Management Of Lichen Planus Research Articles

Leiomyosarcoma of the scrotum

mucous membranes, t,2 In this case, the diagnosis was based on the characteristic clinical features and biopsy of the buccal mucosa. Although antimalarials have been used in the treatment of several dermatoses, they do not seem to have been used in the treatment of lichen planus? lsaacson et aP reviewed the possible mechanisms of action of antimalarials in inflammatory disorders. These include: inhibition of complement activation in vitro, interference with complement-dependent antigen-antibody reaction, reduction of formation of immune complexes, and binding to and sterilizing lysosomal membranes retarding the release of hydrolytic enzymes. They also inhibit chemotaxis of polymorphonuclear leukocytes, macrophages, and eosinophils and suppress cell-mediated immune reactions. It is through one or more of these mechanisms that antimalarial drugs may help in the management of lichen planus, in which various immunologic abnormalities have been found? In this patient, chloroquine phosphate induced remission and the nails were restored to normal. However, 10 weeks after discontinuation of treatment, her nail lesions recurred.