Male Health Research Articles

Urethral Sparing versus Trans-Vesical Robot-Assisted Simple Prostatectomy: A Comparative Analysis of Perioperative, Postoperative Outcomes, and Ejaculation Preservation.

To compare the perioperative and postoperative outcomes between traditional trans-vesical robot-assisted simple prostatectomy (TV-RASP) and the newly introduced urethral-sparing (US) RASP. We retrospectively reviewed 42 patients who underwent TV-RASP (n=22) or US-RASP (n=20) performed by two experienced surgeons at two tertiary centers. Perioperative outcomes including operation time, estimated blood loss, length of hospital stay, and catheterization time were assessed. Postoperative outcomes were evaluated using the International Prostate Symptom Score (IPSS), quality of life (QoL), uroflowmetry parameters, Male Sexual Health Questionnaire-Ejaculation Dysfunction-Short Form (MSHQ-EjD-SF) scores, and maintenance of anterograde ejaculation. This study analyzed 22 and 20 patients who underwent TV-RASP and US-RASP, respectively. Except for the TV-RASP group being older (70.0 years) than the US-RASP group (64.5 years) (p=0.028), no differences among other baseline characteristics existed. Perioperative outcomes indicated that hospital stay and catheterization time were significantly shorter in the US-RASP group than in the TV-RASP group (p<0.001). At postoperative month 1, the median IPSS and QoL scores were significantly better in the US-RASP group than in the TV-RASP group (p=0.001 and p=0.002, respectively). However, at months 6 and 12, no significant differences were noted in IPSS, QoL, maximum flow rate, and postvoid residual urine between the two groups. Sexually active patients in the US-RASP group maintained postoperative MSHQ-EjD functional and bother scores, whereas the TV-RASP group experienced a decline. Notably, 75.0% of patients in the US-RASP group preserved antegrade ejaculation, compared to only 20.0% in the TV-RASP group (p<0.001). US-RASP is not inferior to TV-RASP in terms of functional outcomes. In addition, US-RASP yielded more rapid symptom improvements and preserved antegrade ejaculation than TV-RASP. However, larger prospective studies are required to confirm these findings and to further investigate the long-term efficacy and safety of US-RASP.

Comparative Study of Awareness Impact of Yoga on Overall Health and Wellbeing of Male and Female Population of Meerut District

This study was administered to compare the effectiveness of yogic awareness between the urban and rural male populations of the Meerut district. Sample men from rural and urban areas were randomly selected for the response, where 371 men responded due to the various limitations of the study. A self-made questionnaire on the Effectiveness of Yogic awareness on Overall Health and well-being was prepared and administered in rural and urban areas of Meerut. Welch’s t-test was applied to analyze the data and the results indicate that there is a significant between the means of male and female. Hence null hypothesis was rejected and the alternative hypothesis was accepted. Conclusion: There is a difference between the awareness impact of yoga on the overall health and wellness of males and females during the COVID-19 pandemic.

The Association between Caffeine Consumption from Coffee and Tea and Sleep Health in Male and Female Older Adults: A Cross-Sectional Study.

Poor sleep health is common in older adults and is associated with negative health outcomes. However, the relationship between caffeine consumption and sleep health at an older age is poorly understood. This study investigated the association between caffeine consumption and sleep health in community-dwelling older males and females in The Netherlands. Cross-sectional analyses were performed using data from 1256 participants aged 61-101 years from the Longitudinal Ageing Study Amsterdam. Self-reported questions assessed sleep disturbances (including sleep latency, continuity, and early awakening), sleep duration, and perceived sleep quality. Caffeine consumption was determined with questions about frequency, quantity, and type of coffee and tea consumption. Logistic and linear regression models were used, controlling for potential confounders, and interaction by sex and age was tested. Caffeine consumption showed significant interactions with sex (p < 0.005) in association with sleep health outcomes. Older females who abstained from caffeine consumption reported more sleep disturbances (β = 0.64 [95%CI 0.13; 1.15]) and had greater odds of short sleep duration (<7 h/day) (OR = 2.26 [95% CI 1.22; 4.20]) compared to those who consumed caffeine. No associations were observed for long sleep duration (>8 h/day) and perceived sleep quality. No associations were observed in older males. Caffeine abstinence was associated with more sleep disturbances and short sleep duration in older females, but not in males. The observed association in older females may reflect reverse causation, suggesting that females may have different motivations for discontinuing caffeine consumption than males.

THE SECRETS OF HEALTHY AGING IN MEN: A MULTIDISCIPLINARY APPROACH

This article explores the crucial and frequently disregarded domain of men’s health as they age, specifically focusing on the consistently increased rates of mortality among males worldwide. Although men display increased cardiovascular risk factors and higher rates of injury, there persists an inequity in the focus given to men’s health in comparison to women’s health. Given the projected increase in the global population of individuals aged 60 and beyond, it is essential to emphasize healthcare for elderly males. Initially grounded in andrology and urology, the World Health Organization has broadened the definition of men’s health to include overall well-being, encompassing physical, mental, and social aspects. Given the increasing life expectancy and the corresponding increase in age-related conditions, adopting a multidisciplinary approach involving a range of healthcare providers is crucial. The review examines critical elements of health in aging men, including genitourinary infections, cardiovascular diseases, malignancies, stress-coping strategies, and the distinct challenges associated with urological issues and sexual health in elderly males.

PERSPECTIVES ON MALE AGING AND THERAPEUTIC IMPLICATIONS

This article provides an in-depth analysis of the molecular and cellular alterations linked to the aging process in males. It elucidates the physiological disruptions that give rise to different diseases and a decrease in functional ability. The inquiry explores the complex correlation between aging, sexual dysfunction, and infertility in males, with a focus on the physiological alterations in spermatogonial stem cells and the impact of oxidative stress on male reproductive capacity. The function of testosterone replacement therapy and its potential advantages in enhancing sexual activity, bone density, and overall health in older males are highlighted. Nevertheless, it is prudent to exercise caution as there is a correlation between testosterone replacement therapy and heightened cardiovascular risk. The article summarizes rehabilitation options for elderly men, specifically focusing on exercise regimens and cardiac rehabilitation, as means to tackle erectile dysfunction and mitigate mortality risks. The advantages of yoga in enhancing mental and physical well-being in males, particularly those grappling with prostate cancer or infertility are mentioned. The significance of adopting a comprehensive and interdisciplinary strategy towards men's health is emphasized, with particular attention given to the contributions of primary care physicians, urologists, and nurses. The significance of customized communication tactics for males and the necessity of periodic examinations for promoting healthier aging are emphasized.

The Use of Vaping Among Male Health Sciences Students Compared to Other Male Students in Riyadh.

Background Vaping has become widely used by teenagers due to its accessibility, variety of flavors, peer influence, and the thought that it is a less harmful alternative to tobacco smoking. This study aimed to compare the prevalence of vaping among health sciences students compared to other college students in Riyadh and identify reasons for its usage. Methods A cross-sectional study was conducted in three major universities of Riyadh: King Saud bin Abdulaziz University, King Saud bin Abdulaziz University for Health Sciences, and Al-Imam Mohammad Ibn Saud Islamic University. A self-administered online questionnaire related to the use of e-cigarettes and conventional cigarettes was utilized. It included questions about the use of conventional cigarettes and e-cigarettes and the reasons for using them. Responses were compared between health sciences and non-health sciences students in Riyadh. Results An electronic survey was distributed online, and 442 students responded, but two of them did not agree to participate, so they were removed from the sample. Out of 440 students, 312 (71%) were health sciences students, and 128 (29%) were non-health sciences students. Smoking conventional cigarettes was found among 38 (12%) health sciences students, and 22 (17%) non-health college students smoked conventional cigarettes (p=0.16). Regarding vaping, 117 (38%) health sciences students smoked e-cigarettes. On the other hand, 47 (39%) non-health college students smoked e-cigarettes (p=0.99). Anxiety/stress relief (54%) and peer influence (46%) were the most common reasons for those who smoked conventional cigarettes. Regarding the most common reasons behind using e-cigarettes, the majority (55%) considered e-cigarettes less harmful than conventional cigarettes. The second most common reason was having no distinctive odor (36%). Conclusion The study found that there was a high prevalence of the self-reported use of e-cigarettes. It appears that the use of conventional cigarette smoking is not as common as e-cigarettes among university students. This study found that university students tend to use e-cigarettes more than conventional cigarettes due to the belief thate-cigarettes are less harmful than conventional cigarettes.

Endocrine disruptors and male sexual health.

Endocrine disruptors and male sexual health.

Adult Male Hypogonadism: A Laboratory Medicine Perspective on Its Diagnosis and Management.

Testosterone (T), the principal androgen secreted by the testes, plays an essential role in male health. Male hypogonadism is diagnosed based on a combination of associated clinical signs and symptoms and laboratory confirmation of low circulating T levels. In this review, we have highlighted factors, both biological and analytical, that introduce variation into the measurement of serum T concentrations in men; these need to be considered when requesting T levels and interpreting results. There is an ongoing need for analytical standardisation of T assays and harmonisation of pre- and post-analytical laboratory practices, particularly in relation to the laboratory reference intervals provided to clinicians. Further, there is a need to share with service users the most up-to-date and evidence-based action thresholds for serum T as recommended in the literature. Estimation of free testosterone may be helpful. Causes of secondary hypogonadism should be considered. A comprehensive approach is required in the management of male hypogonadism, including lifestyle modification as well as medication where appropriate. The goal of treatment is the resolution of symptoms as well as the optimisation of metabolic, cardiovascular, and bone health. The advice of an endocrinologist should be sought when there is doubt about the cause and appropriate management of the hypogonadism.

Place de la santé sexuelle en médecine générale

ObjectiveAssessment of the practices and knowledge of general practitioners in Bouches-du-Rhône and Vaucluse regarding their patients's sexual health. MethodA descriptive cross-sectional study was conducted among general practitioners in Bouches-du-Rhône and Vaucluse from January 12, 2023 to February 9, 2023. A questionnaire was developed and sent to general practitioners practicing in Bouches-du-Rhône and Vaucluse. It was distributed by personal and professional emails and numbers, and Bouches-du-Rhône and Vaucluse's medical order. The questionnaire was divided into three parts: the first collected demographic and epidemiological data, the second assessed knowledge and practices of general practitioners regarding the sexual health, and the last evaluated practitioner's obstacles to talking about sexual health. ResultsNinety-nine general practitioners responded to the questionnaire (99/276, 35.9%). In all, 30.3% obtained a rate of correct answers>60%. The general practitioners with the best response rates had training in sexology or a degree in gynecology (P=0.0109). In their practices, some topics such as contraception for adolescents, the reassessment of contraception, the search for vulvuvaginal disorders in postmenopausal patients are more addressed by doctors and in particular those of the female sex. Other topics such as sexual violence, male sexual dysfunction and sexual health in patients over 70 are less discussed in consultation. ConclusionThe care of sexual health is an important part of global health, specific to the profession of general practitioner. The results of our study suggest that the knowledge and practices of general practitioners in Bouches-du-Rhône and Vaucluse, are perfectible. The establishment of professional training, consultation dedicated to prevention, or even better awareness of sexual health professionals would promote a better screening.

Bibliometrics and visualization analysis of literature on male hypogonadism from 2000 to 2023: research focus and frontiers.

Male hypogonadism can seriously affect male health and fertility, yet comprehensive bibliometric and visualization analyses of research in this area have been lacking. This study aimed to examine the distribution of literature, identify research hotspots, and discern development trends in male hypogonadism by analyzing 4026 English documents published between 2000 and 2023 using bibliometric and visual analyses. The results indicated a significant increase in publications and citations related to male hypogonadism over the past two decades, with the United States, the University of Florence, Maggi M, and the Journal of Clinical Endocrinology & Metabolism recognized as the most productive and highly cited country, institution, author, and journal, respectively. The article titled "The GPR54 gene as a regulator of puberty" received the highest number of citations. The keywords were categorized into four distinct clusters, including the etiology and pathogenesis of male hypogonadism, symptoms of late-onset hypogonadism, testosterone replacement therapy and its contraindications, the correlation between male hypogonadism and metabolic syndrome (MetS), obesity, and the epidemiology of male hypogonadism. The most frequently co-occurring keywords were "hypogonadism", "testosterone", and "men", while "oxidative stress" was the most prominent burst keyword. The analysis also identified "male infertility" and "oxidative stress" as the primary burst keywords in the last five years, indicating their emerging high-interest topics. Overall, this study provides a comprehensive overview of male hypogonadism research, offering valuable insights for researchers interested in this area, including potential collaborators, current research hotspots, and future research directions.

Dissociable influences of maternal vs paternal Alzheimer’s risk on neurocognitive and cardiovascular health in men and women

AbstractBackgroundParental history of sporadic Alzheimer’s disease (AD) is considered a prime risk factor since at least the late 1980s. Routinely used clinical samples of at‐risk individuals (8‐16 subjects) may conceal weaker population‐based effects, especially those of paternal inheritance. We performed a phenome‐wide examination of the dissociable influences of maternal vs. paternal AD risk on male vs. female probands in the largest single‐site family‐based at‐risk AD cohort: PREVENT‐AD.MethodWe built sex‐specific PLS‐regression models in which the APOE genotypes (e.g., ɛ3/3, ɛ3/4, ɛ3/2) were estimated based on ∼1,000 patient visits, each covering ∼260 risk indicators, to derive three APOE‐driven intermediate phenotypes (IPs). We examined how much the three IPs vary with regard to sex and maternal vs. paternal AD lineage across the phenome. We assessed the sex‐specific and lineage‐specific variation of the IPs over a 4‐year follow‐up period. Lastly, we examined how matri‐ vs. patrilinear AD risk captured by the IPs were expressed in AD‐vulnerable brain structures.ResultAcross IPs, we linked patrilinear AD risk to verbal‐numerical cognition and cardiovascular health in males. In contrast, we linked matrilinear AD risk to memory performance in both sexes. Over time, the mean difference in cognitive performance decreases with regard to sex but increases with regard to AD lineage. Cis‐ and trans‐generational sex effects in neocortex subregions (e.g., mPFC, PCu) were captured by the first and second IPs, respectively. The third IP mainly captured trans‐generational sex effects in hippocampus subregions (e.g., CA1, CA4).ConclusionWe uncovered IPs of AD susceptibility differently expressed in male and female probands and affected by the diagnosed parent’s sex. Maternal inheritance highlighted memory performance in both sexes, whereas paternal inheritance was particularly linked to cardiovascular health in males. The inheritance of the IPs was reflected in the brain structure at both superficial and deeper layers of the cortex. As the first study of its kind, our cross‐generational analysis of matri‐ vs. patrilinear AD risk bridges the epidemiological and clinical literature by leveraging the power of ∼1,000 patient visits. Our completely data‐driven framework ultimately dissociated phenotypes of maternal and paternal AD risk single‐handedly expressed in male and female probands.

Environmental Exposures: Impact on Male Fertility

It is recognised that male health has a significant impact on male reproductive capacity. These health-related associations may begin before birth. For instance, a man’s sperm count is negatively impacted if his mother smoked during pregnancy, and health trajectories through childhood and adolescence into adulthood may influence male reproductive capacity in later life. Further, other factors such as the age of man at the time of conception may influence the health of their offspring. Of further relevance is the fact that studies have shown a relationship between adult reproductive function and longer-term health outcomes. For instance, adverse associations have been demonstrated between most semen parameters, and other markers of testicular function, with the presence of metabolic syndrome. It has further been shown that there exist an association between erectile dysfunction and future adverse cardiovascular events.

Gender Differential In Symptoms, Morbidity, And Case Fatality Rate In The COVID-19 Pandemic In India

Background: The COVID-19 epidemic has taken a considerable toll worldwide and has harmed both male and female health. Statistics revealed that fewer females were directly affected than males; however, the latter may be more affected by the consequences. Some studies at the global level have suggested gender as the key determining factor in COVID-19, but there is a lack of such studies in developing countries like India. In light of the situation, this study has analyzed the gender-wise pattern of symptoms, morbidity, multimorbidity, and mortality due to COVID-19 in Karnataka, India. Methods: We used patient-level raw data from COVID19-India application programming interface (API) from 09th March to 05th September 2020. We have used descriptive statistics such as frequency, percentage distribution, and latent class analysis (LCA) to carry out this analysis. Findings: The study comprised 78,983 COVID-19 patients who were 63.6% males and 36.4 % females. Out of the total patients, 10.1% were reported as deceased, of which 68.4% were males and 31.6% were females. We found that all three symptoms (cough, breathlessness, and fever) were higher among males than females in the case of disease symptoms. Males had a higher risk of severe infection and mortality in general. In comparison, females suffered from comorbidities like diabetes and hypertension were at higher risk of mortality due to COVID-19 than their male counterparts. The latent class analysis also revealed that females had a more significant proportion of two or more symptoms, whereas males had more than two comorbidities. Interpretation: Given the differences in lethality between the two genders, we believe that our study has found the root causes of the gender differentials in the COVID-19 pandemic. Furthermore, our research mapped gender differences in various aspects of COVID-19, which will help policymakers find suitable interventions to reduce the burden.

Reducing violence and aggression: a quality improvement project for safety on an acute mental health ward

Violence and aggression (V&A) are identified as an issue on mental health wards that negatively affect staff, patients, care delivery and safety. This project took place on a male acute...

Interventions to improve young men’s utilisation of HIV-testing services in KwaZulu-Natal, South Africa: perspectives of young men and health care providers

Introduction: HIV-testing services (HTS) are an important point of entry to prevention and treatment of HIV in South Africa. Despite the availability of HTS across the region and in SA, the uptake among men remains low, especially young men residing in rural and peri-urban communities. This study aimed to explore interventions that could improve the uptake of HTS among young men in KwaZulu-Natal. Methods: A descriptive exploratory qualitative study was conducted in which 17 young men and two health care providers in Ladysmith were purposively and conveniently sampled. Data were collected through semi-structured interviews using WhatsApp and landline audio calls between September and December 2021 and thematically analysed. Results: An improvement in the health care provider attitudes and service delivery, establishment of adherence clubs for young people living with HIV, ensuring a diverse and balanced health care provider staff composition at primary health care facilities, and increased demand creation in spaces frequented by men are vital for enhancing access and utilisation of HTS among young men. Additionally, health care providers believe that the presence of male health care providers, investment in health education, prioritising men in the morning at the primary health care facilities, and the establishment of male clinics within communities as key factors in improving the uptake of HTS among young men. Conclusion: To attract and retain young men in HTS and in HIV treatment and care, several improvements at primary health care facilities need to be implemented. These should focus on addressing the specific needs and preferences of young men, ensuring their comfort and engagement in health care.

Differences in Quality of Female Nursing Work Life Based on Gender and Nursing Perspectives

The quality of a nurse’s work life is the degree of satisfaction regarding personal and organizational needs based on experience in a work organization. A nurse with a dual role is the nurse who acts as a mother and a professional nursing staff at the same time. The purpose was to determine differences in the quality of female nurses’ work life in gender and nursing perspective at Balung General Hospital and Kalisat General Hospital in Jember Regency. The research method uses a comparative study with a quantitative research type. The sampling technique in this research is random sampling with a total of 115 samples. Data collection was conducted by using questionnaires about the quality of nurses’ work life from the nursing perspective and questionnaires conflict with women’s dual role from the gender perspective. Data processing using the Mann-Whitney analysis test with a 95% significance level (α=0.05). The results using Mann-Whitney analysis showed that there is a difference between the gender perspective and the nursing perspective (p=0.000). The mean results showed that the nursing perspective () is higher than the gender perspective (). The conclusion shows that the quality of female nursing work life from the gender perspective needs to be improved. The hospital needed to review further regarding work schedules and shift time; the family needed to provide full support and good cooperation; and female nurses themselves must also have good coping control, time, and energy management. Apart from that, it is necessary to have a policy from the room head and team leader regarding the distribution of schedules for female nursing staff without reducing the feeling of unfairness for male health workers.

남성갱년기의 치료와 기능의학적 접근

Male hypogonadism, also known as androgen deficiency syndrome, refers to age-related alterations in hormone levels and the consequent symptoms observed in middle-aged and elderly men. Testosterone, a crucial male sex hormone, plays a central role in androgen deficiency syndrome. This review aims to investigate the intricate connection between testosterone deficiency and male health. Additionally, we delve into the potential benefits of testosterone replacement therapy in enhancing metabolic function. Furthermore, we explore lifestyle habits and functional strategies for promoting intrinsic testosterone levels.

The Ameliorative Effects of Phyllanthus gomphocarpus Hook. F. on Sperm Parameters of Rats Induced with Bisphenol A

Infertility due to poor sperm quality is a common problem nowadays, particularly in developed countries. Herbs are one of the natural treatment options that have been proposed. Phyllanthus gomphocarpus Hook. F is a tropical plant that has traditionally been used in Malaysia to treat male infertility. Antioxidant characterization of its root aqueous extraction was performed using ferric reducing antioxidant power (FRAP), 1,1-diphenyl-2-picrylhydrazyl (DPPH), total phenolic content (TPC), and total flavonoid content (TFC). Male rats were administered two different concentrations of the extract orally along with BPA for 21 days, and their sperm was evaluated using Computer-Assisted-Sperm-Analysis (CASA). The results showed that this plant has a high antioxidant capacity, with 78.6 ± 0.65 %, 0.14 ± 0.01 mg/ml, 28.52 ± 0.13 mg GAE/g and 164.73 ± 23.13 mg QE/g, for DPPH, FRAP, TPC and TFC respectively. The ability of this plant to enhance sperm concentration, motility, velocity, progression ratio, elongation, and percentages of normal sperm morphology significantly with p&lt;0.05, appears to be due to its high antioxidant capacity. Furthermore, this plant was found to have sperm-protective effects against the endocrine disruptor BPA. A thorough investigation is required to determine the full mechanism of this plant's beneficial effects on male fertility and human health.

Around Male Sexual Health Opportunities

Around Male Sexual Health Opportunities

Discovery of Potent, Selective, and Orally Bioavailable DYRK2 Inhibitors for the Treatment of Prostate Cancer.

Prostate cancer (PCa) seriously threatens male health, and targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) has been verified to reduce PCa burden, while the research progress on the DYRK2 inhibitors was relatively slow. In this work, we discovered DYRK2 inhibitor 12 (IC50 = 9681 nM) through virtual screening. Subsequently, we performed systematic structural optimization to obtain 54 (IC50 = 14 nM). Compound 54 exhibited high selectivity among 215 kinases and significantly suppressed the proliferation and metastasis of PCa cells in vitro. Moreover, compound 54 displayed high safety, favorable bioavailability, and potent tumor growth inhibitory activity in vivo, which could be used as a potential candidate in the discovery of novel anti-PCa drugs.