Main Route Research Articles

Gorjanci Roads and Paths through Time

The paper deals with roads and trails that used to lead to Bela Krajina and Žumberak across the Gorjanci Ridge. Seven main routes have been identified that were sometimes more and sometimes less frequented, depending on the time and political circumstances. In all periods, however, the most important link between the regions of Dolenjska and Bela Krajina was the communication through the Vahta Pass, which gradually changed from a prehistoric path to a road. It was only in the 1880s that it underwent a thorough reconstruction, during which the most dangerous gradients were smoothed out with a series of hairpin bends.

H2-rich syngas generated from forestry waste gasification by recycling hot blast furnace gas

H2-rich syngas injection and decarbonization of blast furnace gas are the main technical routes for achieving low-carbon iron-smelting in the iron and steel industry. In this study, a novel process of H2-rich syngas generated from forestry waste (FW) gasification by hot recycling blast-furnace gas (BFG) is proposed. A model of FW gasification by the hot BFG in an entrained-flow gasifier is constructed using Aspen Plus with a focus on minimizing Gibbs free energy. Meanwhile, the techno-economic analysis of H2-rich syngas generated from FW gasification is also evaluated via taking 36 tones/hr of FW gasification as the objective. The model is experimentally validated with gasification results derived from published studies. The technology analysis reveals that the optimum performance for H2-rich syngas generated from FW gasification by the hot BFG with total energy efficiency of 74.75 % is observed at a gasification temperature of 850 °C, steam/FW ratio of 0.18 kg/kg, and BFG/FW ratio of 2 m3/kg. The economic analysis indicated that the net present value (NPV), payback period (PBR), and internal rate of return (IRR) are in sequence as 336.70 M$, 2.40 yr, and 71.19 % assuming the cost of H2-rich syngas is 0.11 $/Nm3. Meanwhile, 1.67 kg syngas production yield and 1.9 kg CO2 recycled per kg of FW gasification by the proposed process. The proposed process is not only a competitive technology for H2-rich syngas generation, but also an effective strategy to reduce carbon-emitting.

A Cross-Sectional Study on Awareness of Tuberculosis Control Among Post-Treatment Tuberculosis Patients in a City in China.

This study aimed to investigate awareness of tuberculosis control among post-treatment tuberculosis patients, in order to provide a basis for future preventive and control work in this population. A cross-sectional descriptive study was conducted on post-treatment patients with tuberculosis in seven districts of Jinan City between July 2021 and December 2022. A face-to-face or telephone interviews using structured questionnaires for the research subjects were conducted by data collectors. Analyses were carried out first for all subjects, and then separately for male and female subjects. A total of 837 valid questionnaires were collected, of which 495 were males and 342 were females. The awareness rate of the core TB knowledge was 82.46%. The ≥65 year group in the total group (OR=0.43, 95% CI: (0.28, 0.68)), male (OR=0.47, 95% CI: (0.27, 0.83)) and female group (OR=0.40, 95% CI: (0.19, 0.86)) was lower than that of the control group. Educational level and monthly income are the main factors of TB cognition in total group. People with university or higher education (OR=2.05, 95% CI: (1.38, 3.05)) and with a monthly income of ≥6,000 (OR=1.89, 95% CI: (1.10, 3.25)) had a higher awareness rate. The group with current residence in the city was more aware than the reference group. In the future, the communication of the main transmission route, suspicious symptoms, and cure of TB needs to be strengthened for the post-treatment TB patients. The elderly, those with secondary school education or below, agricultural workers and low-income people are the groups with weak knowledge of TB, and they are also the groups that need to be focused on health education. The above information should be focused on the above groups of people in order to educate them in a way that is easily acceptable to them.

Ледовитость российских арктических морей трассы Северного морского пути в современный климатический период

The paper considers the ice cover in the Arctic seas of the Northern Sea Route (NSR): Kara, Laptev, East Siberian and Chukchi since 1946. A comparison of the long-term course of integral average annual air temperature anomalies and seasonal average ice cover anomalies allows identifying a year 2005, starting from which the sea ice cover sharply decreases in a good agreement with the increase and accumulation of positive air temperature anomalies. The researchers reveal that the average level of ice cover has decreased by 1.7 times since 2005, however, the values of the range of fluctuations and standard deviation have remained almost unchanged, i.e. ice cover fluctuates in the same range, but at a lower average level. The main shipping routes are cleared about three decades earlier. The repeatability of complete cleansing of the seas has increased to 60—90%.

Numerical study on the onset of global-scale flow from individual buoyant plumes: Implications for indoor disease transmission

Transport of exhaled droplets and aerosol suspension is a main route for the transmission of highly infectious respiratory diseases. A poorly ventilated room, where human body heat drives the flow and the pathogen motion, is one such paradigmatic situation with an elevated risk of viral transmission. Here, we report a numerical study on human body heat-driven buoyancy convection in a slender rectangular geometry with the geometric size of 12 × 1 × 3 m3. Using large-scale three-dimensional simulations, we reveal how different spacings between human body heat sources can potentially spread pathogenic species between occupants in a room. Morphological transition in airflow takes place as the distance between human heat sources is varied, which shapes distinct patterns of disease transmission: For sufficiently large distance, individual buoyant plume creates a natural barrier, forming buoyant jets that block suspension spread between occupants. Thermal plumes exhibit significant individual effects. However, for small distances, a collective effect emerges and thermal plumes condense into superstructure, facilitating long-distance suspension transport via crossing between convection rolls. In addition, we quantify the impact of morphological transition on the transport of viral particles by introducing tracer particles. The quantitative analysis shows that under certain critical distances, the infection risk becomes significantly elevated due to this transition and collective behavior. Our findings highlight the importance of reasonable social distancing to reduce indoor cross-transmission of viral particles between people and provide new insights into the hidden transitional behavior of pathogen transmission in indoor environments.

Lymphopenia associated with survivin and its downstream pathway in COVID-19 serving as a potential route in COVID-19 pathogenesis

PurposeStarting in 2019, coronavirus disease 2019 (COVID-19) caused an epidemic that was growing rapidly and has harmed millions of people globally. It has been demonstrated that survivin regulates lymphocyte survival, a main route involved in COVID-19 pathogenesis. Survivin belongs to the inhibitor of apoptosis protein (IAP) family, and its primary functions comprise regulating mitosis and inhibiting apoptosis. Since lower survivin expression has been shown to increase the sensitivity of lymphocytes to apoptotic induction, we looked into the function of survivin and its corresponding pathways in COVID-19 pathogenesis. Materials and methodsThe expression of survivin, X-linked inhibitor of apoptosis protein (XIAP), caspases 3, 7, 9, and poly (ADP-ribose) polymerase (PARP) was evaluated at both mRNA and protein levels in peripheral blood mononuclear cells (PBMCs) derived from healthy donors and patients with severe and moderate COVID-19 by qRT-PCR and Western blotting, respectively. Then, we enforced apoptosis to COVID-19 patient-derived lymphocytes, and the percent was assessed by flow cytometry. ResultsSurvivin and XIAP were less expressed in PBMCs derived from COVID-19 patients as apoptosis inhibitors than PARP, cleaved-PARP, caspase 9, and cleaved caspases 3 and 7, according to the results of real-time PCR and Western blot analysis. Additionally, according to the flow cytometry results, the down-regulation of survivin served as a potential factor in the lymphocyte depletion observed in patients with COVID-19. ConclusionThe role of survivin and its related pathway was first discovered in the development of COVID-19 and may serve as a potential prognostic and therapeutic target.

Unmasking Opportunities and Challenges in the Colombo Port Mega Hub Transformation

Unmasking Opportunities and Challenges in the Colombo Port Mega Hub Transformation

A Retrospective Study of the Relationship Between Typhoid and Vestibular Disorders- A Case Series

Background: Typhoid fever is caused by Salmonella enterica serovar Typhi (Salmonella Typhi). faecal-oral is the main route of transmission by contaminated water or food. Over the last few years, the classic presentation of typhoid fever has varied, and the cases with atypical presentation are increasing. In this study we are presenting a retrospective evaluation of patients presenting with giddiness post history of typhoid, to correlate a link between vestibular disorders and typhoid. Aims and Objectives: To retrospectively study the relationship between typhoid and vestibular disorders. Materials and Methods: This is a retrospective hospital-based case series conducted in vertigo clinic in The Department of ENT at SGT Medical College Hospital and Research Institute, Budhera, Gurugram. Five patients who gave positive history of typhoid, their case files were retrospectively evaluated. All the patients were made to undergo routine ENT, vertigo, and audiological evaluation. Results: Total of 5 patients presented to vertigo clinic at SGT hospital with complains of giddiness, all of them gave a history of typhoid in the past few weeks. Majority of patients presented with giddiness within four weeks after history of typhoid infection. Patients developed symptoms of giddiness, nausea, and vomiting. Out of 5 patients,4 were females and one male. Two patients were in the age group of 30-40 years. Two patients were in paediatric age group. On examination, Dix Hallpike test was positive in 3 patients. Patients were treated with vestibular sedatives and corrective manoeuvre like Epley’s. Pure tone audiometry, MRI brain and lab parameters were all normal in all the five patients. Conclusion: Endotoxins of the typhoid bacillus are capable of producing cochleovestibular lesions but only a few isolated reports suggest the same. Since very few literatures has been discussed on the possible correlation between vestibular disorders and typhoid, clinicians should be aware of atypical presentations of typhoid is to avoid any delay in diagnosis and prompt treatment. Therefore, there is a strong need to analyse and study the corelation between typhoid fever and vestibular disorders.

Analysis of characteristic and postexposure practices of occupational blood and body fluid exposures among health care workers in Chinese tertiary hospitals: a retrospective ten-year study

BackgroundOccupational blood and body fluid exposure (OBEs) is a highly concerning global health problem in health facilities. Improper or inadequate post-exposure practices increase the risk of infection with bloodborne pathogens. Understanding risk factors for OBEs and evaluating the post-exposure practices will contribute to healthcare workers’ (HCWs) well-being.MethodsThis study retrospectively synthesized and reviewed the 10-year data (from 2010 to 2020) on OBEs in a tertiary teaching hospital.ResultsA total of 519 HCWs have reported OBEs, increasing yearly from 2010 to 2020. Of these, most were nurses (247 [47.2%]), female (390 [75.1%]), at 23–27 years old (207 [39.9%]). The hepatitis B was the primary bloodborne pathogen exposed to HCWs, with 285 (54.9%) cases, internal medicine was the main exposure site (161 [31.0%]), and sharp injury was the main exposure route (439 [84.6%]). Data analysis shows that there are significant differences between exposure route, exposed pathogens, and exposure site among the different occupational categories (X2 = 14.5, 43.7, 94.3, all P < 0.001). 3.3% of HCWs did not take any post-exposure practices. For percutaneous exposure, 4.7% did not rinse the wound, 3.3% did not squeeze out the wound, and 2.3% did not disinfect the wound. In the case of mucosal exposure, 90.4% clean the exposure area immediately.ConclusionsThe data from the past decade underscores the seriousness of current situation of OBEs in Chinese tertiary hospital, particularly among young HCWs, and with hepatitis B as the predominant blood-borne pathogen. This study also identifies HCWs may take incorrect post-exposure practices. It’s crucial in the future to discuss the effectiveness of main groups targeted for focused specialty-specific guidance for the prevention of such accidents, meanwhile, to include blood-borne disease immunity testing in mandatory health check-ups. Additionally, focus on optimizing post-exposure practices, offering significant steps toward prevention of such incidents and reducing infection risks should also be considered in future studies.

TO THE QUESTION OF THE POSSIBILITY OF RECONSTRUCTION OF THE TERRITORY OF THE ODESA RAILWAY STATION

The article considers the problems of locating large dead-end transport hubs in the city centre. Their interrelationships with the rest of the transport infrastructure and the impact on the overall planning structure of large cities. The article also discusses the problem of depressed areas formed by the main routes to dead-end stations. The article also considers possible options for development and prospects for integration of existing transport infrastructure facilities, taking into account the emergence of fundamentally new urban transport systems in large cities. The article presents an analysis of the history of the structure and examples of international experience. Possibility of reconstruction or renovation of the Odesa transport system around the Odesa-Holovna railway station. One of the tasks of modern urban planning is to create the most comfortable connections, both between cities and countries, and in the city itself. When designing, reconstructing or restoring cities and towns, it is necessary to take into account the primary role of transport in determining the main planning axes and zoning of territories. A special role should be given to the ongoing analysis of the relevance of the existing transport structure and its relationship with the settlement and the city. The purpose of this paper is to identify the possibility of forming or transforming the Odesa-Holovna station into a structural link between separate parts of the city. The overall goal of this project is to create a modern, efficient and sustainable transport system in Odesa that will meet the needs of city residents, passengers and freight company owners, as well as contribute to the further development of the city and its infrastructure.

A pilgrim but a tourist too: re-examining the contemporary links

ABSTRACT The discussion about the definition of ‘tourism’ and ‘pilgrimage’ has been intensified over the time. This paper has as its main goal to understand how pilgrimage routes are perceived and experienced by contemporary pilgrims. The Camino de Santiago has been taken as a case study, as it is one of the main European pilgrimage routes. The methodological strategy applied is quantitative through a structured questionnaire carried out with 414 pilgrims. The model proposed for the analyses allowed to characterise the pilgrims who do the Camino de Santiago. The study identifies and evaluates four main motivations that lead to the Camino de Santiago and that could predictably be extrapolated to other pilgrimage routes: well-being and pleasure; spirituality and avoidance; socialisation and entertainment; and religious motives.

Metastatic lesions of the uterus, fallopian tubes and ovaries in undifferentiated pleomorphic sarcoma of the left tibia (clinical case)

Undifferentiated pleomorphic osteosarcoma belongs to the group of rarely occurring tumors. Despite the treatment, the disease progresses in 30–40 % of patients with osteosarcomas. The main route of metastasis of bone tissue sarcomas is hematogenous, while lymphogenic spread is observed less frequently. As a rule, secondary metastatic changes occur in the lungs. Less often there is a secondary lesion of the bones of the skeleton and brain. Metastatic lesion of uterus, fallopian tubes and ovaries in malignant undifferentiated pleomorphic sarcoma is extremely rare. Therefore, we found it interesting to describe a clinical case of such a rare metastatic lesion. Patient K. underwent amputation of the left limb at the level of the lower third of the femur for undifferentiated pleomorphic sarcoma of the left tibia in 2019, and 4 courses of adjuvant polychemotherapy were performed. In 20 months after completion of complex treatment of the primary tumor, complaints of lower abdominal pain, increased body temperature up to 37.8 °C in the evenings appeared. According to the results of follow-up examination, a voluminous, multinodular, solid mass of merging character was detected in the pelvis, with total dimensions of up to 11 cm, and a cavitary mass of up to 5 cm was detected in the posterior vault. A trepan-biopsy of the mass in the projection of the right ovary was performed. The morphological picture in the volume of trepan biopsy specimens is characteristic of spindle cell sarcoma. Metastasis of undifferentiated pleomorphic bone sarcoma (malignant fibrous histiocytoma) is most likely. Due to metastatic lesions of the uterus, fallopian tubes, ovaries, omentum, mesentery and serous membrane of the colon loops, peritoneum of the bladder, surgical intervention in the volume of removal of the distal part of the sigmoid colon, rectosigmoid, upper ampullary parts of the rectum, uterus with fallopian tubes and ovaries, appendix was performed. Immunohistochemical study of the postoperative material revealed that the immunophenotype of tumor cells confirmed the morphological picture typical for undifferentiated pleomorphic bone sarcoma. The patient was further prescribed antitumor drug therapy. This clinical case demonstrates a rare, atypical metastasis of undifferentiated pleomorphic osteosarcoma, which allows to expand the knowledge about the flow of malignant diseases of this localization.

Оценка обеспеченности территории Санкт-Петербурга наземным общественным транспортом с использованием геопространственного подхода

The authors propose a method for evaluating the public transport accessibility of a city, based on the spatial distribution of real estate and commercial property in its territory, it enables making a rating table of routes and stops. The relevance of the study is related to the high social importance of mass transit, since its accessibility creates a more comfortable urban environment and offers new opportunities to the residents. The significant growth of research on this topic is a result of the social need to improve the use of urban space. The rapid development in the field of big data processing makes it much more relevant to the real situation than any previous models. However, researchers often lack up-to-date information on the distribution of the population in a given territory, because the concept of state open spatial data in Russia is currently in its early stages, and city authorities may decide to make it confidential. The proposed quantitative approach to assessing the provision of urban areas with land transportation means is based on using spatial data available in open sources, as well as methods of geospatial analysis and modelling. It is used to study the public transport in St. Petersburg, RF; the technique has enabled identifying the main municipal routes as well as the parts of the city requiring network expansion

LEISHMANIOSE TEGUMENTAR AMERICANA EM UMA MICRORREGIÃO DA AMAZÔNIA BRASILEIRA ENTRE 2010-2019

Objective: The study sought to analyze the epidemiological profile of people with American Tegumentary Leishmaniasis (ATL) in the Lake Tucuruí Integration Region, between 2010 and 2019. Methods: Descriptive study, with data obtained from the Health System Notifiable Disease Information System. Results: There were 3,305 patients with ATL distributed in seven cities. Males, aged 15-39 and 40-59 years were the most affected. New cases are the main route of transmission and the most prevalent clinical form is cutaneous leishmaniasis. The cure was shown in four of the seven cities studied. The cities of Itupiranga and Novo Repartimento showed that the rural area is the main area of ​​infection. The urban area was the area of ​​greatest contagion for the cities of Jacundá and Tucuruí. Conclusion: The study for ATL showed that this zoonosis is endemic in this Amazon microregion and it mainly affects male individuals, with low education and aged between 15-39 and 40-59 years.

Biotic transformation of methylmercury at the onset of the Arctic spring bloom

Despite the lack of local anthropogenic mercury sources, methylated mercury (MeHg) concentrations in Arctic biota are higher than in biota from lower latitudes. The main entry route occurs during the bioconcentration of seawater monomethylmercury (MMHg) into phytoplankton. Despite the known seasonal changes in biological activity in the region, little is known about the seasonal cycling of total mercury (THg) and MeHg in the Arctic Ocean. Here, we report the concentrations of THg and MeHg in seawater sampled from the northwestern Barents Sea water column during late winter and spring. In the upper 500 m, the THg concentrations are significantly higher in spring (0.64 ± 0.09 pmol L-1) compared to late winter (0.53 ± 0.07 pmol L-1), driven by seasonal inputs to surface waters from atmospheric deposition and the dynamics of changing sea ice conditions. Contrastingly, the MeHg concentrations in spring were significantly lower (41 ± 39 fmol L-1) compared to late winter (85 ± 42 fmol L-1). We suggest that most MeHg is biotically demethylated by both phytoplankton and bacteria, with additional losses from photodemethylation and evasion. Our observations highlight the importance of demethylation during potential uptake of methylmercury coinciding with the Arctic spring bloom. Lastly, we use our new data together with previously published seasonal data in the region to construct a simplified seasonal mercury cycle in an Arctic marginal ice zone.

Toxicological Assessments of Agrochemicals in Stingless Bees in Brazil: a Systematic Review.

The growing concern with the decline of pollinators worldwide is centered on honey bees, due to their wide distribution, economic, and ecological importance. This type of concern remained less evident for stingless bees, which are widely distributed in the Neotropics, until recently. Since exposure to agrochemicals has been identified as one of the potential threats to bees, the present systematic review compiled information from toxicological evaluations in stingless bees in Brazil, home to a considerable portion of the existing species. This systematic review was performed considering species, research institutions, scientific journals, metrics, experimental set ups, and agrochemicals. The first article in this topic was published in 2010. Since then, 93 scientific papers were published, which showed that there are few species of stingless bees used for toxicological evaluations and Brazilian institutions lead these evaluations. Only 1.5% of the stingless bees' species that occur in Brazil were assessed through chronic exposure in the larval stage. The Universidade Federal de Viçosa (UFV) is responsible for 37% of the total publications. The main route of exposure was acute, using adults in laboratory conditions. The main group of agrochemicals studied were insecticides, in particular the neonicotinoids. The current results reveal the advances achieved and point out the gaps that still need to be filled considering toxicological evaluations in stingless bees.

RESEARCH OF FORMATIONS INJECTIVITY IN ORDER TO ORGANIZE RESERVOIR PRESSURE MAINTENANCE IN THE CARBONATE FIELDS

In this item, the top-priority is organization of reservoir pressure maintenance system and fields development under natural mode in order to maintain reservoir pressure in carbonate fields. Currently, the fields are being developed in a natural drive, and arranging a system for maintaining reservoir pressure is a top-priority. Carbonate fields are complicated by tectonic faults in the separate blocks and HC production reveals disturbance of the balance in the geological environment. Longtime fluid sampling without reservoir pressure maintenance leads to change of stress fields in formation, which initiates creation of deformations of earth surface. In order to prevent from these events, it is required to maintain reservoir pressure. It is necessary to maintain reservoir pressure to prevent these events from happening. When water is injected, migration occurs through a complex ramified system of cracks, caverns and pore channels. The most permeable in the productive thickness layer are karst intervals and zones of increased fracturing, which serve as the main routes for fluid migration. Considering complication of RPM system organization due to high wellhead pressure, field distance from water sources and possible creation of cavity and carst, conception of carbonate fields development is developed within the frame of item.

Methods for the Determination of Fire Blight on Pome Fruit Crop Plants in the Western Part of Azerbaijan

Fire blight caused by Erwinia amylovora (Burrill, 1882) Winslow et al., 1920 causes significant production losses in the world’s leading pome fruit crop producing countries. The main route of infection of many fruit crops, including apple and pear trees, is through newly blooming flowers. The bacterium overwinters in the bark tissue along the edges of cankers formed on branches and stems as a result of infection in the previous year and becomes a source of infection in the next year. Determining the prevalence of the disease in areas with a large number of orchards is important from the point of view of disease control. Therefore, the purpose of the work is to study the prevalence of the disease in the Ganja-Dashkesan and Gazakh-Tovuz Economic Regions, as well as the accurate diagnosis of the obtained E. amylovora isolates using classical and molecular methods. For this purpose, trees in the studied apple and pear orchards were examined for the disease, the pathogen was isolated from infected plants, and morphological, biochemical, physiological and molecular analyzes were carried out. Among 36 bacterial isolates obtained from 27 samples of infected plants, Erwinia amylovora was identified in 11 as a result of morphological, biochemical, physiological and molecular tests.

Perkembangan Lahan Terbangun Kota Pekanbaru Tahun 2000-2020

This research aims describe the development of built-up area and identify trends the development of built-up area in Pekanbaru City in 2000-2020. The approach in research is descriptive quantitative with stages of temporal landsat image interpretation, field verification, and spatial analysis. The study population is the entire pixel data in satellite imagery with sampling techniques for the image interpretation process. Supervised classification is used in the interpretation process, kappa index with 22 sample points is used to test the accuracy of the interpretation results, and map overlays are used in spatial analysis. The results of the analysis show that in the last two decades (2000-2020) the built-up area in Pekanbaru City increased by 13,45% (85,99 km2) with an average increase of 0.67% (4,30 km2) annually. Spatially, the distribution of development of built up area is unevenly, but forms a patterns and directions that tends to be the same, namely the pattern of spreading from the city center to the fringe area with development trends in the south and southwest following the main road route.

Why so many polyploids? Accounting for environmental stochasticity in unreduced gamete formation lowers the perceived barriers to polyploid establishment.

While polyploids are common in nature, existing models suggest that polyploid establishment should be difficult and rare. We explore this apparent paradox by focussing on the role of unreduced gametes, as their union is the main route for the formation of neopolyploids. Production of such gametes is affected by genetic and environmental factors, resulting in variation in the formation rate of unreduced gametes (u). Once formed, neopolyploids face minority cytotype exclusion (MCE) due to a lack of viable mating opportunities. More than a dozen theoretical models have explored factors that could permit neopolyploids to overcome MCE and become established. Until now, however, none have explored variability in u and its consequences for the rate of polyploid establishment. Here, we determine the distribution that best fits the available empirical data on u. We perform a global sensitivity analysis exploring the consequences of using empirical distributions of u to investigate effects on polyploid establishment. We determined that in many cases, u is best fit by a log-normal distribution. We found environmental stochasticity in u dramatically impacts model predictions when compared to a static u. Our results help reconcile previous modelling results suggesting high barriers to the polyploid establishment with the observation that polyploids are common in nature.