The purpose of this study is to draw implications for the prevention of major industrial accidents by analyzing the statistic and causes of major industrial accidents according to the Industrial Safety and Health Act. For this purpose, an empirical analysis of major industrial accidents that occurred over the past 17 years was conducted. As a result of the analysis, it was confirmed that the process safety management system is effective in preventing major industrial accidents. In addition, a lot of major industrial accidents occurred during normal operation and maintenance work by not complying with safe operation guidelines or safe work permit procedures. In terms of material and type of accident, there were many fire and explosion accidents caused by flammable liquids and flammable gases, and the main ignition sources were static electricity and electric sparks. By facility, many accidents occurred during maintenance work in storage tanks, reactors, and piping, or due to runaway reactions.