Malonic Acid Dihydrazide Research Articles

Synthesis, Spectroscopy and Biological Activity Study of Some New Complexes with Schiff Base Derived From Malonic Acid Dihydrazide with 2-pyridine Crboxaldehyde

تم تحضير ثلاث معقدات جديدة Ni (II)و Cu (II) و Zn (II) باستخدام الليكند المحضر الجديد من تفاعل حامض مالونيك ثنائي هيدرازايد مع 2-بيريدين كربوكسالديهايد. حيث شخصت المعقدات لمحضرة وكذلك الليكند باستخدام تقنيات مختلفة مثل FT-IR و UV-Vis و Mass و 1H-NMR و 13C-NMR وتحليل العناصر CHN و تقدير محتوى الكلور والموصلية المولارية والحساسية المغناطيسية والامتصاص الذري لتشخيص هذه المركبات. لكل معقد محضر جديد من النيكل والنحاس والزنك ، كشفت نتائج التشخيص عن معقدات ذات شكل هندسي ثماني السطوح سداسي التناسق. تمت دراسة تأثير المواد المحضرة على الفعالية البيولوجية لاثنين من البكتريا موجبة الغرام Staphylococcus aureus و Bacillus subtitles واثنين من البكتيريا سالبة الجرام Escherichia coli و Pseudomonas aeruginosa ، بالإضافة إلى candida fungusاثبتت جميع المركبات المحضرة قابلية تثبيطيه جيدة باستثناء معقد النيكل، الذي فشل في إحداث أي تأثيرات مثبطة فعالة ضد pseudomonas.

Synthesis of Zn(II) and Co(II) Complexes with a Schiff Base Derived from Malonic Acid Dihydrazide for Photo-Stabilizers of Polystyrene

Synthesis of Zn(II) and Co(II) Complexes with a Schiff Base Derived from Malonic Acid Dihydrazide for Photo-Stabilizers of Polystyrene

Russian-Doll-Like Porous Carbon as Anode Materials for High-Performance Potassium-Ion Hybrid Capacitors.

Pore-structure design with the sophisticated and pragmatic nanostructures still remains a great challenge. In this work, porous carbon with Russian-doll-like pores rather than traditional single modal is fabricated via a boiling carbonization approach, accompanied by K+ -pre-intercalation. The most important internal factor is that alkali can penetrate into the stereoscopic space of layered Malonic acid dihydrazide and the confinement effect leads to the in-depth development of different dimensional pore structures. The oxygenated and nitrogenated surface guarantees the K+ intercalation behavior. Benefiting from their open framework and enlarged interlayer spacing, K+ -pre-intercalated porous carbon with Russian-doll-like pores (denoted as KPCRPs) as anode material exhibits promising potassium storage performance. The assembled KPCRP//activated carbon potassium-ion hybrid supercapacitor in 30m CH3 COOK displays a high energy density of 157.29Whkg-1 , an ultrahigh power output of 14kWkg-1 , and a long cycling life (99.58% capacity retention after 10000 cycles), highlighting the superiority of Russian-doll-like pore structure. This work sheds light on the designing of 3D pores structure, especially for multimodal pore architectures.

Manganese and Iron Complexes with Malonic Acid Bis[2-(3,5-di-tert-butyl-2-hydroxybenzyl)hydrazide

New manganese(II) and iron(III) complexes with hydrazones derived from malonic acid dihydrazide and 3,5-di-tert-butylsalicylaldehyde have been synthesized. The structure of the complexes has been studied by IR and electronic spectroscopy and X-ray analysis. Malonic acid bis[(2-hydroxy-3,5-di-tert-butylbenzylidene)-hydrazide] has been shown to form dinuclear complexes with manganese and iron ions, in which ferromagnetic interaction between the metal ions is observed.

Synthesis of large diamond crystals with C3H8N4O2 as organic additive under HPHT conditions

Diamond crystals were successfully synthesized in a NiMnCo-C system by adding Malonic acid dihydrazide (C3H8N4O2) as an organic additive. The synthesized conditions in a series of experiments were about at 1300 °C–1400 °C and 6.0 GPa–7.0 GPa. The color, morphology, and inclusions of the synthetic diamond crystals were characterized by optical microscopy, Fourier transform infrared (FTIR) spectroscope and Raman spectroscope, respectively. The color of the synthesized diamonds changes from light yellow to green with increasing amounts of C3H8N4O2. The morphology of the synthesized diamonds exhibited triangular shape with abundant {111} faces. The FTIR spectra indicated that the nitrogen concentration increased whereas the hydrogen and oxygen concentration decreased with increasing concentration of the C3H8N4O2 additive. The Raman peak positions exhibited a systematic downshift with increasing amounts of C3H8N4O2 additive. According to the synthesized resultant, with increased the content of the C3H8N4O2 additive, the quality of synthesized diamond gets worse. It is interesting that the diamond content more nitrogen and less hydrogen and oxygen with increasing the C3H8N4O2 additive. By studying the effects of nitrogen, hydrogen and oxygen coexistence on the synthesis of diamond, it is would to speculate that the natural diamond nucleation and growth environment may be content more nitrogen source and less hydrogen and oxygen.

Near-infrared reflecting blue inorganic nano-pigment based on cobalt aluminate spinel via combustion synthesis method

CoAl2O4 nanoparticles as a high NIR solar reflectance inorganic pigment was successfully prepared by combustion synthesis using glycine, malonic acid dihydrazide as a simple fuel and mixture of them with different molar ratio, following by annealing in temperature range of 400–1000 °C. As-prepared and annealed products characterized by using various tools such as TGA/DTA, XRD, HRTEM, EDX, DRS, FTIR. The color of products was studied using CIE1978 L∗a∗b∗ colorimetric method. In addition, the solar reflectance was determined by using (JIS) standard k5602-2008. The obtained results referred that powder product exhibits a high solar reflectance with value 38.18% in UV–Visible region, 51.82% in NIR region and total solar reflectance was 43.7% and the optical band gap of products was determined. The blue pigments on glaze give a maximum NIR solar reflectance in range of 61.3–69.08%. These results demonstrate the prepared products are a suitable as cool blue inorganic pigments on glaze.

Low-Temperature Combustion Synthesis and Properties of CoFe2O4 and CoGa x Fe2 – xO4 (x = 0.05, 0.10) Nanoparticles

CoFe2O4 and CoGa x Fe2 – xO4 (x = 0.05, 0.10) nanopowders have been synthesized via low-temperature combustion using cobalt, gallium, and iron complexes of malonic acid dihydrazide as precursors. Presynthesized precursors have been shown to decompose at temperatures as low as 250–300°C to form mineral residues with an amorphous structure after the combustion of the organic component. Heat treatment above 700°C leads to an onset of crystallization. The formation of the spinel structure reaches completion at 1200°C. The average particle size of the CoFe2O4, CoGa0.05Fe1.95O4, and CoGa0.1Fe1.9O4 powders has been determined to be 476, 435, and 317 nm, respectively. The electrical resistance and dielectric permittivity of the samples have been measured as functions of annealing temperature.

Photocatalytic Chemoselective Aerobic Oxidation of Thiols to Disulfides Catalyzed by Combustion Synthesized Bismuth Tungstate Nanoparticles in Aqueous Media

Bismuth tungstate (Bi2WO6) nanoparticles were synthesized by solution combustion synthesis method using different N-containing organic compounds as fuels (urea, glycine, hexamethylenetetramine (HMTA), malonic acid dihydrazide (MDH)). The Bi2WO6 nanoparticles have been characterized using XRD, UV–Vis–DRS, photoluminescence, FESEM, HRTEM and sorptometric techniques. Glycine as fuel was effective for synthesis of phase pure Bi2WO6 nanoparticles. Employing HMTA and MDH as fuel lead to mixed phase complex oxide system with Bi14W2O27 as minor (impurity) phase. The nature of the fuel significantly influences the particle size and morphology. Formation of spherical, flake like and elongated polyhedral particles were observed in FESEM study depending upon the nature of the fuel. TEM study of Bi2WO6 prepared using glycine fuel depicted the presence of spherical particles with size in the range of 5–8 nm. The Bi2WO6 nanoparticles were used as an efficient photocatalyst for the visible light driven chemoselective oxidation of substituted thiophenols to disulfide using air as oxidant. The effect of various reaction parameters such as catalyst amount, reaction media, time, along with catalyst recyclability were studied in detail. Structurally diverse diphenyl disulfide moieties were obtained in high yield and excellent selectivity within a time span of 6 h of visible light irradiation.

Chemical speciation studies on the complexation of ditopic ligands : Interaction of malonic acid dihydrazide with some divalent transition metal ions in aqueous medium

Chemical speciation studies on the complexation of ditopic ligands : Interaction of malonic acid dihydrazide with some divalent transition metal ions in aqueous medium

Synthesis, characterization and biocidal activity of some transition metal(II) complexes with isatin salicylaldehyde acyldihydrazones

Cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes with two new unsymmetrical ligands, isatin salicylaldehyde oxalic acid dihydrazide (isodh) and isatin salicylaldehyde malonic acid dihydrazide (ismdh) were synthesized and characterized by elemental analyses, electrical conductance, magnetic moments, electronic, NMR, ESR and IR spectral studies. The isodh acts as a dibasic tetra dentate ligand bonding through two >C=N-, a deprotonated phenolate and deprotonated indole enolate groups to the metal. The ismdh ligand shows monobasic tetra dentate behaviour in bonding with metal ion through two >C=N-, indole >C=O and a deprotonated phenolate group. The electronic spectral data suggest 4-coordinate square planar geometry for Co(II), Ni(II) and Cu(II) complexes of isodh, whereas, 6-coordinate octahedral structure for the ismdh complexes. The ESR studies also indicate a square planar and distorted octahedral environment around Cu(II) for isodh and ismdh complexes, respectively. Most of the metal complexes show better antifungal activity than the standard and a significant antibacterial activity against various fungi and bacteria.

Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide

A novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N′, N′ 2 -bis[(1 E)-1-(2-pyridyl)ethylidene]propanedihydrazide was synthesized and characterized by elemental analysis, spectroscopy (NMR and infrared), and X-ray crystal analysis. The complex showed a moderate activity towards Artemia salina. The highest cytotoxic potential of the complex was observed on the epithelial breast cancer (MDA-361) cell line. The investigated complex induced apoptosis, the early apoptotic cells comprising 28.18%, compared to 5.64% of control cells in the same phase. The interaction of the complex with calf thymus DNA (CT-DNA) was monitored by blue shift and hyperchromism in the UV–vis spectra. The observed intrinsic binding constant ( K b = 4.2 × 10 5 M − 1 ) together with structural analysis of the complex indicate the groove binding.

A comparative study of DNA binding and cell cycle phase perturbation by the dinuclear complex of Cd(II) with the condensation product of 2‐acetylpyridine and malonic acid dihydrazide N′,N′2‐bis[(1E)‐1‐(2‐pyridyl)ethylidene]propanedihydrazide

Organometallic Cd(II) compounds have recently attracted attention for their anticancer activity. The interaction of the dinuclear complex of Cd(II) with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2) -bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide (Cd(II)H(2) L), with calf thymus DNA (CT-DNA) was monitored by blue shift in UV-vis spectra of the complex. The binding constant of Cd(II)H(2) L complex with CT-DNA was determined (K(B) = 1.8 × 10(4) M(-1) ) and was indicative of minor groove binding. Agarose gel electrophoretic changes in mobility of supercoiled and circular forms of pBR322 and pUC18 plasmids in the presence of the complex suggest that conformational changes in the plasmids occur upon binding of the Cd(II)H(2) L complex. The Cd(II)H(2) L complex induced perturbation of the cell cycle phase distribution and an increase in the percentage of cells in the sub-G1 phase of human cervical cancer HeLa cell line and murine melanoma B16 cell line. Immunoblotting analysis showed the overexpression of Bcl-2 protein with the Cd(II)H(2) L complex.

Synthesis from L-menthol of optically active macrolides with N-containing (azine or hydrazide) groups

Potentially useful 15- and 20-membered macrolides containing azine or hydrazide groups were synthesized from L-menthol via [1+1]-condensation at room temperature of 3R,7-dimethyl-6-oxooctyl-3R,7-dimethyl-6-oxooctanoate, which was obtained from 3R,7-dimethyl-6-oxooctanal via a Tishchenko reaction, with hydrazine hydrate or malonic acid dihydrazide.

Metal assisted self-assembled nano sized porous 2-D structures incorporating malonic acid dihydrazide and melamine

The solids Cu(MADH)2·Cl2·2TAT·9H2O and Zn(MADH)2·Cl2·2TAT·2H2O (MADH = malonic acid dihydrazide and TAT = melamine) characterized by spectroscopic and elemental analysis, have been investigated by transmission electron microscope. Microstructure at high magnification revealed the supramolecular assembly of MADH and TAT into a mesh structure in presence of Cu(II) metal ions and tubular structure with intermittent openings on the tube walls and Y- junctions for Zn(II) complex. The mesh structure of the Cu(II) complex has uniformly spaced 40–50 nm long and 20–30 nm wide openings, while the diameter of the tubular structure of the Zn(II) complex is 50–200 nm.The assembly of the supramolecular structure is attributed to H-bonding and the different architectures of the assembly with different metal ions to the difference in waters of crystallization. The potential of the complex for gas adsorption was also investigated.

Conversions of Coumarins Accompanied by Intermediate Opening and Recyclization of the Lactone Ring. 2. Study of the Interaction of Malonic Acid Hydrazide and Amide Derivatives with 3-Acyl(3-cyano, 3-ethoxycarbonyl)Coumarins

Reaction between the N,N′-diisopropylidene and N,N′-diacetyl derivatives of malonic acid dihydrazide and 3-acyl(3-cyano, 3-ethoxycarbonyl)coumarins under the conditions of the Michael reaction lead to the formation of N′-isopropylidene and N′-acetyl derivatives of coumarin-3-carboxylic acid hydrazide. Ethoxycarbonylacethydrazide reacts in an analogous manner. Special features have been studied of the interaction of malonic acid amide derivatives with unsubstituted coumarin and with coumarins containing electron-withdrawing groupings in position 3 of the ring.

Supramolecular Motifs in Metal Complexes of Malonic Acid Dihydrazide: Copper(II) and Zinc(II) Assisted Assembly of Malonic Acid Dihydrazide with Melamine

One pot condensation of malonic acid dihydrazide (MADH) in the presence of metal salts (CuCl2·H2O and ZnCl2) with melamine (TAT) has been achieved. The solids Cu(MADH)2Cl2·2TAT·9H2O and Zn(MADH)2Cl2·TAT·1/2H2O thus obtained were characterized by elemental analysis, FAB mass, i.r., n.m.r., u.v.–visible and e.p.r. spectral data together with their powder X-ray diffraction, optical microscopy, scanning electron microscopy (SEM) and atomic force microscopy (AFM)(Zn complex only). Variable temperature solid slate conductance measurements have also been made.

Combustion Synthesis and Magnetic Properties of Nanosize Barium Hexaferrite

Nanosize (< 50 nm) barium hexaferrite (BaFe12O19) has been prepared by solution combustion method using ferric nitrate, barium nitrate and hydrazine based fuels like oxalyl dihydrazide (ODH), malonic acid dihydrazide (MDH) and maleic hydrazide (MH). The formation of BaFe12O19, has been confirmed by its characteristic powder X-ray diffraction pattern. The nanosize nature of BaFe12O19 particles has been determined from X-ray line broadening, Mossbauer spectrum, BET surface area measurements and Transmission Electron Micrographs (TEM). The variation of magnetic properties of the powders with sintering temperature and particle size has been investigated. The Hc and Ms values are in the range of 500–1600 Oe and 25–45 emu/gm respectively. Microstructures of the sintered specimens show grain size in the range of 2–6 μm.

Reversible and irreversible cross-linking of immunoglobulin heavy chains through their carbohydrate residues

After periodate oxidation and incubation with a dihydrazide, cross-linking of the two heavy chains of immunoglobulins G from several species proceeds specifically through their oligosaccharides. We have used malonic acid dihydrazide, adipic acid dihydrazide and dithiodipropionic acid dihydrazide. The last compound is introduced in this work as a cleavable-carbohydrate-specific cross-linker. It was found that in rabbit and human immunoglobulins the degree of cross-linking was strongly dependent on the oxidation conditions but only very weakly dependent on the concentration and size of the dihydrazides. Papain cleavage of the cross-linked rabbit IgG indicated that the cross-linking occurred predominantly, if not exclusively, in the Fc region, probably through the two glycans linked to Asn-297 in the CH2 domain of each of the two heavy chains. The immunoglobulins from sheep, pig, goat and guinea pig show a comparable cross-linking pattern, indicating that the sugar chains from these immunoglobulins have a spatial structure closely related to that of rabbit and human IgG. When dithiodipropionic acid dihydrazide was used as the cross-linker, the cross-link could be cleaved by mercaptoethanol.

銅（ＩＩ）イオンを選択的に捕集するマロン酸ジヒドラジド系キレート樹脂

銅（ＩＩ）イオンを選択的に捕集するマロン酸ジヒドラジド系キレート樹脂

Reactions of uranyl(VI) complexes of acid dihydrazides with ?-diketones

Uranyl(VI) complexes of malonic acid dihydrazide (MDH2) and phthalic acid dihydrazide (PDH2) and the products of their reactions with four β-diketones have been characterised by elemental analysis and by electrical conductance, and spectral (i.r. and electronic) measurements. The MDH2 and PDH2 complexes UO2(L)2(H2O)2 are eight coordinate whereas the macrocyclic UO2(L′)(H2O)2 complexes are six coordinate. In each complex MDH2 and PDH2 act as bidentate liglands having the coordination sites at secondary amide-nitrogen atoms.