Background: Individuals with intellectual disability (ID) experience substantial inequalities and barriers accessing health care despite requiring constant accessibility to healthcare providers as they are more likely to die from avoidable causes of death than those without ID. Telehealth technologies have the capacity to improve access to health providers and health information and could greatly reduce morbidity and mortality rates in people with ID. This study aims to explore the use of mobile health technology in the medical management of adults with intellectual disability. Methodology: PubMed, IEEE Explore, ACM, and Scopus databases were examined to extract peer-reviewed articles published from January 2000 to January 2022. Original research, published in English and focused on the use of telehealth technologies in the medical management of intellectual disability were deemed eligible. A narrative synthesis of the results was completed, structured around the characteristics of telehealth technologies used and the outcomes of the studies. Results: Thirteen of 1008 reviewed articles were considered eligible for inclusion. Most of the studies used videoconferencing platforms for real-time telehealth, while others focused on symptom or medication monitoring applications. The evidence supports the feasibility, potential effectiveness and satisfaction of using telehealth to manage intellectual disability among adults despite accessibility issues including poor internet connectivity and poor knowledge of technology which may limit its use. Conclusion: The use of telehealth was feasible, acceptable and potentially effective for the management of ID among adults though the varied methodology of included studies maybe inadequate. A more structured methodology will be useful in future studies.