Malignant Round Cell Tumor Research Articles

Ewing sarcoma presenting in the lung: a case report

BackgroundEwing sarcoma is a malignant round-cell tumor that primarily affects bones in children. It can also arise in extraosseous tissues, such as the lung, kidneys, and liver. The presentation symptoms of Ewing sarcoma may include cough, dyspnea, and chest pain.Case presentationThis report details the history of a 15-year-old Syrian boy with a previous diagnosis of Hodgkin lymphoma who presented with chronic shoulder pain. Imaging studies revealed an 80 mm mass in the apex of the left lung, which was confirmed through histopathological examination to be Ewing sarcoma following a computed-tomography-guided biopsy. The patient received multiple cycles of chemotherapy and subsequently underwent surgical resection of the remaining mass.ConclusionsThis case highlights the rare occurrence of Ewing sarcoma in the lung and the unusual clinical presentation of shoulder pain without other accompanying symptoms.

Ewing Sarcoma of Kidney: A Rare Entity

AbstractPrimary renal origin of Ewing sarcoma/PNET (primitive neuroectodermal tumor) is a rare entity in the adult population and has an aggressive outcome. The entity was first coined by Arthur Purdy stout in 1918 and recognized under family of small round cell tumor. Radiologically it is difficult to distinguish from primary clear cell carcinoma of kidney from Ewing/PNET. Diagnosis of this requires histopathology, immunohistochemistry (IHC), and cytogenetics studies.A 40-year-old female presented with hematuria and radiology found a mass lower pole of left kidney with extension into renal hilum. Nephrectomy was done for the case and the histopathology diagnosis of small round cell tumor of left kidney was given. Followed by IHC, diagnosis of malignant round cell tumor was suggestive of Ewing sarcoma.Microscopy showed cells with small, round, hyperchromatic nuclei, scant cytoplasm, and inconspicuous nucleoli. Increased mitosis was noted (15/10 high power field). Multiple foci of pseudorosettes, areas of hemorrhage, and necrosis lymphovascular emboli were seen.IHC done outside showed NKX 2-2, synaptophysin positivity, CD99 diffuse membranous positivity, cytokeratin perinuclear dot like positivity, and negative for CD20, CD3, desmin, CD34, S100, and Pax8. Impression of malignant round cell tumor was suggestive of Ewing sarcoma.Ewing sarcoma is one of the rare yet highly aggressive tumors. This should be kept as differential diagnosis in young adults with renal mass, as on radiologically it cannot be differentiated from renal cell carcinoma. Diagnosis of Ewing sarcoma is done using histopathology, IHC, and cytogenetic study. Early diagnosis helps in initiation of surgery, chemotherapy, and radiotherapy and helps in increasing the survival rate.

Renal CIC-LEUTX rearranged sarcoma with multiple pulmonary metastases: a case report and literature review

BackgroundCIC-rearranged sarcomas (CRS) are a group of heterogeneous tumors which mostly occur in the soft tissues of limbs and trunk, and are highly invasive with poor prognosis. Here, we describe a rare case of CRS that occurred in the left kidney with a CIC-LEUTX rearrangement.Case presentationA 45-year-old male was admitted to hospital with a dry cough for more than two months without obvious cause. Physical examination and laboratory tests revealed no notable abnormality. The CT scan demonstrated a mass in the left kidney and multiple nodules in both lungs. The percutaneous core needle biopsy showed similar histomorphology and immunophenotype of small round cell malignant tumors. Genetic test revealed a CIC-LEUTX gene fusion.ConclusionsWe present a rare primary renal CRS with multiple pulmonary metastases, and LEUTX is confirmed as the fusion partner of CIC gene for the first time in a renal case.

Case Report: Cytodiagnosis of primitive neuroectodermal tumor (PNET) of sinonasal tract

Malignant sinonasal tumors are rarely encountered in the practice of oncology as they constitute only 1% of total body tumors. The occurrence of primitive neuroectodermal tumor (PNET) in the sinonasal tract is even more uncommon. The PNET belongs to Ewing sarcoma family and forms the differential diagnosis of a large group of lesions generally described as malignant round cell tumors. The unique pathogenetic chromosomal alteration in this lesion is the EWS FLI1 fusion gene. This case report describes the unusual occurrence of PNET for its cytomorphological diagnosis along with its clinical features, radioimaging findings and immunohistochemistry. Such case reports are scarce in literature and cytodiagnosis of PNET in sinonasal tracts warrants its sharing with medical fraternity as such diagnoses are stumbled along rarely in clinical practice.

Primary Nodal Merkel Cell Carcinoma: Rare Presentation

Merkel cell carcinoma (MCC) is a very rare high-grade neuroendocrine carcinoma that is frequently located in the skin. Although most cases are associated with Merkel cell polyomavirus, there are also cases in which the virus cannot be detected. The purpose of presenting the case of MCC with primary nodal involvement is due to its rare presentation. 
 A 59-year-old male patient presented to the hospital with painless mass in the neck. Imaging analyses revealed necrotic lymphadenopathies on the neck, measuring up to 4.5 cm in size. After an explorative surgery with preliminary diagnoses of lymphoma and squamous cell carcinoma , samples taken from the excised mass showed high-grade neuroendocrine carcinoma morphology. In addition to neuroendocrine markers, CK7 and CK20 positivity were observed in the immunohistochemical tests performed. As a result, the case was evaluated in favor of MCC with negativity of markers performed to exclude other malignancies. Subsequently, a diagnosis of primary nodal MCC was made due to the absence of a different focus other than lymph node on PET imaging analysis.
 The differential diagnosis should be kept broad due to the histopathological morphology of small round cell malignant tumors. In addition in high-grade neuroendocrine carcinomas, the possibility of MCC should be ruled out especially if CK20 positivity is present. Although is has been reported that primary nodal MCC cases have a better clinical course compared to nodal metastatic cases with a known primary, there are limited case series studies on this topic. A multisystem approach is recommended for proper clinical management.

Long term follow-up results of enucleation as the definitive treatment for melanocytic neuroectodermal tumour of infancy and a review on its treatment.

Melanotic Neuroectodermal tumour of Infancy (MNTI) is a rare entity of pigmented neoplasms of head and neck region. It predominantly occurs within the first year of life. The authors present enucleation as the definitive surgical treatment, with reference to the five departmental cases of MNTI with no recurrence at 5years and 1year of follow-up of other 4 cases. Five cases of MNTI (age group of 2.5months-7 months) presented to our department as a large bluish-brown non tender swelling protruding into the oral cavity. Radiologic imaging revealed a well-circumscribed solid-cystic enhancing lesion causing elevation of orbit and nasal obliteration in maxillary region and causing buccolingual expansion in mandible. The tumor was enucleated without any bony margin. Histopathological and immunohistochemical evaluation (EMA, Pan Cytokeratin, HMB45, S100, p53, ki67) were done. Patients were followed up at regular intervals and had no recurrence at mean 3years follow-up. A detailed mention of surgical pearls, differential diagnosis and a brief literature review are also done. MNTI is a pigmented neoplasm that occurs in infants and in head and neck region mostly involves the upper alveolus and maxilla, followed by skull and mandible. Incisional biopsy is needed to confirm the tumour and rule out other malignant round cell tumours. Enucleation of the lesion is necessary without the need for any extra bony margin removal. Close long term follow up is necessary. Conservative surgical approach is usually the best first choice for MNTI treatment.

Multicentric malignant round cell tumour in a cria: Clinical presentation, pathologic findings and differential diagnoses

AbstractA 2‐month‐old cria that died following a short episode of constipation and diarrhoea was presented for a postmortem examination. The main macroscopic findings were widely disseminated, multinodular, whitish lesions involving liver and kidney and severe and diffuse haemorrhagic jejunitis. Histopathologically, the nodules are characterised by sheets of neoplastic round cells. An immunohistochemical panel including lymphoid, histiocytic/myeloid and pan‐neuroendocrine markers was performed. Taking into account the epidemiology of malignant round cell tumours in camelids, the neoplastic cell morphology as well as the negativity to all the tested markers, null cell lymphoma is considered as the most likely differential diagnosis. As recently highlighted by the literature, these findings confirm lymphoma as a potential systemic and aggressive neoplasm in young alpacas.

Cases of CHOP Chemotherapy - Unresponsive Primary Cutaneous Diffuse of Large B-Cell Lymphoma in Abdul Wahab Sjahranie Regional Public Hospital: A Case Presentation and Brief Review of Literature

Introduction: Primary cutaneous diffuse large B-cell lymphoma (PCDLBCL) is a variety of B-cell neoplasms that are present in the skin with no evidence of extra-cutaneous disease at the time of diagnosis or even after 6 months of the diagnosis. Cutaneous B-cell Lymphoma (CBCL) comprises 25 to 35% of all primary cutaneous lymphomas. Due to the relative rarity of PCDLBCL, there are no completed randomized trials to clarify the optimal treatment. Reported therapy options include radiotherapy, multiagent chemotherapy, chemotherapy, polychemotherapy with rituximab, and rituximab as a single agent.Case Presentation: Several red nodular lesions on the back developed over 10 months are found in a 40-year-old woman. The first Incision biopsy revealed these lesions were malignant roundcell tumors. After being treated with 10 cycles of chemotherapy regimens comprising cyclophosphamide, doxorubicin, vincristine, dan prednisone (CHOP), there was a progressive response as several red nodular lesions are getting larger and turned into an ulcerated wound. Wide excisions and skin flaps were done. Anatomical pathology examination showed diffuse non-Hodgkin lymphoma, a large B cell that belongs to intermediate malignancy, as immunohistochemistry was positive for CD20 and CD45. The patient was then diagnosed with primary cutaneous diffuse large B-cell lymphoma and given rituximab, a CD20-targeted therapy. The patient was allowed to be discharged on the second day after surgery.Conclusions: This case report presents cases of CHOP chemotherapy-unresponsive PCDLBCL in Abdul Wahab Sjahranie Regional Public Hospital of Samarinda, East Kalimantan.

A CASE REPORT OF SOFT TISSUE EWING'S SARCOMA OF NASAL SEPTUM

Ewing's sarcoma, an aggresive malignant round cell tumour of bones , arising most commonly in long bones and in young age group. This is a case report of Ewing's sarcoma of extra osseous origin arising from cartilagenous septum and in atypical age group, A 51 year old male, presented to ENT opd with 2 years history of right sided nasal obstruction and reccurent unprovoked anterior epistaxis. Biopsy taken from the mass in right nasal cavity revealed small round blue cell tumor on HPE , and, NKX2.2, CK and Synaptophysisn are positive. PET CT conrmed a local metastatic node ( level 1B ). Post surgery( excision of tumour with free margins ) , Patient is on chemotherapy and is on regular follow up. No evidence of reccurence and metastases were observed so far

Primary Non Hodgkin Lymphoma on the left breast of a 53 year old woman: A rare case report

Primary breast lymphoma (PBL) is a rare but distinct subtype of extranodal lymphoma, comprising 0.5% of breast malignancies, approximately 1% of all non-Hodgkin's lymphomas (NHL) and <3% of extranodal lymphomas. Because the cases are rare, the diagnosis is difficult to establish by routine histopathological examination alone. This paper reports a case of a 53-year-old woman, complaining of a lump in the left breast. The lump is said to have been noticed since approximately 2 years ago on the nipple. The patient said that initially the lump was the size of a grape and then realized that it had enlarged since 3 weeks ago with a more chewy texture. Ultrasound of the left mammary, heterogeneous solid lesion with indistinct borders with dilatation of the drawerous duct with the appearance of intraductal calcification filling the superolateral and superomedial quadrants of the left mammary suggestively malignant (BIRADS 5). The microscopic appearance of the FNAB suggested a malignant round cell tumor. Based on the results of the biopsy and immunohistochemical examination, the results were positive CD 45, CD 20 positive, CD 3 negative, and Ki67 positive in 90% of tumor cell nuclei. It was concluded that it was a non-Hodgkin's lymphoma, with a large diffuse pattern. The patient was reported did not survive.

C-Reactive Protein Pretreatment-Level Evaluation for Ewing's Sarcoma Prognosis Assessment-A 15-Year Retrospective Single-Centre Study.

A pathological/inflamed cellular microenvironment state is an additional risk factor for any cancer type. The importance of a chronic inflammation state in most diffuse types of tumour has already been analysed, except for in Ewing's sarcoma. It is a highly malignant blue round cell tumour, with 90% of cases occurring in patients aged between 5 and 25 years. Worldwide, 2.9 out of 1,000,000 children per year are affected by this malignancy. The aim of this retrospective study was to analyse the role of C-reactive protein (CRP) as a prognostic factor for Ewing's sarcomas. This retrospective study at Klinikum rechts der Isar included 82 patients with a confirmed Ewing's sarcoma diagnosis treated between 2004 and 2019. Preoperative CRP determination was assessed in mg/dL with a normal value established as below 0.5 mg/dL. Disease-free survival time was calculated as the time between the initial diagnosis and an event such as local recurrence or metastasis. Follow-up status was described as death of disease (DOD), no evidence of disease (NED) or alive with disease (AWD). The exclusion criteria of this study included insufficient laboratory values and a lack of information regarding the follow-up status or non-oncological resection. Serum CRP levels were significantly different in patients with a poorer prognosis (DOD) and in patients who presented distant metastasis (p = 0.0016 and p = 0.009, respectively), whereas CRP levels were not significantly different in patients with local recurrence (p = 0.02). The optimal breakpoint that predicted prognosis was 0.5 mg/dL, with a sensitivity of 0.76 and a specificity of 0.74 (AUC 0.81). Univariate CRP analysis level >0.5 mg/dL revealed a hazard ratio of 9.5 (95% CI 3.5-25.5). In Ewing's sarcoma cases, we consider a CRP pretreatment value >0.5 mg/dL as a sensitive prognostic risk factor indication for distant metastasis and poor prognosis. Further research with more data is required to determine more sensitive cutoff levels.

Cytological diagnosis of olfactory neuroblastoma at metastatic sites, with emphasis on role of insulinoma-associated protein 1 immunocytochemistry.

Olfactory neuroblastoma (ONB) is a rare neuroectodermal tumor with a propensity for lymph node and distant metastases in a proportion of cases, presenting opportunities for cytological diagnosis. Insulinoma-associated protein 1 (INSM1) is a recently identified marker of neuroendocrine differentiation with higher sensitivity and specificity than traditional neuroendocrine immunostains used in diagnosis of ONB. Archival aspirates diagnosed as metastatic ONB were retrieved and reviewed for described characteristics of ONB. Spare direct smears with sufficient cellular material from each case were selected, if available, and immunocytochemistry for INSM1 was performed on the destained alcohol-fixed smears. INSM1 was also performed on non-neuroendocrine malignant round cell tumors (MRCT). Seven fine needle aspirates (FNA) from five patients were identified, all of which showed a small round cell tumor with fine to coarse granular chromatin. Most cases had moderate to high cellularity, comprised of loosely cohesive clusters and dispersed cells. While two-cell pattern, nuclear streaking and moulding were frequent, background neuropil, fibrillary cytoplasm, and rosettes were uncommon. INSM1 immunostaining performed on spare direct smears showed strong positivity in 30%-100% of tumor cells (mean: 62%) in all aspirates tested (100%). In comparison with other immunostains, INSM1 showed more robust staining, and was easier to interpret. All non-neuroendocrine MRCTs were negative for INSM1. Metatstatic ONB can resemble other small round cell tumors, as all the diagnostic features of ONB may not be readily evident. INSM1 immunocytochemistry has high sensitivity and specificity and can reliably be used as a single marker to support the cytomorphology for a confirmatory diagnosis of ONB, even on direct smears if a cell block is not available.

AML-034 Granulocytic Sarcoma Disguised as Lymphoblastic Lymphoma

Acute myeloid leukemia (AML) is a malignant clonal disease of hematopoietic stem cells affecting the blood and bone marrow. Granulocytic sarcoma (chloroma) is a rare disease characterized by an extramedullary myeloid cell mass with or without bone marrow infiltration. We report a case of AML presented with granulocytic sarcoma causing cord compression. An 18-year-old male presented in January 2022 with acute onset and progressive low backache and lower limb weakness with no history of associated trauma. The condition was followed one week later by urine and stool incontinence. Clinical examination revealed motor and sensory impairment with bladder and bowel dysfunction. Pan CT scan showed an anterior mediastinal amalgamated lymph node with central necrosis and heterogeneous enhancement measuring 3.5×6 cm. MRI study detected a dorso-lumbar intradural extramedullary lesion 5×8×6 cm and a heterogeneously enhancing pre-sacral soft tissue mass measuring 3.2×7×6 cm. Biopsy and pathological examination of the dorsal mass showed infiltration by sheets and aggregates of malignant round cell tumor with diffuse, positive reaction of the tumor cells by LCA, CD99, PAX5, and BCL2 and 80%-90% of the cells positively stained by Ki-67, a picture suggestive of B-cell lymphoblastic lymphoma. A complete blood count revealed the following: white blood cell count 6.5×109/l, absolute neutrophil count 2.4×109/l, hemoglobin 11.9 g/dl, mean corpuscular volume 88.6 fl, platelets 217×109/l. Along with further immunohistochemical assessment of the dorsal lumbar mass, bone marrow examination showed 70% of blast cells positively stained for MPO, CD117, CD33, CD34, HLADR, and CD58 and negatively stained for TdT, CD79, cCD3, CD22, CD19, CD10, and CD20 with further immune staining of the spinal mass. The picture was consistent with AML. Treatment commenced, and the patient achieved complete remission following 2 induction therapies with a "7+3" regimen. On the clinical level, the patient showed noticeable improvement in sensation and motor power and was under high-dose cytarabine while the article was written. Myeloid sarcoma is a rare tumor consisting of immature granulocytic cells and is frequently misdiagnosed particularly in the absence of clinical suspicion of myeloid malignancies. Competent diagnostic clinical, laboratory, and radiological imaging of granulocytic sarcoma are crucial for proper management.

Expression and diagnostic value of NKX3.1 and NKX2.2 in mesenchymal chondrosarcoma

Objective: To investigate the immunohistochemical expression of NKX3.1 and NKX2.2 in mesenchymal chondrosarcoma (MC), and to explore the differential diagnostic value of NKX3.1 and NKX2.2 in MC and other types of small round cell malignant tumors. Methods: A total of 12 cases of MC and 97 other small round cell malignant tumors diagnosed in Jinling Hospital, Nanjing University School of Medicine from 2001 to 2020 were collected for NKX3.1 and NKX2.2 immunohistochemical detection. Among them, two kinds of NKX3.1 antibodies [rabbit polyclonal antibody and rabbit monoclonal antibody (EP356)] were used for detection in 12 cases of MC, and one NKX3.1 antibody (rabbit polyclonal antibody) was detected in 97 cases of other small round cell malignant tumors, and the relevant literature was reviewed. Results: The 12 MC patients included 7 females and 5 males, with a mean age of 33 years (14-54 years). Nine cases were from bone and three from soft tissue. Among the 12 MC patients, 8 patients had postoperative recurrence or metastasis, and 3 of them died of tumor recurrence or metastasis. Histologically, 12 cases of MC showed typical bidirectional differentiation.The positive rate of both NKX3.1 antibodies in MC was 12/12, NKX3.1 was focal weakly positive in only one of 12 chondrosarcomas (grade 3), 5 alveolar rhabdomyosarcomas, 5 embryonal rhabdomyosarcomas, and 5 solitary fibrous tumors, respectively. The remaining 70 cases of other small round cell malignant tumors were negative. The positive rates of NKX2.2 in MC, Ewing sarcoma and olfactory neuroblastoma were 12/12, 15/15 and 4/5, respectively. In 12 cases of chondrosarcoma (grade 3), 5 cases of poorly differentiated synovial sarcoma, 5 cases of alveolar rhabdomyosarcoma, and 5 cases of solitary fibrous tumor, NKX2.2 was focally and weakly positive in only one case, respectively, and all the remaining 50 cases of other small round cell malignant tumors were negative. Conclusions: The expression of NKX3.1 and NKX2.2 proteins are significant indicators in the diagnosis of MC, and the combined detection of NKX3.1 and NKX2.2 can help distinguish MC from most other small round cell malignant tumors.

Prevalence of Tumors in the Posterior Cerebral Fossa in Children and Adults, as well as their Histological Kinds: a Cross-Sectional Study

Aim: To determine the prevalence of posterior fossa tumors in children and adults, as well as their histological kinds. Study design: A cross-sectional study Place and duration: From February 2012 to January 2019, the Department of Neurosurgery at Riyadh Care Hospital Methodology: We undertook a descriptive analysis of patients with posterior fossa space-occupying lesions. The neurosurgical intervention was done in all of the instances due to the critical location. Specimens were sent for histological evaluation after surgery. The data from these patients, as well as histology reports, were examined. The data was analyzed using SPSS version 21. Results: Males made up 57.14 percent (n=48) of the 84 patients, while children made up 41.66 percent (n=35). The most common tumor was schwannoma, seen in 34.52 percent (n=29) of cases, 72.41 percent of adults, and 27.58 % of children. In 22.61 %, 15.47 %, and 14.28 % of cases, meningioma, pilocytic astrocytoma (PCA), and Meduloblastoma were found, respectively. Metastasis was only seen in adults, and malignant round blue cell tumors were only found in children. Astrocytoma and schwannoma were prevalent in adults. Children were more likely to develop Meduloblastoma, Pilocytic astrocytoma, and malignant round blue cell tumors. Conclusion: High-grade Astrocytoma and Schwannoma are dominantly present in adults. Malignant round blue cell tumor, Pilocytic astrocytoma Medulloblastoma is more prevalent in children. Metastasis was only observed in adults. Because of their location, risk of excision, and involvement of the brain stem structures and fourth ventricle, posterior fossa tumors are widely known for their significant morbidity and mortality. Early diagnosis is now possible due to modern diagnostic and therapy technologies, which help to lower mortality rates and improve postoperative prognosis. Keywords: posterior cerebral fossa tumors, children, adults

Congenital orbital malignant tumor in a neonate: Anesthetic management

Neonatal tumors are clinically diagnosed before the first month of life. Some of them are congenital and exist at birth. Since neonatal neoplasms account for 2% of all pediatric tumors, neonatal neoplasms are considered to be rare. Its incidence is estimated to be 2.8-3.74 cases per 100000 newborns per year. Perinatal tumors are different from the tumors commonly found in older children and adults in terms of pathogenesis, behavior, response to treatment, and outcome [1]. The most common neonatal tumors include neuroblastoma, CNS tumors, retinoblastoma, sacrococcygealteratoma, and other rare tumors such as leukemia, renal tumors, and sarcoma [2]. Malignant round cell tumors are extremely malignant and aggressive with poor prognosis. Congenital undifferentiated sarcoma is a subgroup of round cell tumors. It is a rare tumor on which a handful of research studies have been done [3,4]. Its true incidence is largely unknown. We present a rare case of congenital orbital malignant round cell tumor in a neonate and discuss its anesthesia management.

Machine learning to differentiate small round cell malignant tumors and non-small round cell malignant tumors of the nasal and paranasal sinuses using apparent diffusion coefficient values

ObjectiveWe used radiomics feature–based machine learning classifiers of apparent diffusion coefficient (ADC) maps to differentiate small round cell malignant tumors (SRCMTs) and non-SRCMTs of the nasal and paranasal sinuses.MaterialsA total of 267 features were extracted from each region of interest (ROI). Datasets were randomized into two sets, a training set (∼70%) and a test set (∼30%). We performed dimensional reductions using the Pearson correlation coefficient and feature selection analyses (analysis of variance [ANOVA], relief, recursive feature elimination [RFE]) and classifications using 10 machine learning classifiers. Results were evaluated with a leave-one-out cross-validation analysis.ResultsWe compared the AUC for all the pipelines in the validation dataset using FeAture Explorer (FAE) software. The pipeline using RFE feature selection and Gaussian process classifier yielded the highest AUCs with ten features. When the “one-standard error” rule was used, FAE produced a simpler model with eight features, including Perc.01%, Perc.10%, Perc.90%, Perc.99%, S(1,0) SumAverg, S(5,5) AngScMom, S(5,5) Correlat, and WavEnLH_s-2. The AUCs of the training, validation, and test datasets achieved 0.995, 0.902, and 0.710, respectively. For ANOVA, the pipeline with the auto-encoder classifier yielded the highest AUC using only one feature, Perc.10% (training/validation/test datasets: 0.886/0.895/0.809, respectively). For the relief, the AUCs of the training, validation, and test datasets that used the LRLasso classifier using five features (Perc.01%, Perc.10%, S(4,4) Correlat, S(5,0) SumAverg, S(5,0) Contrast) were 0.892, 0.886, and 0.787, respectively. Compared with the RFE and relief, the results of all algorithms of ANOVA feature selection were more stable with the AUC values higher than 0.800.ConclusionsWe demonstrated the feasibility of combining artificial intelligence with the radiomics from ADC values in the differential diagnosis of SRCMTs and non-SRCMTs and the potential of this non-invasive approach for clinical applications.Key Points• The parameter with the best diagnostic performance in differentiating SRCMTs from non-SRCMTs was the Perc.10% ADC value.• Results of all the algorithms of ANOVA feature selection were more stable and the AUCs were higher than 0.800, as compared with RFE and relief.• The pipeline using RFE feature selection and Gaussian process classifier yielded the highest AUC.

Management and quality of life extranodal non hodgkin lymphoma of testis

Extranodal non-Hodgkin lymphoma still seems to be a rare case and an issue to discuss a lot. Clinical evidence and guidelines on treatment have not yet been widely published and accessible. We present a case of a forty-five-year-old male with the chief complaint of a bulky and huge right mass in the testis with an ulcer on it. The patient underwent an orchiectomy, and the biopsy showed a malignant round cell tumor, suspected as non-Hodgkin lymphoma. The patient then received the following treatment: chemotherapy with R-CHOP regiment every three weeks, consisting of 6 cycles showing shrinkage size of the testis by day 7 and final complete response after 4th cycle with ADE grade 0 no sexual activity disorder after chemotherapy. This raises hope in developing treatment modalities that the right choice on chemotherapy regimen with complete control on the drug effects may improve clinical outcome and patient’s quality of life.

Primitive Neuroectodermal Tumor of Maxilla in a 4-year-old Child

Primitive neuroectodermal tumor (PNET) belongs to the class of malignant round cell tumor. PNETs show varying degree of neuroectodermal differentiation. They are one of the most common tumors of childhood occurring in bone and also within soft tissues. Light microscopy with the aid of immunohistochemical stains was suitable for the diagnosis. Immunohistochemistry plays a pivotal role in differentiating this tumor entity. The EWSR1-FLI1 fusion is present only in PNET cells and codes for oncogenic protein. In this article, we present a case of maxillary swelling in a 4-year-old girl child who was diagnosed with PNET. We have highlighted the challenges of diagnosing the round cell tumors.

A Case Report on Malignant Rhabdoid Round Cell Tumor in Pelvis

The malignant neoplasm is called as malignant rhabdoid tumor or renal tumor. The Malignant tumor had the highest rate of proliferation. Tiny, round, and generally undifferentiated cells make up malignant small round cell tumours. A round cell tumor is a group of malignant tumors composed of relatively small and undifferentiated cells with an increased nuclear - cytoplasmic ratio. Soft tissue malignant tumours of the abdomen and pelvis are a rare but serious kind of cancer. Examples of these tumours include Ewing's sarcoma, peripheral neuroectodermal tumour, rhabdomyosarcoma, synovial sarcoma, non-lymphoma, Hodgkin's retinoblastoma, neuroblastoma, and hepatoblastoma. Mast cell tumour, histiocytoma, lymphoma, plasmacytoma, and transmissible venereal tumours are some of the different types of round cell tumours. Melanomas are the cytologic "great impostor," as they might look on cytology as round cell tumours despite being classed as mesenchymal cancers. Rhabdoid tumours have long been thought to be extremely malignant and have a bad prognosis. Children with this form of tumour have a six to eleven-month median survival duration. They're also less common. In 5% of small round cell tumor patients, can be curable, and it is best achieved by combining systemic chemotherapy with thorough cytoreductive surgery. Here we report a 9-year-old female child who was diagnosed with a malignant rhabdoid round cell tumor in the pelvis. She has undergone excision of pelvic floor tumor andfurther managed with Chemotherapy.