Aim: This study was carried out to evaluate the long-term impact of manuring, fertilization and liming on soil resilience, enzyme activities and system productivity under changing climate scenarios. Methodology: The soil samples were collected from 67 year old long-term experiment going on, at Birsa Agricultural University, Jharkhand during 2022-23 under maize-wheat cropping system from seven treatments, viz. T1: control, T2: 100 % N, T3: 100 % FYM, T4: ½ (N+FYM) + PX/2 + KY/2, T5: 100 % NPK, T6: Lime + NPK, T7: Lime + FYM +P(A-X) + K(B-Y). To assess soil resistance and resilience, surface samples were subjected to with and without heat stress (48±2°C for 80 hrs) and substrate addition (0.02 g glucose g-1 soil). Results: Application of FYM/lime with NPK significantly improved bulk density, pH, SOC and system productivity. The highest enzyme activities and cumulative respiration were observed in lime + FYM + P(A-X) + K(B-Y) treatment. It exhibited the highest resistance index (0.92) and resilience index (0.34). Interpretation: The integrated use of inorganic, organic along with liming proved to be a useful management strategy for maintaining soil quality, resistance and resilience, and crop productivity in acid soil of Jharkhand. Key words: Enzyme, Heat stress, Maize-wheat system, Soil acidification, Substrate induced respiration, Wheat-maize