Male Subjects Research Articles

A Study of Handgrip Strength in the South Indian Male Population

Background: The anatomical system of the hand is complex and includes both static and moving parts. For the most part of our lives, we take our grip strength for granted. It is necessary to preserve the integrity of the handgrip and provides information regarding general muscle strength, endurance, and power. Handgrip strength can also serve as a straightforward, cost-effective, and practical tool in occupational health research; it can be used to assess nutritional status, track the loss of muscle strength, and develop prevention or intervention measures. The present study aimed to compare maximal hand grip strength in men of different age groups. Materials and methods: 150 male subjects in total, whose ages ranged from 20 to 60, participated in the study. Subjects in the age group of 40–60 years were taken as Group I, and those in the age group of 20–39 years were taken as Group II. The strength of the dominant hand's grip was compared between the two groups in the current study. The grip strength of the dominant hand was measured three times at an interval of 1 minute, and the mean value recorded was considered to be the maximum hand grip strength. The data was analyzed by paired t tests using SPSS version 22. Results: The handgrip strength in males aged 20–39 years was statistically significant (p < 0.001) as compared to the other group. Conclusion: Handgrip strength is higher in younger males when compared to men over 40, probably due to increased muscle mass. Keywords: hand grip strength, hand dynamometer, male

Parents' Awareness and Knowledge of G6PD Deficiency in the Eastern Province Saudi Arabia: A Cross-Sectional Study.

Background Glucose-6-phosphate dehydrogenase deficiency, known as G6PD deficiency, is a common hematological disease in the Eastern Province. The presence of Glucose-6-phosphate dehydrogenase enzyme in the erythrocyte is crucial, as it aids in the protection of RBCs by preventing cellular damage. It was found that more than 400 million people in the world lack this enzyme, making it the most common enzyme deficiency worldwide. Because of the high prevalence of the disease in the world and the paucity of research in Saudi Arabia about G6PD deficiency, the idea of examining and assessing the awareness and knowledge of parents who have children affected with G6PD emerged. Objective This study aimed to evaluate parental knowledge regarding G6PD deficiency, identify the common and spreadmisconceptions regarding the disease, provide general insightfor physicians about parental knowledge, and propose strategies to educate parents about G6PD deficiency. Methods Thiscross-sectional study was conducted from September 2022 to May 2023 on 459 individuals from the Eastern Province, Saudi Arabia. Using aquestionnaire, parents with variable education levels and incomes participated. The questionnaire was available in bothArabic and English. The study aimed to gather comprehensive data regarding parental awareness and knowledge of G6PD deficiency, it focused on evaluating levels of awareness, knowledge, and misinformation of the participants. Data were analyzed by using Statistical Package for the Social Sciences, ver22 (IBM Corp., Armonk, NY). The chi-square test was applied to check any association between demographics and level of knowledge (Good and Poor). Multiple logistic regression analysis was performed on significant demographic variables and an odds ratio with a 95% confidence interval was calculated. P < 0.05 was considered statistically significant. Results The study included a total of 459 participants, 309 (67.3%) were females and 150 (32.7%) were males. Regarding the demographics, the majority of the participants were <40 years old (61.9%), Saudi (99.3%), married (98.5%), having bachelor's/diploma level or above (Master/PhD) (76.9%), having inherited disorder (44.2%), and having a family history of chronic diseases (82.6%). Furthermore, regarding the knowledge of the disease, the majority of the participants who recognized the disease (82.1%)were familiar with the term fava bean anemia rather than it being called G6PD deficiency anemia. On the other hand, 73.2%of the participants were unable to recognize the disease and had never heard of G6PD deficiency anemia. In addition, the majority of participants had deficient information regarding medication triggers (61.4%), whether the gender of a person is linked to G6PD (77.5%), and whether both parents must be carriers to have a child with G6PD deficiency anemia (50.9%). Female respondents proved to be more knowledgeable regarding this topic as 57.9%of them showed good knowledge as compared to (44.7%) of the male subjects. Conclusion There are discrepancies in the level of awareness among research participants. Our result indicates the need for educational interventions regarding the nomenclature, medication triggers, inheritance mode and its relation to gender, and the symptoms of the disease and its severity. Therefore, it is advised to spread awareness in the eastern province through brochures, medical campaigns, and by healthcare professionals in different medical organizations.

Association of serum uric acid Levels with metabolic syndromes in Korean adolescents.

The study findings investigated uric acid reference values and their association with a cluster of cardiometabolic risk factors among adolescents using the Korea National Health and Nutrition Examination Survey (KNHANES). A retrospective cross-sectional study was conducted using the KNHANES database from 2016 to 2018, involving a total of 2,462 participants aged between 10 and 18 years. Based on age- and sex-specific percentile curves for serum uric acid (SUA) levels from the KNHANES, we examined the correlation between cardiometabolic risk factors and serum uric acid levels. The percentile values of SUA varied with sex and age. In male subjects, SUA levels tended to increase from 10 to 14 years of age and plateaued after 14 years of age. Moreover, the overall uric acid level in females was found to be lower than that in males; the levels tended to increase at approximately 10 to 12 years old but were relatively consistent according to age. Mean uric acid levels increased according to obesity status in both males and females. However, correlation analysis revealed that SUA levels were associated with several metabolic risks even after adjusting for obesity. The detailed metabolic syndrome (MetS) components that were observed to be associated with an increase in uric acid levels were different between males and females, but overall, high uric acid levels increased MetS risk. Additionally, a significant increase in MetS-related odds ratio (OR) for components, including waist circumference (WC), triglyceride (TG) levels, and low high-density lipoprotein cholesterol (HDL-c), was observed. However, differences between sexes were apparent, with a more pronounced increase in OR based on SUA levels in girls. SUA levels were closely associated with MetS and its components, even in nonobese subjects. Therefore, high SUA levels in children and young adolescents should be closely monitored to prevent MetS.

The 50 Most Cited Papers on Rugby since 2000 Reveal a Focus Primarily on Strength and Conditioning in Elite Male Players.

We sought to conduct a bibliometric analysis and review of the most cited publications relating to rugby since 2000 in order to identify topics of interest and those that warrant further investigations. Clarivate Web of Science database was used to perform a literature search using the search term "rugby." The top 200 papers by citation count were extracted and reviewed for the inclusion criteria: all subjects were rugby players. The top 50 manuscripts were included for analysis of author, publication year, country of lead authors, institution, journal name and impact factor, topic, participant sex, and level of rugby. The total number of citations was 9,071 (average of 181.4 citations/article), with an average journal impact factor of 7.21; the top article was cited 407 times at the time of analysis. The most frequent publication was the Journal of Strength and Conditioning Research (26%), followed by the British Journal of Sports Medicine (20%) and the Journal of Sports Sciences (18%). Forty-eight (96%) of the manuscripts contained only male subjects, with 1 manuscript including females only and 1 manuscript containing mixed sexes. Thirty-three (66%) of the manuscripts focused on professional rugby players, with the next highest player group being mixed levels (10%). Twenty-eight (56%) concentrated on topics regarding strength and conditioning, 11 (22%) on injury, and 4 (8%) on physiology. Despite rugby being one of the most injurious sports and community players representing the largest component of the player pool, most of the top-cited rugby articles are cohort studies of professional male athletes focused on performance and strength and conditioning, noting the bias in research towards socially relevant topics that may not impact the majority of stakeholders and long-term health of rugby athletes. These findings highlight the need for further research among women and community athletes and on topics in injury prevention.

Utilizing Real-Time Heart Rate Variability during Psychological Intervention Program for Complex Post-Traumatic Stress Disorder: A Case Study

This study explores the use of real-time heart rate variability (HRV) monitoring as an innovative tool in a psychological intervention program for complex post-traumatic stress disorder (CPTSD). The research focuses on a 25-year-old male subject, presenting severe symptoms of CPTSD resulting from prolonged exposure to traumatic events. The intervention program, conducted over four sessions, integrated cognitive and physical therapies, including bottom-up and top-down approaches. Real-time HRV data, reflecting autonomic nervous system activity, were collected using a wearable heart rate sensor and analyzed alongside qualitative data from session transcripts and observational notes. The findings demonstrated a significant correlation between HRV changes and the subject’s psychological state during therapeutic interventions. Key HRV metrics, such as the change ratio of the RMSSD and SDNN, responded notably to traumatic event recounting and stabilization techniques, suggesting their potential as indicators of emotional and physiological states during therapy. The study, while limited by its single-subject design, lays the groundwork for further investigations into HRV-assisted psychotherapy for a broader CPTSD patient cohort.

Correlation of serum kisspeptin and leptin with non-obstructive azoospermia: A cross-sectional study in a subset of Karachi population.

To determine the association of serum kisspeptin, leptin, and other hormonal profile with non-obstructive azoospermia (NOA) in infertile male subjects. This cross-sectional study was conducted at Australian Concept Infertility Medical Center, and Ziauddin University, Karachi from March 2018 to March 2020. The duration of the study was two years. Serum samples of 106 azoospermic participants were taken. Division of the subjects was done on a histological basis into obstructive azoospermia (OA) n=36, NOA n=70 which were further divided into spermatid maturation arrest (SMA), n=41, and sertoli cell-only syndrome (SCOS) n=29. Serum kisspeptin and leptin were measured by ELISA (Cloud-Clone Corp). The follicle-stimulating hormone (FSH) (p<0.01), luteinizing hormone (LH) (p<0.01), thyroid-stimulating hormone (TSH) (p<0.01), and estradiol (p<0.01) was significantly high in the NOA group. However, kisspeptin was significantly decreased (p<0.01) in the NOA group. In the multivariate analysis after adjusting for other variables, the results showed that with the decrease in kisspeptin, the chances of being NOA were increased. Moreover, with the increase in Leptin, FSH, LH, and TSH the chances of being NOA were significantly enhanced. Serum kisspeptin, leptin, FSH, LH, TSH, and estradiol can be a potential marker for NOA in terms of better diagnosis, targeted therapeutic management, and the decision to proceed with surgical intervention.

Efficacy of human living skin equivalent in the treatment of inherited epidermolysis bullosa

Background: inherited epidermolysis bullosa is a group of genetic skin disorders caused by mutations in genes encoding structural proteins of epidermis and dermo-epidermal junction. Clinical manifestations are characterized by spontaneous or trauma-induced skin and/or mucosal blistering, and extensive wounds. Cell therapy is considered to be a perspective therapeutic approach in improving wound healing process.&#x0D; Aims: to assess safety and efficacy of human skin equivalent in the treatment of inherited epidermolysis bullosa patients&#x0D; Materials and methods: 7 patients (5 female and 2 male subjects from the age of 20 to 55) with inherited epidermolysis bullosa with different clinical subtypes were enrolled in the study: 3 patients with intermediate recessive dystrophic epidermolysis bullosa, 2 patients with severe recessive dystrophic epidermolysis bullosa, 1 patient with dominant dystrophic epidermolysis bullosa and 1 patient with junctional epidermolysis bullosa. Transplantation of composite allogeneic living skin equivalent comprising allogeneic keratinocytes and fibroblasts in low concentration (5 mg/ml) embedded within a type I collagen gel matrix was performed. The living skin equivalent was developed at N.K. Koltsov Institute of Developmental Biology. 19 erosions and ulcers with a surface area between 0,4 cm2 and 120 cm2 were evaluated. At day 14 clinical assessment was performed. To assess level of expression immunofluorescence antigen mapping was used.&#x0D; Results: at day 14 complete erosion closure was achieved in 10 (53%) erosions. 4 (21%) erosions reduced in size 75%. Size reduction between 25% and 75% was shown in a single (5%) case. No clinical efficacy was demonstrated in 4 (21%) cases. Collagen VII expression increased comparing to baseline level and accompanied clinical improvement.&#x0D; Conclusions: the obtained data showed clinical efficacy of topical treatment with living skin equivalent, although no statistically significant difference was seen between living skin equivalent and atraumatic non-adhesive dressings.&#x0D; Keywords: inherited epidermolysis bullosa, junctional epidermolysis bullosa, recessive dystrophic epidermolysis bullosa, erosions, healing, topical treatment.

Fasting for 48h induced similar glucose intolerance in both sexes despite greater perceived stress and decreased estradiol levels in females.

The purpose of this study was to compare the effects of fasting for 48 h on the evoked insulin and glucose responses in males and females, and to explore factors such as stress and estrogen levels that might influence these responses. Healthy, nonobese male (n = 14) and female (n = 14) subjects underwent 48-h fasting trial. Changes in glucose tolerance and insulin levels in response to the oral glucose tolerance test, subjectively perceived stress and catecholamine concentrations were measured in all participants. Estrogen levels were also measured in the female participants during the 48-h fast. Glucose area under the curve (AUC) values increased similarly in both sexes after 48-h fasting (P < 0.05), but females displayed a greater rise in insulin AUC values than males (P < 0.05). Fasting increased plasma epinephrine concentrations in both sexes (P < 0.05), whereas plasma norepinephrine concentrations and subjective stress increased only in females (P < 0.05). Plasma 17-β-estradiol concentrations in females decreased after fasting (P < 0.05). Fasting for 48h induced a similar glucose intolerance in females and males, despite decreased 17-β-estradiol levels and greater psychological and physiological stress in females. These differences represent a plausible explanation for the gender-based differences observed in insulin responses. Retrospectively registered on ClinicalTrials.gov(NCT05545943) in September 19, 2022.

A Comparison of ICSI Outcomes and Reactive Oxygen Species Levels in Seminal Plasma between Normozoospermia and Sperm Abnormalities Groups for Infertile Men

Background: Social life and the healthcare systems are affected by infertility. Infertility could be primary or secondary; secondary infertility is the inability to conceive after one successful pregnancy while primary infertility is the inability to conceive at all. As sperm abnormalities cause male infertility, Intracytoplasmic Sperm Injection (ICSI) is a particular type of in vitro fertilization (IVF) used to treat severe male-factor infertility. Free radical oxygen derivatives are reactive oxygen species (ROS). Reactive oxygen species may cause 30% to 80% of male infertility. Aims of the study: the present study aims to determine the reactive oxygen species level in seminal plasma and to study the Intracytoplasmic Sperm Injection outcomes for Normospermia group and compare it with Oligozoospermia, Asthenozoospermia and the Teratozoospermia Groups. Material, and Methods: a cross-sectional study was conducted between January 2023 to June 2023 in Najaf, on a non-random sampling including 50 couples who suffered from a minimum of 12 months of primary fertility with regular unprotected sexual intercourse and who had attended the fertility center in Najaf requesting fertility treatment. A gynecological examination and assessment were done for the female participants while the urologists examined and assessed the male subjects; then, a semen analysis was carried out followed by macroscopic and microscopic examinations. After the preparation of the sample for ICSI and performing ICSI, pregnancy was assessed and the outcomes of the different groups were compared. At the same time, reactive oxygen species levels were assessed by using the Human Reactive Oxygen Species ELISA kit. Then, the SPSS version 26 was used to perform the statistical analysis. Results: Among the twenty-one patients with Normozoospermia, seven with Asthenospermic, seven with Oligozoospermia and fifteen with Teratozoospermia, there was a significant difference among the four groups regarding sperm concentration, progressive motility, and sperm normal morphology. There was no significant difference among the type of sperm, Normo, Astheno, Tearato, and Oligozoospermia, regarding birth rate and ICSI outcomes. Males with higher progressive motility showed a higher pregnancy rate. In conclusion, despite the presence of reactive oxygen species, Intracytoplasmic Sperm Injection was advantageous and effective for all four groups. reactive oxygen species had no significant effect on Intracytoplasmic Sperm Injection outcomes, however Normozoospermia was associated with greater pregnancy rates. Despite the presence of reactive oxygen species, Intracytoplasmic Sperm Injection was advantageous and effective for all four groups. ROS had no significant effect on Intracytoplasmic Sperm Injection outcomes, however Normozoospermia was associated with greater pregnancy rates.

Effects of food and ethnicity on the pharmacokinetics of venadaparib, a next-generation PARP inhibitor, in healthy Korean, Caucasian, and Chinese male subjects

AimVenadaparib is a next-generation poly(ADP-ribose) polymerase inhibitor under development for treating gastric cancer. This study aimed to evaluate the effects of food and ethnicity on the pharmacokinetics (PKs) and safety of venadaparib after a single oral administration in healthy Korean, Caucasian, and Chinese male subjects.MethodsIn this randomized, open-label, single-dose, two-sequence, two-period, and crossover study, Korean and Caucasian subjects received venadaparib 80 mg in each period (fasted or fed state) with a seven-day washout. In an open-label, single-dose study, Chinese subjects received venadaparib 80 mg only in the fasted state. Serial blood samples were collected up to 72 h post-dosing.ResultsTwelve subjects from each ethnic group completed the study. The geometric mean ratios (90% confidence intervals) of the maximum plasma concentration (Cmax) and area under the plasma concentration-time curve from time zero to the last measurable time point (AUClast) of venadaparib for the fed to fasted state were 0.82 (0.7457–0.9094) and 1.02 (0.9088–1.1339) in Koreans, and 0.77 (0.6871–0.8609) and 0.96 (0.9017–1.0186) in Caucasians, respectively. No statistically significant differences were observed in Cmax (P-value = 0.45) or AUClast (P-value = 0.30) among the three ethnic groups. A single venadaparib dose was well-tolerated.ConclusionThe overall systemic exposure of venadaparib was not affected by the high-fat meal, despite delayed absorption with a decreased Cmax in the fed state. The PK profiles were comparable among the Korean, Caucasian, and Chinese subjects. A single venadaparib 80 mg dose was safe and well-tolerated in both fasted and fed states.

Analisis Kemampuan Berpikir Kritis Matematis Siswa pada Distribusi Peluang Binomial Ditinjau dari Jenis Kelamin

Entering the 21st century, having 21st century capabilities is very necessary to be able to answer all the challenges that are present in this century. One of the abilities of the 21st century is the ability to think critically. One of the factors that influences critical thinking skills is gender. Therefore, this research aims to use qualitative descriptive research techniques to describe students' mathematical critical thinking abilities, especially in the material on binomial probability distribution. The research subjects were taken using a purposive sampling technique, namely 4 students were selected, namely 2 male students and 2 female students in class XII MIPA 1 MAN 1 Semarang City. Considerations for selecting research subjects are seen from students' daily mathematics scores, students' gender, students' responses when learning mathematics. The data collection technique used in this research is the test method. The form of test used is an essay test. The data analysis technique is carried out through data reduction followed by data presentation and drawing conclusions. The data validity test was carried out through triangulation of data sources based on gender, namely male and female. The results of this research show that there are significant differences in analysis and inference indicators related to mathematical critical thinking abilities between male and female research subjects.

Magnetic Resonance Imaging Infarct Volume Correlates with Carotid Intima-Media Thickness and Plaque Echotexture in Ischemic Stroke.

To determine the correlation between cerebral infarct volume, carotid intima-media thickness (CIMT), and plaque echotexture in patients with ischemic stroke. This was a cross-sectional study of 70 patients with ischemic stroke who were imaged using the head coil of a 1.5T Toshiba magnetic resonance machine. The volumes of infarcts were documented and calculated using the manual tracing of the infarct perimeter method. The common carotid CIMT was measured on ultrasound using a linear high-frequency 7.5 MHz transducer. Seventy subjects were evaluated. The mean magnetic resonance imaging cerebral infarct volume was 8.07% volume. Hyperechoic plaques were the most prevalent (36.7%) compared to the hypoechoic (33.3%) and isoechoic (30%) plaques. There was a moderate positive correlation between CIMT and infarct volume (r = 0.70; P = 0.001) in the entire study population. Similarly, positive correlations between CIMT and infarct volume were recorded in both the male (r = 0.73; P = 0.001) and female (r = 0.67; P = 0.001) subjects. Furthermore, subjects who presented in the acute phase (1-3 days) of ictus showed a moderate positive correlation (r = 0.621; P = 0.0001) between CIMT and infarct volume, while there was a strong positive correlation (r = 0.74; P = 0.0001) in subjects that presented in the subacute phase (4-7 days). Common carotid artery CIMT correlated positively with cerebral infarct volume in patients with ischemic stroke. Furthermore, hyperechoic plaques were associated with significantly larger infarct volumes compared to hypoechoic and isoechoic plaques.

Variability of anterolateral thigh flap perforator locations - clinical implications.

&lt;b&gt;&lt;br&gt;Introduction:&lt;/b&gt; The anterolateral thigh flap is an example of a free flap widely applied for reconstruction of tissues within various areas of the body.&lt;/br&gt; &lt;b&gt;&lt;br&gt;Aim:&lt;/b&gt; The aim of the study was to determine the most common locations of the ALT flap perforators in men and women as well as to clarify any potential differences in the location of the vessel in male vs. female subjects.&lt;/br&gt; &lt;b&gt;&lt;br&gt;Material and method:&lt;/b&gt; In years 2021-2022, a study was conducted at the Plastic, Reconstructive, and Aesthetic Surgery Clinic in a group of 90 volunteers (45 women and 45 men, a total of 180 lower extremities) to determine the location of the anterolateral thigh flap perforator against the flap surface using a portable Doppler probe.&lt;/br&gt; &lt;b&gt;&lt;br&gt;Results:&lt;/b&gt; Variable locations were revealed for the anterolateral thigh flap perforator within the study. In women, the perforator is located more distally from the anterior superior iliac spine, most frequently within the inferolateral quadrant, while being located closer to the anterior superior iliac spine, and most frequently within the superolateral quadrant, in men. No perforator was found in 3.3% of the examined limbs. No statistically significant differences were observed between the course of the perforators within the left and right lower limbs in individual patients.&lt;/br&gt; &lt;b&gt;&lt;br&gt;Conclusions:&lt;/b&gt; The location of the ALT flap perforator is subject to sexual dimorphism, which facilitates the investigation area being narrowed down to the well-defined locations of its most frequent occurrence when planning anterolateral thigh flap reconstructive procedures.&lt;/br&gt.

Correlation between Postural Stability and Lower Extremity Joint Reaction Forces in Young Adults during Incline and Decline Walking

Postural stability may be affected during slope walking, as there are different body kinetics and kinematic responses compared with level walking. Understanding body adaptations toward different inclinations is essential to prevent the risk of injury from falls or slips. This study was conducted to determine the correlations between stability parameters and loading response in terms of joint reaction force at the lower-extremity joints during inclined and declined walking. Twenty male subjects walked in the level, incline, and decline directions on a custom-built platform at three different slope angles (i.e., 5°, 7.5°, and 10°). To determine the ground reaction force (GRF), joint reaction force (JRF), center of pressure (COP), and center of mass (COM), a motion capture system was used to read the data of the ten reflective markers and transfer them to visual three-dimensional (3D) software. Pearson’s correlation test was performed with statistical significance set at p &lt; 0.05 to evaluate the correlation of the required coefficient of friction (RCOF), postural stability index (PSI), and COP-COM distance with the JRF. This study has identified that the JRF changes in opposition to the changes in the RCOF during the initial strike during incline and decline walking, as JRF increases, the RCOF decreases with different strengths of correlation. There is also a strong positive correlation between the PSI and JRF in the proximal–distal direction, where the JRFs change in accordance with the change in the PSI, and the JRF increases with the increment of PSI. In addition, the JRF of the lower extremity also changed in a manner similar to the COP-COM distance in the medial–lateral direction. Overall, each stability parameter was correlated with the JRF of the lower-extremity joints in different directions and strengths. This study demonstrated that slope walking is particularly affected by surface inclination in terms of stability and loading. Therefore, this research can serve as a basis for future studies on slopes, as there is no specific basis for a maximum degree of inclination that is safe and suitable for all applications.

Multiple integrated social stress induces depressive-like behavioral and neural adaptations in female C57BL/6J mice

Despite women representing most of those affected by major depression, preclinical studies have focused almost exclusively on male subjects, partially due to a lack of ideal animal paradigms. As the persistent need regarding the sex balance of neuroscience research and female-specific pathology of mental disorders surges, the establishment of natural etiology-based and systematically validated animal paradigms for depression with female subjects becomes an urgent scientific problem. This study aims to establish, characterize, and validate a “Multiple Integrated Social Stress (MISS)” model of depression in female C57BL/6J mice by manipulating and integrating daily social stressors that females are experiencing. Female C57BL/6J mice randomly experienced social competition failure in tube test, modified vicarious social defeat stress, unescapable overcrowding stress followed by social isolation on each day, for ten consecutive days. Compared with their controls, female MISS mice exhibited a relatively decreased preference for social interaction and sucrose, along with increased immobility in the tail suspension test, which could last for at least one month. These MISS mice also exhibited increased levels of blood serum corticosterone, interleukin-6 L and 1β. In the pharmacological experiment, MISS-induced dysfunctions in social interaction, sucrose preference, and tail suspension tests were amended by systematically administrating a single dose of sub-anesthetic ketamine, a rapid-onset antidepressant. Compared with controls, MISS females exhibited decreased c-Fos activation in their anterior cingulate cortex, prefrontal cortex, nucleus accumbens and some other depression-related brain regions. Furthermore, 24 h after the last exposure to the paradigm, MISS mice demonstrated a decreased center zone time in the open field test and decreased open arm time in the elevated plus-maze test, indicating anxiety-like behavioral phenotypes. Interestingly, MISS mice developed an excessive nesting ability, suggesting a likely behavioral phenotype of obsessive-compulsive disorder. These data showed that the MISS paradigm was sufficient to generate pathological profiles in female mice to mimic core symptoms, serum biochemistry and neural adaptations of depression in clinical patients. The present study offers a multiple integrated natural etiology-based animal model tool for studying female stress susceptibility.

Aortic regurgitation in athletes: the challenges of echocardiographic interpretation

BackgroundBicuspid aortic valve (BAV) is the most common congenital cardiac defect and prone to premature degeneration causing aortic regurgitation (AR). The assessment of AR in athletic individuals poses several challenges as the pathological left ventricle (LV) remodelling caused by AR may overlap with the physiological remodelling of intense exercise. The purpose of this study is to highlight these challenges, review the existing literature and discuss how to tackle these conundrums. As a real-world example, we compare the resting transthoracic echocardiographic (TTE) findings in a cohort of individuals with BAV and AR, sub-grouped into “highly active” or “lightly active”.MethodsAdult male subjects with an index TTE performed at a tertiary referral centre between 2019 and 2022 were included if the TTE confirmed a BAV and at least moderate AR. Further strict inclusion criteria were applied and parameters of valve disease severity was made in accordance with existing guidelines. Subjects completed a physical activity questionnaire over the telephone, and were classified into either group 1: “highly active” or group 2: “lightly active” based on their answers. Demographics and TTE parameters were compared between the two groups.Results30 male subjects (mean age 44 ± 13 years) with BAV-AR were included – 17 were highly active, and 13 lightly active. There was no significant difference in age (group 1, 45 ± 12.7 years vs. group 2, 42 ± 17 years; p = 0.49), height (p = 0.45), weight (p = 0.268) or severity of AR, when quantitative assessment was possible. Group 1 had a significantly higher stroke volume (131 ± 17mls vs. 102 ± 13 mls; p = 0.027), larger LV volumes, diastolic dimensions and significantly larger bi-atrial and right ventricular size. This LV dilatation in the context of AR and athleticism poses a diagnostic and management conundrum. Despite this, none of these 17 highly active individuals demonstrated any of the traditional criteria used to consider surgery.ConclusionThere is significant overlap between the physiological adaptations to exercise and those caused by AR. Multi-modality imaging and stress testing can aid clinicians in diagnostic and management decisions in exercising individuals when there is discordance between AR severity and symptoms.

Still air resistance during walking andrunning.

In everyday life during terrestrial locomotion our body interacts with two media opposing the forward movement of the body: the ground and the air. Whereas the work done to overcome the ground reaction force has been extensively studied, the work done to overcome still air resistance has been only indirectly estimated by means of theoretical studies and by measurements of the force exerted on puppets simulating the geometry of the human body. In this study, we directly measured the force exerted by still air resistance on eight male subjects during walking and running on an instrumented treadmill with a belt moving at the same speed of a flow of laminar air facing the subject. Overall, the coefficient of proportionality between drag and velocity squared (Aeff) was smaller during running than walking. During running Aeff decreased progressively with increasing average velocity up to an apparently constant, velocity independent value, similar to that predicted in the literature using indirect methods. A predictive equation to estimate drag as a function of the speed and the height of the running subject is provided.

A field study on thermal acceptability and energy consumption of mixed-mode offices building located in the hot-dry climate of Burkina Faso

To ensure thermal comfort in hot dry climates such as the climate of Burkina Faso, occupants of buildings often rely on air conditioning systems. Defining the appropriate conditions for thermal comfort is crucial to reduce energy consumption. This paper presents the findings of a field study that aimed to assess acceptable temperatures for thermal comfort and analyze the energy consumption related to the use of air conditioning systems in a mixed-mode office building. Surveys were also conducted to gather occupants’ feedback on thermal comfort. The results of the study revealed that the average air temperature was 27.1 °C with standard deviation of 1.7 °C. Fifty-four offices were investigated and all 93 occupants to the survey consider their thermal environment comfortable. The study also identified neutral air temperature and operative temperature which are between 26.2 °C and 26.5 °C, and 26.3 °C and 26.5 °C, respectively. The results show a non-significant gap between the neutral temperature of male and female subjects. It was observed that the energy consumption for comfort is linked to the neutral temperature. These findings can serve as a starting point for establishing thermal comfort parameters for mixed-mode office buildings in Sudano-Sahelian climates having a particular socio-cultural context.

"Knees Out" or "Knees In"? Volitional Lateral vs. Medial Hip Rotation During Barbell Squats.

Chiu, LZF. "Knees out" or "Knees in"? Volitional lateral versus medial hip rotation during barbell squats. J Strength Cond Res 38(3): 435-443, 2024-Medial or lateral hip rotation may be present during barbell squats, which could affect the hip frontal and transverse plane moments. Male (n = 14) and female (n = 18) subjects performed squats using their normal technique and with volitional medial and lateral hip rotation. Hip net joint moments (NJM) were calculated from 3-dimensional motion capture and force platform measurements. Statistical significance was set for omnibus tests (α = 0.05) and Bonferroni's corrected for pairwise comparisons (αt-test = 0.0056). Normal squats required hip extensor, adductor, and lateral rotator NJM. Lateral rotation squats had smaller hip extensor (p = 0.002) and lateral rotator (p < 0.001) NJM and larger hip adductor (p < 0.001) NJM than normal squats. Medial rotation squats had smaller hip extensor (p = 0.002) and adductor (p < 0.001) NJM and larger hip lateral rotator (p < 0.001) NJM than normal squats. These differences exceeded the minimum effects worth detecting. As gluteus maximus exerts hip extensor and lateral rotator moments, and the adductor magnus exerts hip extensor and adductor moments, these muscles combined would be required to meet these hip demands, supporting previous research that has established these muscles as the primary contributors to the hip extensor NJM. Lateral rotation squats reduce hip lateral rotator and increase hip adductor NJM, which may be hypothesized as preferentially loading adductor magnus. Medial rotation squats increase hip lateral rotator and decrease hip adductor NJM; therefore, this variant may shift loading to the gluteus maximus.

Jump-to-Box exercise has an increasing effect on jumping ability in adolescents

Aim: To determine the most effective dose of the box jump exercise for increasing explosive leg muscle strength in adolescents, as measured by vertical jump height.Methods: This study is a field experimental study using a randomized control group pretest-posttest design by providing different doses of jump-to-box exercise. The experiment was conducted on Buqa’tum Mubarakah Junior High School students in Makassar, Indonesia, on February 16 to August 16, 2022 and obtained a total sample size of 60 male subjects aged 15-16 years. The participants were randomly divided into four experimental groups, each consisting of 15 people who were given jump-to-box exercises with different doses.Results: The results of the ANOVA test analysis showed that training with a loading dose of 24 cm and 5 minutes duration had a significant effect on increasing leg muscle explosive power with a p-value = 0.005. The other three groups did not show statistically significant improvements in jump height.Conclusion: The jump-to-box exercise with the box height of 24 cm and training duration of 5 minutes resulted in the highest average vertical jumping ability compared to other dose groups. This exercise protocol has an optimal effect on vertical jumping ability and limb explosive power in adolescents compared to other protocols.