While progress has been made in learning more about American Indians and Alaska Natives (AI/ANs) who reside in Hawai'i, much more research is needed regarding adolescents' mental health and the major life events that they encounter. Utilizing a large cross-sequential epidemiologic design (N = 7,214; 1992-1996), this study found AI/AN-Hawaiian youth self-reported higher risk of predominantly negative major life events and mental health symptoms than for the non-Indigenous adolescent ethnic group, with the AI/AN and Native Hawaiian ethnic groups falling generally in between. However, when statistically controlling for covariates, overall, Native Hawaiian youth self-reported higher mental-health-symptom risk than the other three ethnic groups. Implications are discussed, including protective factors, prevention, and future research.