Management Of Several Diseases Research Articles

Capparis spinosa L.: a natural source of pharmaceuticals

Capparis spinosa L. (Caper) is an important source of different secondary metabolites of beneficial activities on human health. Phytochemical studies have shown the presence of many bioactive compounds such as spermidine, rutin, quercetin, kaempferol, stigmasterol, tocopherols, and carotenoids. Biological studies reveal important antimicrobial, antioxidative, anti-inflammatory, antidiabetic, immunomodulatory, and antiviral properties. The present review summarizes information concerning biological activities of some compounds isolated from C. spinosa for the management of several diseases.

Nanotechnology in oncology: A concern on its unwanted effects and ethics

Nanotechnology is the new advent in science at present. The medical nanotechnology is present useful tool for the management of several diseases. For cancer, the application of nanotechnology can be seen, and it is approved for the usefulness. On the other side of the coin, there are also unwanted effects of nanotechnology application in oncology. In this article, the authors review and discuss on the possible unwanted adverse effects of nanotechnology in oncology. The specific ethical concern for nanotechnology in oncology is also mentioned. Interesting quote from leading ethicists and case studies are also presented in this short article.

Investigation of Anti-inflammatory Activity Polyherbal Formulation (Calotropis gigantea and Glycyrrhiza glabra)

Traditional medicine is defined as therapeutic practices that have been in existence, for hundreds of years before the development and spread of modern sciences. This is due to the fact that traditional medicine is the most affordable and accessible health care system available. Ayurveda mentions number of plants for the management of several diseases. Several researchers had given their contributions for finding hidden therapeutic activities of Ayurvedic drugs, but still number of plants need a comprehensive study on them. The present study is focused on the investigation of the potent medicinal herbs such as Calotropis gigantea belongs to family Asclepiadaceae, Glycyrrhiza glabra belongs to family Leguminosae for their anti-inflammatory activity in the form of polyherbal formulation. In carrageenan induced inflammation the polyherbal formulation showed a maximum anti-inflammatory effect at 120 min (71.17%) and progressively increased by 180 min (78.1%). And similarly in formalin induced inflammation the anti-inflammatory effect induced by polyherbal formulation progressively increased and reached a maximum of 72.24% at 180 min. The present investigation concluded that the plants Calotropis gigantea and Glycyrrhiza glabra in the form of polyherbal formulation having anti-inflammatory activity.

Anticholinesterase constituents from the leaves of Spondias mombin L. (Anacardiaceae).

Spondias mombin has been used in traditional medicine for the management of several diseases, including memory loss. This study aimed to evaluate the cholinesterase inhibitory activity of the methanol extract of the leaves and its derived fractions, as well as carry out detailed phytochemical investigations leading to the isolation and characterization of bioactive compounds from the plant. The acetyl cholinesterase (AChE) and butyryl cholinesterase (BUChE) inhibitory activities were evaluated by colorimetric and thin-layer chromatography bioautographic assay techniques. The ethyl acetate fraction was most active against both enzymes, with percentage inhibition of 58.10 ± 1.08% and 52.66 ± 1.34% against AChE and BUChE, respectively. Three compounds, namely, botulin, campesterol and phytol, with IC50 of 0.88 μg/mL (AChE), 4.67 μg/mL (BuChE); 1.89 μg/mL (AChE), 4.08 μg/mL (BuChE) and 12.51 μg/mL (AChE), 23.89 μg/mL (BuChE), respectively, were isolated from the supernatant of the ethyl acetate fraction. The isolated cholinesterase inhibitory compounds correlate with the known memory-enhancing property of the plant and thus support one of its uses in ethnomedicine.

Multiple pharmacological targets, cytotoxicity, and phytochemical profile of Aphloia theiformis (Vahl.) Benn.

Aphloia theiformis (Vahl.) Benn. (AT) is traditionally used in Sub-Saharan African countries including Mauritius as a biomedicine for the management of several diseases. However, there is a dearth of experimental studies to validate these claims. We endeavoured to evaluate the inhibitory effects of crude aqueous extract as traditionally used together with the crude methanol extracts of AT leaves on urease, angiotensin (I) converting enzyme (ACE), acetylcholinesterase (AChE), cholesterol esterase (CEase), glycogen phosphorylase a (GPa), and glycation in vitro. The crude extract showing potent activity against the studied enzymes was further partitioned using different solvents of increasing polarity. The enzyme inhibitory and antiglycation activities of each fraction was assessed. Kinetic of inhibition of the active crude extract/fractions on the aforementioned enzymes was consequently determined using Lineweaver-Burk plots. An ultra-high performance liquid chromatography (UHPLC-UV/MS) system was used to establish the phytochemical profile of AT. The real time cell analysis system (iCELLigence™) was used to monitor any cellular cytotoxicity of AT. Crude methanolextract (CME) was a potent inhibitor of the studied enzymes, with IC50 ranging from 696.22 to 19.73μg/mL. CME (82.5%) significantly (p<0.05) inhibited glycation and was comparable to aminoguanidine (81.5%). Ethyl acetate and n-butanol fractions of CME showed non-competitive, competitive, and uncompetitive mode of inhibition against ACE, CEase, and AChE respectively. Mangiferin, a xanthone glucoside was present in CME, ethyl acetate, and n-butanol fractions. Active extract/fractions were found to be non-cytotoxic (IC50>20μg/mL) according to the U.S National Cancer Institute plant screening program. This study has established baseline data that tend to justify the traditional use of AT and open new avenues for future biomedicine development.

Dermal/transdermal delivery of small interfering RNA and antisense oligonucleotides- advances and hurdles.

A diverse array of nucleic acids has been studied by several researchers for the management of several diseases. Among these compounds, small interfering RNA and antisense oligonucleotides have attracted considerable attention. Antisense oligonucleotides are synthetic single stranded strings of nucleic acids that bind to RNA and thereby alter or reduce expression of the target RNA while siRNAs, on the other hand, are double-stranded RNA molecules which can hybridize with a specific mRNA sequence and block the translation of numerous genes. One of the main obstacles in the dermal or transdermal delivery of these compounds is their low skin permeability. In this review, various techniques used to enhance the delivery of these molecules into or across the skin are described and in some cases, the correlation between enhanced dermal/transdermal delivery and therapeutic efficacy is highlighted.

PP148 Development And Evaluation Of A Tool Supporting Prescription Behavior

INTRODUCTION:The increasing complexity of decision-making in clinical practice and the financial pressure requires clinicians to develop some background about the economic consequences of their decisions and to become more and more managers of pre-defined budgets. The present work aims at describing a simple technology solution that could support prescription decisions and illustrates the results of a preliminary assessment of the tool in a sample of professionals. The solution has been developed to allow informed decision-making in the prescription of oral anti-diabetic drugs (OADs) in type II diabetes mellitus (T2DM) patients by supporting prescriptive appropriateness.METHODS:The tool developed is compatible with many kinds of hardware architectures and the most diffused web browsers. The system allows real-time reproduction of economic evaluation of the different therapeutic options for the management of T2DM patients. Assessment of “ease to use” and “usefulness” of the tool was performed in a convenience sample of clinicians and pharmacists through a specific questionnaire.RESULTS:The tool was developed to compare dipeptidyl-peptidase inhibitors (DPP4i) with sulfonylureas, as second line therapy, for T2DM patients. The tool has a user-friendly Graphical User Interface allowing users to quickly and easily select the therapeutic options to compare, choosing geographical context, perspective of analysis, and changing some model parameters. Feedbacks obtained from thirty-three different professionals were generally positive for the “ease to understand information offered”, “ease of introduction of the tool to support usual working activity”, “usefulness within the usual working activity”.CONCLUSIONS:The study showed that the introduction of the tool as a support for clinicians in optimizing their practice could satisfy unmet needs of professionals by supporting informed prescriptive appropriateness in the choice of OADs as it allows to consider diabetes drug related costs in a comprehensive way. The routinely use of the tool developed could become a solution helping clinicians in the management of several diseases.

MEDICAL DEVICES AND THEIR APPROVAL PROCEDURE IN INDIA

Therapeutic treatment based on medical devices is providing technologically advanced solutions for the management of several diseases. Thereby continues to grow in market at tremendous rate. However, these treatments also carry significant risk with them, which if neglected can lead to life threatening consequences. Therefore rules and regulations are required for monitoring the entry of such devices into the market. Presently Regulatory bodies governing such regulations are at their initial stage and are improving at each step to safeguard public health as well as to ensure that effective and technologically advanced inventions reach out patient.

Shared Decision Making for Urolithiasis: The Use of a Patient Decision Making Aid

IntroductionPatients desire an active role in health care decisions. We evaluated whether a patient decision making aid is useful when considering surgical treatment for urolithiasis. MethodsPatients with a history of urolithiasis were recruited for study. They were asked to consider a hypothetical case of an asymptomatic 10 mm proximal ureteral stone for which elective surgical intervention was recommended. Shock wave lithotripsy and ureteroscopy were presented as potential options. A patient decision making aid was developed to explain and compare the options. A urologist presented the information to the patients, once using the patient decision making aid and then without the aid. We assessed participant satisfaction with each format, and invited comments about the aid and its content, design and clarity. ResultsMean ± SD age of the 4 male and 10 female participants was 61 ± 9 years. Of the participants 86% found the patient decision making aid helpful but identified areas for improvement. Specifically, patients wanted more information on stent placement, stent discomfort, long-term effects and cost. Of the participants 79% reported that the aid improved their understanding of the treatment options compared to the session without the aid. While 8 of 14 participants preferred hearing surgeon recommendations, most still reported value in the patient decision making aid. ConclusionsPatient decision making aids are increasingly used in the management of several diseases and they require patient input into development. In our study the aid improved patient self-reported understanding of surgical options for ureteral stone removal. Notably, most participants still preferred to make decisions based on the surgeon recommendation. Modification of the patient decision making aid based on patient suggestions will enhance its usefulness and applicability in the clinical setting.

Quercetin and Its Role in Chronic Diseases.

Quercetin, a member of the flavonoid class of polyphenol, is one of the most abundantly distributed flavonoids found in various food sources such as fruits, vegetables, nuts, wine and seeds. Quercetin and quercetin-rich foods have been reported to have wide range of health promoting effects, especially in the prevention and management of several diseases; however, the subject of its solubility and bioavailability has limited its use. This section will therefore, consider quercetin as a food-rich flavonoid, the various food sources, the limitations in its use and new approaches at improving its solubility and bioavailability. The therapeutic potentials of quercetin at the prevention/management of some degenerative diseases such as diabetes, hypertension and neurodegenerative diseases, as well as the underlying biochemical mechanisms such as free radical scavenging and enzyme inhibition will also be discussed.

Antimicrobial effect of vancomycin electro-transferred water against methicillin-resistant &lt;i&gt;Staphylococcus aureus&lt;?i&gt; variant

Background: There is a number of alternative and complementary therapeutics that are unproven or have not been properly tested. For past twenty years, the transfer of bio-energetic information has been recognized as a novel scientific approach capable of contributing to improved therapy in the management of several diseases through the so-called bio-resonance therapy (BRT). Although BRT was discovered in the late 1980s, it is still poorly studied. The aim of this study was to evaluate the antibacterial effect of water samples transferred with electronic information of vancomycin, a well known drug against methicillin-resistant Staphylococcus aureus (MRSA), by using a BRT device on bacterial cultures.Material and Methods: MRSA cultures were treated with vancomycin electro-transferred water samples, vancomycin (4.0 and 8.0 μg/mL), sham electro-transferred (water to water) and non-transferred water samples (medium alone). Growth inhibition was evaluated in liquid and solid culture medium, spectrophotometrically and by CFU determination respectively.Results: The obtained data showed that by transferring vancomycin (4.0 and 8.0 μg/mL) information to water samples, the growth of cultured MRSA was significantly (p&lt; 0.05) inhibited (up to 35%), compared with those cultures treated with electro-transferred water to water or cultured in medium alone (0% growth inhibition).Conclusion: This in vitro study suggests that water samples that are electronically transferred with vibration sustained information of vancomycin are capable of inhibiting growth of axenically cultured methicillin resistant S. aureus.Key words: Antimicrobial effect, electro-transferred water, bio-resonance, vancomycin, Sthaphylococcus aureus.

Targeting therapeutics across the blood brain barrier (BBB), prerequisite towards thrombolytic therapy for cerebrovascular disorders-an overview and advancements.

Cerebral tissues possess highly selective and dynamic protection known as blood brain barrier (BBB) that regulates brain homeostasis and provides protection against invading pathogens and various chemicals including drug molecules. Such natural protection strictly monitors entry of drug molecules often required for the management of several diseases and disorders including cerebral vascular and neurological disorders. However, in recent times, the ischemic cerebrovascular disease and clinical manifestation of acute arterial thrombosis are the most common causes of mortality and morbidity worldwide. The management of cerebral Ischemia requires immediate infusion of external thrombolytic into systemic circulation and must cross the blood brain barrier. The major challenge with available thrombolytic is their poor affinity towards the blood brain barrier and cerebral tissue subsequently. In the clinical practice, a high dose of thrombolytic often prescribed to deliver drugs across the blood brain barrier which results in drug dependent toxicity leading to damage of neuronal tissues. In recent times, more emphasis was given to utilize blood brain barrier transport mechanism to deliver drugs in neuronal tissue. The blood brain barrier expresses a series of receptor on membrane became an ideal target for selective drug delivery. In this review, the author has given more emphasis molecular biology of receptor on blood brain barrier and their potential as a carrier for drug molecules to cerebral tissues. Further, the use of nanoscale design and real-time monitoring for developed therapeutic to encounter drug dependent toxicity has been reviewed in this study.

Bridging the gap between nature and antioxidant setbacks: delivering caffeic acid to mitochondria.

As mitochondria have an important role as ATP supplier, cellular ROS producer and apoptosis regulator, these organelles are a promising target for pharmacological intervention in the treatment and management of several diseases. Consequently, research on mitochondria-targeted drugs, which exclude other intracellular structures or extracellular processes, is becoming a hot topic. One approach to address the specific targeting is to conjugate bioactive molecules to a lipophilic cation such as the triphenylphosphonium (TPP(+)). In this chapter, the development of a new antioxidant based on the dietary cinnamic acid-caffeic acid-is described as well as the demonstration of its mitochondriotropic activity.

In Vivo Antidiabetic Activity and Safety In Rats of Cissampelos pareira Traditionally Used In The Management of Diabetes Mellitus In Embu County, Kenya

Cissampelos pareira Linn has been used traditionally in the management of several diseases including diabetes mellitus but its efficacy and safety after long term use is not scientifically evaluated. The aim of this study was to determine in vivo hypoglycemic activity and safety of aqueous leaf extracts of C. pareira in white male albino rats. The extracts were screened for their hypoglycemic activity in alloxan induced diabetic rats using the oral and intraperitoneal routes. The safety of these extracts was studied in rats orally or intraperitoneally administered with 1 g/kg body weight daily for 28 days by recording the changes in body and organ weight, hematological and biochemical parameters and histology. Mineral composition of the extracts were estimated using total reflection X-ray fluorescence system (TRXF) while the types and quantities of phytochemicals present were assessed using standard procedures. Aqueous extracts orally and intraperitoneally administered at 50 mg/kg, 100 mg/kg and 150 mg/kg body weight demonstrated hypoglycemic activity with the intraperitoneal route being more effective than the oral route. Oral and intraperitoneal dose of 1 g/kg body weight of the leaf extracts significantly reduced the body weight gain. The same intraperitoneal dose increased the liver and spleen, and decreased the testis weight; and reduced the hemoglobin levels, packed cell volume and increased the platelet count; increased the activity of aspartate aminotransferase, and lactate dehydrogenase, and decreased the activity of alkaline phosphatase, γ-glutamyltransferase, and creatine kinase and histologically slightly injured the liver and spleen and orally increased the activity of alanine aminotransferase, lactate dehydrogenase, and creatine kinase, and decreased the activity of aspartate aminotransferase and γ-glutamyltransferase. The extracts contained phenols, tannins, flavonoids, alkaloids, terpenoids, sterols, and reducing sugars. Potassium, calcium, and iron levels in the extracts were below the recommended daily allowance. In conclusion, the observed hypoglycemic activity and slight toxicity could be associated with the phytonutrients present in this plant extract. This study recommends continued use of this plant as an herbal medicine.

Brain-derived neurotrophic factor and its clinical implications.

Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity, which is essential for learning and memory. It is widely expressed in the CNS, gut and other tissues. BDNF binds to its high affinity receptor TrkB (tyrosine kinase B) and activates signal transduction cascades (IRS1/2, PI3K, Akt), crucial for CREB and CBP production, that encode proteins involved in β cell survival. BDNF and insulin-like growth factor-1 have similar downstream signaling mechanisms incorporating both p-CAMK and MAPK that increase the expression of pro-survival genes. Brain-derived neurotrophic factor regulates glucose and energy metabolism and prevents exhaustion of β cells. Decreased levels of BDNF are associated with neurodegenerative diseases with neuronal loss, such as Parkinson's disease, Alzheimer's disease, multiple sclerosis and Huntington's disease. Thus, BDNF may be useful in the prevention and management of several diseases including diabetes mellitus.

ANTIMICROBIAL EFFECT OF VANCOMYCIN ELECTRO-TRANSFERRED WATER AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS VARIANT

Background: There is a number of alternative and complementary therapeutics that are unproven or have not been properly tested. For past twenty years, the transfer of bio-energetic information has been recognized as a novel scientific approach capable of contributing to improved therapy in the management of several diseases through the so-called bio-resonance therapy (BRT). Although BRT was discovered in the late 1980s, it is still poorly studied. The aim of this study was to evaluate the antibacterial effect of water samples transferred with electronic information of vancomycin, a well known drug against methicillin-resistant Staphylococcus aureus (MRSA), by using a BRT device on bacterial cultures.&#x0D; Material and Methods: MRSA cultures were treated with vancomycin electro-transferred water samples, vancomycin (4.0 and 8.0 µg/mL), sham electro-transferred (water to water) and non-transferred water samples (medium alone). Growth inhibition was evaluated in liquid and solid culture medium, spectrophotometrically and by CFU determination respectively.&#x0D; Results: The obtained data showed that by transferring vancomycin (4.0 and 8.0 µg/mL) information to water samples, the growth of cultured MRSA was significantly (p&lt; 0.05) inhibited (up to 35%), compared with those cultures treated with electro-transferred water to water or cultured in medium alone (0% growth inhibition).&#x0D; Conclusion: This in vitro study suggests that water samples that are electronically transferred with vibration sustained information of vancomycin are capable of inhibiting growth of axenically cultured methicillin resistant S. aureus.

Clinical presentation and management of severe Ebola virus disease.

Clinicians caring for patients infected with Ebola virus must be familiar not only with screening and infection control measures but also with management of severe disease. By integrating experience from several Ebola epidemics with best practices for managing critical illness, this report focuses on the clinical presentation and management of severely ill infants, children, and adults with Ebola virus disease. Fever, fatigue, vomiting, diarrhea, and anorexia are the most common symptoms of the 2014 West African outbreak. Profound fluid losses from the gastrointestinal tract result in volume depletion, metabolic abnormalities (including hyponatremia, hypokalemia, and hypocalcemia), shock, and organ failure. Overt hemorrhage occurs infrequently. The case fatality rate in West Africa is at least 70%, and individuals with respiratory, neurological, or hemorrhagic symptoms have a higher risk of death. There is no proven antiviral agent to treat Ebola virus disease, although several experimental treatments may be considered. Even in the absence of antiviral therapies, intensive supportive care has the potential to markedly blunt the high case fatality rate reported to date. Optimal treatment requires conscientious correction of fluid and electrolyte losses. Additional management considerations include searching for coinfection or superinfection; treatment of shock (with intravenous fluids and vasoactive agents), acute kidney injury (with renal replacement therapy), and respiratory failure (with invasive mechanical ventilation); provision of nutrition support, pain and anxiety control, and psychosocial support; and the use of strategies to reduce complications of critical illness. Cardiopulmonary resuscitation may be appropriate in certain circumstances, but extracorporeal life support is not advised. Among other ethical issues, patients' medical needs must be carefully weighed against healthcare worker safety and infection control concerns. However, meticulous attention to the use of personal protective equipment and strict adherence to infection control protocols should permit the safe provision of intensive treatment to severely ill patients with Ebola virus disease.

Gas chromatography‐mass spectrometry identification of anticancer phytochemicals in Aframomum danielli (LB579)

Aframomum danielli is one of the African spices used in folklore medicine for the management of several diseases. This study identified the phytochemical components present in the n‐hexane seed extract of the A. danielli by gas chromatography‐mass spectrometry (GC‐MS) analysis and also evaluated the anti‐cancer potential of the identified phytochemicals by performing molecular docking against human Vascular Endothelial Growth Factor (VEGF) using Molegro Virtual Docker. The GC‐MS analysis identified the presence of phytochemical components caryophyllene (RT: 18.479), humulene (RT: 19.189), 2‐butanone (RT: 22.976), benzenesulfonamide (RT: 31.651) and 2‐pyridine acetic acid (RT: 32.446). 2‐Butanone was the strongest binding ligand (‐65.744 kcal/mol) while caryophyllene was the weakest bind lingand (‐56.311 kcal/mol). These compounds showed relative strong docking to VEGF with docking energies comparable to an anticancer drug, bevacizumab (‐77.883 kcal/mol). This in silico molecular docking study has shown that these phytochemical components could be responsible for anti‐cancer properties of A. danielli.

PD37-12 PATIENTS PREFER THE USE OF A PATIENT DECISION-MAKING AID WHEN DISCUSSING SURGICAL OPTIONS FOR NEPHROLITHIASIS

You have accessJournal of UrologyStone Disease: New Technology II1 Apr 2014PD37-12 PATIENTS PREFER THE USE OF A PATIENT DECISION-MAKING AID WHEN DISCUSSING SURGICAL OPTIONS FOR NEPHROLITHIASIS Necole M. Streeper, Brian C. Sninsky, Kristina L. Penniston, Sara L. Best, and Stephen Y. Nakada Necole M. StreeperNecole M. Streeper More articles by this author , Brian C. SninskyBrian C. Sninsky More articles by this author , Kristina L. PennistonKristina L. Penniston More articles by this author , Sara L. BestSara L. Best More articles by this author , and Stephen Y. NakadaStephen Y. Nakada More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2030AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Patients desire to have an active role in making their own healthcare decisions. The purpose of this study was to evaluate whether a patient decision-making aid (PDMA) would be useful for patients considering surgical treatment for nephrolithiasis. METHODS Patients with a history of nephrolithiasis were recruited from our stone clinics and were given a hypothetical case of an asymptomatic 10 mm proximal ureteral stone for which the urologist recommends elective surgical intervention. Shock wave lithotripsy (SWL) and ureteroscopy (URS) were presented as acceptable options in this scenario. A PDMA was developed to educate the patients about the two surgical options, comparing equivalent procedural variables and providing pictures of relevant urinary tract anatomy. Patients were presented with information about both surgical therapies by a urologist in a lecture format, both utilizing the PDMA and without the aid. We assessed patients’ satisfaction with each format and invited comments about the PDMA and its content, design, and clarity. RESULTS Participants (n=14; 4 male, 10 female) were 61.3±8.8 years of age. The majority of the participants found the PDMA helpful (85.7%), but identified areas for improvement. Specifically, patients wanted more information about the possibility of stent placement, details about stent discomfort, information about long-term effects for each surgical modality and financial comparison. There was a preference for utilization of a PDMA (78.6%) because it was felt to help them understand the treatment options more clearly with the visual aid compared to the session without the aid. Interestingly, 8 of 14 participants prefer to decide based on the surgeon’s recommendations but still reported a utility for the PDMA in this process. CONCLUSIONS PDMAs are increasingly used in medical and surgical management of several diseases and require patient input in their development. In our study, the use of a PDMA was preferred by patients and assists in making an informed decision with regard to surgical options for the management of stone disease. Of note, most of our patients still preferred to make decisions based on the surgeon's recommendation. Patients suggested the addition of specific information to the PDMA that may enhance its utility and applicability in the clinical setting. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e950 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Necole M. Streeper More articles by this author Brian C. Sninsky More articles by this author Kristina L. Penniston More articles by this author Sara L. Best More articles by this author Stephen Y. Nakada More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

Potential Biological Spices Available in Bangladesh: A comprehensive review

Nature is the major sources of natural medicines. Spices contain several phytochemical constituents which possess a variety of pharmacological activities. In advancement of technology of investigation research, the traditional plant spices assessment different properties can be done by new experimental researches, which have both human clinical trials and pre-clinical pharmacological animal experiments. Numerous studies indicate in past few decades, which proved digestive stimulatory, anti-inflammatory, antioxidant, anti diabetic, hypolipidemic, anti cancer, chemopreventive, anti mutagenic actions of a range of spices. Spices are used in the diet to provide advance natural treatment of mild to moderate diseases. Present studies suggested that several biologically active compounds can be discovered from those natural spices. Traditional studies show that Bangladeshi plants represent a vast resources for possible lead compound in drug development. This review indicates on the beneficial effects of spices in the management of several diseases. This review is advantageous to implement traditional and scientific knowledge together to use of some spices on several diseases.