Objective: This retrospective study aimed to compare Class III malocclusion treatment changes performed with two different preadjusted bracket prescriptions: Biofunctional and Roth.
 Material and Methods: The sample comprised 84 Class III malocclusion patients treated with compensatory approaches. The sample was divided into 2 groups: Group 1 (Biofunctional): 36 patients (23 female, 13 male) with a mean initial age of 20.04 years and a mean treatment time of 2.53 years. Group 2 (Roth): 48 patients (28 female and 20 male) with a mean initial age of 19.05 years and a mean treatment time of 2.64 years. Intergroup comparisons at the pre- (T1) and posttreatment (T2) stages and of the treatment changes (T2-T1) were performed with t tests.
 Results: There were greater maxillary and mandibular incisors labial and lingual tipping and greater occlusal plane counterclockwise rotation in the Roth than in the Biofunctional prescription.
 Conclusion: Compensatory Class III malocclusion treatment performed with the Biofunctional prescription minimizes the side effects of Class III elastics.