The main objective of this paper is to evaluate the effect of implementing four Unconventional Arterial Intersection Designs (UAIDs) including median U-Turn, Superstreet, Jughandle and Single Quadrant Intersection on a major arterial road using SYNCHRO microscopic simulation software. For this purpose, Wadi Saqra Signalized Intersection on Shaker Bin Zaid major arterial road in Amman, Jordan was selected. The simulation results showed that only the Jughandle improved the intersection Level of Service (LOS) slightly, F–E. Nevertheless, the intersection delay was significantly reduced by 64.81%, 76.6%, 91.28% and 75.60% on the proposed Median U-Turn, Superstreet, Jughandle and Single Quadrant unconventional intersection design, respectively. This indicated that these UAIDs don't perform well under heavy traffic volumes. Also, since the Jughandle was the only UAID which improved the LOS on the main intersection, the operational performance of Prince Shaker Bin Zaid arterial after implementing the Jughandle at the main intersection was evaluated including the main intersection: Wadi Saqra intersection, one prior to the main intersection and one after the main intersection. It was found that the use of the Jughandle increased the average travel speed by 35% and decreased the average stopped delay by 28.68% on the arterial road. Also, this paper evaluated the current transportation system and road user's attitude towards UAIDs' implementation through a questionnaire survey. The results indicated high acceptance of UAIDs. Finally, the construction cost for each UAID type was estimated. It was found that the Jughandle had the highest construction cost due to its high acquisition cost.