Background: Adherence to the best standards of nursing practice is the fundamental principle to improve patient outcome and prevent nursing procedure related-infections. Venipuncture is the most common invasive procedure performed in nursing care. Its poor performance could expose patients to bloodstream-related infections and generating major economic costs for health service providers. Nurses have a crucial role in the management of peripheral venous catheters across all health care settings. Aim of the study: The aim of this study was to assess nursing students’ knowledge towards management of peripheral venous catheters evidence-based guidelines. This is the first Iraq study specifically designed to assess knowledge of management of peripheral venous catheters. The study was undertaken to inform curriculum development and to improve the resultant quality of care and patient health outcomes. Results :The study result showed that nursing students’ had good knowledge 5 (8.33%) and 50 (83.33%) of them were having average knowledge, and 5 (8.33%) were having poor Conclusions: In general, the study referred to a low mean total of knowledge score of 3rd year post-basic nursing students that needs to be improved. knowledge.