Male To Female Research Articles

Associations between phenotypes of childhood and adolescent obesity and incident hypertension in young adulthood.

We investigated whether empirically derived childhood obesity phenotypes were differentially associated with risk of hypertension in young adulthood, and whether these associations differed by sex. Data came from 11,404 participants in the Growing Up Today Study, a prospective cohort study in the US established in 1996. We used a childhood obesity phenotype variable that was previously empirically derived using latent class analysis. The childhood obesity phenotypes included an early puberty phenotype (females only), a mothers with obesity phenotype, a high weight concerns phenotype, and a mixed phenotype. Participants without overweight or obesity in childhood or adolescence were the reference group. We then used logistic regression models with generalized estimating equations to examine associations of childhood obesity phenotypes with incident hypertension between ages 20-35 years. All analyses were stratified by sex. Among females, participants in all of the empirically derived childhood obesity phenotypes were more likely than their peers without childhood overweight/obesity to develop hypertension in young adulthood (early puberty subtype odds ratio (OR) = 2.52; 95% confidence interval (CI) = 1.75, 3.62; mothers with obesity (MO) subtype OR = 2.98; 95% CI = 1.93, 4.59; high weight concerns (WC) subtype OR = 2.33; 95% CI = 1.65, 3.28; mixed subtype OR = 1.66; 95% CI = 1.25, 2.20). Among males, the childhood obesity phenotypes were associated with a higher risk of developing hypertension, although males in the MO (OR = 2.65; 95% CI = 1.82, 3.87) and WC phenotypes (OR = 3.52; 95% CI = 2.38, 5.20) had a greater risk of developing hypertension than the mixed subtype (OR = 1.51; 95% CI = 1.23, 1.86) (p = 0.004). Risk for incident hypertension in young adulthood varied by childhood obesity phenotypes, as well as by biological sex. If replicated, these results may suggest that increased surveillance of specific childhood obesity phenotypes might help in targeting those at highest risk for hypertension.

Can Expressing Feelings About Violence be a Protective Buffer in the Linkage Between Bullying Victimization and Delinquent Activities?

The current study explores whether expressing feelings about violence through journal or notebookand/or school assignment might be associated with a decrease in delinquent activities, such as substance use, theft of property, and assaultive behaviors. A cross-sectional study with purposive sampling was conducted. The participants were comprised of African American adolescents in four Chicago's Southside neighborhoods. Measures included bullying victimization, substance use, theft of property, assaultive behavior, expressing feelings about violence, and the covariates (age, biological sex, and government assistance). Analyses were univariate analyses and a two-step hierarchical multiple regression. Regarding the study sample, the average age was 15.84years, 45.6% were males, and 75.7% received government assistance. Bullying victimization was positively associated with substance use, and expressing feelings about violence moderated the association between the two. Bullying victimization was also positively associated with theft of property, and expression feelings about violence moderated the association between the two. Although bullying victimization was positively associated with assaultive behavior, expressing feelings about violence did not moderate the association betweenthe two. Findings suggest a significant role of expressing feelings about violence in buffering the adverse outcomes of bullying victimization among adolescents in low-resourced neighborhoods. Expressing feelings about violence may serve as an effective coping mechanism for adolescents who areconsistently exposed to violence.

Affirmative sexual consent and the Theory of Planned Behavior (TPB): A multiple-group analysis regarding the impact of biological sex, sexual self-esteem, sexual assertiveness, and sexual history on TPB relationships

ABSTRACT The current investigation uses the Theory of Planned Behavior (TPB) to explore the behavior of affirmative sexual consent. Specifically, multiple-group analyses (N = 225) explored the effects of biological sex, sexual self-esteem, sexual assertiveness, and sexual relationship history on the strength of TPB relationships between affirmative sexual consent attitudes, norms, perceived behavioral control, behavioral intention, and observed affirmative consent behavior. Findings revealed significant effects across the three forms of affirmative sexual consent (i.e. nonverbal, initiating, and verbal), which are discussed in conjunction with TPB, practical implications, limitations, and future directions.

The Battle for the Sexual Heritage of Our Children and Youth: The Slippery Slope from Transgenderism to Transhumanism

The transgender movement, better termed the transgender industry, is just the tip of the iceberg to a much bigger agenda where reproduction without copulation or gestation may be the norm as well as serving the political groundwork for the burgeoning rights discourse surrounding the transhumanism movement, which embraces that idea of self-directed human evolution using technology to transcend their current natural state and limitations, i.e. disease, ageing, and even death. The ideology behind the transgender movement can be traced to the objectives specified in the manifestos of the Humanist Association, which, according to this author, also provides the basis for transhumanism. Transgenderism, framed as a human rights movement, promotes the idea that children have the right to change their minds, try out new styles and express themselves. However, this is a cover-up by a vast new industry to win the battle of the minds of innocent children to select to change their sexual heritage using dangerous drugs and mutilate their bodies by removing body parts according to their ‘sexual’ whim. This movement is a prelude to the transhumanism movement as self-selecting to be sterilized through the mutilation of one’s biological sex opens society to ethically loaded issues like hiring mothers, artificial wombs and the selection of sperm and ovaries used to produce the next generation. Transgender individuals, therefore, also play into the hands of the eugenics movement aimed at selective breeding and restraining population growth. Among other issues, this article explores the history, problems, players, and implications of transgenderism. It also opens the debate between novelty as progressive and hereditary as congenital or inbred. Living according to our sexual orientation does not mean we have to mutilate our bodies or deconstruct our inherent biological identity; our gender preference can also change over time. In conclusion, I suggest that we must explore and discover our spiritual nature and the spiritual underpinning of reality to protect our children and create a society that lives in harmony with each other and Nature, including our given inherent nature.

Using environmental and exercise physiology to address gender inequalities in climate change and occupational health research.

Climate change is a health-risk and health-inequity multiplier with excessive heat exposure a direct climate change impact already affecting the health and livelihood of billions globally. Women face greater risks and burdens from climate change impacts. Biological sex may or may not influence an individual's thermoregulatory capacity, heat tolerance or heat susceptibility. However at a population level, sex differences in physiological characteristics (anthropometrics, aerobic capacity, etc.) likely affect thermoregulatory capacity. Still, gender appears to play the most significant role in heat exposure and resulting health impacts. For climate change resilience and adaptation strategies to be effective, public health and occupational guidance/governance must be based on comprehensive and representative evidence. The current dearth of empirical evidence on how excessive heat exposure affects women prohibits this. Environmental and exercise physiology can help address this lack of empirical evidence by adhering to inclusive research guidelines. This paper is based on a symposium presentation given at Physiology 2023 in Harrogate, UK. Using a multi-year cohort study on industrial agricultural workers (the Adelante Initiative) as a case study, this review discusses the role of environmental and exercise physiology in generating inclusive research and evidence to inform occupational and public health guidance/governance for climate change resilience and adaptation, specifically heat exposure.

Comparing Intra- and Inter-individual Correlational Brain Connectivity from Functional and Structural Neuroimaging Data.

Inferring brain connectivity from inter-individual correlations has been applied to various neuroimaging modalities, such as glucose metabolic activity measured by positron emission tomography (PET) and brain structures assessed using MRI. The variability that drives these inter-individual correlations is generally attributed to individual differences, potentially influenced by factors like genetics, life experiences, and biological sex. However, it remains unclear whether long-term within-individual effects, such as aging, and state-like effects also contribute to the correlated structures, and how intra-individual correlations are compared to inter-individual correlations. In this study, we analyzed longitudinal data spanning a wide age range, examining regional brain volumes using structural MRI, and regional brain functions using both regional homogeneity (ReHo) of resting-state functional MRI and glucose metabolic activity measured with Fludeoxyglucose (18F) FDG-PET. In a first dataset from a single individual scanned over 15 years, we found that intra-individual correlations in both ReHo and regional volumes resembled resting-state functional connectivity. In a second dataset, involving multiple longitudinal points and participants for FDG-PET and MRI, we replicated these findings, showing that both intra- and inter-individual correlations were strongly associated with resting-state functional connectivity. Correlations in functional measures (i.e., ReHo or FDG-PET) showed greater similarity with resting-state connectivity than structural measures. Moreover, matrices from the same modality showed higher similarity between the two datasets, indicating modality specific contributions. These results suggest that multiple factors may contribute to both inter- and intra-individual correlational measures of connectivity. Understanding or controlling for these factors could enhance the interpretability of the inter-individual connectivity measures.

Neutrophil but not lymphocyte response to matched interval and continuous running differs between protocols and sex.

When considering the acute effects of different modalities of endurance training on cellular immune components, the matching of duration and mean intensity and the consideration of sex-dependent differences have received less attention so far. The aim of the study was to compare the effects of interval running (IR) vs. continuous running (CR) on circulating immune cells and cellular immune inflammation markers. Additionally, we analyze sex-dependent differences in these effects. In a cross-over study design, 24 recreational runners completed a mean intensity and duration-matched session of IR and CR. Blood samples were taken immediately before, after, and 1h after exercise cessation for cell counts and cortisol level quantification. Neutrophil counts showed a sustained increase after both exercise modalities with significantly greater values after IR compared to CR at 1h after exercise and greater increases in females. Neutrophil-to-lymphocyte ratio and systemic immune-inflammation index increased 1h after exercise with significantly higher values after IR compared to CR with greater values in females. Platelet-to-lymphocyte ratio decreased in both immediately after IR and 1h after exercise in both sexes and modalities. The cortisol level shows a lower value immediately after CR compared to IR with no sex-dependent differences. The IR protocol induces greater immune cell mobilizations in comparison to CR, which is primarily based on a systemic increase in neutrophil counts. Neutrophil-to-lymphocyte ratio and systemic immune-inflammation index are suitable to distinguish this effect between training modalities. Sex-dependent differences confirm that biological sex influences the immune cells response to acute exercise. Protocol registration:German Clinical Trials Register,DRKS00017686,Date of registration: 11.02.2020.

Practitioner preferences in the analysis of cremation deposits in archaeology and biological anthropology: An overview of current osteoarchaeological practices with a focus on sex estimation.

Osteological data, such as biological sex, constitute a base for research in paleodemography and palaeopathology, as well as for understanding past socio-cultural practices. Despite extensive research efforts concerning cremated human remains over the past decades, an internationally acknowledged, standardized osteological protocol is not fully agreed upon. Furthermore, assessing cremation research practices from the literature is challenging because analysis reports are often written in the national languages of practitioners, which makes them difficult to access by an international audience. This study addresses this gap by directly reaching out to experts working with cremated human remains through an online questionnaire in Lime Survey. The aim is to identify and characterize patterns in cremation analysis practices. A particular emphasis was put on the methods of biological sex estimation. While the significance of these data is widely acknowledged, the ways in which they are obtained in practice are seldom examined. The results of this survey reveal an absence of standardization in protocols of analysis, and data collection, as well as in reporting on the cremated remains in publications and reports. Notably, the findings reveal regional preferences in methodological choices and inconsistent institutional training. A majority of respondents expressed a preference for traditional morphological methods over recently published metric and alternative methods for sex estimation. These variations underscore the complexity of establishing standardized cremation analysis protocols and highlight the importance of considering regional contexts and training in shaping future research practices.

Sex-specific DNA methylation signatures of autism spectrum disorder in newborn blood.

Autism spectrum disorder (ASD) comprises a group of neurodevelopmental conditions currently diagnosed by behavioral assessment in childhood, although neuropathology begins during gestation. A poorly understood male bias for ASD diagnosis is thought to be due to both biological sex differences and cultural biases against female diagnosis of ASD. Identification of molecular biomarkers of ASD likelihood in newborns would provide more objective screening and early intervention. Epigenetic dysregulation has been reported in multiple tissues from newborns who are later diagnosed with ASD, but this is the first study to investigate sex-specific DNA methylation signatures for ASD in newborn blood, an accessible and widely banked tissue. DNA methylation was assayed from ASD and typically developing (TD) newborn blood (discovery set n = 196, replication set n = 90) using whole genome bisulfite sequencing (WGBS) . Sex-stratified differentially methylated regions (DMRs) were assessed for replication, comparisons by sex, overlaps with DMRs from other tissues, and enrichment for biological processes and SFARI ASD-risk genes. We found that newborn blood ASD DMRs from both sexes significantly replicated in an independent cohort and were enriched for hypomethylation in ASD compared to TD samples, as well as location in promoters, CpG islands and CpG shores. Comparing females and males, we found that most DMRs with sex differences amongst TD individuals were also found in ASD individuals, plus many additional DMRs with sex differences that were only found in those with ASD. Newborn blood DMRs from females were enriched for the X chromosome and both sexes showed significant overlap with DMRs from umbilical cord blood and placenta but not post-mortem cortex. DMRs from all tissues were enriched for neurodevelopmental processes (females) and SFARI ASD-risk genes (females and males). This study is primarily limited by sample sizes, particularly amongst females. Overall, we found a highly replicated sex-specific DNA methylation signature of ASD in newborn blood that showed support for the female protective effect and convergence with epigenetic and genetic signatures of ASD in newborns. These results demonstrate the utility of newborn blood in ASD screening and emphasizes the importance of sex-stratification in future studies.

Resting-State Functional Connectivity Predicts Attention Problems in Children: Evidence from the ABCD Study.

Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, and numerous functional and structural differences have been identified in the brains of individuals with ADHD compared to controls. This study uses data from the baseline sample of the large, epidemiologically informed Adolescent Brain Cognitive Development Study of children aged 9-10 years old (N = 7979). Cross-validated Poisson elastic net regression models were used to predict a dimensional measure of ADHD symptomatology from within- and between-network resting-state correlations and several known risk factors, such as biological sex, socioeconomic status, and parental history of problematic alcohol and drug use. We found parental history of drug use and biological sex to be the most important predictors of attention problems. The connection between the default mode network and the dorsal attention network was the only brain network identified as important for predicting attention problems. Specifically, we found that reduced magnitudes of the anticorrelation between the default mode and dorsal attention networks relate to increased attention problems in children. Our findings complement and extend recent studies that have connected individual differences in structural and task-based fMRI to ADHD symptomatology and individual differences in resting-state fMRI to ADHD diagnoses.

Which Sex- and Gender-Based Explanatory Variables are Associated with Memory Function Post-Stroke? A Cross Sectional Analysis of the National Health and Aging Trends Study.

To identify sex- and gender-based variables associated with immediate and delayed recall in individuals with stroke. This was a secondary analysis of data from the National Health and Aging Trends Study (NHATS) using general linear models with a standard stepwise approach. Community INTERVENTIONS: Not Applicable PARTICIPANTS: Participants were eligible for the current analysis if they had a self-reported history of stroke at NHATS Round 1 (2011), and data available on our variables of interest. The final analyses included 366 participants for the immediate recall model and 365 participants for the delayed recall model. Independent variables of interested included sex- (eight variables, for example biological sex, depression and anxiety, and comorbidities) and gender-related factors (fourteen variables, for example education, income, independence with banking). The dependent variables of interest were the 10-word immediate and delayed recall tests, respectively. Higher immediate recall scores were associated with younger age, female biological sex, independence with banking, higher income, giving financial gifts, not requiring assistance with ADLs, and higher education (p<0.001-0.04). Higher delayed recall scores were associated with younger age, higher BMI, higher education, placing importance in socializing, and independence with banking (p<0.001-0.04). We conducted the largest analysis to date of sex- and gender-based factors associated with cognition in individuals with stroke. Stroke rehabilitation scientists and clinicians may consider both biological and sociodemographic factors associated with cognitive function, which may guide holistic post-stroke assessments and interventions.

The risk and distribution of second primary cancers according to subsite of primary stomach cancer: a retrospective cohort population-based study.

The development of second primary cancers (SPCs) following a diagnosis of stomach cancer presents a significant clinical challenge, with varying risks depending on the anatomic subsite of the primary tumor, patient demographics, and treatment modalities. This study aims to assess the risk of SPCs in stomach cancer survivors, focusing on differences across anatomic subsites, sex, age, and treatment periods. The authors conducted a retrospective cohort study using data from stomach cancer patients, analyzing the incidence of SPCs based on the anatomic location of the primary tumor, with stratifications by sex, age, latency period, and year of diagnosis. Standardized incidence ratios (SIRs) were calculated to compare the observed SPC rates with those expected in the general population. Elevated stomach SPC risk was observed across most anatomic subsites, particularly in the body (SIR 8.84) and fundus (SIR 7.34). Females exhibited higher SIRs compared to males, especially in the fundus (SIR 13.33 for females vs. 4.55 for males). Younger patients (<50 years) had significantly higher SPC risks, particularly for cancers originating in the fundus (SIR 49.56). Notably, patients diagnosed after 2010 showed the highest SIRs, indicating a potential impact of advances in diagnostic and therapeutic modalities. Nonstomach SPCs, including colorectal, lung, and thyroid cancers, were significantly elevated, with distinct patterns based on the primary tumor site. The study highlights the critical role of primary tumor location, sex, age, and treatment era in determining SPC risk in stomach cancer survivors. These findings underscore the need for tailored surveillance strategies to manage long-term cancer risks in this population.

How does the dose and type of exercise impact acute cardiovascular function in healthy individuals?

During aerobic exercise, the cardiovascular system is tasked with delivering oxygen to active skeletal muscle via muscle blood flow while regulating mean arterial blood pressure. The impact of aerobic exercise on acute cardiovascular function may be modulated by the dose and type of exercise. Acutely, dose is the product of exercise intensity and time, while the exercise type may refer to common aerobic modalities like cycling, running, swimming or rowing. Each modality is unique for their medium of completion as well as the implications on blood flow arising from the position of active muscle mass relative to heart level. The purpose of this review was to address how an acute exercise dose influences cardiovascular function between prominent aerobic exercise modalities in healthy individuals. Across all modalities, all doses may transiently reduce both left and right ventricular systolic and diastolic function as well as both macro and micro -vascular function. However, accurately quantifying and comparing exercise dose across the literature is challenging due to methodological differences in exercise prescription and the cardiovascular demands imposed by differing modalities of exercise. Further, potential confounding influence of cardiovascular drift alongside variation in age, the composition of cohorts with respect to biological sex and timing of cardiovascular measures further complicates interpretation. Future work should focus on exercise intensity prescription according to modality specific physiological thresholds in order to provide a comparable dose. This approach may serve to standardize the physiological stimulus and allow for objective assessments to be compared with confidence.

Stigma and lack of access to quality healthcare in the transgender population.

More than 1.6 million US adults identify as transgender (that is, a gender different than the one traditionally associated with the biologic sex assigned to them at birth). These patients suffer from healthcare inequity and lack of access to healthcare, causing a public health crisis. This article seeks to raise awareness of this issue and encourage clinicians and healthcare systems to make meaningful changes to reduce healthcare stigma for transgender patients.

Surgical Anatomy of the Lateral Thoracic Artery and Its Perforators: A Computed Tomographic Angiography and Cadaveric Dissection Study

Objective: This study explores the anatomical variations and characteristics of the lateral thoracic artery (LTA) and its perforators through thoracic computed tomographic angiographies (CTA) and cadaveric dissection, aiming to enhance surgical planning and patient outcomes. Materials and Methods: Data were recorded for both thoracic CTA patients (n = 40) and soft cadavers (n = 13) for subsequent retrospective analyses of biological sex, age, body mass index (BMI), LTA characteristics (length, diameter, origin, number of perforators, number of lymph nodes), and locations (rib level and distance from the pectoralis major, latissimus dorsi, and acromioclavicular joint). Results: Average LTA parameters for thoracic CTAs were 89.6 millimeters in length from origin and 2.1 millimeters in diameter, while cadavers were 117.0 millimeters in length and 2.3 millimeters in diameter. At least 1-2 cutaneousperforators and 1 proximal lymph node were found across both thoracic CTAs and cadavers. No significant differences were observed between the left and right sides for both groups. On average, 73.8% and 66.4% of LTAs from thoracic CTAs and cadavers, respectively, originated from the axillary artery. Conclusion: This knowledge is crucial for surgical planning, both to minimize damage to the LTA and ensure the inclusion of its perforators and proximal lymph nodes in the lateral thoracic region. The researchers recommend lateral thoracic artery perforator flap harvest between the lateral border of the pectoralis major and the anterior border of the latissimus dorsi, specifically above the 3rd-6th ribs, which is correlated to the length of LTA at 89.6-117 millimeters from origins.

Automated Segmentation of Fetal Intracranial Volume in Three-Dimensional Ultrasound Using Deep Learning: Identifying Sex Differences in Prenatal Brain Development.

The human brain undergoes major developmental changes during pregnancy. Three-dimensional (3D) ultrasound images allow for the opportunity to investigate typical prenatal brain development on a large scale. Transabdominal ultrasound can be challenging due to the small fetal brain and its movement, as well as multiple sweeps that may not yield high-quality images, especially when brain structures are unclear. By applying the latest developments in artificial intelligence for automated image processing allowing automated training of brain anatomy in these images retrieving reliable quantitative brain measurements becomes possible at a large scale. Here, we developed a convolutional neural network (CNN) model for automated segmentation of fetal intracranial volume (ICV) from 3D ultrasound. We applied the trained model in a large longitudinal population sample from the YOUth Baby and Child cohort measured at 20- and 30-week of gestational age to investigate biological sex differences in fetal ICV as a proof-of-principle and validation for our automated method (N = 2235 individuals with 43492 ultrasounds). A total of 168 annotated, randomly selected, good quality 3D ultrasound whole-brain images were included to train a 3D CNN for automated fetal ICV segmentation. A data augmentation strategy provided physical variation to train the network. K-fold cross-validation and Bayesian optimization were used for network selection and the ensemble-based system combined multiple networks to form the final ensemble network. The final ensemble network produced consistent and high-quality segmentations of ICV (Dice Similarity Coefficient (DSC) > 0.93, Hausdorff Distance (HD): HDvoxel < 4.6 voxels, and HDphysical < 1.4 mm). In addition, we developed an automated quality control procedure to include the ultrasound scans that successfully predicted ICV from all 43492 3D ultrasounds available in all individuals, no longer requiring manual selection of the best scan for analysis. Our trained model automatically retrieved ultrasounds with brain data and estimated ICV and ICV growth in 7672 (18%) of ultrasounds in 1762 participants that passed the automatic quality control procedure. Boys had significantly larger ICV at 20-weeks (81.7 ± 0.4 mL vs. 80.8 ± 0.5 mL; B = 2.86; p = 5.7e-14) and 30-weeks (257.0 ± 0.9 mL vs. 245.1 ± 0.9 mL; B = 12.35; p = 8.2e-27) of pregnancy, and more pronounced ICV growth than girls (delta growth 0.12 mL/day; p = 1.8e-5). Our automated artificial intelligence approach provides an opportunity to investigate fetal brain development on a much larger scale and to answer fundamental questions related to prenatal brain development.

Sex differences in the affective-cognitive dimension of neuropathic pain: Insights from the Spared Nerve Injury rat model

Over 40% of neuropathic pain patients experience mood and cognitive disturbances, often showing reduced response to analgesics, with most affected individuals being female. This highlights the critical role of biological sex in pain-related affective and cognitive disorders, making it essential to understand the emotional and cognitive circuits linked to pain for improving treatment strategies. However, research on sex differences in preclinical pain models is lacking. This study aimed to investigate these differences using the spared nerve injury (SNI) rat model, conducting a comprehensive series of behavioural tests over 100 days post-injury to identify key time points for observing sex-specific behaviours indicative of pain-related conditions. The findings revealed that female rats exhibited greater mechanical and cold hypersensitivity compared to males following nerve injury and showed earlier onset of depression-related behaviours, while males were more prone to anxiety, social, and memory-related alterations. Interestingly, by the 14th week post-injury, females displayed no signs of these emotional and cognitive impairments. Additionally, fluctuations in the oestrous cycle or changes in testosterone and oestradiol levels did not correlate with sex differences in pain sensitivity or negative affect. Recognizing the influence of biological sex on pain-induced affective and cognitive alterations, especially in later stages post-injury, is crucial for enhancing our understanding of this complex pain disorder. Data availabilityAccess to the raw data constituting the findings presented in this manuscript can be requested from the corresponding author of the publication.

Colorectal Neoplasia Detection Rates in Lynch Syndrome.

The expected and optimal adenoma detection rate (ADR) is not well characterized in Lynch syndrome (LS). The aim of this study is to determine the ADR, the overall colorectal neoplasia detection rate (CNDR), proximal serrated detection rate (PSDR), and CRC detection rate (CRCDR) in an LS cohort. A retrospective study was performed of individuals with LS who were evaluated at a single tertiary care center from May 2001 to September 2023 (n = 542). Data from procedure and pathology reports were collected along with relevant demographic, clinical history, and family history data. Fisher's exact test and the Kruskal-Wallis test were used to assess factors associated with colorectal neoplasia. Amongst 542 individuals with LS, 352 met the inclusion criteria, and their 1296 colonoscopies/sigmoidoscopies were used for analysis. The cohort was primarily female (64.5%), white (87.5%), and privately insured (76.1%), with a near even distribution across genotypes. CNDR was 27.9%, ADR was 21.4%, PSDR was 7.7%, and CRCDR was 1.5%. Advanced age, Medicare insurance, prior colonic resection, and prior history of non-CRC were significantly associated with an increased CNDR and ADR (p < 0.05). PSDR remained constant with age. There was no association with genotype, biological sex, race, smoking, BMI, aspirin use, nor family history. Despite frequent colonoscopies/sigmoidoscopies, individuals with LS maintain a high rate of colorectal neoplasia, primarily driven by increased detection of adenomas with advancing age. Neoplasia rates may serve as helpful "ballpark rates" for endoscopists performing colonoscopies/sigmoidoscopies in LS. However, further studies need to determine whether neoplasia rates are predictive of CRC risk and outcomes in LS.

Aerobic performance in rats subjected to incremental-speed running exercise: a multiple regression analysis study emphasizing thermoregulation-related variables.

Single-variable analyses have limited ability to explain complex phenomena such as the regulation of prolonged physical (aerobic) performance. Our study aimed to identify predictors of performance in rats subjected to incremental-speed running exercise. Notably, most variables assessed were associated with rats’ thermoregulation. We extracted data from 355 records obtained in 216 adult Wistar rats. Hierarchical multiple linear regression analyses were conducted to identify the predictive power of eight variables. The distance traveled, a performance index, was the dependent variable. The independent variables included body mass, biological sex, body core temperature (TCORE) measurement site, and the following thermoregulation-related variables: ambient temperature (TAMB), initial TCORE, exercise-induced change in TCORE (ΔTCORE), ΔTCORE from 0 to 10 min (ΔTCORE 0-10; when TCORE increase is fastest), and heat loss index (HLI). This analysis with eight variables revealed an adjusted R2 of 0.495; TAMB, ΔTCORE, body mass, and ΔTCORE 0-10 had the highest predictive powers (β values: -0.700, 0.463, -0.353, and -0.130, respectively). Additional analyses consisted of separate regressions for each TCORE index measured: abdominal (TABD), brain (TBRAIN), and colonic (TCOL) temperature. These analyses yielded adjusted R2 values of 0.608 (TABD), 0.550 (TBRAIN), and 0.437 (TCOL). Again, the distance traveled was primarily predicted by body mass and thermoregulation-related variables (TAMB, ΔTCORE, and ΔTCORE 0-10). Among these four variables, ΔTCORE was the only one with a positive β value (directly predicted performance), while the others had negative values. Collectively, these findings advance our understanding of performance regulation in rats, especially regarding the role of thermoregulation-related variables.

Sex-Related Differences in Pancreatic Ductal Adenocarcinoma Progression and Response to Therapy.

Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly malignancies with an increasing incidence rate and limited therapeutic options. Biological sex has an impact on many aspects of PDAC development and response to therapy, yet it is highly unappreciated in both basic and translational research, and worryingly in PDAC clinical trials. In this review, we summarize how biological sex influences PDAC incidence and mortality, genetic and epigenetic landscapes, anti-tumor immunity, responses to hormones, cachexia, and the efficacy of therapy. We highlight the importance of sex as a variable and discuss how to implement it into preclinical and clinical research. These considerations should be of use to researchers aiming at improving understanding of PDAC biology and developing precision medicine therapeutic strategies.