumen narrowing that may incur progressive dyspnea and life-threatening hypoxemia. There is no consensus on which patients should be treated with endoscopic or surgical method. This study investigates the outcomes of bronchoscopic dilatation in the treatment of benign tracheal stenosis using a device equipped with a blade to cut the stenotic lesions with dense fibrosis.Materials and methodsThe procedure was carried out in an operating room under general anesthesia. All patients were intubated with a Rigid Bronchoscope (RB) placed just above the stenosis. Through Rigid Bronchoscopy combined modalities were used as needed: radial incisions of the mucosal stenosis with blade at the levels of 4, 8 and 12 o’clock, with back and forth movements, then the stenotic area was dilated more easily with a rigid bronchoscope. Dilatation was performed by passing the RB of increasing diameter through stenotic areas and then Balloon dilatation of increasing diameter. There were no complications during the procedure.ResultWe conducted an observational, retrospective, single-centre study in the Thoracic Surgery Unit of the University of ‘Luigi Vanvitelli’ of Naples from November 2011 to September 2021. We included all consecutive patients with benign tracheal stenosis inoperable. During the study period, 113 patients were referred to our department with benign tracheal stenosis inoperable. 61 patients were treated with the blade. During the follow-up, a recurrence of the stenosis was observed in 8 patients in the first month and in 4 patients in the third month. Instead in the patients treated with the use of laser (52 patients), during the follow-up a recurrence was observed in 16 patients in the first month and in 6 patients in the third month; no patient relapsed after 6 months and after 1 year. Long term successful bronchoscopic management with blade was attained by 99% in simple and 93% in mixed stenosis and in complex type stenosis.ConclusionOur study underlines the importance of the use of the blade in bronchoscopic treatment as a valid conservative approach in the management of patients with inoperable benign tracheal stenosis as an alternative to the use of the laser, reducing the abnormal inflammatory reaction in order to limit recurrences.

New Challenges for Long-Term Investors: Navigating a Dynamic Financial Landscape

Long-term investors are integral to fostering stability and promoting growth in financial markets, embodying a historical commitment to patient and strategic investment approaches. However, the contemporary financial landscape is undergoing a paradigm shift, presenting long-term investors with unprecedented challenges. This paper delves into the multifaceted challenges confronting long-term investors in today's dynamic environment. Technological advancements stand out as a pivotal factor reshaping the investment landscape. The rapid integration of automation, artificial intelligence, and big data is altering traditional investment paradigms, compelling long-term investors to recalibrate their strategies. Concurrently, regulatory changes are introducing increased complexity, demanding a meticulous understanding of evolving frameworks to ensure compliance while adhering to long-term objectives. Environmental considerations are emerging as a critical aspect, with the growing emphasis on Environmental, Social, and Governance (ESG) factors. Long-term investors now grapple with the necessity of integrating sustainability into their decision-making processes, aligning financial goals with broader environmental and social responsibilities. Furthermore, shifting market dynamics marked by geopolitical uncertainties and economic fluctuations amplify the challenges faced by long-term investors. The paper also delves into strategies for mitigating these challenges, underscoring the indispensability of adaptability and foresight. Successful long-term investment management in this dynamic milieu necessitates a proactive response to technological shifts, adept navigation of regulatory changes, and a commitment to integrating ESG considerations into decision-making processes. As the financial landscape evolves, this paper asserts that long-term investors must embrace innovation and strategic flexibility to ensure their continued role as stabilizing forces in the financial markets. Keywords: Long-term investors, Financial markets, Stability, Unprecedented challenges, Technological advancements, Regulatory changes ,Environmental considerations ,Shifting market dynamics, Economic fluctuations, Decision-making processes

DIGITALISED TALENT MANAGEMENT IN PUBLIC SECTOR: A LESSON LEARNED FROM THE WEST JAVA PROVINCIAL GOVERNMENT

Objective: This empirical study aims to address the existing gap in scholarly research pertaining to talent management within the public sector. Specifically concentrating on the West Java Provincial Government in Indonesia, the research investigates the practical implementation of digital-based talent management for civil service personnel through a case study approach. Methods: The research adopts a qualitative methodology employing interviews, observation, and documentation studies to delve into the intricacies of talent management within the governmental context. Result and Conclusion: The findings underscore the pivotal role of talent management in upholding the merit system, ensuring equitable and objective placement in critical positions. Implementation strategies encompass various steps, ultimately leading to the realization of benefits from a digitalized approach, including the generation of comprehensive and measurable talent data. The digital transformation not only enhances Human Resources management but also promotes objectivity and operational efficiency. Implication of the research: This study bears significance in emphasizing the critical factors contributing to successful digital-based talent management implementation, namely top leadership commitment, HR manager capability, and IT infrastructure support. These insights provide practical implications for organizations seeking to enhance talent management practices within the public sector. Originality: While contributing valuable insights into the talent management process, it is imperative to acknowledge the limitations of this study, primarily its exclusive focus on the procedural aspects without exploring the subsequent impact on individual or organizational performance. Future research endeavors could leverage our findings as a foundational reference, expanding upon these areas for a more comprehensive understanding.

A multidisciplinary approach to managing lymphorroea in primary lymphoedema: a case study.

This case study describes the successful management of a patient with primary lymphoedema, who was experiencing lymphorrhoea and epidermolysis, using a multidisciplinary approach. The patient had Klippel-Trenaunay syndrome. The multidisciplinary team, in an outpatient clinic in Japan, included a certified lymphoedema therapist, plastic surgeons, and a wound, ostomy and continence nurse. The team performed complex physical therapy and lymphaticovenular anastomosis, which promoted the resolution of the lymphorrhoea. This resulted in improvements in skin condition, the prevention of recurrent cellulitis, and no increase in limb circumferences during the 1-year follow-up period. This report highlights the importance of a multidisciplinary approach to lymphoedema management, including lymphorrhoea control that fitted in with the patient's daily life. It is hoped that this article will contribute to the improvement of the quality of life of patients with lymphoedema.

Pain Management of Sciatic Nerve Injury Induced by Intramuscular Injection Using Distal Nerve Block

Abstract Injury to the sciatic nerve from dorsogluteal intramuscular (IM) injection is not an uncommon iatrogenic cause. This case report discusses the successful management of a child with sciatic nerve injury due to an IM injection in the left gluteal region. The child experienced severe pain that was not responding to pharmacological therapy and was limiting physiotherapy, which forms an important step in the management of patients with peripheral nerve injuries. The case report outlines the use of a posterior tibial nerve block, which provided immediate relief of pain sensations in the sole of the foot, allowing the child to walk and eventually improving sleep and appetite. The report suggests that distal nerve blocks may be an effective treatment option for patients with severe neuropathic symptoms resulting from peripheral nerve injury.

Successful Management of Early Cervical Ectopic Pregnancy with Single Dose Methotrexate

Cervical ectopic pregnancy is an uncommon but a potentially life-threatening condition due to risk of severe haemorrhage and occasional need of hysterectomy. Transvaginal ultrasonogram is a key way to diagnose such a case. Early detection and conservative approach of treatment could limit the morbidity and preserve fertility in many cases. Here, we present a case of cervical pregnancy diagnosed by ultrasonogram at 6 weeks of gestation and treated successfully by a single dose of intramuscular methotrexate. Delta Med Col J. Jan 2021;9(1):58-61

A successful endovascular aortic repair of aortoesophageal fistula following esophagectomy: a case report and literature review

BackgroundAortoesophageal fistula (AEF) is an extremely rare and highly fatal complication leading to a high risk of morbidity and mortality. Successful management of AEF after esophagectomy for esophageal carcinoma has rarely been reported in the literature.Case presentationHere we present a rare case of a 44-year-old female with complications of AEF after esophagectomy for esophageal carcinoma, mainly presented as vomiting of blood. Both computed tomographic and computed tomography angiography of the chest showed bilateral pleural effusion and atelectasis, while gastroscopy showed large gastrointestinal bleeding. Emergency surgery was performed that included the removal of the mediastinal abscess, left lower pulmonary wedge resection, and thoracic endovascular aortic repair (TEVAR), followed by supportive treatment. The surgery went successful, and the patient was followed up for 1 year after discharge and showed good recovery. We also reviewed previous literature on the history, causes, pathophysiology, clinical presentation, diagnosis, and treatment of AEF after esophagectomy for esophageal adenocarcinoma.ConclusionsIn our case, thoracotomy combined with TEVAR was effective in treating AEF after esophagectomy for esophageal adenocarcinoma. This case provides successful experiences for clinical diagnosis and treatment of AEF after esophagectomy for esophageal carcinoma.

Suspected Mal de Debarquement Syndrome: A Case Report Highlighting the Difficulty in Diagnosis and Management.

MdDS is syndrome of oscillating vertigo following cessation of passive motion. The pathogenesis of this disorder is not well understood, but functional imaging studies suggest cortical connectivity dysfunction in feedback loops of the vestibulo-ocular system and visuo-spatial system. Patients go through multiple appointments and often specialist referrals before being diagnosed. After diagnosis, optimal management is difficult. Several treatment modalities, including medication, vestibular rehabilitation, and neuromodulation, have had variable success in management. We present the case of a young, female active duty Air Force Captain who developed symptoms while deployed. She underwent multiple treatments with variable success. Her clinical course highlights the difficulties for patients and providers posed by suspected MdDS.