Main Problems Research Articles

Versatile Nanoparticulate Systems as a Prosperous Platform for Targeted Nose-Brain Drug Delivery.

The intranasal route has proven to be a reliable and promising route for delivering therapeutics to the central nervous system (CNS), averting the blood-brain barrier (BBB) and avoiding extensive first-pass metabolism of some drugs, with minimal systemic exposure. This is considered to be the main problem associated with other routes of drug delivery such as oral, parenteral, and transdermal, among other administration methods. The intranasal route maximizes drug bioavailability, particularly those susceptible to enzymatic degradation such as peptides and proteins. This review will stipulate an overview of the intranasal route as a channel for drug delivery, including its benefits and drawbacks, as well as different mechanisms of CNS drug targeting using nanoparticulate drug delivery systems devices; it also focuses on pharmaceutical dosage forms such as drops, sprays, or gels via the nasal route comprising different polymers, absorption promoters, CNS ligands, and permeation enhancers.

CURRENT DIRECTIONS OF WORK OF SOCIAL SECURITY BODIES OF THE BSSR IN THE FIRST POST-WAR YEARS

The article examines certain areas of work of the social security bodies of the BSSR, developed to provide assistance to the families of front-line soldiers and partisans, employment and vocational training for disabled people of the Great Patriotic War, their prosthetics and sanatorium-resort treatment. The main problems and difficulties faced by the social security system in the process of personnel formation are shown, and the measures that were taken to solve them are identified.

Establishment and Practice of Physical Education Evaluation Using Grey Cluster Analysis Under the Data Background

This article uses scientific methods and means to evaluate the value, elements, and processes of physical education, consistent with preset evaluation indicators through sample calculation, and then derives the characteristics of decision-making, the objectivity of indicators, the order, and other characteristics of the process. The authors have analyzed the main problems in current physical-education evaluation and its future reform and development trends under the requirements of quality education.

Improving Internal Control System

The Internal Audit Service is not just a global trend, but an urgent need in the conditions of actively developingand increasingly complicated economic relations. The purpose of this article is to identify the main problems of internalaudit in Uzbekistan. It is argued that the concept of internal audit correctness provides conceptual tools for studyinginternal audit as a disciplinary mechanism in the conditions of corporate governance of modern organizations. The articledevelops the initial conceptual formulation and internal audit, audit and control to improve the rationality of economicactivity and related control measures.

Studying the problem of constructing an automated control system to ensure the safe passage of unmanned vessels through shipping locks

The option of introducing an automated control system to ensure the safe passage of unmanned vessels on inland waterways has been explored. An analysis of domestic and foreign scientific and technical literature was carried out to determine conceptual provisions that allow choosing a rational way of interaction of this system with known ones. It is noted that the automated ships locking control system should provide the necessary level of navigation safety, and the implementation of this system should not affect the operation of other subsystems and metasystems. Currently, cases of constructing such systems for automated mooring of unmanned vessels at navigational hydraulic structures are unknown. Therefore, based on the engineering-cybernetic approach, a list of provisions that contribute to the successful organization of research of a conceptual and operational nature has been formulated. Conceptual provisions for the synthesis of structure and factors that allow you to develop a rational version of the system structure to obtain the greatest efficiency and safety of its operation are proposed. In addition to the development of locking control systems, an equally important task is the creation of technical means in the lock chamber, the operation of which can ensure the required level of security. Therefore, the process of mooring an unmanned vessel to an automated mooring ring, for a utility model of which the authors of this study had received a patent, is theoretically described. To achieve the goal of formulating the problems of developing and constructing an automated locking control system, an analysis of mooring devices used at shipping locks, including abroad, which confirms that fixed and movable mooring devices with vacuum grips are currently used, is carried out. A review of scientific and technical literature on the use of automatic and automated mooring systems makes it possible to develop proposals for organizing an auto-mooring system of a shipping lock to ensure the unmanned vessels passage, as well as to formulate the main problems and tasks that must be solved to ensure the passage of both unmanned and ordinary vessels.

Mesocellular Silica Foam as Immobilization Carrier for Production of Statin Precursors.

The employment of 2-deoxyribose-5-phosphate aldolase (DERA) stands as a prevalent biocatalytic route for synthesizing statin side chains. The main problem with this pathway is the low stability of the enzyme. In this study, mesocellular silica foam (MCF) with different pore sizes was used as a carrier for the covalent immobilization of DERA. Different functionalizing and activating agents were tested and kinetic modeling was subsequently performed. The use of succinic anhydride as an activating agent resulted in an enzyme hyperactivation of approx. 140%, and the stability almost doubled compared to that of the free enzyme. It was also shown that the pore size of MCF has a decisive influence on the stability of the DERA enzyme.

Sparks of New Metaphysics and the Limits of Explanatory Abstractions

Abstract Physical reality as an explanatory model is an abstraction of the mind. Every perceptual system is a user interface, like the dashboard of an aeroplane or the desktop of a computer. We do not see or otherwise perceive reality but only interface with reality. The user interface concept is a starting point for a critical dialogue with those epistemic theories that present themselves as veridical and take explanatory abstractions as ontological primitives. At the heart of any scientific model are assumptions about which things exist, how they are related, and how we can know them. Scientific models take our knowledge beyond ordinary experience toward explanatory abstractions. The main problem with veridical models lies in why we cannot express our theories and the explanatory abstractions associated with them other than through classical perceptual interface symbols. This study analyses the limits, possibilities and constraints of explanatory abstractions.

Analysis of the Main Achievements of the Negotiation Process for the Accession of the European Union to the European Convention on Human Rights of 1950 (2019-2023)

Introduction. The article examines the main stages and achievements in the work of the ad hoc group (46+1) based on the results of the past 14 rounds of the negotiation process on the accession of the European Union to the European Convention on Human Rights of 1950. The author examines the fundamental problems prevented the European Union from accessing to the European Convention on Human Rights in 2013, as well as the novellas included in the revised draft Agreement on the Accession of the European Union to the European Convention on Human Rights, such as the application of Articles 33 and 53 of the European Convention on Human Rights 1950, as well as Protocol No. 16 thereto in relation to the law of the European Union. Materials and methods. The methodological ground of the study based on the following general scientific and special methods of the recognition of legal phenomena and processes in the field of European law: the method of system-structural analysis, the method of synthesis of social phenomena, the comparative legal method, the formal logical method. For certain questions, statistical data was involved in the study. To identify further vectors for the development of interaction between judicial bodies used the content analysis.Results of the study. Based on the results of the study, the author comes to the conclusion that the main problems preventing the European Union from the accession to the European Convention on Human Rights, are the specifics of the application of Articles 33 and 53 of the European Convention on Human Rights and Protocol No. 16 thereto in relation to European Union law, as well as the reluctance of the European Union to limit the sovereignty and autonomy of European Union law in order to strengthen the European system for the protection of human rights.Discussion and conclusion. The adjustments made by the ad hoc group (46+1) in relation to the Accession Agreement are very significant and, on the one hand, even unnecessary. They fully cover the observations indicated in the Opinion of the Court of Justice of the European Union No. 2/13 and at the same time satisfy the representatives of the European Union, which gives reason to believe that the accession attempt will have a positive outcome. Of course, if the European Union joins the European Convention on Human Rights of 1950, human rights, freedoms, and their guarantees will reach a new level, since their protection will be comprehensive.

DETEKSI DINI KADAR GLUKOSA DARAH SEWAKTU DAN TEKANAN DARAH DI MASYARAKAT DESA CARANG WULUNG KECAMATAN WONOSALAM KABUPATEN JOMBANG

Insufficient knowledge and minimal public awareness of the importance of health checks are the main problems that must be addressed immediately. Diabetes mellitus and blood pressure are the two non-communicable diseases that most people suffer from. So the target of implementing the community service program is to provide education by means of health education and early detection of instantaneous blood glucose levels and blood pressure in the community with the aim of increasing community knowledge about disease and increasing awareness of the importance of early screening in the community of Carang Wulung Village, Wonosalam District. , Jombang Regency. The result was that almost half of the people who took blood sugar checks experienced hyperglycemia, 37 people (49.3%) and the majority of people who took blood pressure checks experienced hypertension, 44 people (58.7%). Regarding knowledge before health education was carried out, the majority of people still had insufficient knowledge about diabetes mellitus and hypertension with a total of 52 people (69.3%). After health education was carried out, almost all people had good knowledge about diabetes mellitus and hypertension with a total of 69 people (92%). In conclusion, the service activities that have been carried out run smoothly and receive support from all parties, so it is hoped that the public will better understand the importance of early prevention so that more serious health problems do not occur

M6A methylation-regulated autophagy may be a new therapeutic target for intervertebral disc degeneration.

Degeneration of intervertebral discs is considered one of the most important causes of low back pain and disability. The intervertebral disc (IVD) is characterized by its susceptibility to various stressors that accelerate the senescence and apoptosis of nucleus pulposus cells, resulting in the loss of these cells and dysfunction of the intervertebral disc. Therefore, how to reduce the loss of nucleus pulposus cells under stress environment is the main problem in treating intervertebral disc degeneration. Autophagy is a kind of programmed cell death, which can provide energy by recycling substances in cells. It is considered to be an effective method to reduce the senescence and apoptosis of nucleus pulposus cells under stress. However, further research is needed on the mechanisms by which autophagy of nucleus pulposus cells is regulated under stress environments. M6A methylation, as the most extensive RNA modification in eukaryotic cells, participates in various cellular biological functions and is believed to be related to the regulation of autophagy under stress environments, may play a significant role in nucleus pulposus responding to stress. This article first summarizes the effects of various stressors on the death and autophagy of nucleus pulposus cells. Then, it summarizes the regulatory mechanism of m6A methylation on autophagy-related genes under stress and the role of these autophagy genes in nucleus pulposus cells. Finally, it proposes that the methylation modification of autophagy-related genes regulated by m6A may become a new treatment approach for intervertebral disc degeneration, providing new insights and ideas for the clinical treatment of intervertebral disc degeneration.

Antimicrobianos en la salmonicultura global: Resistencia, efecto en la salud humana y medio ambiente, y perspectivas futuras

Salmon farming in the face of antimicrobial resistance and effects on human health and environment. Abstract: The present review compiles and analyzes studies of the last five years on antibiotic use in the salmon industry, reported effects on fish and humans, and impacts on the environment. There is a growing concern regarding the current management of veterinary therapeutic plans used for the treatment and control of bacterial infections. The main problems are related to the increase of resistance to antibiotics by pathogenic and non-pathogenic bacteria communities, horizontal transfer of resistance genes between bacterial cells, and a major number of cases of failed medical treatments in human and animal populations. Therefore, the challenges for the future will be to reduce dependence on antibiotics in animal production through research into alternatives technologies, the collection of epidemiological information from productive sectors that allow detailed monitoring in the different cultivation phases, biosafety measures from an approach of One Health, and strict supervision in the formulation of medicines by professionals in the animal area.

Depression, anxiety, lower sleep quality and social support in square cabin hospitals during Shanghai's COVID-19 lockdown, China.

To investigate and compare the associated factors of depression, anxiety, and other psychological differences between patients with Corona Virus Disease 2019 quarantined in square cabin hospitals (SCH) and isolation wards (IW) in China. Cluster sampling method was performed during Shanghai's Two-Month Lockdown in 2022. Hospital Anxiety and Depression Scale Depression subscale (HADS-D), 7-tiem Generalized Anxiety Disorder Scale (GAD-7), Pittsburgh sleep quality index (PSQI), and Perceived Social Support Scale (PSSS) were used to investigate psychological differences. The HADS-D and GAD-7 scores of SCH patients were significantly higher than those in IW (p < 0.001; p = 0.0295). Sleep latency (SCH-IW = -3.76, p < 0.001), sleep duration (SCH-IW = -2.22, p < 0.05), habitual sleep efficiency (SCH-IW = -4.11, p < 0.001), sleep disturbance (SCH-IW = -3.59, p < 0.001) and use of sleep medication (SCH-IW = -5.18, p < 0.001) of SCH patients were significantly worse. Depression was the main emotional problem of quarantined patients. Patients in SCH had lower social support. Sleep disorders and the lowest oxygen saturation ≤ 93% were risk factors for depression, while social support and child status were protective factors. Myalgia and constipation were risk factors for anxiety, while marital status was the protective factor. Patients quarantined in SCH had higher risks of depression and anxiety, lower sleep quality and social support. Somatic discomfort and sleep disorders exacerbated depression and anxiety, which could be ameliorated by social support and taken into consideration in future SCH construction.

Trace element levels: How Substance Use Disorder (SUD) contributes to the alteration of urinary essential and toxic element levels.

Increasing illicit drug use is one of the main problems in most countries or societies. Monitoring heavy metals and trace elements in this vulnerable group seems to be necessary. Therefore, we assessed the urinary trace element and toxic metals/metalloids concentrations (Zinc (Zn), Iron (Fe), Copper (Cu), Chromium (Cr), Lead (Pb), Cadmium (Cd), Arsenic (As), Nickel (Ni), and Mercury (Hg)) in opium, tramadol, and cannabis users compared to healthy subjects. In this cross-sectional study, patients with substance use disorder (SUD) (n = 74) were divided into four groups: cannabis, tramadol, opium, and mixed (simultaneous use of more than one of the three studied substances), along with a healthy group (n = 60). Urine samples were prepared by dispersive liquid-liquid microextraction method so that heavy metals/metalloids could be measured by ICP-MS. The mean urinary concentration of Cu (48.15 vs. 25.45; 89.2%, p<0.001), Hg (1.3 vs. 0.10; 1200%, p < 0.001), and Zn (301.95 vs. 210; 43.8%, p < 0.001) was markedly lower among patients with SUD. The mean urinary concentration of other elements including As (1.9 vs. 4.1; 115.8%), Cd (0.1 vs. 1.10; 1000%), Cr (6.80 vs. 11.65; 71.3%), Ni (2.95 vs. 4.95; 67.8%), and Pb (1.5 vs. 7.9; 426.6%) were significantly higher among patients with SUD compared to healthy subjects. When sub-groups were compared, no significant differences were observed between their trace element levels (Kruskal-Wallis test, p > 0.05). This can be an indication that regardless of the type of drug, the levels of trace elements are changed with respect to healthy individuals. Our results showed that illicit drug use causes changes in urinary trace element/heavy metal/metalloid levels and highlights the need for monitoring heavy metals and trace elements in individuals with substance use disorder. Assessment of different elements in biological samples of drug dependents may be useful for implementing new prevention and treatment protocols. In case of changes in their levels, complementary recommendations, attention to diet, and periodic assessment of toxic metal levels within treatment programs will be needed.

TEACHING GEOGRAPHY AND TEACHER EDUCATION: A HISTORY IN THE MAKING

This work is an excerpt from a final research paper on the topic of Geography education and teacher training: a history in the making. The objectives of this research were to engage in a discussion about teacher training and the challenges faced by teachers in public basic education, as well as to reflect on the particularities of Geography teacher training. It highlights the main problems encountered by Geography courses in public universities in Brazil. Methodologically, the research was developed through theoretical analysis. In order to support this work, we sought theoretical input from authors such as Nóvoa (1995), Elliot (1998), Brzenziski (2001), Barreiro and Gebran (2006), Calvacanti (2008-2011), Callai (2011-2013), and Gatti (2010-2014). Through this research, it was possible to reflect on the dilemmas faced by teachers in basic education, such as the devaluation of education as a whole, and to understand the initial training process. It also shed light on the internal conflicts within Geography courses in public universities in Brazil.

Hydrophilic Modification of Polylactic Acid Fiber and the Usage of Natural Dye for Multi-Levered Improvement of the Fabric Staining Depth and the Stability Effect.

Polylactic acid (PLA) fiber is a degradable material with good environmental friendliness for textile applications. However, the main problems of difficult dyeing of PLA fibers were: high crystallinity to the adsorption of dyes, more ester and methyl groups producing non-hydrophilic problems, long chains making dyes difficult to penetrate, and producing a low dyeing rate. Here, we attempted to change the crystallinity of the PLA fiber to a lower degree from hydrophobic to hydrophilicity property variation, destroy the long chain structure to grant more staining sites, and improve the PLA fiber staining depth and the resilience dyeing effect with deep eutectic solvent (DES) treatment and natural dyes. We discovered that a controlled DES treatment process could make PLA fibers less crystallized, help amorphous areas form, and break up long chains, which lead to more dye sites. After DES treatment, the crystallinity decreased from 56.12 to 29.86%, and the instantaneous water contact angle decreased from 108.79 to 64.39°. The DES-treated PLA fabric exhibited a higher K/S value of 15.14 for natural dyes under specific conditions. The fabric, which had remarkable fastness characteristics and wash resistance, could endure frequent laundering and fulfill the demands of everyday use. Moreover, the fabric had good antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans and possessed a certain level of biocompatibility with fibroblasts. This DES treatment and natural dye combination method offered a new strategy for improving PLA fabric staining depth and color fastness, making it a promising option for low-carbon environmental protection in the textile industry.

A Study of Human Resource Management in 21st Century

The topic of this research is 21st-century human resource management. It will concentrate on the problems, obstacles, and solutions to become competitive in the current environment. The HR phenomena in the current environment will be the main topic of this research study, which will also identify the new problems of the twenty-first century and offer the greatest number of potential answers. Everything has changed significantly as a result of technology, including new equipment, hiring procedures, training methods, and production strategies. Now, in order to manage the workforce as effectively as possible, HR staff members must work with their roles as outlined below. We have covered the main problems and difficulties that organizations are currently facing in these essays. HR managers will need to create a standard structure that enables managing all available workforce alternatives in order to solve these problems and challenges. The company keeps its competitive advantages in this way. To finish the investigation, recommendations and findings are also considered.

Current study on multi-robot collaborative vision SLAM

Simultaneous Localization and Mapping (SLAM) stands as a vital technology for automatic control of robots. The significance of vision-based multi-robot collaborative SLAM technology is noteworthy in this domain, because visual SLAM uses cameras as the main sensor, which offers the benefits of easy access to environmental information and convenient installation. And the multi-robot system has the advantages of high efficiency, high fault tolerance, and high precision, so the multi-robot system can work in a complex environment and ensure its mapping efficiency, these may be a challenge for a single robot. This paper introduces the principles and common methods of visual SLAM, as well as the main algorithms of multi-robot collaborative SLAM. This paper analyzed the main problems existing in the current multi-robot collaborative visual SLAM technology: multi-robot SLAM task allocation, map fusion and back-end optimization. Then this paper listed different solutions, and analyzed their advantages and disadvantages. In addition, this paper also introduces some future research prospects of multi-robot collaborative visual SLAM technology, aiming to provide a reference direction for subsequent research in related fields.

Planning Purposeful Activities Autonomous Intelligent Robot with Knowledge Update in Short-Term Memory

The main problems associated with the creation of autonomous intelligent robots capable of performing various complex tasks in a priori undescribed unstable problematic environments, based on the processing of knowledge presented in an abstract way, are outlined. To store typical elements of an abstract knowledge representation model, the article recommends using long-term and short-term memory. Long-term memory with associative search and data retrieval is designed to permanently store information necessary for planning a variety of purposeful activities that provide the robot with the ability to solve various complex behavioral tasks. In short-term memory, submodels of knowledge representation are entered from long-term memory, which are necessary for solving the current task of a certain type in the short term, related to the fulfillment of the task formulated for the autonomous intelligent robot. At the same time, with each change in the type of the current task of behavior being solved by an autonomous intelligent robot, a corresponding update of knowledge stored in short-term memory is simultaneously carried out. Original constructions of typical elements of the model for representing abstract knowledge in the form of various behavioral skills, set regardless of a particular subject area, have been developed. This approach to building a knowledge representation model allows autonomous intelligent robots to adapt to the current operating conditions and, on this basis, organize purposeful activities in complex unstable problematic environments. Various tools and rules for processing abstract knowledge are proposed, which endow autonomous intelligent robots with the ability to eliminate the differences between the current and target situation of the problem environment both in terms of the values of structurally equivalent relations of the same name in them, and in the current states of objects in the environment. This, in turn, makes it possible to create intelligent problem solvers for autonomous intelligent robots for various purposes, capable of performing complex tasks in unstable a priori uncertain conditions of a problematic environment.

Implementation outcomes of the integrated district evidence to action (IDEAs) program to reduce neonatal mortality in central Mozambique: an application of the RE-AIM evaluation framework.

Scarce evidence exists on audit and feedback implementation processes in low-resource health systems. The Integrated District Evidence to Action (IDEAs) is a multi-component audit and feedback strategy designed to improve the implementation of maternal and child guidelines in Mozambique. We report IDEAs implementation outcomes. IDEAs was implemented in 154 health facilities across 12 districts in Manica and Sofala provinces between 2016 and 2020 and evaluated using a quasi-experimental design guided by the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. Reach is the proportion of pregnant women attending IDEAs facilities. Adoption is the proportion of facilities initiating audit and feedback meetings. Implementation is the fidelity to the strategy components, including readiness assessments, meetings (frequency, participation, action plan development), and targeted financial support and supervision. Maintenance is the sustainment at 12, 24, and 54 months. Across both provinces, 56% of facilities were exposed to IDEAs (target 57%). Sixty-nine and 73% of pregnant women attended those facilities' first and fourth antenatal consultations (target 70%). All facilities adopted the intervention. 99% of the expected meetings occurred with an average interval of 5.9 out of 6 months. Participation of maternal and child managers was high, with 3076 attending meetings, of which 64% were from the facility, 29% from the district, and 7% from the province level. 97% of expected action plans were created, and 41 specific problems were identified. "Weak diagnosis or management of obstetric complications" was identified as the main problem, and "actions to reinforce norms and protocols" was the dominant subcategory of micro-interventions selected. Fidelity to semiannual readiness assessments was low (52% of expected facilities), and in completing micro-interventions (17% were completed). Ninety-six and 95% of facilities sustained the intervention at 12 and 24 months, respectively, and 71% had completed nine cycles at 54 months. Maternal and child managers can lead audit and feedback processes in primary health care in Mozambique with high reach, adoption, and maintenance. The IDEAs strategy should be adapted to promote higher fidelity around implementing action plans and conducting readiness assessments. Adding effectiveness to these findings will help to inform strategy scale-up.

Evaluation of TV White Space Implementation in Indonesia: A Case Study in Yogyakarta

TV white space is a technology that utilizes unused spectrum owned by primary users, namely TV broadcasters in a particular area and time. There are two main problems related to the use of white space, namely protection of primary users and identification of white space channels. The prohibited, strict, moderate, and loose (PSML) method has previously been proposed, dividing the TV protection area into four zones to model the white space system. Researchers generally use additional protection areas and television coverage areas with a location probability of less than 70% to consider the possibility of overlap between white space and protected areas. However, this method has not been in implementation in the field. In this study, the author implemented the PSML method in the city of Yogyakarta by using the coverage area of TVRI Patuk as a sample. Based on the measurement results, the author discovered that the deviation between the simulation results and the measurement results was 7.32 dB or 1.82 dB higher than ITU’s recommendation. This deviation indicates that, based on geographical conditions, Yogyakarta has a higher variation in field strength values than ITU’s recommendations.