BackgroundThe selection of China annual major medical innovation organized by Chinese Academy of Medical Sciences (CAMS) has attracted increasing attention from the Chinese government and all sectors of society. It aims to explore a classification evaluation system that can reflect the characteristics of medical scientific and technological achievements, and advocate the proper value orientation of scientific and technological innovation. This study is the first public report on the selection process and results of China annual major medical innovation 2022. MethodsThe selection of "China annual major medical innovation 2022" was supported by multidimensional data, and the quantitative evaluation of key analysis indicators was combined with peer expert review. It is the first time to put forward the inflection point calculation theory in individual academic domains and apply it to the evaluation of medical achievements, which shows the characteristics of each subject. The classification and evaluation were carried out according to the six medical domains of clinical medicine, stomatology, fundamental medicine and biology, pharmacology, public health and environment, and biomedical engineering and information. ResultsThe 31 major healthcare items were recognized in "China annual major medical innovation 2022", including 7 items in clinical medicine, 4 in stomatology, 8 in fundamental medicine and biology, 2 in pharmacology, 5 in public health and environment, and 5 in biomedical engineering and informatics. ConclusionsThe selection of China annual major medical innovation has been organized and carried out by the CAMS for four consecutive years, and it is released once a year. The scientificity and credibility of the evaluation method and process have been continuously improved, bringing a certain social influence. At the same time, this study has a certain further space in the selection and weight design of key analysis indicators, the accuracy of the subject category for the results, the richness of the inflection point calculation theory in individual academic domains, and the scientific nature of multi-subject peer review.