Major Errors Research Articles

QMAC-dRAST for the direct testing of antibiotic susceptibility for Enterobacterales in positive blood-culture broth: a comparison of the performances with the MicroScan system and direct disc diffusion testing methods.

To evaluate the performances of the QMAC-dRAST GN (Gram-negative) kit for rapid antimicrobial sensitivity testing (AST) and two other methods, directly on positive blood-culture broth (PBCB), by comparison with a reference method: the MicroScan method based on broth microdilution on colonies isolated on PBCB subculture. In total, 156 samples were collected prospectively from blood cultures positive for a Gram-negative rod. Each sample was tested with four AST techniques: (i) the QMAC dRAST GN kit, (ii) the disc diffusion (DD) method, (iii) the MicroScan method applied directly to PBCB; and (iv) MicroScan with isolates from PBCB subculture, as a reference. For 124 PBCB containing Enterobacterales, overall essential agreement (EA) and categorical agreement (CA) between the QMAC-dRAST on PBCB and the reference reached 95.7% and 93.5%, respectively. There were 3.0% very major errors (VME), 4.0% major errors (ME) and 2.8% minor errors (mE). A comparison of MicroScan on PBCB and the reference yielded 98.8% EA, 98.5% CA, and rates of 0.6% VME, 0.9% ME and 0.7% mE. The DD method on PBCB gave a CA of 95.8% and rates of 1.7% for VME, 2.0% for ME and 1.9% for mE. Results were obtained more rapidly for QMAC-dRAST (median of 6 h 37 min versus 18 h for the MicroScan and DD methods on PBCB). The QMAC-dRAST system provided rapid results well correlated with the reference method on PBCB containing Enterobacterales. Given the shorter time-to-results, the QMAC-dRAST system constitutes a fast and reliable alternative to conventional AST methods.

Reporting antimicrobial susceptibilities and phenotypes of resistance to vancomycin in vancomycin-resistant Enterococcus spp. clinical isolates: A nationwide proficiency study

IntroductionThe ability of Spanish microbiology laboratories to (a) determine antimicrobial susceptibility (AS), and (b) correctly detect the vancomycin resistance (VR) phenotype in vancomycin-resistant Enterococcus spp. (VRE) was evaluated. MethodsThree VRE isolates representing the VanA (E. faecium), VanB (E. faecium) and VanC (E. gallinarum) VR phenotypes were sent to 52 laboratories, which were asked for: (a) AS method used; (b) MICs of ampicillin, imipenem, vancomycin, teicoplanin, linezolid, daptomycin, ciprofloxacin, levofloxacin and quinupristin–dalfopristin, and high-level resistance to gentamicin and streptomycin; (c) VR phenotype. Results(a) The most frequently used system was MicroScan; (b) according to the system, the highest percentage of discrepant MICs was found with gradient strips (21.3%). By antimicrobial, the highest rates of discrepant MICs ranged 16.7% (imipenem) to 0.7% (linezolid). No discrepant MICs were obtained with daptomycin or levofloxacin. Mayor errors (MEs) occurred with linezolid (1.1%/EUCAST) and ciprofloxacin (5.0%/CLSI), and very major errors (VMEs) with vancomycin (27.1%/EUCAST and 33.3%/CLSI) and teicoplanin (5.7%/EUCAST and 2.3%/CLSI). For linezolid, ciprofloxacin, and vancomycin, discrepant MICs were responsible for these errors, while for teicoplanin, errors were due to a misassignment of the clinical category. An unacceptable high percentage of VMEs was obtained using gradient strips (14.8%), especially with vancomycin, teicoplanin and daptomycin; (c) 86.4% of the centers identified VanA and VanB phenotypes correctly, and 95.0% the VanC phenotype. ConclusionMost Spanish microbiology laboratories can reliably determine AS in VRE, but there is a significant percentage of inadequate interpretations (warning of false susceptibility) for teicoplanin in isolates with the VanB phenotype.

Improving the performance of tropospheric mapping function in low elevation angle using artificial neural network

Tropospheric delay is one of the major error sources in global navigation satellite systems (GNSS). The position accuracy determined using GNSS depends on the satellite’s geometry factor. However, in low elevation angle GNSS signals have a high tropospheric slant delay error and need a good mapping function model to cover this error. In this paper, two new tropospheric mapping functions (hydrostatic and non-hydrostatic) were developed based on an artificial neural network (ANN). The first model (Model A) was based on the day of the year (DOY), latitude and longitude. The second model (Model B) added real-time surface pressure to the parameters of Model “A.” The two developed models showed a strong correlation with the ray tracing mapping function, with a significant t-test value.The applicability of these mapping functions was tested over the Egypt region. The comparison was done with ray tracing of 5220 traces for 145 days from 2014 to 2017 as well as by assessing it (Mohamed et al., Vienna and Niell). This evaluation showed that the new model “B” agrees very well with the ray trace value. Model “B” and ray traces are on par with each other for a very low elevation angle 2⁰ the hydrostatic and non-hydrostatic mapping functions. Models “B” and “A” gave hydrostatic mean biases of 32 and 39 mm, respectively, and for non-hydrostatic, 4.5 and 4.9 mm, respectively. Vienna, Niell, and Mohamed et al. gave 46, 45, and 94 mm in hydrostatic, respectively, and 5.4, 5.2 and 9.2 mm in non-hydrostatic, respectively.

An Error Analysis on the Use of English made by Local Tourism Workers of Jatiluwih Tourism Destination at Tabanan Bali

The research in general aimed on analyzing English language errors made by local tourism workers of Jatiluwih tourism destination in Tabanan, Bali, and specifically it aimed in revealing and analyzing types of errors made by the local tourism workers of Jatiluwih Tourism Destination in using English with foreign tourists. The primary research data are directly collected from the English language expressions used by the local tourism workers as informan of Jatiluwih Tourism Destination during their communication activities with the foreign tourists. The data informan are selected using purposive, snowball and abundant sampling techniques with the total number of 30 samples of the local tourism workers of Jatiluwih Tourism Destination in Tabanan, Bali. The collected data are analyzed using Error Analysis Theory proposed by Tarigan (1985) and Ellis (1986) (cited in Tarigan and Tarigan, 2011:63-64). The research reveal that the English language errors committed by local tourism workers of Jatiluwih Tourism Destination i Tabanan, Bali can be categorized into two major errors, which are: (1) errors of linguistic taxonomy category, which consists of two errors types, such as : (a) morphology errors and, (b) syntactic errors; (2) Errors of surface strategy taxonomy.

Evaluation of treatment planning system accuracy in estimating the stopping‐power ratio of immobilization devices for proton therapy

To assess treatment planning system (TPS) accuracy in estimating the stopping-power ratio (SPR) of immobilization devices commonly used in proton therapy and to evaluate the dosimetric effect of SPR estimation error for a set of clinical treatment plans. Computed tomography scans of selected clinical immobilization devices were acquired. Then, the water-equivalent thickness (WET) and SPR values of these devices based on the scans were estimated in a commercial TPS. The reference SPR of each device was measured using a multilayer ion chamber (MLIC), and the differences between measured and TPS-estimated SPRs were calculated. These findings were utilized to calculate corrected dose distributions of 15 clinical proton plans for three treatment sites: extremity, abdomen, and head-and-neck. The original and corrected dose distributions were compared using a set of target and organs-at-risk (OARs) dose-volume histogram (DVH) parameters. On average, the TPS-estimated SPR was 19.5% lower (range, -35.1% to 0.2%) than the MLIC-measured SPR. Due to the relatively low density of most immobilization devices used, the WET error was typically <1mm, but up to 2.2mm in certain devices. Overriding the SPR of the immobilization devices to the measured values did not result in significant changes in the DVH metrics of targets and most OARs. However, some critical OARs showed noticeable changes of up to 6.7% in maximum dose. The TPS tends to underestimate the SPR of selected proton immobilization devices by an average of about 20%, but this does not induce major WET errors because of the low density of the devices. The dosimetric effect of this SPR error was negligible for most treatment sites, although the maximum dose of a few OARs exhibited noticeable variations.

Evaluation of in-vitro colistin susceptibility and clinical profile of carbapenem resistant Enterobacteriaceae related invasive infections

PurposeTo determine the colistin susceptibility. To compare E-test vs broth-microdilution (BMD) method for invasive carbapenem resistant Enterobacteriaceae (CRE) infections. To study treatment options for the CRE. To analyze the clinical profile and outcome of CRE infections. MethodsAntimicrobial susceptibility testing was performed for 100 invasive CRE isolates. Gradient diffusion and BMD methods were performed to determine colistin MICs. Essential agreement (EA), categorical agreement (CA), very major error (VME), and major error (ME) were worked out between BMD method and E-test. The clinical profile of patients was analyzed. ResultsThe majority of the patients suffered from bacteremia [47(47%)]. Klebsiella pneumoniae was the most common organism isolated overall as well as among bacteremic isolates. 9(9%) CRE isolates were colistin resistant by BMD of which six were Klebsiella pneumoniae. There was 97% CA between E-test and BMD. EA was 68%. VME was found in three out of nine colistin resistant isolates. No ME was found. Among the other antibiotics tested for CRE isolates, the highest susceptibility was seen to tigecycline [43(43%)] followed by amikacin [19 (19%)]. The most common underlying condition was post solid organ transplantation [36(36%)]. A higher survival rate was seen among non-bacteremic CRE infections (58.49%) than bacteremic CRE infections (42.6%). Four out of nine patients with colistin resistant CRE infections survived and had a satisfactory outcome. ConclusionKlebsiella pneumoniae was the most common organism causing invasive infection. Survival rates were higher in non-bacteremic CRE infections than bacteremic infections. Good CA was seen between E-test and BMD for colistin susceptibility, but the EA was poor. VME was more common than ME when E-tests were used for colistin susceptibility testing resulting in false susceptibility. Tigecycline and aminoglycosides are possible adjunct drugs for the treatment of invasive CRE infections.

Evaluation of Broth Disk Elution Method to Determine Colistin Resistance in Klebsiella pneumoniae and Escherichia coli Strains.

The reference broth microdilution (rBMD) method for the determination of colistin resistance is very laborious and time consuming, and many manual errors can occur. There are also limitations in detection of colistin heteroresistance. Therefore, alternative methods with satisfactory performance are required for routine laboratory work. In our study, the colistin broth disk elution (CBDE) method recommended by the Clinical and Laboratory Standards Institute (CLSI) for the detection of colistin resistance in routine applications was compared with rBMD. The compatibility and error rates of the method were evaluated and its usability in routine laboratory studies was examined. Eighty-nine multidrug resistant Klebsiella pneumoniae and five Echerichia coli strains isolated from various clinical specimens were included in the study. Identification of strains and antibiotic susceptibility tests were performed with MALDI-TOF MS (bioMerieux, France) and Vitek-2 (bioMerieux) system. Minimum inhibitory concentration (MIC) was studied in 0.125 - 128 mg/L dilution range by using polystyrene microplate and colistin sulfate salt according to ISO-standard (20776-1) recommendations for the reference BMD test. The CBDE method was performed according to the CLSI recommendations. Isolates with MIC ≤ 2 mg/L were considered susceptible, while isolates with MIC > 2 mg/L were considered resistant according to EUCAST recommendations. The performance of the CBDE method was evaluated according to ISO criteria (Categorical agreement > 90%; major error and very major error rates < 3%). Categorical agreement for all 58 and 36 isolates found to be resistant and susceptible, respectively, by rBMD was found to be 100% with CBDE test. Since < 1 and > 4 µg/mL values could not be determined with the CBDE method, essential agreement (EA) could not be calculated. No major or very major errors were detected. Our results showed that the performance of the CBDE test is good when compared to the rBMD method. According to our data, we believe that the CBDE method can be used in routine laboratories for the detection of colistin resistance.

Concordance between HB&amp;L system and conventional culture method for bacterial antibiotic susceptibilities from positive blood samples at Hospital for Tropical Diseases from 03/2020 to 04/2021

Presently, shortening the time-to-result of antimicrobial susceptibility test (AST) is of the utmost importance for sepsis management in an effort to reduce mortality and antibiotic resistance rate. HB&amp;L ((Human Biological Liquid Culture), a product of the Alifax company (Italy), can detect replicating microorganisms and their antibiotic resistance in a few hours with high sensitivity and specificity by using light scattering technique. This study aims to evaluate the correlation between rapid antibiogram using the HB&amp;L system and the routine methods on positive blood cultures at the Hospital for Tropical Diseases in Ho Chi Minh City from March 2020 to April 2021. Gram-positive bacteria blood samples were tested against Cefoxitin, Vancomycin while Gram-negative bacteria samples were trialed with Ceftriaxone, Levofloxacin, Piperacillin-Tazobactam and Meropenem. The concordance of the two methods was defined by the categorical agreement (CA), very major errors (VME), major errors (ME) and minor errors (mE) in Cumitech 31A. Of the 81 blood culture samples containing Gram-negative bacteria, the CA of Ceftriaxone, Meropenem, Levofloxacin and Piperacillin-Tazobactam were 90%, 100%, 67% and 88%. The maximum VME was 22% for Levofloxacin. On the other hand, of the 32 Gram-positive samples, CA and VME of Cefoxitin were 53% and 65% respectively while CA of Vancomycin was 100%. The median time to receive rapid AST results of the HB&amp;L system is 4.43 hours faster than the standard that.

Simulating Dynamic of Suspended Sediment Flow Based on Data of Primorskaya Water Balance Station

Soil loss rate, suspended load, and suspended sediment discharge were simulated for the drainage basin of the Komarovka R., located at the territory of the former Primorskaya Water Balance, Russian Far East. The study was based on an open-code SWAT model. The model was calibrated and verified using archive measurement data on sediment load and suspended sediment discharge at PWBS by data of Tsentral’nyi hydrological gage (157 km2). The simulation efficiency of the suspended load and suspended sediment discharge corresponds to categories satisfactory and higher. On the average for the drainage basin, the rate of soil washout is 11–12 t/ha per year. The washout rate is maximal in the period of active snow melting. The mean monthly value for April–May is 75 thous. t. The mean annual washout is 171 thous. t, and the maximal is 800 thous. t/year. The mean annual runoff of suspended sediments in the outlet section of the drainage basin is 2.6 thous. t. The highest monthly values of sediment runoff correspond to the period of summer floods in August, when with average of 1 thous. and maximum of 7.7 thous. t. The obtained data on the heterogeneity of the spatial distribution of the simulated values of washout rate are in good agreement with the landscape and climatic features of runoff formation in the drainage river basin. The major errors in the estimation of sediment load are due to the simulation quality of the hydrological regime and dynamics of runoff components that form flood hydrographs.

Prenuptial Rituals in Scotland: Blackening the Bride and Decorating the Hen

Prenuptial Rituals in Scotland: Blackening the Bride and Decorating the Hen

A Comparative Analysis of ChatGPT and Google’s AI’s “Bard” in Medicine

Background: Bard AI, an AI chatbot developed by Google, emerged as a response to the success of OpenAI's ChatGPT. Bard utilizes natural language processing and machine learning techniques to emulate human-like dialogue. Objectives: In this paper, we wanted to compare the Bard’s performance to that of ChatGPT at various medical and surgical related tasks. Methods: The responses generated were then examined by three doctors based at three different institutions to compare the performance of each AI chatbot for each specific prompt. Results: Bard had the ability to generate a discharge summary, summarize medical literature, and recommend relevant medical guidelines. However, Bard’s generated responses were not always clinically appropriate and contained both minor and major errors. Bard and ChatGPT will likely be followed by even more capable AI systems. Conclusions: As these new tools are released it is important that they be viewed cautiously, ensuring that patient safety remains the fundamental priority.

Classification of key human factors in the area of information resources security management in small enterprises in Poland

This paper attempts to classify major errors affecting the security of information resources made by employees. Human factors that can be a direct cause of these errors were enumerated. The empirical part presents surveys conducted among small businesses in 2019 and 2022 related to the human factors discussed in the theoretical part. The study compared the results obtained before and after the COVID-19 pandemic. A discussion related to the factors and the results was presented.The main aim of the present research, conducted twice on a group of 287 small businesses in Poland, was to show changes in attitudes toward the security of intangible resources and how the COVID-19 pandemic has transformed the way of thinking of people responsible for information security in terms of behavioral security.

Internet-Based Procurement: An Analysis of the Malpractices and Errors in the use of PHilGEPS Website of the Philippine Center for Postharvest Development and Mechanization

The strict implementation of the use of PHilGEPS has been a major practice in government agencies, going to lengths such as moving the dates of procurement activities or cancelling bidding projects due to errors in the posting of advertisements. Moreover, it is in no discreet information that PHilGEPS experienced major errors and technical difficulties last year, even opting to use a temporary facility for revamping and improvement of the old PHilGEPS Website. However, despite the strict implementation of the use of the website, errors and malpractices are still a major problem for some government agencies leading up to disallowances and even show-cause orders. This descriptive study aimed to determine the cause of the transgressions and errors in the use of the PHilGEPS Website and the possible solutions to avoid such malpractice in the Philippine Center for Postharvest Development and Mechanization. To obtain the needed information, a survey questionnaire in the form of Google Forms was undertaken for this aim. The participants of the study are employees of the agency that uses and manages the PHilGEPS account of the procurement unit. Findings show the lack of training related to the use of the website contributes to the errors in the transactions. Also, strengthening and continuous improvement of PHilGEPs must be prioritized to avoid errors and transgressions in required postings.

Undergraduate students’ perceptions of teachers’ written feedback in academic writing class: A survey study

This survey study aims to describe the students’ perception of teachers’ written feedback in an academic writing class in a private university in Indonesia. 119 students filled in the questionnaire on students’ perceptions of teachers’ written feedback adapted from Ouahidi and Lamkhanter (2020). A descriptive statistic measuring mean, frequency, and standard deviation were used to analyze the data from the questionnaire. The results showed that the teacher’s written feedback to the writing results in the academic writing class was useful and students did not find it difficult to understand any feedback given by the teacher. Most of the students answered often when being asked about their understanding to the feedback. Students were also able to use teacher comments to revise their writing. Revision and rewriting were also found as the follow-up activities that are most often done by students after receiving feedback. Then, it was also revealed that students preferred their teacher to give them correction with comments to all the major errors in their writing. In addition to the feedback, students also preferred their teachers to give praise and criticism. Regarding the correction of students' writing work, students preferred the teacher to correct the errors in content or ideas. Further implications and suggestions are also discussed in this article.

Antimicrobial Susceptibility Profile of Rare Anaerobic Bacteria.

Anaerobes play an important role in clinically relevant infections and resistance is increasing worldwide. We tested 120 rare anaerobic isolates belonging to 16 genera for antimicrobial resistance using the agar dilution method and compared those results to the time-saving E-test method. The susceptibility data for 12 antimicrobial substances (benzylpenicillin, ampicillin/sulbactam, piperacillin/tazobactam, imipenem, meropenem, cefoxitin, metronidazole, moxifloxacin, clindamycin, doxycycline, tigecycline, eravacycline) were collected. Susceptibility testing showed low resistance to β-lactam/β-lactamase inhibitor combinations and no resistance to carbapenems and tigecycline. We observed moderate to high rates of resistance to moxifloxacin and clindamycin which differed depending on the methodology used. The essential and categorical agreement was over 90% for ampicillin/sulbactam, meropenem, moxifloxacin, and tigecycline. For metronidazole and clindamycin, the essential agreement was below 90% but the categorical agreement was near or above 90%. Penicillin presented with the lowest categorical agreement of 86.7% and a very high very major error rate of 13.3%. The resistance rates reported in this study are concerning and show the importance of routine susceptibility testing. Further investigations are necessary to determine the reason for high error rates and how to improve susceptibility testing of fastidious anaerobes.

Evaluation of errors during susceptibility reporting of glycopeptide antibiotics for enterococcal isolates on sole basis of widely used disk diffusion test

In resource limited settings, very often susceptibility reports glycopeptide antibiotics are released only on the basis of disk diffusion test. Determination of MIC by either E-strips or microbroth dilution tests can be of paramount importance in checking the errors that may have incurred with the singular use of disk diffusion tests. Distribution of errors in Vancomycin and Teicoplanin susceptibility reporting by disk diffusion test was evaluated in comparison with MIC determination with reference method of E-strip. A total of 40 isolates of Enterococcus species were obtained during the study period. In vancomycin susceptibility reporting, very major errors, major errors and minor errors were observed in 33.3%, 5.4% and 5% instances respectively. For teicoplanin, major errors were observed in 5.3% of instances. E test can be used in conjunction with disk diffusion where resources are limited. We have observed that by using a combination of both disk diffusion and MIC determination by E-strip methods for glycopeptide antibiotics, a majority of reporting errors can be addressed.

Clinical usefulness of the QMAC-dRAST system for AmpC β-lactamase-producing Enterobacterales

Background: Rapid antimicrobial susceptibility testing (RAST) is important for the appropriate treatment of bloodstream infections. The QMAC-dRAST system (QuantaMatrix Inc., Korea) can directly perform RAST using positive blood culture samples with microscopic imaging. This study aimed to evaluate the performance of the QMAC-dRAST system for AmpC β-lactamase-producing Enterobacterales. Methods: Eighty isolates (20 Morganella morganii, 20 Serratia marcescens, 10 Klebsiella aerogenes, 10 Enterobacter cloacae, and 20 Citrobacter freundii) and 14 antimicrobial agents were included in the antimicrobial susceptibility testing (AST). The performance of the QMAC-dRAST system was evaluated by simulating the clinical blood culturing process. We conducted a comparative evaluation of the QMAC-dRAST and Vitek 2 systems (bioMérieux Inc., France). Broth microdilution tests were performed as the reference method to resolve any discrepancies in the AST results between the two systems. Results: For 20 M. morganii and 20 S. marcescens, the categorical agreement (CA) between the QMAC-dRAST and Vitek 2 systems increased from 55.4% to 83.8% after AST algorithm optimization. Moreover, the discrepancy rates decreased as follows: from 19.1% to 5.4% very major errors (VME), from 38.3% to 4.3% major errors (ME), and from 14.6% to 12.1% minor errors (mE) for the QMAC-dRAST system compared to the Vitek 2 system. For all 80 tested isolates, the QMAC-dRAST system showed 93.0% CA, 1.7% VME, 2.3% ME, and 4.9% mE. Conclusion: The QMAC-dRAST system was comparable to the Vitek 2 system after AST algorithm optimization for AmpC β-lactamase-producers, which are major pathogens and require time to express the enzyme. However, further modifications of the AST algorithm are still warranted.

Evaluating the drop test method in measuring colistin susceptibility of Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa.

Introduction. Colistin is an antibiotic used to treat Gram-negative bacterial infections, particularly those caused by multidrug-resistant bacteria.Hypothesis/Gap Statement. The broth microdilution (BMD) reference method is the recommended protocol for detecting colistin susceptibility; however, it is laborious and expensive and cannot be performed in all laboratories.Aim. To evaluate the colistin susceptibility in Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa using an alternative method, which has been referred to as the drop test.Methodology. A 16 µg ml-1 colistin solution was deposited on a Mueller-Hinton agar plate previously swabbed with the strain and incubated overnight, and the presence or absence of an inhibition zone was observed.Results. The categorical agreement (CA) of the drop test with respect to BMD was 100 % when 190 Enterobacterales (19 E. coli and 171 K. pneumoniae) were used, and no major errors (MEs) or very major errors (VMEs) were detected. The CA of the drop test with respect to the BMD was 99.2 % for 119 P. aeruginosa isolates, while no ME was detected and only 1 VME (6.7%) was observed.Conclusion. The drop test is an alternative method for antimicrobial susceptibility testing of colistin against K. pneumoniae and E. coli. It is an adequate method for detecting resistant strains of P. aeruginosa, but susceptible isolates should be confirmed using BMD. The drop test is a simpler alternative to the BMD that does not require additional equipment and allows for the testing of numerous isolates in a short period of time.

Investigation of refrigerant pipe pressure drop and charge reduction of mobile air conditioning units with R1234yf

In this study, the pressure drop of automotive refrigerant pipes with the refrigerant R1234yf is investigated in detail. For this purpose, 1D and 3D simulations are compared with respect to prediction accuracy using liquid lines from a production car. It is shown that for a combined approach of the methods a very good agreement with the measured values can be obtained, whereas simplified modeling of the line as a straight pipe of equal length significantly underestimates the experimental values. The transition pieces between the pipe and the hose are of particular importance, since they account for up to 85% of the total pressure drop and therefore result in major errors if neglected. If hoses were eliminated, the lines could be designed smaller, resulting in a charge reduction of up to 56%.

Crosstalk Suppression in Individually Addressed Two-Qubit Gates in a Trapped-Ion Quantum Computer.

Crosstalk between target and neighboring spectator qubits due to spillover of control signals represents a major error source limiting the fidelity of two-qubit entangling gates in quantum computers. We show that in our laser-driven trapped-ion system coherent crosstalk error can be modeled as residual Xσ[over ^]_{ϕ} interaction and can be actively canceled by single-qubit echoing pulses. We propose and demonstrate a crosstalk suppression scheme that eliminates all first-order crosstalk utilizing only local control of target qubits, as opposed to an existing scheme which requires control over all neighboring qubits. We report a two-qubit Bell state fidelity of 99.52(6)% with the echoing pulses applied after collective gates and 99.37(5)% with the echoing pulses applied to each gate in a five-ion chain. This scheme is widely applicable to other platforms with analogous interaction Hamiltonians.