Thecoronavirus disease 2019 (COVID-19) pandemic is a major public health crisis worldwide. In less than 12 months since the World Health Organization declared the outbreak, severaldifferent COVID-19 vaccines have beenapprovedand deployed mostly indevelopedcountries sinceJanuary2021.However, hesitancy to accept the newlydeveloped vaccines is a well-known public health challenge that needs to be addressed.Theaimof this study wasto measurewillingness and hesitancy toward COVID-19 vaccines amonghealth care practitioners' (HCPs)in Saudi Arabia. Methods:A cross-sectional study using an online self-reported surveywas conducted among HCPsin Saudi Arabia betweenApril4thtoApril25th2021using snowball sampling. Multivariate logistic regression was employed to identify the possible factors affectingHCPs'willingnessand hesitancytoreceiveCOVID-19 vaccines. Results:Out of 776 participants who started the survey, 505 (65%) completed itand were included in the results. Among all HCPs,47 (9.3%) either said "no" to receive the vaccine[20 (4%)]or were hesitant to receive it[27 (5.3%)]. Of the total number of the HCPs, 376 (74.5%) already received the COVID-19 vaccine,and48 (9.50%) were registered to receive it.The main reason of agreement toreceivethe COVID-19 vaccine was "wanting to protect self and others from getting the infection" (24%). Conclusion:Our findings have shown that hesitancy toward receiving COVID-19 vaccines among HCPs in Saudi Arabia is limited and therefore may not be a serious issue.The outcomes of this studymayhelp to understand factors that lead to vaccine hesitancy in Saudi Arabia and help public health authorities to design targeted health education interventions aiming to increaseuptakeof these vaccines.