Mammary Fibromatosis Research Articles

Fibromatosis Mimicking clinically in vas! ve breast carcinoma

Our purpose is to report two cases of fibromatosis in two women of 34 and 48 years oid respectively that clinically appeared as ainvasive breast carcinoma, particular!y for the cutaneous retraction they showed. The histopathological diagnosis vas done basedon specimens studied with the common technique of paraffin embedding and Hematoxilin & Eosin staining. Both patients had firTn poorly demarcated nodules with the histopathological pattern of classic fibromatosis. Mammary fibromatosis is un infrequent relapsing entity, not suspected in differentiai ci inical diagnoses. The pathologist should bea it in niind , especially in frozen biopsiescialmente en las biopsias intraoperatorias.

Mammary fibromatosis in a female dog: case report

Fibromatosis, or desmoid tumour, is characterized by excessive and infiltrative proliferation of connective tissue originating from aponeurotic muscle structures. Mammary fibromatosis is rare in humans and animals and its precise aetiology is unknown. A 10-year-old mixed-breed female dog developed a mass in the right cranial thoracic mammary gland (M1) and underwent lumpectomy. The mass was firm, with an irregular surface and distinct limits. Microscopically, it was a neoplastic proliferation of fusiform cells with low atypia, interspersed with abundant dense collagenous tissue, confirmed by histochemical staining with Gomori's trichrome and Masson's trichrome and immunopositivity for vimentin and smooth muscle actin, confirming mammary fibromatosis. Mammary fibromatosis in dogs needs further studies to elucidate its clinical, epidemiological and aetiopathogenic aspects.

A Case Report of Breast Fibromatosis Mimicking Breast Cancer

Introduction: Breast Fibromatosis is a rare benign stromal tumor that accounts for 0.2% of all breast tumors. The clinical presentation and imaging features may mimic a malignant tumor. We reported a case of breast fibromatosis mimicking breast cancer.Case Presentation: A 22-years-old woman with a palpable breast lump was present and being examined. The ultrasound and mammography features suggested malignancy. Magnetic Resonance Imaging (MRI) and Multislice Computerized Tomography (MSCT) evaluation showed invasion of a tumor to muscle without intrathoracic involvement. A core biopsy was performed with the pathologic conclusion suspected as a phyllodes tumor with a differential diagnosis as mammary fibromatosis. The pathology result of intraoperative examination favor for fibromatosis. A wide excision procedure with a free margin could be achieved. The histopathological examination revealed spindle cells tumor infiltrating into muscle tissue. The result of immunohistochemistry examination excluded metaplastic carcinoma and Phyllodes tumor. Therefore, it confirmed a diagnosis of breast fibromatosis.Conclusions: Breast fibromatosis is a rare benign tumor of the breast that can mimic malignancy. This entity should be considered as one of the differential diagnoses in a patient with a breast lump. A pre-operative tissue diagnostic is mandatory to prevent radical treatment for this nonmalignant case.

Desmoid-type fibromatosis of the breast: A report of 2 cases.

Mammary fibromatosis is a rare and locally aggressive benign tumor of the breast; it originates from fibroblasts and myofibroblasts within the breast parenchyma and does not metastasize. The condition is locally aggressive and has a high rate of recurrence. The etiology of mammary fibromatosis is unknown. Breast imaging examinations are not specific for fibromatosis and often imitate breast cancer. The current study presents 2 cases of women with breast fibromatosis, the first of which exhibited a locally advanced aggressive form of the disease, where breast surgery and en bloc resection of the underlying regions of the thoracic wall were required. In the second case, breast imaging examinations suggested an invasive breast tumor, probably carcinoma, infiltrating the muscles of the chest wall. An ultrasound-guided core needle biopsy revealed a low-grade myofibroblastic proliferation consistent with breast fibromatosis. The patient underwent a right quadrantectomy, with a partial resection of the underlying musculature. The patients remain disease-free at the time of writing. As involvement of the breast in patients with desmoid-like fibromatosis as rare, the present study reports 2 cases with clinical features and histological findings in order to improve and add to the knowledge of this disease.

Unusual Ultrasonography Findings of Recurred Mammary Fibromatosis Mimicking Subareolar Mastitis: A Case Report

본원 내원 당시 이학적 검사에서 유륜 주위에 수술 상처가 있 Fibromatosis, also known as an extra-abdominal desmoid tumor, rarely occurs in the breast and is often mistaken for carcinoma, clinically and radiologically. Desmoid tumor is a monoclonal myofibroblastic neoplasm which is locally aggressive, but rarely metastasizes. We herein report a case of a 64-year-old woman who experienced two episodes of recurrence of mammary fibromatosis. The mass was initially detected by screening mammography. It appeared as an irregularly shaped mass which was confined within the mammary zone. Recurrences were excised from the right breast 10 and 17 months later. The second recurrence occurred in the subareolar area accompanied by skin thickening and showed an anechoic component on ultrasonography, which mimicked subareolar mastitis with an abscess.

Mammary fibromatosis (desmoid tumor) in a dog: cytological, pathological, and immunohistochemistry studies

In the present study, we describe an ill-defined firm mass in the mammary tissue in an 8-year-old terrier dog. Fine-needle aspiration (FNA) cytology showed a moderate cellularity with numerous bland bare nuclei and proliferating fibroblasts in a bloody background. Occasional clusters of spindle cells also were present. Histopathologically, a proliferation of spindle cells without atypia forming or interlacing fascicles was observed. A variable amount of collagen was seen in the background. There was no evidence of mitotic figures. Immunohistochemical analysis presented that the neoplastic cells expressed vimentin and smooth muscle actin (SMA) but did not stain for cytokeratin, S-100 protein, and CD 34. Based on cytology, histopathology, and immunohistochemical findings, the present tumor was diagnosed as mammary fibromatosis. Although fibromatosis has been reported rarely in the veterinary literature, it could be considered in differential diagnosis list of any spindle cell lesions in the breast. Histopathological examination in conjunction with the judicious use of immunohistochemistry (IHC) is required in order to reach a correct diagnosis.

P351 Mammary fibromatosis in a young woman with ipsilateral hypoplastic breast

P351 Mammary fibromatosis in a young woman with ipsilateral hypoplastic breast

Ultrasound elastographic findings of mammary fibromatosis.

Mammary fibromatosis is an uncommon, benign tumor of the breast. It is locally aggressive and has a high rate of recurrence. Its clinical presentation and imaging results always call for suspicion of malignancy. Here we describe a case of mammary fibromatosis with clinical manifestation, radiographic and pathologic results, and imaging findings from ultrasound elastography.

Extra abdominal mammary fibromatosis (Desmoid tumor) of breast in an elderly female

The extra-abdominal form of desmoid tumor is very rare and the incidence of mammary desmoid tumor is <0.2% of primary breast neoplasm. We report a case of mammary fibromatosis in an elderly female in which no associated risk factor was discernible. After simple mastectomy as per the patient’s wish, in view of posterior margin positivity, adjuvant radiotherapy was given. The patient has remained recurrence free after one year of follow up.

Primary fibromatosis of the breast in a 13 years old girl

The mammary fibromatosis is a rare clinical entity. The etiopathogeny remains unclear. The clinical and radiological characteristics of this injury are often worrying within the main differential diagnosis of the mammary carcinoma; however only the histological examination can confirm the diagnosis. It is characterized by a strictly local evolution with an infiltration and recidivism tendancy without giving metastasis. The treatment is basically surgical. We report here-with an observed case of 13-year-old girl, presenting with a huge tumor located in the left breast with ulceration of the nipple-areolar plate. The diagnosis is confirmed by the histological study. The treatment consisted of a mastectomy. Suites are simple. In view of the clinical evidence of the literature, we call back the difficulties of management of this tumor.

Primary fibromatosis of the breast in a 13 years old girl

The mammary fibromatosis is a rare clinical entity. The etiopathogeny remains unclear. The clinical and radiological characteristics of this injury are often worrying within the main differential diagnosis of the mammary carcinoma; however only the histological examination can confirm the diagnosis. It is characterized by a strictly local evolution with an infiltration and recidivism tendancy without giving metastasis. The treatment is basically surgical. We report here-with an observed case of 13-year-old girl, presenting with a huge tumor located in the left breast with ulceration of the nipple-areolar plate. The diagnosis is confirmed by the histological study. The treatment consisted of a mastectomy. Suites are simple. In view of the clinical evidence of the literature, we call back the difficulties of management of this tumor.

Fibromatosis of breast mimicking sarcoidosis

Primary mammary fibromatosis is a rare skin condition which can arise after trauma or previous surgery. The exact etiology is unknown. Very few cases have been reported in literature and the main emphasis is to differentiate this condition from breast carcinoma. We report here an unusual case of a 60 year old female who presented with skin lesion which clinically looked sarcoid with history suggestive of sarcoidosis, but on histopathology fibromatosis of breast was revealed. Complete work up ruled out any carcinomatous changes. Surgical excision of the lesion was done with no recurrence seen in one year follow up period.

Fibromatosis of the Breast: Case Report and Current Concepts in the Management of an Uncommon Lesion

Fibromatosis is an uncommon breast lesion that can mimic breast carcinoma in its clinical presentation. We present a case in which excisional biopsy was necessary to establish a diagnosis of fibromatosis. Clinical, diagnostic imaging, and pathologic features are discussed. Magnetic resonance imaging (MRI) has emerged as a tool for further characterization of breast lesions and as a screening modality in high-risk patient populations. Ours marks the second case in which dynamic MRI has been correlated with histologically confirmed primary mammary fibromatosis. Unlike the previous report, MRI in this case mimics breast carcinoma in its morphologic and pharmacokinetic features of enhancement. Wide local excision with clear margins remains the treatment of choice. Current data on radiotherapy and pharmacologic therapy for mammary fibromatosis are reviewed.

Mammary fibromatosis mimicking recurrent breast cancer: radiological findings

Sir: A 61-year-old female was diagnosed with invasive ductal carcinoma in the left breast in February 2000. She underwent left wide local excision and axillary nodal dissection. Lymphnodes were negative for metastases. The patient received chemotherapy as well as radiotherapy to the preserved left breast. She was under postoperative imaging follow-up. Bilateral mammography in March 2001 revealed a spiculated density without calcifications under the surgical scar of the left breast that correlated with post-surgical changes. Suspect breast lesions were not found on clinical examination. The mammogram performed in February 2002 showed the same findings but the density in the left breast seemed to increase in size. The sonography showed a solid mass with irregular margins and anechoic nodules in a postsurgical breast, but although fat necrosis was suggested, periodic mammographic follow-up of this probably benign lesion was performed. The last mammography (Fig. 1) showed again an increase in size of the density suspected of local recurrence. The magnetic resonance imaging (MRI) (Fig. 2) revealed postoperative scarring in the left breast and there were findings compatible with early tumor recurrence after conservative surgery, so surgical excision was performed. Histopathologically the tumor was fibromatosis of the breast and there was no evidence of malignancy (Fig. 3). Mammary fibromatosis is an uncommon benign lesion that clinically and radiologically may simulate breast cancer [1–5]. This unusual lesion has been presented in literature as a diagnostic challenge in a few cases series, describing its clinical, radiological and pathological features, but we did not find any report of fibromatosis of the breast after conservative cancer treatment simulating recurrent carcinoma. This lesion is included as a variant of spindle cell tumor of the breast, which can result in a wide spectrum of

Tumeur desmoïde du sein chez l’homme dans le cadre d’un syndrome de Gardner. À propos d’un cas

Fibromatosis (Desmoid tumor) of the male breast is an exceptional location. We present a case of such a tumor, in the context of Gardner’s syndrom. A palpable mass was discovered in the right breast of a 52 years old man, with a history of rectocolic adenomatous polyposis. Mammography ant thoracic CT scan showed a stellar tumor, mimicking a breast cancer. Treatment consisted of wide excision and histology revealed a desmoid tumor. Desmoid tumors of the breast are benign lesions; they should be widely excised because of a high risk of recurrence. Coloscopy is indicated in the presence of mammary fibromatosis, to look for associated multiple polyps, confirming the diagnosis of Gardner’s syndrom.

Benign and malignant spindle cell lesions of the breast

Spindle cell lesions of the breast constitute a wide spectrum of benign and malignant proliferations. Myofibroblasts, normal cellular constituents of the mammary intra- and interlobular stroma, compose many of these lesions, which include reactive proliferations and benign or locally aggressive neoplasms. Because of its morphology, low-grade metaplastic spindle cell carcinoma, “fibromatosis-like” is also considered together with spindle cell lesions of the breast. Although certain of the lesions do not occur commonly, they represent diagnostic challenges. This review outlines the morphology of certain spindle cell lesions of the breast including pseudoangiomatous stromal hyperplasia, reactive spindle cell nodule, nodular fasciitis, myofibroblastoma, primary mammary fibromatosis, and low-grade metaplastic spindle cell carcinoma, “fibromatosis-like.” The differential diagnosis and diagnostic work-up of these lesions is discussed, and their clinical treatment and prognosis briefly summarized.

Fibromatosis of the breast: a clinical, radiological and pathological study of 6 cases

We describe the clinical, radiological and pathological features of a series of six cases of primary fibromatosis of the breast. Most patients (5 of 6) were women of 22-58 years of age; one case occurred in a 47-year-old man. The fibromatosis of the breast in all cases presented as a monolateral solid nodule, clinically suspicious for malignancy and in three cases was also associated with cutaneous and/or nipple retraction. None of the patients was affected by any genetic disorder characterized by fibromatoses involving multiple sites, including breast. Both echographic and mammographic examinations revealed solid masses with irregular margins but without calcifications, mimicking scirrhous carcinoma. All cases were surgically treated by lumpectomy (4 of 6) or quadrantectomy (2 of 6), and after a follow-up period ranging from 5 months to 13 years all patients are well and disease-free. Histological examination revealed finger-like infiltrating margins entrapping adjacent breast parenchyma and adipose tissue in all cases. The hallmark of the lesion was the presence of bland-looking spindle cells, with a low mitotic index, organized in long sweeping and intersecting fascicles. Three different morphological phases (i.e. proliferative, involutional and residual), identical to those observed in Dupuytren's superficial fibromatosis, variably coexisted in each case. At immunohistochemistry the cells which comprised the lesion exhibited a diffuse expression of vimentin and a heterogeneous immunoreactivity to a-smooth muscle actin, thus confirming their fibro-myofibroblastic nature. No expression of estrogen, progesterone or androgen receptors or of pS2 correlated-estrogen protein was observed. We discuss both the pathogenesis of the mammary fibromatosis, pointing to the fibroblastic cells of the mammary stroma as the putative precursors, and the differential diagnosis versus the bland-looking, monomorphic spindle cell tumor-like or tumorous lesions of the breast.

Primary Fibromatosis of the Breast in a Patient with Multiple Desmoid TumorsReport of a Case with Evaluationof Estrogen and Progesterone Receptors

Fibromatosis (or desmoid tumor) is an infiltrative fibroblastic/myofibroblastic lesion presenting a moderate risk for local recurrence and no metastatic potential. Classically, these lesions are classified whether in abdominal or extra-abdominal sites, and may be multicentric or familial. Primary fibromatosis of the breast (PFB) is an uncommon lesion that shows histological similarities with abdominal fibromatosis (AF), and frequently poses difficulties in the differential diagnosis with other spindle cell tumors of the breast. It has been demonstrated that AF usually shows immunoreactivity for estrogen (ER) and progesterone (PR) receptors; conversely, in most of the studies, the cells from PFB are consistently negative for both receptors. We report on a case of a 41-year-old female with two desmoid tumors, affecting the abdominal wall and the breast tissue. To the best of our knowledge, there is no previous report in which hormonal receptors were evaluated in abdominal and mammary desmoid tumors in the same patient. We assessed the immunohistochemical expression of ER and PR in both lesions; while the AF showed immunoreactivity for both receptors, the cells from PFB were all negative. Although we have considered just this case, we still believe that these findings could support a distinctive etiopathogenesis of abdominal and mammary fibromatosis.

Fibrous Lesions of the Breast: A Review.

Fibrous lesions of the breast are challenging for a number of reasons. They occur infrequently and there is significant clinical, radiologic, and histologic overlap between reactive and neoplastic lesions, as well as with some nonfibrous lesions. Pure fibrous lesions of the breast encompass reactive conditions, such as scars and nodular fasciitis, and neoplastic entities, such as the distinct benign mammary myofibroblastoma, locally aggressive fibromatosis, and rare true sarcomas. In this review, we focus on nodular fasciitis, mammary myofibroblastoma, and primary mammary fibromatosis. We also briefly discuss spindle cell metaplastic carcinoma because it represents the most important differential diagnosis through its ability to closely simulate nodular fasciitis and fibromatosis. Caution should be exercised in the interpretation of fibrous lesions of the breast, especially if the tissue sample is limited. Int J Surg Pathol 8(2):99-108, 2000

A CASE OF MAMMARY FIBROMATOSIS

Mammary fibromatosis is a rare entity. In Japan, only several cases have been reported. We present a case of mammary fibromatosis with a review of the Japanese literature. A 56-year-old woman was seen at the hospital because of a tumor of the left breast. The tumor measuring 6×4cm in diameter with an unclear border was palpated in the upper quadrant of the left breast with reddness and retraction of the overing skin. IN clinical, radiological and ultrasonographic examinations, it was difficult to distinguish from brest cancer. Cytologic examination was negative for malignant cells. Because we could not rule out a possible malignancy, quadrantectomy was carried out. So a diagnosis of mammary fibromatosis was made. There has not been evidence of recurrence, as of 27 months after the surgery. They are characterised by infiltrative growth and a tendency to recurrence even after resection, but they never metastasize. So follow-up should be especially vigilant.