Major System Changes Research Articles

Key updates and interpretation of the ninth version of AJCC staging system for neuroendocrine tumors of the stomach

The cancer staging system of the American Joint Committee on Cancer (AJCC) is the most widely used clinical basis for tumor staging. In October 2023, AJCC released the staging system (ninth version) for the neuroendocrine tumors of stomach (NET), which has been implemented in January 2024. The ninth version of NET staging system mainly updated the histopathologic classification, diagnosis and staging methods, clinical and pathological staging, prognosis grade, tumor and non-tumor prognostic features. The update and implementation of the staging system provide a more detailed reference for the accurate diagnosis, staging and precise treatment of gastric neuroendocrine tumors. Moreover, it is convenient for clinicians to carry out clinical practice. The purpose of our article is to provide a high-level overview of the major changes in AJCC staging system (version 9) for gastric NET based on the latest evidence-based medical research.

Accounting Learning Model Following ICT Development to Be Sustainable

The discovery and advancement of information technology in the form of computers is something that is very important and fundamental. Various types of computers have occupied their position in society. The computer not only helps carry out work, but changes work procedures and at the same time creates new challenges and problems in the environment. The 21st century is known as the century of globalization and the century of information technology. In this century there have been major changes in technological systems, including information technology. The proper use and utilization of information technology in the form of computers and the internet in education is able to overcome the emergence of obstacles and distractions for students or teachers in the teaching and learning process. The use of information technology must be based on the right selection so that it can enlarge the meaning and function in supporting the success of the teaching and learning process. The digital classroom connects teachers and students with the digital resources and tools needed to collaborate in the classroom and around the world. Schools of the future are schools that are based on ICT (Information Communication and Technology) in real terms.

Conceptual Study of the National Education Policy 2020

The New Education Policy announced by the Government of India (NEP 2020) was a greeting change and fresh news amidst all the negativities surrounding the world due to the challenges posed by Covid- 19 pandemic. The announcement of NEP 2020 was purely unexpected by many. The changes that NEP 2020 has recommended were something that many educationists never noticed. Though the education policy has impacted school and college education equally, this article mainly focuses on NEP 2020 and its impact on Higher Education. This paper also outlines the salient features of NEP and analyses how they affect the existing education system. Design/Methodology/Approach: The research questions of this study are pursued using a systematic theoretical analysis. We conducted this research by systematically searching and screening for relevant research articles through secondary sources and analyzing them to answer our scientific study. This research is a descriptive study. The necessary secondary data was collected from various websites including those of the Government of India, magazines, journals, other publications, etc. This data was then analyzed and reviewed to arrive at the inferences and conclusions. Expected Outcomes of National Education Policy 2020: The major focus of the NEP 2020 is to bring holistic and major changes in the educational system upgrading the levels. It aims to concentrate on bringing forth inclusiveness in the education system.

Communal factors in rater severity and consistency over time in high-stakes oral assessment

This article focuses on rater severity and consistency and their relation to major changes in the rating system in a high-stakes testing context. The study is based on longitudinal data collected from 2009 to 2019 from the second language (L2) Finnish speaking subtest in the National Certificates of Language Proficiency in Finland. We investigated whether rater severity and consistency changed over that period and whether the changes could be explained by major changes in the rating system, such as the change of lead examiner, the modus of rating and training (on-site or remote), and the composition of the rater group. The data consisted of 45 rating sessions with 104 raters and 59,899 examinees and were analysed using the many-facet Rasch model and generalized linear mixed models. The analyses indicated that raters as a group became somewhat more lenient over time. In addition, the results showed that the rater community and its practices, the lead examiners, and the modus of rating and training can influence rating behaviour. Finally, we elaborate on implications for both research and practice.

Cretaceous extensional and contractional stages in the Colombian Andes unraveled by a source-to-sink geochronological and thermochronological study in the Upper Magdalena Basin

Extensional and flexural basins can evolve through multiple stages under the same plate tectonic regime over tens of millions of years. The Cretaceous tectonic evolution of the Colombian Andes is characterized by shifts between contractional and extensional tectonics. The upper plate response to these changes is recorded in the Cretaceous sedimentary rocks along the Western, Central, and Eastern cordilleras, and their adjacent basins, including the Upper Magdalena hinterland basin. We integrated field observations, petrography, geochronology, and thermochronology in the Cretaceous sedimentary units in the southern Upper Magdalena Basin and in the adjacent crystalline basement to decipher the provenance of these units and the exhumation patterns of the source areas. These results suggest that the source areas were exhumed between the Late Jurassic to Early Cretaceous, which may have resulted from the combination of Jurassic contraction and the Early Cretaceous extension. Between ∼120 and 100 Ma, a major stage of crustal extension is recorded in the Caballos Formation. Subsequently, between ∼100 and 80 Ma, sedimentation in the Villeta Group marks the end of the extension and the onset of contraction. This contractional phase was characterized by minor rock uplift within the basin. Basin modification continued between 80 and 65 Ma, involving two successive contractional stages that changed the sedimentary patterns, leading to the burial of a previously exhumed horst block and the appearance of new source areas. These major changes in source areas and sedimentary systems are the result of deformation episodes during prolonged extensional and contractional phases. This geologic evolution highlights the stages that characterize extensional to contractional settings.

Nanotechnology and The Use of Nanoparticles and Its Effect on Wheat Growing

The rapid increase in the human population and the improvement in the living standards of many countries in the world cause the increasing supply of agricultural land to be unmet. Therefore, soil fertility is gaining importance day by day and soil texture is becoming a strategic element. With the development of nanotechnology, the usability of nanoparticles in many fields, especially in agriculture, has started to be investigated or discussed. Studies in agricultural nanotechnology have generally focused on using less pesticides, increasing yields or developing stress-resistant crops. Some studies in this field have started to yield positive results. However, more studies are needed for nanotechnology to be used in agriculture. Because deciding on the use of nanoparticles is an issue that can be reached in the long term. In recent years, the application of nanotechnology-based applications in agriculture is one of the strategies that attract the attention of researchers. Nanotechnology explores a wide spectrum of applications in the fields of biotechnology and agriculture sector, creating a broad spectrum for various applications. Nanotechnology has become a new technology that can be used in various industries such as industry, medicine, food science and safety, smart packaging and agriculture. Nanotechnology, which has been used in many stages of agriculture in recent years, has been widely applied in product production, development, processing, packaging, storage and transportation, and has brought about major changes in food and agricultural systems. It is also used to increase plant resistance and to control the efficacy and safety of pesticides and fertilizers. Thus, the application of nanostructured materials designed for sustainable crop production reduces nutrient losses, suppresses diseases and increases yields. In this study, the strengths, weaknesses, opportunities and targets for the use of nanotechnology and nanoparticles in wheat agriculture were identified and presented.

THE APPROACH OF ISLAMIC EDUCATION MANAGEMENT IN FACING GLOBAL CHALLENGES

This research aims to explore appropriate strategies for Islamic education organizations in facing global challenges. The globalization of education has brought major changes in education systems throughout the world, while technological advances, the challenges of multiculturalism, and global competition are some of the key issues faced by Islamic education organizations in facing the dynamics of educational globalization. Therefore, the management of Islamic education organizations must have the skills to face these challenges and maintain high quality in Islamic education. This research utilized a library research approach. Researchers conducted a literature review, observing writings and sources related to the research issue. Data collection was carried out by searching for sources from various media such as books, journals, and related research. Data obtained from literature observations were analyzed using an interactive qualitative approach. The data analysis process includes steps such as data collection, data reduction, data presentation, and conclusion. The conclusion that can be drawn from this research is that an effective approach to facing global challenges involves improving quality, innovation, cooperation, understanding the challenges of multiculturalism, and increasing human resource capacity. These steps are expected to help the management of Islamic education organizations maintain the quality and relevance of education in the face of changes in the globalization of education.

Environmental problem shifting from climate change mitigation: A mapping review

Abstract Climate change mitigation will trigger major changes in human activity, energy systems, and material use, potentially shifting pressure from climate change to other environmental problems. We provide a comprehensive overview of such “environmental problem shifting” (EPS). While there is considerable research on this issue, studies are scattered across research fields and use a wide range of terms with blurred conceptual boundaries, such as trade-off, side effect, and spillover. We identify 506 relevant studies on EPS of which 311 are empirical, 47 are conceptual–theoretical, and 148 are synthetic studies or reviews of a particular mitigation option. A systematic mapping of the empirical studies reveals 128 distinct shifts from 22 categories of mitigation options to 10 environmental impacts. A comparison with the recent IPCC report indicates that EPS literature does not cover all mitigation options. Moreover, some studies systematically overestimate EPS by not accounting for the environmental benefits of reduced climate change. We propose to conceptually clarify the different ways of estimating EPS by distinguishing between gross, net, and relative shifting. Finally, the ubiquity of EPS calls for policy design which ensures climate change mitigation that minimizes unsustainability across multiple environmental dimensions. To achieve this, policymakers can regulate mitigation options—for example, in their choice of technology or location—and implement complementary environmental policies.

The Relationship between Ethics and Law in the Indian Legal System

The moral issue of the legal department is an extremely important and controversial issue. The scope of this paper is to discuss the role of morality in the current legal system, with particular emphasis on India 's recent judgments and their implications for society. This paper also focuses on the debate between freedom and security, the importance of intention in determining whether an act is criminal, and the role of the state in promoting and maintaining certain moral standards. It further discusses the impact of moral concepts in the future era and the way forward, distinguishing between illegal and immoral. It also discusses in detail the judgments that mark major changes in the country 's belief system, such as the decriminalization of adultery, the recognition of the rights of LGBTQ + groups, and the right to die with dignity. The purpose of this paper is to present the relationship between law and morality in society and to examine its current relevance, particularly in the Indian legal system.

How should rural development be chosen? The mechanism narration of rural regional function: A case study of Gansu Province, China

Several major changes in China's land policy, economic system, and development strategy have contributed to the continuous transformation of rural patterns and urban-rural relations. The deepening of urban-rural interaction has led to an increasing complexity of rural territorial functions, and the importance of territorial multifunctional mechanisms in the dynamic process of rural development in China has been highlighted. However, the current choice of a rural development model lacks comprehensive thinking that combines the functional mechanisms of rural areas with the elements of the development environment. In this paper, we define and identify the functions of rural areas in Gansu Province, China, and analyze and construct a rural development model by analyzing the interaction between the mechanisms of rural regional functions and the “rural revitalization” strategy. We find that under the control of “rural revitalization,” a sustainable development tool, the countryside is constantly developing into a multifunctional complex, and its development mode should be dynamically adjusted according to functional changes. Finally, we summarize the general evolutionary cycle of the multifunctional system of rural regions and attempt to extrapolate the dynamic developmental village type classification process of “rural revitalization” from the perspective of rural regional functions in China.

The Pervasiveness of Power: Dilemmas for Researchers of Major System Change in Healthcare Comment on "'Attending to History' in Major System Change in Healthcare in England: Specialist Cancer Surgery Service Reconfiguration".

To study major system change (MSC) in healthcare, it is crucial to consider the influence of power. Despite this, dominant perspectives on MSC in healthcare present these as relatively neutral processes, where reconfigurations are logical solutions to clearly defined problems. Perry and colleagues' paper adds to a growing body of research which challenges the presentation of MSC as neutral, managerial processes, instead identifying how power dynamics lie at the heart of why service change happens, how it unfolds, and its outcomes. However, the introduction of power considerations raises several overlapping methodological and ethical dilemmas for researchers, and questions regarding research design and dissemination. In this commentary, we use the insights generated by Perry et al to further explore these issues.

Citizensourcing policy advisory systems in a turbulent era

Abstract Extending previous works on major changes in policy advisory systems (PASs), such as externalization (locus) and politicization (government control), this study examines whether and how democratization (citizensourcing) of PASs works based on the case of the Kwanghwamun Citizensourcing Policy Platform, which operated for 4 years under the Moon Jae-in administration in South Korea. Analyzing more than 11,000 policy suggestions proposed by ordinary citizens on the digital policy platform, this study investigates how citizensourced policy ideas are discussed, incubated, and finally adopted through interactions among ordinary citizens, policy experts, and government agencies. Based on the belief that the operation of PASs becomes increasingly complicated and often dysfunctional as societies face more “wicked”, cross-cutting, and volatile policy problems than ever, this study argues that citizensourcing policymaking is critical to ensuring policy legitimacy and receptivity. This study suggests that both the quality and features of citizensourced policy ideas are important for advancing policymaking processes. This study also finds that political cycle and active citizen policy entrepreneurs are also critical factors, while it shows noteworthy limits on the quality and features of citizensourced policy ideas, which, in fact, lead to a frustratingly low policy adoption rate. This study suggests that governments need to actively capitalize on the power of ordinary citizens as citizen experts, while the shortcomings and risks of citizensourcing PASs also need to be carefully addressed.

FISCAL POSITION OF THE UNION BUDGET IN INDIA DURING COVID-19

The present study analyzes the fiscal position as an instrument to measure the amount of government borrowing to require the financial position and their budget shortfall. This study traces the major current changes in the Indian fiscal system during the period 2019-22, though the union's Government adopt the fiscal rule to reduce the financial crisis during the epidemic period of Covid-19. However, the current study also traces the percentage of GDP decrease because of the problem of lockdown during Covid-19 and also studies the budget position in India. The paper concludes with a discussion on the composition of union government receipts and expenditure position in the current scenario and indicated the situation of fiscal and revenue deficit of the government budget. Finally argue that subsidy rationalization is the way forward to fund the much-needed health expenditures and transfers while maintaining fiscal discipline.

The GIG Economy – Result of the Labour Market Platformization

The platformization of the economy, a term that recently appeared in economic theory as a result of the trend to optimize business processes through the development of digital platforms, has induced major changes in economic processes and systems, affecting all economic spheres, including the labour market. The trends of platformization of the labour market have transformed the Gig phenomenon, which refers to short-term work relationships, per project, into a large-scale trend, which includes an increasing number of specialists available to provide their services on this market. The article aims to analyze the premises that led to the development of the Gig economy, but also the impact that the Gig economy has on the players on this market. Particular attention in the article is given to the types of platforms that mediate Gig work relationships, but also the analysis of factual materials that confirm the importance of this phenomenon, respectively the need to carry out research in the field.

Association of activins, follistatins and inhibins with incident hip fracture in women with postmenopausal osteoporosis: a proof of concept, case-control study.

The activins-follistatins-inhibins (AFI) hormonal system is considered to regulate muscle and bone mass. We aimed to evaluate AFI in postmenopausal women with an incident hip fracture. In this post-hoc analysis of a hospital based case-control study, we evaluated circulating levels of the AFI system in postmenopausal women with a low-energy hip fracture admitted for fixation compared with postmenopausal women with osteoarthritis scheduled for arthroplasty. Circulating levels of follistatin (p = 0.008), FSTL3 (p = 0.013), activin B and AB (both p < 0.001), as well as activin AB/follistatin and activin AB/FSTL3 ratios (p = 0.008 and p = 0.029, respectively) were higher in patients than controls in unadjusted models. Differences for activins B and AB remained after adjustment for age and BMI (p = 0.006 and p = 0.009, respectively) and for FRAX-based risk for hip fracture (p = 0.008 and p = 0.012, respectively) but were lost when 25OHD was added to the regression models. Our data indicate no major changes in the AFI system in postmenopausal women at the time of hip fracture compared to postmenopausal women with osteoarthritis except for higher activin B and AB levels, whose significance, however, was lost when 25OHD was added to the adjustment models. Clinical Trials identifier: NCT04206618.

Introducing virtual classrooms for undergraduate physiology teaching during the COVID-19 pandemic: Acceptance by students and subjective impact on learning.

COVID-19 pandemic and complete lockdowns brought about major changes in the education system. There was a sudden obligatory shift toward the utilization of digital resources for teaching and learning purposes in those critical times. Medical education, specifically physiology teaching comprises much of laboratory works and hands-on trainings; such curriculums are very difficult to implement in the virtual mode. The present study was designed to evaluate and validate the efficiency and impact of online physiology teaching through a virtual classroom system in a class of 83 first year undergraduate MBBS students. Questions based on the availability and use of technology, ease and effectiveness, the adeptness of faculty, and learning outcomes were circulated among the undergraduate MBBS students of a tertiary medical college and hospital via digital mode and responses were recorded and analysed. Validation through principal components and factor analysis had showed that the online teaching is not much effective and has a limited application in the physiology education of undergraduate MBBS students. Our study revealed that virtual physiology teaching to undergraduate medical students during COVID-19 pandemic had a moderate level of effectiveness.

Predicting the Potential of China’s Geothermal Energy in Industrial Development and Carbon Emission Reduction

The goal of carbon peaking and carbon neutrality requires major systemic changes in the energy supply sector. As one of the major non-carbon-based energy sources, geothermal energy is characterized by large reserves, stability, and reliability. This paper summarizes the current situation of geothermal resource endowment and industrial development in China. Based on this, a system dynamics model of geothermal industrialization is established, and the potential of geothermal industrialization and carbon emission reduction in China is predicted. The prediction results show that the growth rate of geothermal heating and cooling areas in the next 40 years will follow a trend of acceleration followed by deceleration. China’s geothermal energy heating and cooling area will reach 11.32–14.68 billion m2 by 2060, an increase of about 9–12 times compared to 2020. The proportion of geothermal heating and cooling area to the total building area in China will reach 13.77–17.85%. The installed capacity of geothermal power generation will reach 14,452.80–20,963.20 MW by 2060 under the scenario with electricity subsidies. The proportion of geothermal energy in China’s primary energy consumption structure will reach 3.67–5.64%. The annual carbon emission reduction potential of the geothermal industry will reach 436–632 million tons, equivalent to 4.41–6.39% of China’s carbon emissions in 2020. The results of this study can provide a reference for the healthy and high-quality development of China’s geothermal industry and help to achieve carbon peaking and carbon neutrality goals.

Parliamentary roll-call voting as a complex dynamical system: The case of Chile.

A method is proposed to study the temporal variability of legislative roll-call votes in a parliament from the perspective of complex dynamical systems. We studied the Chilean Chamber of Deputies' by analyzing the agreement ratio and the voting outcome of each vote over the last 19 years with a Recurrence Quantification Analysis and an entropy analysis (Sample Entropy). Two significant changes in the temporal variability were found: one in 2014, where the voting outcome became more recurrent and with less entropy, and another in 2018, where the agreement ratio became less recurrent and with higher entropy. These changes may be directly related to major changes in the Chilean electoral system and the composition of the Chamber of Deputies, given that these changes occurred just after the first parliamentary elections with non-compulsory voting (2013 elections) and the first elections with a proportional system in conjunction with an increase in the number of deputies (2017 elections) were held.

Plastic loss of motile cilia in the gills of Polypterus in response to high CO2 or terrestrial environments.

The evolutionary transition of vertebrates from water to land during the Devonian period was accompanied by major changes in animal respiratory systems in terms of physiology and morphology. Indeed, the fossil record of the early tetrapods has revealed the existence of internal gills, which are vestigial fish-like traits used underwater. However, the fossil record provides only limited data on the process of the evolutionary transition of gills from fish to early tetrapods. This study investigated the gills of Polypterus senegalus, a basal ray-finned/amphibious fish which shows many ancestral features of stem Osteichthyes. Based on scanning electron microscopy observations and transcriptome analysis, the existence of motile cilia in the gills was revealed which may create a flow on the gill surface leading to efficient ventilation or remove particles from the surface. Interestingly, these cilia were observed to disappear after rearing in terrestrial or high CO2 environments, which mimics the environmental changes in the Devonian period. The cilia re-appeared after being returned to the original aquatic environment. The ability of plastic changes of gills in Polypterus revealed in this study may allow them to survive in fluctuating environments, such as shallow swamps. The ancestor of Osteichthyes is expected to have possessed such plasticity in the gills, which may be one of the driving forces behind the transition of vertebrates from water to land.

Annual-scale assessment of mid-20th century anthropogenic impacts on the algal ecology of Crawford Lake, Ontario, Canada.

Meromictic Crawford Lake, located in SW Ontario, Canada is characterized by varved sediments, making it suitable for high-resolution paleoecological studies. Freeze cores, the only coring method available that reliably preserves the fragile laminations representative of seasonal deposition in the lake, were used to document siliceous diatom and chrysophyte community structure at an annual resolution from 1930-1990CE. Stratigraphically constrained cluster analysis identified major assemblage changes that are believed to have been caused by local, regional and possibly global anthropogenic impacts. The assemblage changes within the siliceous algae are attributed to regional weather and increased industrial emissions and related effects of acid deposition on the lake's catchment associated with the Great Acceleration -the massive economic, industrial, and demographic expansion beginning in the mid-20th century. Observed increases in spheroidal carbonaceous particles (SCPs) in varved lake sediment dating to the early 1950s record rapidly expanding steel production without emission controls around 30 km upwind of the lake. The findings reported here reflect major changes in earth systems that the Anthropocene Working Group recommends for a proposed epoch to be termed the Anthropocene, providing support for the laminated sediments from Crawford Lake as a potential Global boundary Stratotype Section and Point (GSSP).