Background and Aim: Physical inactivity and resultant obesity are highly prevalent in the contemporary world. Studies reveal that even an acute bout of physical exercise can bring about health benefits similar to that of regular exercise. Our study aims to assess the effect of single acute bout of exercise on cognition, oxidative stress and inflammatory markers between athletes and non-athletes and to compare the effect of moderate and high intensity exercise on those parameters. Methods: The study is a double-arm parallel design randomized controlled study. Eighty healthy male volunteers (40 athletes and 40 non-athletes) were recruited and further randomized into four subgroups: Athlete moderate-intensity exercise, athlete high-intensity exercise, non-athlete moderate-intensity exercise and non-athlete high-intensity exercise. A single acute bout of treadmill exercise was given to all the subgroups. Cognitive parameters, oxidative stress and inflammatory markers were assessed before and after acute bout of exercise and compared between the groups. Results: At baseline, athletes had reduced oxidative stress and inflammation than non-athletes, which is evident by increased total anti-oxidant status and decreased leptin in athletes, whereas no significant changes in cognitive parameters between the groups. In addition, we found that moderate intensity exercise is superior to high intensity exercise in decreasing inflammation and oxidative stress in both the groups. However, no such changes were observed with respect to cognitive parameters with different intensities of exercise. Conclusion: A single acute bout of exercise is sufficient to improve oxidative and inflammatory parameters in both athletes and non-athletes, whereas cognitive functions does not improve by single acute bout of exercise.
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