Although the increase in water pollution, the amount of water consumption also increased in population and their activities. The effect of climatic changes are considered as the main effect on Iraqi water resources on its quality and quantity. The goal of the present research is to explain the negative effect of the decreasing of water flow and climate change on the quality of water over the years 2005 to 2010 along the Euphrates river starting from AlHindyia Barrage through Al-Samawa to Al-Nasiriya sites. Historical climatological data of rainfall and temperature for the period 1990 to 2020 and hydrological data of discharge and hydrochimecal analysis for the period 2005 to 2010 were applied in this research. Three gauging stations were chosen on the stretch of the Euphrates River, Al-Hindyia Barrage, Al-Samawa and Al-Nasiriya city. The discharge of Euphrates river is correlated with the Total Dissolved Solids, the major cations (Na+, Ca2+, Mg2+ and K+) and anions (Cl-, SO42-, HCO3-). It was found that the decrease of discharge due to shortage of water resources and climate change led to increase salinity, Total Dissolved Solids and major ions were became higher with time. The concentration of Total Dissolved Solids increased significantly to reach about 846 ppm in Al-Hindyia Barrage and this rate continue to rise in Samawa to about 2545 ppm and Nasiriya 2724 ppm. it was found that the ions Na+, So42- dominated in Al-Hindyia Barrage water while Na+ and Cl- dominated in Samawa and Nasiriya city water.