Health Risk Management Research Articles

Beliefs and behaviors associated with the first named heat wave in Seville Spain 2022

Heat waves pose a substantial and increasing risk to public health. Heat health early warning systems (HHEWSs) and response plans are increasingly being adopted to alert people to the health risks posed by days of extreme heat and recommend protective behaviors. However, evidence regarding the effectiveness of HHEWSs remains limited. We examined the impact of heat wave naming on heat-related beliefs and behaviors to ascertain the potential effectiveness of heat wave naming as a heat health risk communication and management tool. Specifically, we surveyed members of the public exposed to the proMETEO Sevilla HHEWS messaging campaign which in the summer of 2022 applied a name to heat waves considered to pose the greatest risk to public health. During the heat season we evaluated, the proMETEO Sevilla HHEWS campaign applied a name to one heat wave, heat wave “Zoe”. Our analysis of the post-survey of 2022 adults indicated that the 6% of participants who recalled the name Zoe unaided reported greater engagement in heat wave safety behaviors and more positive beliefs about naming heat waves and their local governments’ heat wave response. These results provide initial evidence for potential utility in naming heat waves as part of HHEWSs and HAPs.

Safety and Health Risk Management in Selected Kenya Tea Development Agency Factories in Bomet County, Kenya

Safety and Health Risk Management in Selected Kenya Tea Development Agency Factories in Bomet County, Kenya

The interrelation between happiness and workplace safety: A bibliometric review

Ensuring a safe and secure work environment promotes employee well-being and satisfaction. This bibliometric study aims to examine the correlation between happiness and workplace safety. This study uses a bibliometric approach to reveal notable research patterns and areas of inadequacy in the current literature on happiness and workplace safety. We acquired the Web of Science (WoS) and Scopus datasets and analysed them using VOSviewer and ScientoPy. Since the 1990s, there has been a steady increase in the volume of literature related to happiness and workplace safety. In 2021, a notable number of publications across both databases, amounting to 61, were documented. This result indicated an upsurge in interest in this topic. The subject of “Psychology” has achieved the highest ranking, with 248 publications. The top five author keywords associated with this subject are “well-being”, “mental health”, “quality of life”, “psychological well-being”, and “depression”. The term “well-being” has garnered significant attention recently, particularly in 2022 and 2023. Bibliometric studies have revealed that happiness research has consistently and steadily gained academic attention. This article scrutinises a range of research that has investigated various facets of this interconnectedness, including the comprehension of accidents, analysis of accidents, modelling accidents, and management of workplace safety and health risks. Furthermore, this study recognises the need for future research to investigate different frameworks that elucidate the relationship between happiness and workplace safety. It also emphasises the intricacies associated with this subject matter.Ensuring a safe and secure work environment promotes employee well-being and satisfaction. This bibliometric study aims to examine the correlation between happiness and workplace safety. This study uses a bibliometric approach to reveal notable research patterns and areas of inadequacy in the current literature on happiness and workplace safety. We acquired the Web of Science (WoS) and Scopus datasets and analysed them using VOSviewer and ScientoPy. Since the 1990s, there has been a steady increase in the volume of literature related to happiness and workplace safety. In 2021, a notable number of publications across both databases, amounting to 61, were documented. This result indicated an upsurge in interest in this topic. The subject of “Psychology” has achieved the highest ranking, with 248 publications. The top five author keywords associated with this subject are “well-being”, “mental health”, “quality of life”, “psychological well-being”, and “depression”. The term “well-being” has garnered significant attention recently, particularly in 2022 and 2023. Bibliometric studies have revealed that happiness research has consistently and steadily gained academic attention. This article scrutinises a range of research that has investigated various facets of this interconnectedness, including the comprehension of accidents, analysis of accidents, modelling accidents, and management of workplace safety and health risks. Furthermore, this study recognises the need for future research to investigate different frameworks that elucidate the relationship between happiness and workplace safety. It also emphasises the intricacies associated with this subject matter.

Analysis of Fatal Construction Accidents in Indonesia—A Case Study

Booming demand for facilities and infrastructure in Indonesia has led to an increase in construction-related accidents. Court rulings provide valuable data on accident circumstances, which can help improve safety standards. Although information on these accidents is scarce and not systematically consolidated, effective data gathering and analysis can lead to better safety outcomes. This study analyzes 150 court rulings in construction industry accident cases and their related decision frameworks to identify seven risk categories using scenario analysis. The correlative patterns and their associated significance are explored via descriptive statistical analysis, and four categories, namely project, task, accident, and medium, were found to be correlated. The results of the cross-tabulation test between two categories were used to highlight correlated categories. Toll road works accounted for 52% of accident cases, with collisions with construction machinery being the most frequent accident type (36%, 76 cases). Lifting and moving goods had respective phi and Cramer values of 0.534 and 0.001. It is obvious that future safety improvement efforts should focus on roadway projects and utilizing construction vehicles for transportation and lifting work. This can be achieved through increased regulatory compliance, proper utilization of standard operating procedures (SOPs), and ensuring vehicle suitability. The results of this study are highly relevant to workplace health and safety officers and risk management personnel.

Imbalance of cell differentiation clusters associated with contamination of biological media by lanthanides in workers of the titanium and rare metals recovery and distillation workshop

The professional activity of a person, depending on the working conditions, modifies the regulation of a single homeostatic mechanism, ultimately forming a breakdown of adaptation associated with an imbalance of immunological 
 parameters.
 The study aims to evaluate changes in the surface molecules of leukocytes of the immune system specifically induced by the presence of lanthanides in workers in the production environment.
 The authors examined 88 people working in the metallurgical industry. The observation group consisted of 24 people with an average work experience of 7.4±0.9 years, the comparison group included 64 people with an average work experience of 7.3±0.9 years. The scientists determined the identification of membrane markers (CD11a, CD277+, CD304+) by flow cytometry, and they also identified specific IgG to lanthanides by allergosorbent testing.
 Excessive concentrations of lanthanides in the blood are formed in workers of the titanium and rare metals recovery and distillation workshop, which are reliably associated with indicator indicators of cellular differentiation of immune regulation clusters: inhibition of expression of immunological phenotypes CD11a, CD304+, CD277+, hyperproduction of specific IgG class reagins to lanthanides. The established immunological scenario is characteristic of the phenotypic characteristics of classical dendritic cells involved in autoimmune inflammatory reactions during the formation of vascular disorders of the central nervous system in workers in these production conditions.
 The results obtained indicate that under conditions of industrial exposure to rare earth metals (lanthanides), workers in the workshop for the recovery and distillation of titanium and rare metals form maladaptive processes of disorders of immune regulation and expression of mediators of cellular differentiation, the markers of which include inhibition of cellular immunity associated with neurovascular mediators (CD11a, CD277+, CD304+), hyperproduction of specific IgG to lanthanides.
 Ethics. The study was approved by the Ethics committee of Federal Scientific Center for Medical and Preventive Health Risk Management Technologies. All patients were informed about the purpose of the study, and voluntary informed consent was obtained.

Climate change and zoonotic diseases: a conceptual framework for predicting and managing health risks in the USA

The executive summary will provide a concise overview of the conceptual framework aimed at understanding the relationship between climate change and zoonotic diseases in the USA. It will highlight the significance of addressing this issue, the objectives of the framework, expected outcomes, and the proposed methodology for research and implementation. It encapsulates the essence of the proposed framework, highlighting its significance, objectives, methodology, and expected outcomes. Climate change poses a significant threat to public health, exacerbating the emergence and transmission of zoonotic diseases across the USA. This executive summary underscores the critical need for a proactive approach to understanding and managing the complex interplay between climate change and zoonotic diseases to safeguard the health of communities. The framework aims to address this pressing issue by elucidating the mechanisms through which climate change influences the dynamics of zoonotic diseases. By integrating multidisciplinary research, predictive modeling, and public health strategies, the framework seeks to enhance the nation's capacity to predict, prevent, and mitigate the health risks associated with climate change-driven zoonotic diseases. Key objectives of the framework include developing predictive models to identify high-risk areas and vulnerable populations, elucidating the pathways of disease transmission, and proposing evidence-based interventions to mitigate health risks. By fostering collaboration among researchers, policymakers, and public health practitioners, the framework aims to translate research findings into actionable strategies and policies that protect public health and promote resilience in the face of climate change. Expected outcomes of the framework include improved understanding of the complex relationship between climate change and zoonotic diseases, enhanced surveillance and early warning systems, and informed decision-making to guide public health interventions. Ultimately, the framework seeks to empower communities and decision-makers with the knowledge and tools needed to adapt to changing environmental conditions and mitigate the health impacts of zoonotic diseases in the USA.

Vitamin D and Geriatric Assessment: A Cross-Sectional Study on the Cohort of Centenarians in the Central Region of Russian Federation

Background. The trend towards aging of the population is global, which makes the study of etiology, prevention and treatment of age-related disorders relevant. Increasing number of studies highlights the influence of 25-hydroxyvitamin D deficiency on health state in older people, as well as its correlation with geriatric syndromes prevalence. However, at the moment it is not known whether these patterns persist in patients older than 90 due to the limited number of studies on this population.Aim. To assess the prevalence of vitamin D deficiency in a cohort of centenarians in the central region of Russian Federation and to study its relationship with the presence of geriatric syndromes.Materials and methods. The study was carried out by Russian Gerontology Research and Clinical Centre of Pirogov Russian National Research Medical University and Center for Strategic Planning and Management of Medical and Biological Health Risks. It was a cross-sectional study on the cohort of centenarians (90 years and older). Complex geriatric assessment was performed. Complex geriatric assessment included past medical history, geriatric scales and questionnaires (MMSE, SARC-F, MNA scores). Blood samples were taken to assess the 25-OH vitamin D levels using chemiluminescence method. The study is reviewed by the ethics committee (№ 30 24.12.2019). The statistical analysis was performed using Python version 3.9 and R version 4.1.3.Results. The study included 3,235 people aged 90 to 107 years. Median level of 25-hydroxyvitamin D was 9 ng/ml, 86.7% of participants were found to be 25(OH)D deficient, and in 8.3% insufficiency 25(OH)D was detected. Using the intergroup analysis, the association between 25-OH vitamin D levels and some geriatric syndromes, such as malnutrition, sarcopenia and cognitive impairment was observed. However, after adjusting to physical activity and nutrition statistically significant association was demonstrated only for cognitive impairment.Conclusion. The results obtained on the association between low levels of 25-OH vitamin D and cognitive impairment among centenarians confirm the importance of vitamin D deficiency prevention and might be starting point for future studies.

Compliance to OSHA 2007 Legislation in TVET Education and Training Centres, Kisumu County, Kenya

Occupational Health and Safety refers to an academic discipline area which is related to the protection of the safety, health and wellbeing of people in any kind of profit generating activity. In TVET institutions the role of promoting and protecting safety, health and environment in education is even more significant since the courses offered there are practical in nature hence the risk of injury is higher. The main objective of this study was to investigate compliance to the legislation of Occupational Safety, Health and of safe systems of work as stipulated in the OSHA 2007 in public TVET Education Institutes in Kisumu County, Kenya. Descriptive survey was employed by the researcher for collection of statistical data to describe the compliance to OSHA 2007 in Kisumu County, Kenya. The research targeted 26 registered public TVET institutions, 26 principals, 416 trainers, 234 workshop technicians and 32,000 trainees in Kisumu County, Kenya. The researcher adopted stratified random sampling. The sample size obtained was 24 public TVET institutions, 24 principals, 203 trainers, 148 workshop technicians and 395 trainees. Quantitative statistical data and qualitative statistical data was obtained by the use of tools such as questionnaires for quantitative data and observation checklist for qualitative data. The researcher obtained data which was then analysed thematically. The software used for the analysis is the Statistical Package for Social Sciences software. The data was then presented using descriptive statistics. The findings: compliance to OSHA 2006, Occupational Safety, Health risk management and safe working systems were neglected in most TVET institutions in Kisumu County Kenya. The study recommends that; emphasis be placed in knowledge, awareness and compliance on the OSHA 2007 in public TVET institutions, the OSHA 2007 statutes be enforced in TVET Education institutions, the top leadership in TVET Education institutions to comply and enforce OSHA 2007 in the work places.

Ultra-sensitive analysis of exhaled biomarkers in ozone-exposed mice via PAI-TOFMS assisted with machine learning algorithms

Ground-level ozone ranks sixth among common air pollutants. It worsens lung diseases like asthma, emphysema, and chronic bronchitis. Despite recent attention from researchers, the link between exhaled breath and ozone-induced injury remains poorly understood. This study aimed to identify novel exhaled biomarkers in ozone-exposed mice using ultra-sensitive photoinduced associative ionization time-of-flight mass spectrometry and machine learning. Distinct ion peaks for acetonitrile (m/z 42, 60, and 78), butyronitrile (m/z 70, 88, and 106), and hydrogen sulfide (m/z 35) were detected. Integration of tissue characteristics, oxidative stress-related mRNA expression, and exhaled breath condensate free-radical analysis enabled a comprehensive exploration of the relationship between ozone-induced biological responses and potential biomarkers. Under similar exposure levels, C57BL/6 mice exhibited pulmonary injury characterized by significant inflammation, oxidative stress, and cardiac damage. Notably, C57BL/6 mice showed free radical signals, indicating a distinct susceptibility profile. Immunodeficient non-obese diabetic Prkdc-/-/Il2rg-/- (NPI) mice exhibited minimal biological responses to pulmonary injury, with little impact on the heart. These findings suggest a divergence in ozone-induced damage pathways in the two mouse types, leading to alterations in exhaled biomarkers. Integrating biomarker discovery with comprehensive biopathological analysis forms a robust foundation for targeted interventions to manage health risks posed by ozone exposure.

A Proposal for a Multidisciplinary Integrated Oral Health Network for Patients Undergoing Major Orthopaedic Surgery (IOHN-OS).

The passing of the years of life physiologically leads to the accumulation of changes in tissues in the oral cavity, influencing dentition, chewing and swallowing mechanisms, and the oral microbiota. Some diseases and medications can aggravate oral symptoms and negatively influence eating behaviours, increasing the likelihood of becoming malnourished. This could make older individuals more vulnerable to complications when undergoing major orthopaedic surgery. Hidden infection foci in the oral cavity are a recognised cause of post-operative periprosthetic joint infections. Dysfunctional oral problems might also compromise feeding after surgery when good nutrition represents a fundamental aspect of a proper recovery. To manage these shortcomings, in this article, the authors hypothesise a multidisciplinary path of care named the Integrated Oral Health Network applied to major Orthopaedic Surgery (IOHN-OS). This peri-operative initiative would include pre-operative oral health screening and risk management by a dental team, patient education programmes before and after surgery, and bedside gerodontology actions like oral care and meal and eating support for fragile individuals. The IOHN-OS has the potential to reshape the concept of suitability for major orthopaedic surgery and generate momentum for designing community-based surveillance programmes that can keep the mouths of older subjects healthy for a long time.

Immune and genetic profile of workers with metabolic syndrome contaminated with benzene (based on the example of the petrochemical industry)

Exposure to harmful chemical factors of production can contribute to the development of metabolic disorders in workers in the petrochemical industry. Oil production conditions are associated with exposure to endocrine disruptors, such as aromatic hydrocarbons, whose effects are associated, among other things, with disorders of immuno-endocrine regulation.
 The aim of the study was to analyze the features of the immune and genetic status of workers in the oil-producing segment of the petrochemical industry with metabolic syndrome contaminated with benzene.
 142 operators of the oil production enterprise with pathology with metabolic syndrome were examined. The observation group included workers (n=94) characterized by contamination of the biological medium with benzene. The comparison group consisted of 48 people who were not contaminated with benzene. The state of cellular immunity was assessed by flow cytometry (CD3+CD8+, CD3+CD95+, CD3+), cytokine profile by enzyme immunoassay (IL‑6). Gene polymorphism was studied by real-time PCR.
 In workers with metabolic syndrome contaminated with benzene, the features of the clinical course of the metabolic syndrome, accompanied by functional and laboratory signs of atherosclerotic vascular changes, as well as an imbalance of the immune profile, whose phenotypes were: an increase in the absolute and relative content of CD3+CD8+ lymphocytes (1.3–1.6 times, respectively) (p<0.05), CD3+ lymphocytes (1.2–1.3 times) (p<0.05) relative to the comparison group, CD95+ cluster deficiency in relation to the reference interval and the indicators of the comparison group (1.4–1.9 times; p<0.05), IL-6 hyperproduction (1.6 times; p<0.05) relative to the values of the corresponding indicators of the group of workers where benzene contamination was absent. The genetic profile of workers (SNP) contaminated with benzene allowed us to establish a 1.4-fold increased prevalence of the C-allele of the FADS2 gene (OR=2.13; 95% CI: 1.05–4.29, p<0.05); 2.3 times the G-allele (OR=3.30; 95% CI: 1.46–7.33, p<0.05) of the TP53 gene.
 Established in operators of the oil-producing segment of the petrochemical industry with metabolic syndrome contaminated with benzene, features of the immune status: an increase in the expression of CD3+ and CD8+ lymphocyte clusters, IL-6 cytokine, and a decrease in CD95+ lymphocyte reception (p<0.05) were accompanied by polymorphisms of candidate genes FADS2 (rs174583) and TP53 (rs 1042522) associated with obesity and apoptosis.
 Ethics. The study was approved by the ethics committee of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies. All patients were informed about the purpose of the study, and voluntary informed consent was obtained.

High pesticide tolerance of S. mansoni: implications for the risk of schistosomiasis

BackgroundSchistosomiasis is a neglected tropical disease caused by trematodes of the genus Schistosoma. The pathogen is transmitted via freshwater snails. These snails are highly tolerant to agricultural pesticides and indirectly benefit from exposure due to adverse effects on their more sensitive enemy species. Pesticides in surface waters may thus increase the risk of schistosomiasis transmission unless they also affect the pathogen. We tested the tolerance of the free-swimming life stages (miracidia and cercariae) of Schistosoma mansoni to the insecticides diazinon and imidacloprid. We also investigated whether these pesticides decrease the ability of miracidia to infect and further develop as sporocysts within the host snail Biomphalaria pfeifferi.ResultsExposure to imidacloprid for 6 and 12 h immobilized 50% of miracidia at 150 and 16 µg/L, respectively (nominal EC50); 50% of cercariae were immobilized at 403 and 284 µg/L. Diazinon immobilized 50% of miracidia at 51 and 21 µg/L after 6 and 12 h; 50% of cercariae were immobilized at 25 and 13 µg/L. The observed insecticide tolerance is lower than those of the host snail B. pfeifferi and comparable to those of other commonly tested freshwater invertebrates. Exposure for up to 6 h decreased the infectivity of miracidia at high sublethal concentrations (48.8 µg imidacloprid/L and 10.5 µg diazinon/L, i.e. 20–33% of EC50), but not at lower concentrations commonly observed in the field (4.88 µg imidacloprid/L and 1.05 µg diazinon/L). The development of sporocysts within the snail host was not affected at any of these test concentrations.ConclusionsInsecticides did not affect the performance of S. mansoni at environmentally relevant concentrations. Particularly within its host snail the pathogen can escape exposure peaks that have been shown to affect other sensitive invertebrates and their biological control of host snails. Our findings suggest that freshwater pollution with agricultural pesticides increases the risk of schistosomiasis; they illustrate the need to integrate an environmental and public health risk assessment and management.

Multi-scenario PM2.5 distribution and dynamic exposure assessment of university community residents: Development and application of intelligent health risk management system integrated low-cost sensors

Exposure scenario and receptor behavior significantly affect PM2.5 exposure quantity of persons and resident groups, which in turn influenced indoor or outdoor air quality & health management. An Internet of Things (IoT) system, EnvironMax+, was developed to accurately and conveniently assess residential dynamic PM2.5 exposure state. A university community “QC”, as the application area, was divided into four exposure scenarios and five groups of residents. Low-cost mobile sensors and indoor/outdoor pollution migration (IOP) models jointly estimated multi-scenario real-time PM2.5 concentrations. Questionnaire was used to investigate residents' indoor activity characteristics. Mobile application (app) “Air health management (AHM)” could automatic collect residents' activity trajectory. At last, multi-scenario daily exposure concentrations of each residents-group were obtained. The results showed that residential exposure scenario was the most important one, where residents spend about 60 % of their daily time. Closing window was the most significant behavior affecting indoor contamination. The annual average PM2.5 concentration in the studied scenarios: residential scenario (RS) < public scenario (PS) < outdoor scenario (OS) < catering scenario (CS). Except for CS, the outdoor PM2.5 in other scenarios was higher than indoor by 5–10 μg/m3. The multi-scenario population weighted annual average exposure concentration was 37.1 μg/m3, which was 78 % of the annual average outdoor concentration. The exposure concentration of 5 groups: cooks > outdoor workers > indoor workers > students > the elderly, related to their daily activity time proportion in different exposure scenario.

Inulin alleviates perinatal 2-ethylhexyl diphenyl phosphate (EHDPHP) exposure-induced intestinal toxicity by reshaping the gut microbiota and suppressing the enteric-origin LPS/TLR4/NF-κb pathway in dams and pups

Organophosphorus flame retardants (OPFRs), such as 2-ethylhexyl diphenyl phosphate (EHDPHP), are ubiquitously used, leading to pervasive environmental contamination and human health risks. While associations between EHDPHP and health issues such as disruption of hormones, neurotoxic effects, and toxicity to reproduction have been recognized, exposure to EHDPHP during perinatal life and its implications for the intestinal health of dams and their pups have largely been unexplored. This study investigated the intestinal toxicity of EHDPHP and the potential for which inulin was effective. Dams were administered either an EHDPHP solution or a corn oil control from gestation day 7 (GD7) to postnatal day 21 (PND21), with inulin provided in their drinking water. Our results indicate that inulin supplementation mitigates damage to the intestinal epithelium caused by EHDPHP, restores mucus-secreting cells, suppresses intestinal hyperpermeability, and abates intestinal inflammation by curtailing lipopolysaccharide leakage through reshaping of the gut microbiota. A reduction in LPS levels concurrently inhibited the inflammation-associated TLR4/NF-κB pathway. In conclusion, inulin administration may ameliorate intestinal toxicity caused by EHDPHP in dams and pups by reshaping the gut microbiota and suppressing the LPS/TLR4/NF-κB pathway. These findings underscore the efficacy of inulin as a therapeutic agent for managing health risks linked to EHDPHP exposure.

A decision-aid system for subway microenvironment health risk intervention based on backpropagation neural network and permutation feature importance method

Subway has become an important commute mode in daily life. However, subway microenvironment poses a threat to people's health and there is growing concern about its health risks. In this paper, a decision-aid system for subway microenvironment health risk intervention was proposed based on the combination of backpropagation neural network algorithm and permutation feature importance method. The non-linear relationship between indicators and the risks of subway microenvironment was established using the neural network. On this basis, the implementation of stepwise intervention, neural network prediction, and the generation of strategies was achieved utilizing MATLAB programming. Moreover, a subway station in Nanjing was taken as an example to illustrate the implementation and verify the effectiveness of the system. With the help of the system, health risks in the subway microenvironment can be systematically analyzed, efficiently optimized, and gradually solved. Our research contributes to breaking the deadlock in subway microenvironment intervention, which has long been confined to predicting and summarizing strategies. It provides more objective and effective intervention strategies for the health risk management of subway microenvironments.

Health risk management: The ASL BT experience

ASL BT, born from the merger of three company branches, now eighteen years old, has a transversal departmental organization. In the Staff Department, there is the Clinical Risk Management Unit, which carries out prospective planning activities in the medium/long term. The systematic monitoring of all incident reporting systems, as well as requests for compensation and the economic aspects relating to direct costs (for damages related to adverse events) and indirect costs (for disputes), allow the UO to plan the prevention activities. This prevents the health risk and the recurrence of events, which in various ways have generated "losses" for the patient, the Company and the professionals. The establishment of a clinical risk network made up of representatives and facilitators, the sharing of all the proposed procedures and protocols and above all, the training aimed at increasing the culture of safety and awareness among all employees Healthcare, have a crucial role.

Estimation of pan-European, daily total, fine-mode and coarse-mode Aerosol Optical Depth at 0.1° resolution to facilitate air quality assessments

Aerosol Optical Depth (AOD) data derived from satellites is crucial for estimating spatially-resolved PM concentrations, but existing AOD data over land remain affected by several limitations (e.g., data gaps, coarser resolution, higher uncertainty or lack of size fraction data), which weakens the AOD-PM relationship. We developed a 0.1° resolution daily AOD data set over Europe over the period 2003–2020, based on two-stage Quantile Machine Learning (QML) frameworks. Our approach first fills gaps in satellite AOD data and then constructs three components' models to obtain reliable full-coverage AOD along with Fine-mode AOD (fAOD) and Coarse-mode AOD (cAOD). These models are based on AERONET (AErosol RObotic NETwork) observations, Gap-filled satellite AOD, climate and atmospheric composition reanalyses. Our QML AOD products exhibit better quality with an out-of-sample R2 equal to 0.68 for AOD, 0.66 for fAOD and 0.65 for cAOD, which is 23–92 %, 11–13 % and 115–132 % higher than the corresponding satellite or reanalysis products, respectively. Over 91.6 %, 81.6 %, and 88.9 % of QML AOD, fAOD and cAOD predictions fall within ±20 % Expected Error (EE) envelopes, respectively. Previous studies reported that a weak satellite AOD-PM correlation across Europe (Pearson correlation coefficient (PCC) around 0.1). Our QML products exhibit higher correlations with ground-level PMs, particularly when broadly matched by size: AOD with PM10, fAOD with PM2.5, cAOD with PM coarse (R = 0.41, 0.45 and 0.26, respectively). Different AOD fractions more effectively distinct PM size fractions, than total AOD. Our QML aerosol dataset and models pioneer full-coverage, daily high-resolution monitoring of fine-mode and coarse-mode aerosols, effectively addressing existing AOD challenges for further PMs exposures' estimations. This dataset opens avenues for more in-depth exploration of the impacts of aerosols on human health, climate, visibility, and biogeochemical processes, offering valuable insights for air quality management and environmental health risk assessment.

Environmental Health Risk Analysis of Sulfur Dioxide (SO2) Inhalation Exposure in Ambient Air Among the Tirtonirmolo Community, Bantul.

Introduction: Sulfur dioxide (SO2) is one of the gases that can pollute the ambient air and cause respiratory irritation. This study aims to determine the characterization of health risk and risk management of sulfur dioxide (SO2) exposure to prevent health impact in the Tirtonirmolo community, Bantul. Methods: This study was a quantitative descriptive research with an Environmental Health Risk Analysis (EHRA) approach. The study subjects were the Tirtonirmolo community in Bantul, with a sample of 110 respondents. The sampling method uses purposive sampling. Results and Discussion: Most respondents are female (74%) with ages over 54 years (52%), and the majority work as housewives (44%). The description of EHRA variables consists of an inhalation rate of 0.83 m3/hour, exposure time of 22 hours/day, exposure frequency of 354 days/year, and exposure duration for real-time projections of 35 years and 30 years for lifetime projections. The SO2 measurement results did not exceed the national quality standard, with the highest concentration being on Madukismo Road, with a concentration of 11.72 μg/m3. The dose-response analysis uses data from the US-EPA, which is 0.026 mg/kg/day. The real-time average intake value is 0.0039 mg/kg/day, and the 30-year lifetime average intake value is 0.0033 mg/kg/day. Conclusion: All respondents from this study had an RQ value&lt;1, both in the RQ for real-time and lifetime. Risk management needs to reduce health risk by using masks when doing outdoor activities and installing Flue Gas Desulfurization (FGD) in factories that emit SO2 emissions.

Discussion on the status quo and problems of health risk management of hand-transmitted vibration in the workplace

The risk management in workplace is an important measure to effectively prevent and control the harm of hand-transmitted vibration. Based on the relevant developments at home and abroad, this paper expounds the risk of manual vibration operation in workplace by taking contact assessment and hazard assessment as an example. On this basis, the limit management and hierarchical management related to risk management are discussed, and the existing problems are analyzed.

Regulation of BTB (POZ) Structural Domain 6b by MicroRNA-222b in Zebrafish Embryos after Exposure to Di(2-ethylhexyl)phthalate at Low Concentrations.

Di-(2-ethylhexyl) phthalate (DEHP) is a sort of endocrine disruptor that induces abnormal physiological and biochemical activities such as epigenetic alterations, apoptosis, and oxidative stress. MicroRNAs (miRNAs) are a class of short noncoding RNAs that may regulate the expression of many protein-coding genes when organisms are exposed to environmental chemicals. miR-222b is a differentially expressed miRNA after DEHP exposure. miRNA-mRNA prediction suggested that BTB (POZ) structural domain 6b (BTBD6B) might be a target mRNA of miR-222b, and DEHP exposure altered its expression. However, the correlation between miR-222b and BTBD6B has not been experimentally confirmed. The aim of this study was to investigate the regulation of BTBD6B by miR-222b in zebrafish embryos under the effect of low concentration of DEHP. Dual fluorescent protein assays and dual luciferase reporter gene assays confirmed the interaction between miR-222b and the 3'-untranslated region (3'-UTR) of BTBD6B. Ectopic expression assays showed that miR-222b could negatively regulate BTBD6B in ZF4 cells. However, the relative expression of miR-222b and BTBD6B was significantly higher at both transcriptional and post-transcriptional levels in zebrafish embryos exposed to low concentrations of DEHP. The results of this study improved our understanding of the molecular mechanism of DEHP exposure toxicity. It identified that the aberrant expression of miR-222b/BTBD6B may be one of the mechanisms of DEHP toxicity, which can provide a theoretical reference and scientific basis for environmental management and biological health risk assessment.