Multiple odontogenic keratocysts are a rare, but well recognized condition that characteristically affects the jaws of middle-aged women. The radiographic appearance can vary from areas of radiolucency to mixed lesions and to opaque masses which are often bilaterally. This condition has been classified as sclerosing osteitis, multiple enostoses, diffuse chronic osteomyelitis and gigantiform cementoma. The lesion is usually benign and requires no treatment unless cosmetically concerning or becomes symptomatic. For the asympto- matic patient the best management consists of regular recall examination with prophylaxis and maintenance of good oral hygiene According to the recent review of literature, only five patients of florid cemento-osseous dysplasia from India have been reported (less than 2%). Here presentsuch a rare case occurring in a 38 year – old female who came with dull pain in upper right back teeth region since 6 months. Radiographically, it showed mixed radiolucent / radio-opaque mass in both right and left premolar to molar region.