Anthrax, a dreaded bacterial zoonotic disease seen in dairy animals, is caused by Bacillus anthracis and its eradication could only be possible by creating maximum awareness among dairy farmers, for their safety as well as the welfare of the animals. The present study was undertaken with the objective to assess the knowledge level of dairy farmers pertaining to anthrax disease management. A sum total of 240 respondents were selected for the study from 12 villages of Kerala State based on a multi-stage sampling technique. The knowledge level of the respondents was assessed using a pre-developed knowledge test. 44% of dairy farmers had high knowledge about anthrax. Education of the respondent (r = 0.360), land holding (r =0.286), experience in dairying (r =0.179), mass media exposure (r =0.407), and previous exposure to anthrax (r =0.214) was positive and significantly correlated with the knowledge level of the respondents pertaining to anthrax. The relative contribution of the socio-economic characteristics of the respondents with their knowledge level of anthrax was assessed using stepwise multiple regression analysis and seven variables viz. gender, main occupation, education of the respondent, land holding, experience in dairying, mass media exposure, and previous exposure to anthrax were found to be significant in explaining variations in knowledge of anthrax. The best fit prediction model was Y=1.372+ 0.530 X2 - 0.459 X3 + 0.383 X5 + 0.730 X8 + 0.039 X10 + 0.309 X15 + 1.764 X18 + e and the coefficient of determination was found to be 58.90%.