The role of the family carer of a relative with a long-term illness or disability has been the focus of increasing research interest. However, few studies have examined the differential experiences of caring for parents or spouses compared to caring for children. The community-based sample of family carers recruited for the present study included all ages, disabilities, relationship groups, women, and men. Of the carers identified through a random survey of 26,000 households in Victoria, Australia, 78% agreed to be interviewed. This paper reports on the differential impact of the experience on the physical health and emotional wellbeing of (a) male and female carers; and (b) adult offspring, spouse and parent carers, taking into consideration varying ages between relationship groups. In emotional wellbeing and employment opportunities women were more adversely affected than men. Higher intensity caring roles with positive and negative concomitants were associated with parents caring for children and spouses caring for partners, and with younger and co-resident carers generally. Having paid employment was clearly protective.