Malignant Minor Salivary Gland Tumors Research Articles

Carcinoma Ex‐Pleomorphic Adenoma of the Base of Tongue: A Case Report and Review of Malignant Minor Salivary Gland Tumors

Carcinoma Ex‐Pleomorphic Adenoma of the Base of Tongue: A Case Report and Review of Malignant Minor Salivary Gland Tumors

Malignant tumors of the minor salivary glands in northern Pakistan: A clinicopathological study

Malignant tumors of the minor salivary glands comprise a small but significant proportion of oral cancers. We analyzed this group of tumors in our population. The records of all cases of malignant minor salivary gland tumors diagnosed at the Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan, during a period of 10 years (1994-2003) are described. The institute receives biopsy material from armed forces and public and private sector hospitals in northern Pakistan as well as referrals for second opinion. A total of 21168 tumors were recorded at the AFIP Tumor Registry during the study period. These included 70 malignant minor salivary gland tumors. Twenty-three of these (32.8%) arose in the palate while the remaining tumors originated at other sites in the oral cavity. The commonest histological type was adenoid cystic carcinoma, constituting 30 cases (42.8%). The next most common type was mucoepidermoid carcinoma comprising 26 (37.1%) cases. The mean age of cases was 43.4 years and the male-to-female ratio was 1:1.4. There were 2 cases each of polymorphous low-grade adenocarcinoma and clear cell adenocarcinoma. The remaining cases included undifferentiated carcinomas, adenocarcinomas (not otherwise specified) and a few other rare tumors. Adenoid cystic carcinoma was the commonest malignant neoplasm of the minor salivary glands followed by mucoepidermoid carcinoma. The palate was the commonest location of these tumors.

Malignant Minor Salivary Gland Tumors of the Larynx

To report our experience in treating patients with malignant minor salivary gland tumors of the larynx. Thirty-three-year retrospective study. Tertiary referral center specializing in head and neck surgery. Twelve patients with malignant minor salivary gland tumors of the larynx were identified from a search of the institutional databases and pathology records at Memorial Sloan-Kettering Cancer Center, New York, NY, between the years 1970 and 2003. All slides were independently reviewed by 2 pathologists (R.G. and D.C.). Details on patient and tumor characteristics, as well as treatment and surgical outcome, were recorded. Ten patients (83%) had adenoid cystic carcinoma and 2 (17%) had myoepithelial carcinoma. Five (42%) were located in the supraglottis and 7 (58%) in the subglottis. Ten (83%) had surgery (6 with adjuvant radiotherapy) and 2 (17%) were treated with radiotherapy alone. Of the 10 patients who had surgery, total laryngectomy was required in 6 (60%), supraglottic horizontal laryngectomy in 2 (20%), and cricotracheal resection in 2 (20%). With a median follow-up of 55 months (range, 1-194 months), 10 patients are alive, 6 of whom have no evidence of disease. Seven patients (58%) developed recurrent disease, 2 of whom had local recurrence alone, 1 had regional recurrence alone, 3 had distant recurrence alone, and 1 had local and distant recurrence. Up to 60% of patients with malignant minor salivary gland tumors of the larynx will develop recurrent disease locally, regionally, or at distant sites. In adenoid cystic carcinoma, regional recurrence is rare, but distant recurrence is common and may occur up to 10 years after the index therapy. For both adenoid cystic and myoepithelial carcinoma, partial surgery is possible in selected cases, but because of the high propensity for submucosal spread and perineural and lymphovascular invasion, total laryngectomy is usually recommended.

Minor salivary gland tumors of the palate: clinical and pathologic correlates of outcome.

Minor salivary gland tumors of the palate are rare and may pose a diagnostic and therapeutic dilemma for the head and neck surgeon. The authors reviewed their 46 years of experience with minor salivary gland tumors of the palate to determine the factors that influence outcome and their implications for treatment. Malignant tumors were seen in 116 patients (78%) and benign tumors were found in 33 patients (22%). Adenoid cystic carcinoma was the most common malignant tumor, occurring in 43 patients, and pleomorphic adenoma was the most common benign tumor, occurring in 30 patients. Univariate analysis on the malignant lesions showed that grade 3 tumor histology (P < .001), tumor size greater than 3 cm (P < .001), perineural invasion (P = .031), bone invasion (P = .012), positive surgical margins (P < .001), and positive initial but negative final margins (P = .004) were all associated with decreased survival. With multivariate analysis, tumor size, margin status, and grade were shown to be independently associated with decreased survival (P < .05). The recurrence rate at the primary site was significantly higher for adenoid cystic carcinoma than for other histologies (P = .0059). The 2-, 5-, and 10-year disease-specific survival rates for patients with malignant disease were 96%, 87%, and 80%, respectively. Wide surgical excision with adequate margins is essential for a favorable outcome in patients with malignant minor salivary gland tumors. Postoperative radiotherapy is reserved for patients with grade 3 tumor histology, large primary lesions, perineural invasion, bone invasion, cervical lymph node metastasis, and positive margins, although a clear-cut survival advantage has not been proven. Recurrence, especially regional and distant metastasis, portends an extremely poor prognosis.

Minor salivary gland basal cell adenocarcinoma of the palate

Minor salivary gland tumors are found most commonly in the palate.': Of the palatal tumors, more than 50% are malignant, with the most common being adenoid cystic or mucoepidermoid carcinorna.! Adenocarcinoma comprises from 4.6% to 26%1.2 of malignant minor salivary gland tumors. Basal cell adenocarcinoma is a rare type found most often in the parotid or in the submandibular gland; there has been no previous report of this tumor in the oral cavity. The distinction between basal cell adenocarcinoma and other salivary gland tumors is important from a prognostic point of view, as basal cell adenocarcinoma has a more favorable outcome. This low-grade malignant neoplasm is often confused with the more ominous adenoid cystic carcinoma. A case of a minor salivary gland basal cell adenocarcinoma arising in the palate is described. This is the youngest patient with a basal cell adenocarcinoma regardless of site reported to date.

当科における過去１６年間の悪性唾液腺腫ようの臨床統計的観察

34 patients with malignant salivary gland tumors were retrospectively studied. All patients were treated in the Department of Oral and Maxillofacial Surgery, Kyoto University Hospital during 16 years from 1973 to 1988. Malignant minor salivary gland tumors were about twice as frequent as malignant major salivary gland tumors.About twice as many female patients as male.In 34 cases, 17 (50%) were pathologically diagnosed as adenocystic carcinoma. More than 90% of cases were treated surgically. The five year survival rate of the 34 patients was 75.9%

Malignant minor salivary gland tumours of the nose and paranasal sinuses

Present paper describes our experience of treating26 cases of malignant minor salivary gland tumours involving the nasal cavity and the paranasal sinuses(1980–84). Adenoid cystic carcinoma was the commonest lesion(59%) followed by adeno-carcinoma(29%) and muco-epidermoid carcinoma(12%). Overall,54.5 percent determinate cases survived disease free for2 years and40 percent for3 years or more. Patients who underwent radical surgery alone did somewhat better than the ones who had received pre-operative radiotherapy. We have now revised our treatment protocol and routinely perform surgery first followed by post-operative radiotherapy. Patients with adenoid cystic carcinoma had somewhat better prognosis than the adenocarcinoma or muco-epidermoid carcinoma. Prognosis also greatly depends upon the stage of the disease.

Malignant minor salivary gland tumors treated with radiation therapy

Malignant minor salivary gland tumors treated with radiation therapy

Tumors of minor salivary glands

1. 1. One hundred ten cases of minor salivary gland tumors have been critically analyzed. 2. 2. Benign mixed tumors were the most common type of minor salivary gland tumors and constituted forty-nine per cent of all tumors. 3. 3. Cylindroma was the most frequently encountered malignant tumor and constituted 37.3 per cent of all minor salivary gland tumors. 4. 4. The palate was the most common site of minor salivary gland tumors. 5. 5. Surgical removal has been the treatment of choice for benign and malignant minor salivary gland tumors. Benign mixed tumors should be excised with a portion of the normal surrounding tissue. 6. 6. In cylindroma, radiotherapy and chemotherapy are useful as palliative procedures in temporarily controlling the disease.