We present an estimate of the performance that will be achieved during on-orbit operations of the JWST mid-infrared instrument, MIRI. The efficiency of the main imager and spectrometer systems in detecting photons from an astronomical target are presented, based on measurements at subsystem and instrument-level testing, with the end-to-end transmission budget discussed in some detail. The brightest target fluxes that can be measured without saturating the detectors are provided. The sensitivity for long-duration observations of faint sources is presented in terms of the target flux required to achieve a signal-to-noise ratio of 10 after a 10,000 s observation. The algorithms used in the sensitivity model are presented, including the understanding gained during testing of the MIRI flight model and flight-like detectors.
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