Main Manifestations Research Articles

Polycystic Ovarian Syndrome: A Review of Multi-omics Analyses.

Polycystic Ovary Syndrome(PCOS) is among the most prevalent endocrinological abnormalities of young females, posing a grave public health challenge to the society. The objective of the present literature review is to analyze the enormous amount of information available by way of numerous multi-omic studies, and to explore a meaningful relationship between various factors such as genetic, proteomic, environmental etc. to understand the multifactorial metabolic disorder in a proper manner. Detailed literature search was done in various science article repositories and biomedical databases such as PubMed, Google Scholar, BioMed Central, Embase etc. by using several keywords in whole gamut of combinations. PCOS is a heritable disease. It manifests as a result of a combination of several intricately inter-linked symptoms such as anovulation, obesity, type II diabetes, hyperandrogenism, polycystic ovaries etc., the last one being the main manifestation of the disease, thus leading to infertility among several other complications. Such a multifactorial metabolic disorder with extreme symptomatic heterogeneity cannot be fully explained solely based on symptoms or genetic variations; thus, giving some space of thought to other factors such as epigenetic, microbiomic factors etc. playing a role in the causation of the disease. The present scientific survey of literature extensively reviews various aspects of PCOS by critically looking into the vast multi-omic data, and concluded with suggesting treatment options as well as lifestyle changes required to deal with the psychological/ emotional impacts of the condition on affected women.

Neuropsychiatric manifestations in systemic lupus erythematosus and Sjogren's disease.

Autoimmune diseases often present in a systemic manner, affecting various organs and tissues. Involvement of the central and peripheral nervous system is not uncommon in these conditions and is associated with high morbidity and mortality. Therefore, early recognition of the neuropsychiatric manifestations associated with rheumatologic diseases is essential for the introduction of appropriate therapies with the objective of providing a better quality of life for individuals. To provide a literature review of the neuropsychiatric manifestations related to Systemic Lupus Erythematosus (SLE) and primary Sjögren's Disease (pSD), through the description of signs, symptoms, and immunological variables associated with these conditions. A literature review was conducted by searching for national and international articles available in the SciELO and PubMed databases related to the description of neurological and psychiatric manifestations in patients with the rheumatologic diseases of interest in this study. The main NP manifestations presented in SLE and pSD are discussed, focusing on clinical presentation and etiology. Treatment option are, however, mainly based on expert opinion, since a few randomized controlled trials have been done. There is a high prevalence of neuropsychiatric manifestations associated with SLE and pSD. The variety of physiopathology pathways may explain the variety of symptoms, however pathological findings are rare. Multicenter studies on attribution protocols and treatment are necessary to address the current gaps.

Oral lesions and disorders and their prevalence arising from the use of illicit drugs in a prison population.

The dependence on the illicit drugs has been proven to be harmful to the oral cavity and may lead to a series of abnormal manifestations. The main objective of this study was to observe the effects caused by the consumption of illicit drugs in the oral cavity, in a prison population in the North of Portugal. A cross-sectional observational study was conducted involving 91 male inmates aged 25-75 years (mean age 41.14 ± 8.98), from Paços de Ferreira Prison. The participants were subjected to a medical interview and a clinical examination. Descriptive statistics and the Chi-square test were used to assess the association between the qualitative variables. The level of statistical significance used was α ≤ 0.05. The consumption of illicit drugs proved to be a common practice (86.8%), where cannabis, heroin and cocaine were the most prevalent (29.1%). Thirty-one inmates were attending the methadone rehabilitation program (34.1%). Most of patients consuming illicit substances, were also smokers (93.7%) (p<.001). Of the 91 participants, 82 (90.1%) presented oral manifestations, with caries lesions being the most prevalent (61.0%) and oral mucosa lesions the least observed (3.7%). Heavy drug consumption was related with rampant caries lesion (p=.011) and chewing difficulty (p=.024) when compared with cannabis consumption. The main oral manifestations found, associated to the consumption of illicit drugs were caries lesions, tooth loss and sensitivity, periodontal diseases, temporomandibular disorders, xerostomia, and bruxism.

Case Report: Novel ADA2 variants cause atypical adenosine deaminase 2 deficiency

Case presentationA girl aged 2 years and 5 months presented to the hospital with chief complaints of intermittent fever and weakness of the left limb for more than 1 month. The child had transient urticaria appearing on her face for 5 days. The inflammatory biomarkers were significantly increased. Brain MRI showed multiple ischemic lesions in the brain’s small vessels. The patient exhibited significant systemic inflammation and multiple vasculitis. Whole-exome sequencing showed c.1358A&amp;gt;G p. (Tyr453Cys) and c.1082-7T&amp;gt;A compound heterozygous variants in the adenosine deaminase 2 (ADA2) gene, of which the c.1082-7T&amp;gt;A variant has not been reported yet in previous literature. Peripheral blood mRNA reverse transcription-Sanger sequencing confirmed that this variant affected mRNA splicing, resulting in a frameshift with premature stop codon c.1083_1103del p. (Leu362Glnfs*45). Peripheral blood test suggested a significant decrease in ADA2 activity. Eventually, the patient was diagnosed with deficiency of adenosine deaminase 2 (DADA2). Her condition improved after treatment with etanercept. She had no more fevers, and no hemiplegia attacks were observed during the 3 years of follow-up.ConclusionFever and hemiplegia were the main manifestations in this patient, without typical rashes. DADA2 was finally confirmed by enzymology and genetic testing, and we believe this is the first reported case of the c.1082-7T&amp;gt;A intronic variant in DADA2, and the RNA studies conducted in this case have been pivotal in assessing its pathogenicity.

Идентичность как проявление целостности личности

&lt;p style="text-align: justify;"&gt;&lt;strong&gt;Objective.&lt;/strong&gt; Consideration of the phenomenon of identity in the context of integrity as a fundamental characteristic of personality; discussion of the thesis on the possibility of understanding identity as a manifestation of personality wholeness. &lt;br&gt;&lt;strong&gt;Background.&lt;/strong&gt; The consequence of the transition from structural descriptions of personality with an emphasis on its stable characteristics to processual-dynamic descriptions, characteristic of modern personality psychology, is an increased attention to the fundamental properties of personality and a revision of a number of traditional views about personal phenomenology. These fundamental properties include the wholeness of the personality. The development of approaches to the study of wholeness is the most important task of psychology, since it is the "separation" of personality into separate mental formations that is considered one of the main causes of the methodological crisis of psychology of the twentieth century. The description of the wholeness of the personality can be carried out by analyzing personal phenomena that are manifestations of the wholeness of the personality. It is proposed to consider personality identity as the main manifestation of personality wholeness in personal phenomenology. &lt;br&gt;&lt;strong&gt;Methodology.&lt;/strong&gt; A system approach to personality, methodological principles of the processual approach.&lt;br&gt;&lt;strong&gt;Conclusions.&lt;/strong&gt; In modern psychology, the concepts of personal wholeness and identity lose their structural certainty and are considered as dynamic formations. Recognition of its contextual nature is essential for the study of identity. In interaction with the context, identity performs the function of "gathering" a personality, ensuring its integrity.&lt;/p&gt;

Toxoplasmosis in camelids: the last 20 years

Toxoplasmosis is a universal zoonosis caused by an obligate intracellular parasite, Toxoplasma gondii. One of its main manifestations is abortion in humans and animals. The present review aims to clarify the situation of the disease in camelids in different countries across the four continents of the world (Africa, Asia, America and Europe) over the past twenty years. The research strategy involved collecting all published data during this period, focusing on the prevalence of Toxoplasma gondii infection and genotyping in different camelid species, as well as analyzing the various identified risk factors. This review provides a comprehensive epidemiological analysis of Toxoplasma gondii infection worldwide, making it a valuable resource for researchers. In total, 81 studies published between 2004 and 2024 involving 22040 camelids from 23 countries were included for the final analyses (Seropositivity studies covered 21844 camelids, while genotyping studies were performed on 585 camelids). The overall global seroprevalence of Toxoplasma gondii infection in the Camelidae family was 28.76% with 6284 positive cases. The highest seroprevalence rate was in Europe (73.01%), followed by Africa (39.26%), Asia (22.16%) and finally America (22.05%). The current article highlighted a high seroprevalence of Toxoplasma gondii infection in camelids worldwide, thus emphasizing the significant role these animals can play in the transmission cycle of this zoonotic disease. Therefore, it is essential to implement prevention and control measures as well as to raise public awareness to mitigate the public health impact of the disease.

The major roles of intestinal microbiota and TRAF6/NF-κB signaling pathway in acute intestinal inflammation in mice, and the improvement effect by Hippophae rhamnoides polysaccharide.

Acute enteritis, an intestinal disease with intestinal inflammation and injury as the main pathological manifestations. Inhibiting the inflammatory response is critical to the treatment of acute enteritis. Previous studies have shown that the Hippophae rhamnoides polysaccharide (HRP) has strong immune-enhancing effects. However, their functions regarding the intestines and the underlying mechanism are still unclear. In this study, the role of HRP in lipopolysaccharide (LPS)-induced acute enteritis in mice and its related mechanisms are discussed from two aspects: intestinal inflammation and intestinal microbiota. Kunming mice were inoculated with LPS to establish animal models of acute enteritis. The results showed that HRP attenuated the histological damage and maintained the intestine mucosal barrier via up-regulating the expression of occludin, claudin-1, and zona occludens-1 (ZO-1), and suppressing the levels of pro-inflammatory cytokines (tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β)). The relative mRNA and protein levels of nuclear factor-kappa B p65 (NF-κBp65) and tumor necrosis factor-receptor-associated factor 6 (TRAF6) in the intestine tissues of LPS-induced acute enteritis mice significantly increased, whereas these adverse changes were alleviated in the HRP intervention groups. Notably, HRP may regulate the expression of the TRAF6/NF-κB signaling pathway by affecting the diversity of the intestinal microbiota. Microbiota analysis showed that HRP promoted the proliferation of beneficial bacteria, including Clostridia_UCG-014, Candidatus_Saccharimonas, Lachnospiraceae_NK4A136_group, Bacteroidota, Deferribacterota, and reduced the abundance of Atopostipes, Corynebacterium, Actinobacteriota, and Desulfobacterota. The studies conformed that the gut microbiota is crucial in HRP-mediated immunity regulation. HRP shows great potential as an immune enhancer and a natural medicine for treating intestinal inflammatory diseases.

RNA analysis of patients with benign and malignant pulmonary nodules.

Pulmonary nodules are the main manifestations of early lung cancer. Non-small cell lung cancer is the most common histological type of lung cancer, and the main histological classification of non-small cell lung cancer is lung adenocarcinoma. The present study aimed to analyze the differentially expressed genes between patients with benign and malignant pulmonary nodules, and to identify potential therapeutic targets for lung adenocarcinoma. Sequencing data for benign and malignant pulmonary nodule samples and samples with no nodules were obtained from the National Center for Biotechnology Information Gene Expression Omnibus GSE135304 dataset. Differential gene analysis showed that S100 calcium binding protein P (S100P), ribonuclease A family member 2 (RNASE2), cytochrome c oxidase subunit 7C and mast cell expressed membrane protein 1 (C19orf59) were significantly upregulated among the blood samples collected from patients with malignant pulmonary nodules. Results from Kaplan-Meier plotter datasets showed that S100P, RNASE2 and C19orf59 were associated with the prognosis of lung cancer. RNASE2 expression was positively associated with nodule size and negatively associated with lung cancer prognosis. Moreover, RNASE2 was highly expressed in lung adenocarcinoma tissues compared with that in normal tissues. CCK-8 and Transwell assays indicated that overexpressed RNASE2 promoted the proliferation, migration and invasion of lung adenocarcinoma cells. In lung adenocarcinoma cells, RNASE2 was identified as a downstream target of microRNA (miR)-185-5p and was regulated by it. Inhibited cell proliferation, migration and invasion were observed following overexpression of miR-185-5p. Overexpression of RNASE2 reversed the inhibitory effect of miR-185-5p overexpression. In conclusion, in blood samples from patients with malignant pulmonary nodules and lung adenocarcinoma tissues, RNASE2 was found to be upregulated. High RNASE2 expression was associated with poor overall survival. miR-185-5p inhibited the proliferation, migration and invasion of lung adenocarcinoma cells by downregulating RNASE2 expression. These findings have implications for guiding therapeutic strategies.

Research progress of Sinomenium in the treatment of rheumatoid arthritis and suggestions for future research.

Rheumatoid arthritis (RA) is a chronic autoimmune joint disease. Its main pathological manifestations are joint cartilage, bone tissue injury, synovial hyperplasia, and chronic inflammation. At present, the pathogenesis of the disease has not been fully defined, and delaying the disease to improve joint function is the existing treatment. Sinomenium (SIN) is an effective ingredient in Sinomenium acutum (Thunb.) Rehd. et Wils., with anti-inflammatory, analgesic, immunosuppressive, anti-tumor, and other pharmacological activities, which is quite effective in the treatment of RA. There are many SIN compound preparations in the market, such as Zhengqing Fengtongning capsule, Zhubi Huoluo prescription, and Qinxitong tablet. They all exhibit good anti-RA effect with less adverse reactions. This study summarized the mechanism of action of SIN in the treatment of RA and further explored the possibility of SIN in the treatment of RA combined with other diseases for future research.

Ventricular tachycardia as the main manifestation of primary cardiac lymphoma in a dog

Ventricular tachycardia as the main manifestation of primary cardiac lymphoma in a dog

Paradoxical Behçet’s Disease after Ixekizumab: A Case Report and Literature Review

Abstract Behçet’s disease is a chronic inflammatory condition that affects multiple organs and systems. It is characterized by recurrent oral and genital ulcers. A previous study reported that the IL-17A inhibitor secukinumab can improve the skin and mucosal manifestations in patients with refractory Behçet’s disease. Additionally, secukinumab has been shown to effectively improve neurological symptoms when administered for Behçet’s disease. However, we report a case where Behçet’s disease occurred after the treatment of psoriasis with the IL-17A inhibitor ixekizumab. To summarize its clinical characteristics and treatment experience, we consulted relevant domestic and international literature and conducted a literature review. We concluded that anti-IL-17A treatment may lead to the development of Behçet’s disease. The reported cases are more likely to occur in middle-aged men with varying onset times. The main manifestations include oral and vulvar mucosal ulcers. Furthermore, the gut microbiota may be involved in paradoxical Behçet’s disease.

CBCT analysis of the incidence of maxillary lateral incisor dens invaginatus and its impact on periodontal supporting tissues

BackgroundDens invaginatus is a developmental abnormality originating from tooth development, including coronal invaginatus and radicular invaginatus. The reported incidence varies greatly due to diagnostic techniques, classification criteria and race. The incidence of dens invaginatus in China was not clear, and the impact of dens invaginatus on periodontal support tissue were rarely reported. This study aims to clarify the incidence of maxillary lateral incisor dens invaginatus and its impact on periodontal supporting tissues.MethodsFrom the cone-beam computed tomography database, images of 212 maxillary lateral incisors from 106 Chinese patients were selected. Teeth that met the Oehlers classification criteria for coronal invaginatus were recorded as coronal invaginatus, and teeth with radicular cystoid invaginatus or radicular groove were classified as radicular dens invaginatus. The complexity of radicular groove was determined by Gu’s classification standard. Both of coronal invaginatus and radicular dens invaginatus were recorded as dens invaginatus. For 15 patients with unilateral radicular dens invaginatus, the periodontal ligament area of the affected teeth and the corresponding natural teeth in the same jaw were measured and compared.ResultsThe overall incidence of maxillary lateral incisor invaginatus in China is 25.0%. The incidence of coronal invaginatus is 12.3%, and the incidence of radicular dens invaginatus is 14.6%. No significant differences were observed between genders or sides. In this study, all radicular dens invaginatus exhibited as radicular groove, of which 87.1% were Gu type I, 9.7% were Gu type II, and 3.2% were Gu type III. Although the difference was not statistically significant, the average periodontal ligament area of the maxillary lateral incisor with radicular dens invaginatus was 148.93 ± 35.62mm2, smaller than that of the control teeth (152.28 ± 40.22mm2).ConclusionsThe dens invaginatus of the maxillary lateral incisor is common. There is no significant difference in the incidence between genders or between sides. The main manifestation of the radicular dens invaginatus is the radicular groove (Gu’s type I). This anatomical abnormality may reduce the periodontal ligament area. The presence of the additional root of the maxillary lateral incisor is not rare and was supposed to be highly concerned by dentists.

Sensory neuropathy in patients with Pompe disease: a case series in Iran

BackgroundPompe disease is a glycogen storage disease primarily affecting striated muscles. Despite its main manifestation in muscles, patients with Pompe disease may exhibit non-muscle symptoms, such as hearing loss, suggesting potential involvement of sensory organs or the nervous system due to glycogen accumulation.AimsThis study aimed to evaluate the presence of concomitant small and large fiber neuropathy in patients with Pompe disease.MethodsIn this case series study, nine patients with Pompe disease without complaints of neuropathy were evaluated. Small fiber neuropathy was assessed using the Small Fiber Neuropathy Screening List (SFNSL) and SUDOSCANR, while the sympathetic system was evaluated through Sympathetic Skin Response (SSR), and large fiber neuropathy was assessed through electrodiagnostic findings.ResultsSmall fiber neuropathy was detected in seven patients (77.8%) according to the SFNSL. Three patients (3/9, approximately 30%) exhibited positive electrophysiological tests, including SSR, SUDOSCANR, and nerve conduction studies for neuropathy. They also had positive SFNSL results.ConclusionsThis study indicates that neuropathy can be a comorbid condition in Pompe disease, emphasizing the importance of screening for this disabling condition.

Immune-related adverse events with renal colic as the main manifestation: a case report of sintilimab-induced ureteritis/cystitis treated by ureteral stent and review of the literature

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of systemic cancer therapy. During disinhibiting the antitumor responses of immune system, ICIs may also cause unique immune-related adverse events (irAEs) which could affect any organ. Here, we report a rare case of sintilimab-induced ureteritis/cystitis in a 55-year-old male undergoing neoadjuvant chemo-immunotherapy for gastric cancer. The patient presented with severe renal colic, hematuria, and hydronephrosis. Antibiotic antispasmodic and nonsteroidal anti-inflammatory drug treatment failed to alleviate symptoms. The application of corticosteroid was negated for recent extirpative surgery under plan. Bilateral ureteral stenting effectively resolved the pain and improved renal function. The patient later successfully underwent laparoscopic radical gastrectomy with significant tumor regression in postoperative pathology. This case highlights ureteral stenting as a potential corticosteroid-free treatment option for ICI-induced ureteritis/cystitis.

Characteristics of Extra Thoracic Sarcoidosis: A Retrospective Study from Morocco

Background: Sarcoidosis is a multisystem granulomatous disorder with diverse extra thoracic manifestations requiring systematic evaluation. Objectives: To analyse the characteristics and outcomes of extra thoracic manifestations in sarcoidosis patients at Mohamed V Military Hospital, Rabat. Methods: Retrospective study of 54 sarcoidosis patients from January 2021 to January 2024. Clinical, biological, radiological, and therapeutic data were analysed. Results: Extra thoracic involvement occurred in 16 patients (30%), predominantly female (sex ratio 1/3), mean age 41±7 years. Type II radiographic sarcoidosis was most common (50%). Main manifestations were ocular (16.6%), peripheral lymph nodes (9.25%), and cutaneous (7.4%). Biological findings included elevated ACE (20.4%), leukopenia with lymphopenia (7.4%), and hypercalcemia (3.7%), Treatment comprised corticosteroids (75%), immunosuppressants (12.5%), and antimalarial drugs (12.5%). Conclusion: Extra thoracic sarcoidosis presents diverse manifestations requiring vigilant screening. Treatment strategies primarily rely on corticosteroids, with favourable outcomes in most cases.

Complex treatment of the vibration disease by reflexotherapy and pulsed magnetic stimulation

Introduction. In the basic treatment of a number of diseases, including neuropathies, which are one of the main manifestations of vibration disease (VD), preference is given to the complex use of several physical methods, which allows obtainingt an effect that is not achievable if only one of the influencing factors is used. The aim of the study. Improving the effectiveness of drug-free treatment of the vibration disease associated with exposure to local vibration. Materials and methods. Using the combined effects of acupuncture (IRT) and pulsed magnetic stimulation (MS), there were treated thirty eight male patients (average age 47.6±4.3 years, average work experience in contact with local vibration – 20.8±3.4 years). All cases had a diagnosis of VD associated with exposure to local vibration. The effectiveness of treatment was assessed by the results of EEG, electroneuromyography (ENMG), and registration of somatosensory evoked potentials (SSVP), algesimetry, and determination of vibration sensitivity. A psychological examination was conducted. Results. After treatment, an improvement in indices of visual and somatosensory evoked potentials, vibration sensitivity and algesimetry data was found. There was an increase in the time of propagation of arousal along afferent and efferent axons, and the mnestic-attentional and psychoemotional spheres of activity were normalized. The use of therapy methods weakened the chronization of the pathological process, prevented patients from becoming ill. Limitations. The limitation of the study may be that the testing of non-drug treatments was not compared with the results obtained with drug therapy. Conclusion. The proposed therapy has expanded the possibilities of rehabilitation in VD patients. The use of IRT in combination with MS increased the level of compensatory and restorative processes in the central and peripheral nervous systems. The proposed treatment method does not require patients to stay in a hospital, which will reduce treatment costs.

A clinical challenge of cardiomyopathies: Beyond the heart

Introduction: The relation between the cancer and the heart is diverse. It can be affected all parts of the heart directly or indirectly caused by the systemic manifestation of the cancer or by cancer therapy. Paraneoplastic dermatomyositis and tumor lysis syndrome (TLS) are two examples of systemic manifestations of cancer. Being systemic, the cardiovascular system can be affected. Heart failure and arrhythmias are the main cardiac manifestations. Case Report: A 68-year-old man with a recent diagnosis of diffuse large B-cell lymphoma waiting to begin chemotherapy, and paraneoplastic dermatomyositis, presented at the emergency department (ED) with palpitations and dyspnea with a week of evolution. At the physical examination, he presented with pulmonary edema and the novo rapid atrial fibrillation. Also, an Nt-pro BNP of 8957 pg/mL, and echocardiography with severe dilated left ventricle, with a severe reduced ejection fraction. Already in the ward, the patient developed a spontaneous TLS. The etiological interpretation was that paraneoplastic dermatomyositis and TLS were the triggers of atrial fibrillation (AF). Then, the combination of them was responsible for development of the dilated cardiomyopathy (tachymyocardiopathy). The chemotherapy regimen was changed to R-CEOP (Rituximab, cyclophosphamide, etoposide, vincristine sulfate, and prednisone). Conclusion: This clinical case perfectly shows how the world of cardiomyopathies can be challenging and hard to understand all the complexity of the patients.

ENTERPRISE MANAGEMENT: FUNCTIONAL ANALYSIS

The relevance of the functional analysis of enterprise management is since its effectiveness allows to achieve not only the goal of activity, but also several urgent socio-economic problems. However, because of constant changes in the business environment, technological and digital transformation, the list of the main functional manifestations of enterprise management, which requires a comprehensive study, is significantly expanding. During the research, it was determined that today enterprise management should be considered as a kind of art that requires managers to constantly study, master new methods and improve practical skills. The classical approach proposed by A. Fayol was used as a basis for the division of enterprise management functions. In accordance with the main management functions inherent to any enterprise, regardless of the field of activity, we assigned planning, organization, motivation, coordination, control and regulation. However, numerous factors caused by transformational changes and the development of new technologies make it possible to expand this list with specific functions of enterprise management. Marketing, financial, personnel management, production, innovation, logistics, information support, and environmental functions were included in such functions.

Effectiveness and safety of intravenous immunoglobulin for peripheral neuropathy in EGPA patients: a retrospective study.

Eosinophilic granulomatosis with polyangiitis (EGPA) is a chronic inflammatory disease belonging to the spectrum of small-vessel vasculitis associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCAs), also characterized by eosinophilic infiltration of target organs. Peripheral neuropathy (PN) affects about 2/3 of the patients as a presenting symptom and typically represents a vasculitic involvement. A few studies have addressed the role of intravenous immunoglobulin (IVIg) for the treatment of PN in EGPA. This monocentric retrospective study aims at assessing the effectiveness and safety of IVIg in patients with PN as the main acute manifestation at EGPA onset. The treatment with IVIg appears to be effective in inducing sustained remission, reducing the risk of relapses and improving the long-term disability due to its effects on PN.

Perforation of the Sigmoid Colon in Vasculitis in COVID-19 Patients

The aim of the study was to investigate the main manifestations and pathological changes in the tissues under the sigmoid colon perforation in patients with COVID-19. Materials. The study involved analysis of medical histories of 40 patients with sigmoid colon perforation associated with COVID-19. All patients showed similar symptoms (increasing respiratory failure, dyspnea, high body temperature), followed by the development of the sigmoid colon perforation due to the violation of intravascular hemostasis. In 25% of patients, perforation developed already on the second or third day from the onset of ARVI symptoms, in 75% - on the fifth or sixth day from the onset of the disease. Results. The analysed case histories and the results of histological examination of biopsy or pathological material demonstrated similarities in the clinical presentation of the disease and morphological changes in the affected area of the sigmoid colon. The main symptoms and syndromes are presented using the example of a clinical case. Conclusion. The patient developed complications at the final stage of COVID-19 disease and this was associated with inflammation of the mesentery arteriole walls and the formation of occlusive blood clots in their lumen, which led to the development of the sigmoid colon perforation.