Maintain Body Temperature Research Articles

Effect of Collagen Molecules and Hydroxyapatite Salt on Thermal Properties of Rib, Scapula, and Femur of Some Bovines under Normal and Decalcified Conditions

The study of thermal properties such as conductivity and specific heat of biomaterials is very important as most biological processes, in which biological tissues, cells, and molecules are involved are dependent on body temperature. The main source of body heat is the chemical metabolism of food. Various mechanisms are being adopted by different types of animals to maintain body temperature, such as reducing blood flow through the capillaries nearest the skin surface, body hair can be fluffed up to increase insulation, heat production by shivering, etc. The hard and soft tissues, such as the flesh and bone of animals, play a very important role in keeping the required body temperature. The thermal conductivity and specific heat of the femur, rib, and scapula of two different environment animal ox, the wetland and camel desert dry land are investigated in normal and decalcified conditions. Modified Lee’s apparatus has been used to determine the thermal conductivity, while Renault’s apparatus which is based on the principle of the method of mixtures has been employed for determining the specific heat of samples that were pelletized. A difference in conductivities and specific heat of various bones in both animals was observed due to varied calcium phosphate. The decalcified bone samples of ox and camel show higher thermal conductivity compared to normal bones, while a decrease in specific heat was observed in decalcified bones. The specific heat is affected by the variations in the molecular structure due to changes in temperature. The paper suggests that these techniques are simple, elegant, and inexpensive besides being accurate.

An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications.

Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1. Over the last decade, an in-creasing number of studies have found that activating brown adipose tissue and browning of white adipose tissue can protect against obesity and obesity-related metabolic disease. Brown adipose tissue has gradually become an appealing therapeutic target for the prevention and re-versal of obesity. However, some important issues remain unresolved. It is not certain whether increasing brown adipose tissue activity is the cause or effect of body weight loss or what the risks might be for sympathetic nervous system-dependent non-shivering thermogenesis. In this review, we comprehensively summarize approaches to activating brown adipose tissue and/or browning white adipose tissue, such as cold exposure, exercise, and small-molecule treatment. We highlight the functional mechanisms of small-molecule treatment and brown adipose tissue transplantation using batokine, sympathetic nervous system and/or gut microbiome. Finally, we discuss the causality between body weight loss induced by bariatric surgery, exercise, and brown adipose tissue activity.

Noncontact Respiratory Motion Detection in Anesthetized Rodents

Small animal physiology studies are often complicated, but the level of complexity is greatly increased when performinglive-animal X-ray imaging studies at synchrotron radiation facilities. This is because these facilities are typically not designedspecifically for biomedical research, and the animals and image detectors are located away from the researchers in a radiationenclosure. In respiratory X-ray imaging studies one challenge is the detection of respiration in free-breathing anaesthetisedrodents, to enable images to be acquired at specific phases of the breath and for detecting changes in respiratory rate. Wehave previously used a Philtec RC60 sensor interfaced to a PowerLab data acquisition system and custom-designed timinghub to perform this task. Here we evaluated the Panasonic HL-G108 for respiratory sensing. The performance of the twosensors for accurate and reliable breath detection was directly compared using a single anesthetized rat. We also assessedhow an infrared heat lamp used to maintain body temperature affected sensor performance. Based on positive results fromthese comparisons, the HL-G108 sensor was then used for respiratory motion detection in tracheal X-ray imaging studies of21 rats at the SPring-8 Synchrotron, including its use for gated image acquisition. The results of that test were compared toa similar imaging study that used the RC60 for respiratory detection in 19 rats. Finally, the HL-G108 sensor was tested on 5mice to determine its effectiveness on smaller species. The results showed that the HL-G108 is much more robust and easierto configure than the RC60 sensor and produces an analog signal that is amenable to stable peak detection. Furthermore,gated image acquisition produced sequences with substantially reduced motion artefacts, enabling the additional benefit ofreduced radiation dose through the application of shuttering. Finally, the mouse experiments showed that the HL-G108 isequally capable of detecting respiration in this smaller species.

Hydration patterns and beverage consumption among a sample of institutionalized senior adults in Portugal

Water plays an important role in different body functions, being fundamental for cells, tissues, and organs. It is also directly related to various processes, from maintaining body temperature to eliminating compounds. With age the feeling of thirst decreases, which can lead to inadequate consumption of water causing dehydration in the senior population. This dehydration can have consequences on the clinical status of this population, enhancing its clinical decline. The primary objective of the present study was to evaluate the daily consumption of liquid from beverages in institutionalized individuals in a senior adult residence in the Lisbon area. A cross-sectional observational quantitative study views. An adapted version of a specific fluid-validated questionnaire was used to assess the consumption of different beverages and total daily fluid intake. It was observed that institutionalized individuals did not consume enough total fluid intake to meet the European recommendations appropriate for their sex and age group. Nevertheless, individuals receiving artificial nutrition achieve a daily consumption of 1.5 liters of water.

Noncontact Respiratory Motion Detection in Anesthetized Rodents

Small animal physiology studies are often complicated, but the level of complexity is greatly increased when performinglive-animal X-ray imaging studies at synchrotron radiation facilities. This is because these facilities are typically not designedspecifically for biomedical research, and the animals and image detectors are located away from the researchers in a radiationenclosure. In respiratory X-ray imaging studies one challenge is the detection of respiration in free-breathing anaesthetisedrodents, to enable images to be acquired at specific phases of the breath and for detecting changes in respiratory rate. Wehave previously used a Philtec RC60 sensor interfaced to a PowerLab data acquisition system and custom-designed timinghub to perform this task. Here we evaluated the Panasonic HL-G108 for respiratory sensing. The performance of the twosensors for accurate and reliable breath detection was directly compared using a single anesthetized rat. We also assessedhow an infrared heat lamp used to maintain body temperature affected sensor performance. Based on positive results fromthese comparisons, the HL-G108 sensor was then used for respiratory motion detection in tracheal X-ray imaging studies of21 rats at the SPring-8 Synchrotron, including its use for gated image acquisition. The results of that test were compared toa similar imaging study that used the RC60 for respiratory detection in 19 rats. Finally, the HL-G108 sensor was tested on 5mice to determine its effectiveness on smaller species. The results showed that the HL-G108 is much more robust and easierto configure than the RC60 sensor and produces an analog signal that is amenable to stable peak detection. Furthermore,gated image acquisition produced sequences with substantially reduced motion artefacts, enabling the additional benefit ofreduced radiation dose through the application of shuttering. Finally, the mouse experiments showed that the HL-G108 isequally capable of detecting respiration in this smaller species.

Cold stress during room temperature housing alters skeletal response to simulated microgravity (hindlimb unloading) in growing female C57BL6 mice

Laboratory mice are typically housed at temperatures below the thermoneutral zone for the species, resulting in cold stress and premature cancellous bone loss. Furthermore, mice are more dependent upon non-shivering thermogenesis to maintain body temperature during spaceflight, suggesting that microgravity-induced bone loss may be due, in part, to altered thermogenesis. Consequently, we assessed whether housing mice at room temperature modifies the skeletal response to simulated microgravity. This possibility was tested using the hindlimb unloading (HLU) model to mechanically unload femora. Humeri were also assessed as they remain weight bearing during HLU. Six-week-old female C57BL6 (B6) mice were housed at room temperature (22 °C) or near thermoneutral (32 °C) and HLU for 2 weeks. Compared to baseline, HLU resulted in cortical bone loss in femur, but the magnitude of reduction was greater in mice housed at 22 °C. Cancellous osteopenia in distal femur (metaphysis and epiphysis) was noted in HLU mice housed at both temperatures. However, bone loss occurred at 22 °C, whereas the bone deficit at 32 °C was due to failure to accrue bone. HLU resulted in cortical and cancellous bone deficits (compared to baseline) in humeri of mice housed at 22 °C. In contrast, fewer osteopenic changes were detected in mice housed at 32 °C. These findings support the hypothesis that environmental temperature alters the skeletal response to HLU in growing female mice in a bone compartment-specific manner. Taken together, species differences in thermoregulation should be taken into consideration when interpreting the skeletal response to simulated microgravity.

Cooling strategies during neonatal transport for hypoxic-ischaemic encephalopathy.

We reviewed the literature on cooling methods during transport of newborn infants with hypoxic-ischaemic encephalopathy (HIE) born in a non-tertiary centre and transferred to a neonatal intensive care unit for therapeutic hypothermia. The electronic databases CENTRAL, MEDLINE, Embase, CINAHL, and Scopus were searched from inception up to 8 March 2022 for studies comparing cooling versus no cooling, active versus passive cooling, and servo-controlled versus non-servo-controlled cooling. Odds ratio and confidence of interval were calculated for dichotomous outcomes and mean difference and confidence interval for continuous outcomes. The final analysis included 14 studies, 1 randomised and 13 non-randomised, involving 1098 newborn infants. Compared with the other cooling methods, servo-controlled active cooling was more likely to maintain body temperature within the target range of 33°C-34°C on arrival at a neonatal intensive care unit: odds ratio 13.58, 95% confidence interval 4.32-42.66, risk difference 0.33, 95% confidence interval 0.19-0.46; 224 participants; three studies; I2 0%. The certainty of evidence was low. Only five studies reported mortality rates. Servo-controlled active cooling may be the preferred method during transport of newborn infants with HIE. A future area of focus should be long-term neurodevelopmental outcomes after servo-controlled active cooling.

Heat Release by Isolated Mouse Brain Mitochondria Detected with Diamond Thermometer

The production of heat by mitochondria is critical for maintaining body temperature, regulating metabolic rate, and preventing oxidative damage to mitochondria and cells. Until the present, mitochondrial heat production has been characterized only by methods based on fluorescent probes, which are sensitive to environmental variations (viscosity, pH, ionic strength, quenching, etc.). Here, for the first time, the heat release of isolated mitochondria was unambiguously measured by a diamond thermometer (DT), which is absolutely indifferent to external non-thermal parameters. We show that during total uncoupling of transmembrane potential by CCCP application, the temperature near the mitochondria rises by 4-22 °C above the ambient temperature with an absolute maximum of 45 °C. Such a broad variation in the temperature response is associated with the heterogeneity of the mitochondria themselves as well as their aggregations in the isolated suspension. Spontaneous temperature bursts with comparable amplitude were also detected prior to CCCP application, which may reflect involvement of some mitochondria to ATP synthesis or membrane potential leaking to avoid hyperproduction of reactive oxygen species. The results obtained with the diamond temperature sensor shed light on the "hot mitochondria" paradox.

Busting muscle myths

Skeletal muscle is the most abundant tissue in the human body. Known for its primary role in movement, muscle also plays important roles in regulating metabolism, maintaining body temperature and providing large stores of protein, carbohydrates and fats. Muscle cells (known as ‘muscle fibres’) can rapidly adapt to exercise or disuse by changing size and function. Many myths and misconceptions have proliferated through the years related to skeletal muscle, exercise training and human performance. Some of these myths have spanned centuries, but more recent research has passed doubt on these stories. In this article, we address common misconceptions, including the ‘go big or go home’ and ‘if you don’t use it, you lose it’ approaches to training. Clarification of these myths could positively impact individual exercise programs/therapies and their outcomes.

HDL-localized plasma ceramides support body temperature regulation

Abstract As organisms age, the balance of energy expenditure is disrupted. One of the major ways in which this disruption is observed is in an inability to maintain body temperature. Our lab is interested in understanding the signals that regulate this energy balance, and we focus on lipids as energy substrates and signaling molecules to regulate this process. During cold exposure, plasma lipids produced by peripheral tissues are required to fuel and activate heat production in the brown adipose tissue. One of the lipid classes that increases with cold exposure is plasma ceramides. Beyond cold exposure, ceramide lipids are also elevated in aged individuals and are associated with increased cardiovascular disease risk and age-related diseases such as Alzheimer’s disease where they are thought to signal inflammation. However, the functions of ceramides in non-disease states are unknown. To address this gap in knowledge, we have shown that ceramide production in 12-week-old C57Bl6/J mice is required for body temperature maintenance in the cold. Moreover, plasma ceramide levels in 2-year-old mice are unchanged in the cold, and these mice are unable to maintain their body temperature. In disease states, ceramides are transported through the plasma in LDL, but ceramides are enriched in the HDL plasma fraction in the cold. This differential plasma lipid transport suggests dynamic modes of lipid uptake and tissue targeting to regulate energy expenditure. This work will identify molecular mechanisms governing ceramide function in the mammalian response to cold and better our understanding of the systemic lipid metabolism dysregulated in disease.

Characterization of pig skeletal muscle transcriptomes in response to low temperature

The response of mammals to cold environment is a complex physiological activity, and its underlying mechanism must be analyzed from multiple perspectives. Skeletal muscle is an important thermogenic tissue that maintains body temperature in mammals. We dissected the molecular mechanism of pig skeletal muscle response to a cold environment by performing comparative transcriptome analysis in the Enshi black pig. Three pigs were subjected to acute cold stress (3 days), three pigs were subjected to cold acclimation (58 days), and three pigs were used as controls. RNA-seq was used to screen the differentially expressed genes (DEGs) of skeletal muscle. Using RNA-seq methods, we identified 1241 DEGs within the acute cold stress group and 1886 DEGs within the cold acclimation group. Prolonged cold exposure induced more gene expression changes. A total of 540 key cold-responsive DEGs were found, and their trends were consistent within the acute cold stress group and cold acclimation group. Gene expression pattern analysis showed that there were significant differences between the low-temperature treatment groups and the control group, and there were also differences between individuals after long-term low-temperature treatment. Analysis of DEGs revealed that 134 pathways were significantly enriched in the cold adaptation group, 98 pathways were significantly enriched in the acute cold stress group, and 71 pathways were shared between the two groups. The 71 shared pathways were mainly related to lipid, amino acid, and carbohydrate metabolism; signal transduction; endocrine, immune, and nervous system; cardiovascular disease; infectious diseases caused by bacteria or viruses; and neurodegenerative disease. In conclusion, this study provides insights into the molecular mechanism of porcine skeletal muscle response under low-temperature environment. The data may assist further research on the mechanism of pig response to cold exposure.

Primate preoptic neurons drive hypothermia and cold defense

Maintaining body temperature within a narrow range is vital for warm-blooded animals. In rodents, the preoptic area (POA) of the hypothalamus detects and regulates core body temperature. However, knowledge about the thermal regulation center in primates remains limited. Here, we show that activating a subpopulation of POA neurons by a chemogenetic strategy reliably induces hypothermia in anesthetized and freely moving macaques. Comprehensive monitoring of physiological parameters reveals that such hypothermia is accompanied by autonomic changes including a rise in heart rate, skeletal muscle activity, and correlated biomarkers in blood. Consistent with enhanced ambulatory movement during hypothermia, the animals show a full range of cold-defense behaviors. Resting-state fMRI confirms the chemogenetic activation of POA and charts a brain-wide network of thermoregulation. Altogether, our findings demonstrate the central regulation of body temperature in primates and pave the way for future application in clinical practice.

Fermented Cosmetics and Metabolites of Skin Microbiota—A New Approach to Skin Health

The skin covers our entire body and is said to be the “largest organ of the human body”. It has many health-maintaining functions, such as protecting the body from ultraviolet rays and dryness and maintaining body temperature through energy metabolism. However, the number of patients suffering from skin diseases, including atopic dermatitis, is increasing due to strong irritation of the skin caused by detergents that are spread by the development of the chemical industry. The skin is inhabited by about 102–107 cells/cm2 and 1000 species of commensal bacteria, fungi, viruses, and other microorganisms. In particular, metabolites such as fatty acids and glycerol released by indigenous skin bacteria have been reported to have functional properties for the health of the skin. Therefore, skin-domesticating bacteria and the metabolites derived from those bacteria are used in many skincare product ingredients and function as probiotic cosmetics. Japanese traditional fermented stuff, used as foods in Japan for over 1300 years, are now being applied as fermented cosmetics. Fermented cosmetics are expected to have multifaceted health functionality and continue to grow as products in the natural skincare product market. In this review, we consider approaches to skin health using fermented cosmetics and modulation of skin microflora metabolites.

Mothers’ needs in discharge planning for low birth weight babies: A qualitative study

PurposeThis study aimed to identify mothers’ needs in discharge planning for low birth weight (LBW) babies. MethodA qualitative descriptive method with semi-structured interviews was used. Samples were collected via purposive sampling of eight mothers. Interviews were audio-recorded, transcribed, and thematically analysed. ResultsThe key needs of mothers of LBW babies during discharge were classified into three themes: (1) information on routine baby care (i.e. maintaining body temperature, fulfilling the baby's nutritional needs, personal hygiene, supporting baby care, and the baby's growth and development); (2) variation in information sources (e.g. workers, communities, and supporters); and (3) different types of communication (i.e. interactive and non-interactive). ConclusionMothers of LBW babies need information on routine baby care before discharge, variation in their information sources, and the types of communication. Clear hospital policies and discharge planning guidelines that consider mothers’ needs are necessary for successful discharge planning.

Transcriptome-based selection and validation of optimal reference genes in perirenal adipose developing of goat (Capra hircus).

Brown adipose tissue (BAT) is mainly present in young mammals and is important for maintaining body temperature in neonatal mammals because of its ability to produce non-shivering thermogenesis. There is usually a large amount of BAT around the kidneys of newborn kids, but the BAT gradually "whiting" after birth. Screening and validating appropriate reference genes is a prerequisite for further studying the mechanism of goat brown adipose tissue "whiting" during the early stages. In this study, the expression stability of 17 candidate reference genes: 12 COPS8, SAP18, IGF2R, PARL, SNRNP200, ACTG1, CLTA, GANAB, GABARAP, PCBP2, CTSB, and CD151) selected based on previous transcriptome data as new candidate reference genes, 3 (PFDN5, CTNNB1, and EIF3M) recommended in previous studies, and 2 traditional reference genes (ACTB and GAPDH) was evaluated. Real-time quantitative PCR (RT-qPCR) technology was used to detect the expression level of candidate reference genes during goat BAT "whiting". Four algorithms: Normfinder, geNorm, ΔCt method, and BestKeeper, and two comprehensive algorithms: ComprFinder and RefFinder, were used to analyze the stability of each candidate reference genes. GABARAP, CLTA, GAPDH, and ACTB were identified as the most stable reference genes, while CTNNB1, CTSB, and EIF3M were the least stable. Moreover, two randomly selected target genes IDH2 and RBP4, were effectively normalized using the selected most stable reference genes. These findings collectively suggest that GABARAP, CLTA, GAPDH, and ACTB are relatively stable reference genes that can potentially be used for the development of perirenal fat in goats.

Proper regulation of β-adrenergic signal requires Btg2 gene for lipolysis and thermogenesis in response to starvation or cold acclimation in female mice

Mammals maintain constant body temperature in cold environment by activating thermogenesis via adrenergic/protein kinase A (PKA) signaling. B-cell translocation gene 2 (BTG2/Tis21), induced by PKA signaling, regulates glucose and lipid metabolism in liver, yet its role in lipolysis and in thermogenesis is not explored. Here, Btg2-knockout (KO) mice failed to maintain body temperature under starvation, or in cold acclimation. And norepinephrine-induced thermogenic response was turned off earlier in the KO mice. Gender specifically, gonadal white adipose tissues (gWAT) of female-KO were very active in lipolysis in fed state, however, the fat degradation was diminished upon fasting or cold acclimation. Also, insulin sensitivity was increased in female-KO, but not in male-KO mice, along with the low bone mineral density and small brown adipose tissues (BAT). In the mechanistic aspect, expressions of UCP1 and lipases (LPL, ATGL, HSL) in gWAT of female-KO mice were significantly reduced in response to adrenergic signals. Here, we present some data that Btg2 gene is essential for properly respond to β-adrenergic signals, and plays as a negative regulator of insulin signaling in female mice.

Effect of aging on cardiovascular responses to cold stress in humans

Abstract Cold exposure increases the risk of adverse events related to cardiovascular causes, especially in the elderly. In this review, we focus on recent findings concerning the impact of aging on the regulatory mechanisms of cold-induced cardiovascular responses. In response to cold exposure, the initial physiological thermoregulation in healthy young persons, such as cutaneous vasoconstriction to reduce heat loss, is attenuated in older individuals, resulting in a reduced ability of the older persons to maintain body temperature in cold environment. Impaired sympathetic skin response, reduced noradrenergic neurotransmitter synthesis, insufficient noradrenergic transmitters, and altered downstream signaling pathways inside the vascular smooth muscle may be among the underlying mechanisms for the maladaptive vasoconstrictive response to cold stress in the elderly. The increase in blood pressure during cold exposure in young persons may be further augmented in aging adults, due to greater central arterial stiffness or diminished baroreflex sensitivity with aging. Cold stress raises myocardial oxygen demand caused by increased afterload in both young and old adults. The elderly cannot adjust to meet the increased oxygen demand due to reduced left ventricular compliance and coronary blood flow with advancing age, rendering the elderly more susceptible to hypothermia-induced cardiovascular complications from cold-related diseases. These age-associated thermoregulatory impairments may further worsen patients' health risk with existing cardiovascular diseases such as hypertension, coronary artery disease, and heart failure. We searched PubMed for papers related to cold stress and its relationship with aging, and selected the most relevant publications for discussion.

The relationship between operation duration and shivering in post-spinal anaesthesia patients

Background: Giving spinal anaesthesia is an effort to relieve pain to create optimal conditions for surgery operation consciously. A shivering event frequently follows the phenomenon of the long duration of the operation. 
 Purpose: The study aimed to determine the relationship between operation duration and shivering in post spinal anaesthesia patients.
 Methods: The study design is a quantitative study and uses a cross-sectional approach. Sampling used a systematic sampling technique on the population of patients undergoing surgery under spinal anaesthesia. The instrument used Croessley and Mahajan’s observation sheet. This study uses Spearman rank rho as the statistical test with a significant value of p=0.05. 
 Results: The study showed almost respondents, as many as 86.15 respondents (56 patients) experienced shivering. Based on the Spearman statistical test, the p-value is 0.046.
 Conclusions: It can be concluded that there was a relationship between operation duration and incidence of shivering. Therefore, to reduce the occurrence of shivering, it is necessary to take measures such as giving warm blankets, warm fluids, and tools to maintain body temperature (force air warming).

Multimotor Drive Control Method of Upper-Retort-Robot Based on Machine Vision

In the cold season, wine aids in maintaining body temperature and is advised for military officers. This paper proposes a study on the multimotor drive control method of the upper-retort-robot based on machine vision for wine brewing automation to meet the demand of military areas located in cold regions, as wine is recommended to keep soldiers’ body temperatures normal in China’s extremely cold regions. Based on machine vision, the target is converted into an image signal by an image pickup device and is sent to the image processing system. Pixel distribution, brightness, color, and other data are transformed to digital signals, and target attributes are retrieved to control the field equipment’s operations. The Monte-Carlo approach is used to generate joint variables at random within each joint’s fluctuation range. The positive aspects of kinematics model are utilized and the working space of the upper-retort-robot is calculated using multimotor drive control method. The multimotor drive compensates the harmonic ripple torque and establishes the fault-tolerant automatic control of the system to maintain quality of the liquor. The results of the experiments reveal that the robot arm can reach any place within the barrel’s set range. To control the quality of the liquor, the robot will function in an automatic manner. The robot’s transmission performance is capable of meeting the requirements for automated liquor quality control during the production of wine from grapes. The results show that the suggested multimotor drive control (MMDCM) approach is robust and viable in terms of robot transmission performance and dexterity.

Prospective comparative analysis of noninvasive body temperature monitoring using zero heat flux technology (SpotOn sensor) compared with esophageal temperature monitoring during pediatric surgery.

Maintaining body temperature in pediatric patients is critical, but it is often difficult to use currently accepted core temperature measurement methods. Several studies have validated the use of the SpotOn sensor for measuring core temperature in adults, but studies on pediatric patients are still lacking. The aim of this study was to investigate the accuracy of the SpotOn sensor compared with that of esophageal temperature measurement in pediatric patients intraoperatively. Children aged 1-8 years with American Society of Anesthesiology Physical Condition Classification I or II scheduled to undergo elective ear surgery for at least 30 min under general anesthesia were enrolled. Body core temperature was measured every 15 min after induction till the end of anesthesia with an esophageal probe, axillary probe, and SpotOn sensor. We included 49 patients, providing a total 466 paired measurements. Analysis of Pearson rank correlation between SpotOn and esophageal pairs showed a correlation coefficient (r) of 0.93 (95% confidence interval [CI] 0.92-0.94). Analysis of Pearson rank correlation between esophageal and axillary pairs gave a correlation coefficient (r) of 0.89 (95% CI 0.87-0.91). Between the SpotOn and esophageal groups, Bland-Altman analysis revealed a bias (SD, 95% limits of agreement) of -0.07 (0.17 [-0.41-0.28]). Between the esophageal and axillary groups, Bland-Altman analysis showed a bias (SD, 95% limits of agreement) of 0.45 (0.22 [0-0.89]). In pediatric patients during surgery, the SpotOn sensor showed high correlation and agreement with the esophageal probe, which is a representative core temperature measurement method.