Main Core Research Articles

Research Status and Development Trend of Key Technologies for Pineapple Harvesting Equipment: A Review

Pineapple harvesting is a key step in pineapple field production. At present, pineapple fruits are usually picked manually. With decreasing labor resources and increasing production costs, machines have been used instead of manual picking approaches in the modern pineapple industry. This paper briefly describes the basic situation of pineapple planting worldwide. Based on the degree of automation of mechanized pineapple harvesting equipment, the main structural forms, core technologies, and operation modes of semi-automatic, automatic, and intelligent pineapple harvesting equipment are summarized. The research status and existing problems of key pineapple fruit picking robots, such as fruit recognition, maturity classification, positioning, and separation of pineapple fruits, are analyzed. Considering the problems of pineapple harvesting equipment, such as difficulty entering the ground, low harvesting efficiency, low picking success rate, and fruit damage, innovative future research directions for mechanized pineapple harvesting technology are proposed, such as combining agricultural machinery and agronomical principles, integrating mechanized, automated, and intelligent technology, and developing modular designs and generalized approaches.

OPPORTUNITIES AND RESULTS OF INTEGRATION OF KAZAKHSTAN'S TRANSPORT SYSTEM WITH INTERNATIONAL TRANSPORT SYSTEMS

The article examines the transport and transit industry of Kazakhstan, strategic planning for improving the logistics infrastructure, creating a network of multimodal transport and logistics centers integrated into regional transport and logistics systems, ensuring close integration of the Kazakh transport system as an equal partner with international transport systems. The main components of the logistics infrastructure of multimodal transport and logistics centers, international transport corridors that ensure coordinated interaction of modes of transport and other participants in the transport and logistics process in Kazakhstan are considered as strategic points for the development of the economy of Kazakhstan. Modern international transport corridors are becoming the main core of the effective development of interstate economic relations in the era of globalization of the world economy. This industry is considered as an important factor of socio-economic prosperity and the Republic of Kazakhstan, which is heading towards an innovative path of development. Because international transport corridors are one of the most important industries that contributes to the prosperity of the global economy, facilitating trade and exchange of goods between countries of the world.

Seismic Assessment of Self-Centering Rocking Braced Systems with Story Energy Dissipation

Self-centering rocking braced (SCRB) system provides enhanced seismic performance and reduced post-earthquake residual drift. However, the effect of higher modes is controversial, affecting shear demands and bending moments in the structure. This functional deficiency is addressed by developing SCRB frames equipped with buckling-restrained columns (BRCs) and buckling-restrained braces (BRBs), performing as exchangeable fuse frames. The system consists of external columns branching off from the main core and connected to it via butterfly-shaped fuses, and BRC and BRB are incorporated into the core at four different height levels to be compared with conventional SCRB as the baseline. Three sets of 12-, 16- and 20-story structures are numerically developed in OpenSees finite element framework with regard to geometrical and material nonlinearities, making a total of 12 SCRB prototypes. The suit of 22 ground motions used in FEMA P695 was scaled to DBE and MCE hazard levels and applied to the structures. Results indicate the capability of the new system in reducing the destructive effects of higher modes, especially in the case of a fuse frame located in the middle of the height. In addition, the core moment and shear force largely reduced, almost 60%, in higher positions of the fuse frame, while those configurations led to large residual drift at the restrained level. However, all structures met the DBE-level 2% drift target. Moreover, increasing structural height nearly reduced seismic demands and increased response reductions. Overall, the system demonstrated acceptable performance in terms of high capacity for energy absorption.

Bioactive compounds from dichloromethane extract of Artemisia rupestris L. alleviates CCl4/ConA-induced acute liver injury by inhibiting PI3K-AKT pathway

Ethnopharmacological relevanceArtemisia rupestris L. (AR) is a traditional medicinal herb commonly used in the Uyghurs and Kazakhs; it was first documented in the Supplement to Compendium of Materia Medica written by Zhao Xuemin in the Qing Dynasty of China and is used clinically to treat colds, hepatitis, and allergic diseases. Aim of the studyThe material basis and mechanisms of AR in acute liver injury (ALI) remain unclear. The purpose of this study was to reveal the possible active components involved in liver protection in AR and to preliminarily explore their pharmacological mechanisms. Materials and methodsThe chemical composition of the ethanolic extract (ARA) was identified by UPLC-Q-Exactive-MS/MS and confirmed by 32 reference standards. The pharmacodynamic results were utilized to screen the active part within the ARA that contribute to the amelioration of CCl4/ConA-induced ALI. The main active components and core targets were predicted by network pharmacology and verified by molecular docking combined with qPCR and Western blotting. ResultsA total of 131 chemical components were identified in the ARA. The extraction parts of ARA had different therapeutic effects on ALI, among which the dichloromethane extract (ARA-D), which might constitute the main effective fraction of ARA, had significant anti-ALI effects. The network pharmacology results showed that targets including PIK3R1, AKT1, and EGFR, as well as 7 compounds, such as artemetin, vitexicarpin and rupestonic acid may play pivotal roles in treating CCl4/ConA-induced ALI. GO and KEGG pathway enrichment analyses revealed that the PI3K-AKT signaling pathway was the main pathway involved. In each model, ARA-D dose-dependently reduced the increase in ALT levels. High-dose ARA-D markedly decreased ALT activity from 196.79 ± 24.82 to 66.37 ± 16.19 U/L in the CCl4 model group and from 178.00 ± 28.39 to 50.67 ± 7.39 U/L in the ConA model group. Further studies revealed that ARA-D significantly inhibited TNF-α, IL-1β, and IL-6 expression and inhibited the protein expression of PI3K, p-PI3K, and p-AKT in CCl4/ConA-induced ALI. ConclusionARA-D exhibits protective effects against ALI induced by CCl4/ConA, potentially through inhibition of the PI3K-AKT signaling pathway. These findings may help to determine the material basis and mechanisms of action of ARA-D for liver protection and provide ideas for future comprehensive studies.

Application of STEEP and Interpretive Structural Modeling in the Design Imagery of Taiwan Public Ceramic Relief Murals

Ceramic relief mural is a contemporary landscape art that is carefully designed based on human nature, culture, and architectural wall space, combined with social customs, visual sensibility, and art. It may also become the main axis of ceramic art in the future. Taiwan public ceramic relief murals (PCRM) are most distinctive with the PCRM pioneered by Pan-Hsiung Chu of Meinong Kiln in 1987. In addition to breaking through the limitations of traditional public ceramic murals, Chu leveraged local culture and sensibility. The theme of art gives PCRM its unique style and innovative value throughout the Taiwan region. This study mainly analyzes and understands the design image of public ceramic murals, taking Taiwan PCRM’s design and creation as the scope, and applies STEEP analysis, that is, the social, technological, economic, ecological, and political-legal environments are analyzed as core factors; eight main important factors in the artistic design image of ceramic murals are evaluated. Then, interpretive structural modeling (ISM) is used to establish five levels, analyze the four main problems in the main core factor area and the four main target results in the affected factor area; and analyze the problem points and target points as well as their causal relationships. It is expected to sort out the relationship between these factors, obtain the hierarchical relationship of each factor, and provide a reference basis and research methods.

Islam and Pluralism in the Qur'anic Perspective:Thematic Interpretive Studies

Contemporary Issues is a study that discusses various issues in the modern era. The main core of this study is Islam and pluralism. The discussion covers contemporary issues that are analyzed through a thematic interpretive lens. The purpose of this study is to examine contemporary issues related to Islam and pluralism through the interpretation of the Quran. The discussion includes the meaning of pluralism itself and the interpretations of classical and contemporary commentators. The research method is the search for meaning and references. The findings of the study on Islam and pluralism show that pluralism means diversity, this has been repeatedly explained in the Quran, such as Surah Al-Baqarah verse 62 and Surah Ar-Rum verse 22. This research is useful in advancing teaching activities and providing learning materials to those who need them.

A Novel Approach to Managing System-on-Chip Sub-Blocks Using a 16-Bit Real-Time Operating System

Embedded computers are ubiquitous in products across various industries, including the automotive and medical industries, and in consumer goods such as appliances and entertainment devices. These specialized computing systems utilize Systems on Chips (SoCs), devices that are made up of one or more main microprocessor cores. SoCs are augmented with sub-blocks that perform dedicated tasks to support the system. Sub-blocks contain custom logic or small-footprint microprocessors, depending upon their complexity, and perform support functions such as clock generation, device testing, phase-locked loop synchronization and peripheral management for interfaces such as a Universal Serial Bus (USB) or Serial Peripheral Interface (SPI). SoC designers have traditionally obtained sub-blocks from commercial vendors. While these sub-blocks have well-defined interfaces, their internal implementations are opaque. Without visibility of the specifics of the implementation, SoC designers are limited to the degree to which they can optimize these off-the-shelf sub-blocks. The result is that power and area constraints are dictated by the design of a third-party vendor. This work introduces a novel idea: using an open-source, small, multitasking, real-time operating system inside an SoC sub-block to manage multiple processes, thereby conserving code space. This OS is TurbOS, a new operating system whose primary goal is to provide the highest performance using the least amount of space. It is written in the assembly language of a new pipelined 16-bit microprocessor developed at the University of Florida, the Turbo9. TurbOS is derived from and incorporates the design benefits of an existing operating system called NitrOS-9, and reduces the code size from its progenitor by nearly 20%. Furthermore, it is over 80% smaller than the popular FreeRTOS operating system. TurbOS delivers a rich feature set for managing memory and process resources that are useful in SoC sub-block applications in an extremely small footprint of only 3 kilobytes.

Network Pharmacology Study on Herb Pair Bletilla striata-Galla chinensis in the Treatment of Chronic Skin Ulcers.

Herb pair Bletilla striata-Galla chinensis (BS-GC) is a classic combination of topical traditional Chinese medicine formulae in the treatment of chronic skin ulcers (CSUs). The aim of this study is to explore the effective active ingredients of BS-GC, as well as the core targets and signal transduction pathways of its action on CSUs. The ingredients of BS-GC were obtained from TCMSP and HERB databases. The targets of all active ingredients were retrieved from the SwissTargetPrediction database. The targets of CSUs were obtained from OMIM, GeneCards, Drugbank, and DisGeNET databases. A drug-disease target protein-protein interaction (PPI) network was constructed to select the most core targets, and an herb-ingredient-target network was built by utilizing Cytoscape 3.7.2. Furthermore, we performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes database (KEGG) analysis and verified the results of network pharmacology through molecular docking. A total of 40 active ingredients from the herb pair BS-GC were initially screened, and a total of 528 targets were retrieved. Meanwhile, the total number of CSU targets was 1032. Then, the number of common targets between BS-GC and CSUs was 107. The 13 core targets of herb pair BS-GC with CSUs were filtered out according to the PPI network, including AKT1, TNF, EGFR, BCL2, HIF1A, MMP-9, etc. The 5 main core active ingredients were 1-(4-Hydroxybenzyl)-2-methoxy-9,10-dihydrophenanthrene-4,7-diol, 1-(4- Hydroxybenzyl)-4-methoxy-9,10-dihydrophenanthrene-2,7-diol, physcion, dihydromyricetin, and myricetin. The main biological processes were inflammation, oxidative stress, and immune response, involving the AGE-RAGE signaling pathway in diabetic complications, HIF-1 signaling pathway, NF-κB signaling pathway, and calcium signaling pathway. Molecular docking results showed good binding activity between the 5 main core active ingredients and 13 core targets. This study predicted the core targets and signal transduction pathways in the treatment of CSUs to provide a reference for further molecular mechanism research.

Supramaximal resection: retrospective study on IDH-wildtype Glioblastomas based on the new RANO-Resect classification.

The prognostic value of the extent of resection in the management of Glioblastoma is a long-debated topic, recently widened by the 2022 RANO-Resect Classification, which advocates for the resection of the non-enhancing disease surrounding the main core of tumors (supramaximal resection, SUPR) to achieve additional survival benefits. We conducted a retrospective analysis to corroborate the role of SUPR by the RANO-Resect Classification in a single center, homogenous cohort of patients. Records of patients operated for WHO-2021 Glioblastomas at our institution between 2007 and 2018 were retrospectively reviewed; volumetric data of resected lesions were computed and classified by RANO-Resect criteria. Survival and correlation analyses were conducted excluding patients below near-total resection. 117 patients met the inclusion criteria, encompassing 45 near-total resections (NTR), 31 complete resections (CR), and 41 SUPR. Median progression-free and overall survival were 11 and 15months for NTR, 13 and 17months or CR, 20 and 24months for SUPR, respectively (p < 0.001), with inverse correlation observed between survival and FLAIR residual volume (r -0.28). SUPR was not significantly associated with larger preoperative volumes or higher rates of postoperative deficits, although it was less associated with preoperative neurological deficits (OR 3.37, p = 0.003). The impact of SUPR on OS varied between MGMT unmethylated (HR 0.606, p = 0.044) and methylated (HR 0.273, p = 0.002) patient groups. Results of the present study support the validity of supramaximal resection by the new RANO-Resect classification, also highlighting a possible surgical difference between tumors with methylated and unmethylated MGMT promoter.

Analysis of Student Communication in the Discovery Learning Model Using Transcript-based Lesson Analysis

This study aimed to analyze student and teacher communication in discovery learning through transcript-based lesson analysis (TBLA). The research was conducted in one of the junior high schools in Garut Regency on science subjects. The learning material studied in this research was about Coulomb’s Law. The learning video was taken from one of the open class activities from a series of lesson study activities. As many as 16 students of grade 9 were included in the study. Through descriptive research methods, researchers revealed learning trajectories and student communication methods while learning through the transcripts made. Learning activities are divided into three main parts, namely introduction, core activities, and closing. There are five stages in the core activity, namely literacy activities, critical thinking, collaboration, communication, and creativity. The results of the analysis show that in the preliminary activity, communication is dominated by the teacher. The dialogue that appears is just a minimalistic dialogue. In core activities, student communication had started to dominate, especially at the collaboration and communication stages. The use of interactive simulation media at the collaboration stage improved the communication between students. The creativity stage was mostly dominated by the teacher, until the closing activity, and less by student communication. The lag time between teacher questions and student answers is the key to student responses. When the pause is given too quickly, there was no communication from students at almost all stages. Keywords: student communication, discovery learning, transcript-based lesson

Revisiting Gradient Bach Solitons via Maximum Principles

Supposing that the Ricci curvature has an appropriate lower bound and applying suitable maximum principles, we establish triviality results which guarantee that a gradient Bach soliton must be trivial and Bach-flat. Our approach is based on three main cores: convergence to zero at infinity, polynomial volume growth (both related to complete noncompact Riemannian manifolds) and stochastic completeness.

Big cats persisting in human-dominated landscape: Habitat suitability and connectivity of leopards in central North China

ContextThe leopard (Panthera pardus), the only large carnivore species occurring in central North China, has undergone substantial range contraction and population decline due to anthropogenic pressure across the region.ObjectivesIn this study, we aimed to map its current suitable habitats and assess the degree of connectivity between core habitats to inform future conservation planning of this big cat at the landscape scale.MethodsWe conducted this study in central North China (34°11´ ~ 43°49´N, 103°11´ ~ 123°54´E, about 936,000 km2). We collected occurrence locations (N = 196) of leopards from 2014–2020, and modeled its habitat suitability using an “ensemble” species distribution model by incorporating environmental and anthropogenic variables. We then identified the potential dispersal corridors between core habitat patches (≥ 100 km2) through connectivity analysis.ResultsThe leopards preferred humid forests at higher elevations with less human disturbance. Their suitable habitats were highly fragmented, with main core habitats located in Shanxi, Shaanxi, and the border between Gansu and Ningxia provinces. Among all the 8,679 km2 suitable habitats, we identified 14 core habitats (139–1,084 km2, mean = 495.21 km2) with a total area of 6,933 km2, among which only 25.26% (1,751 km2) are covered by nature reserves and only 11 core habitats were confirmed with leopard occurrence. We also identified 8 least-cost pathways among these core habitats with an average length of 57.22 km.ConclusionsOur results revealed that, leopards are persisting in highly fragmented habitats with fragile connectivity among core habitats. The leopards remaining in North China should be considered and managed as a regional meta-population for their long-term persistence in the human-dominated landscape.

Multi-omics and chemical profiling approaches to understand the material foundation and pharmacological mechanism of sophorae tonkinensis radix et rhizome-induced liver injury in mice

Ethnopharmacological relevanceSophorae tonkinensis Radix et Rhizoma (STR) is an extensively applied traditional Chinese medicine (TCM) in southwest China. However, its clinical application is relatively limited due to its hepatotoxicity effects. Aim of the studyTo understand the material foundation and liver injury mechanism of STR. Materials and methodsChemical compositions in STR and its prototypes in mice were profiled by ultra-performance liquid chromatography coupled quadrupole-time of flight mass spectrometry (UPLC-Q/TOF MS). STR-induced liver injury (SILI) was comprehensively evaluated by STR-treated mice mode. The histopathologic and biochemical analyses were performed to evaluate liver injury levels. Subsequently, network pharmacology and multi-omics were used to analyze the potential mechanism of SILI in vivo. And the target genes were further verified by Western blot. ResultsA total of 152 compounds were identified or tentatively characterized in STR, including 29 alkaloids, 21 organic acids, 75 flavonoids, 1 quinone, and 26 other types. Among them, 19 components were presented in STR-medicated serum. The histopathologic and biochemical analysis revealed that hepatic injury occurred after 4 weeks of intragastric administration of STR. Network pharmacology analysis revealed that IL6, TNF, STAT3, etc. were the main core targets, and the bile secretion might play a key role in SILI. The metabolic pathways such as taurine and hypotaurine metabolism, purine metabolism, and vitamin B6 metabolism were identified in the STR exposed groups. Among them, taurine, hypotaurine, hypoxanthine, pyridoxal, and 4-pyridoxate were selected based on their high impact value and potential biological function in the process of liver injury post STR treatment. ConclusionsThe mechanism and material foundation of SILI were revealed and profiled by a multi-omics strategy combined with network pharmacology and chemical profiling. Meanwhile, new insights were taken into understand the pathological mechanism of SILI.

The principle of magnetic flux switch

This paper introduces an innovative Magnetic Switch (MFS) designed to control and alter magnetic flux within energy system components, offering an alternative to conventional power electronic devices. The MFS comprises a low-current control coil, a control core, and a high-density magnetic flux-carrying main core combined with a main coil energy system. In this novel magnetic configuration, when a low-power current excites the control coil, the magnetic flux in the main core (supplied by the main coil) decreases to nearly zero. Conversely, when the control coil disconnects from the power source, the magnetic flux within the main core attains its maximum value. This operation positions the MFS as a groundbreaking concept within magnetic-based energy systems, akin to transistors in power electronics. The main outcomes of the MFS concept are that it can vary the magnetic flux of the main core in the large range, and it is a fast magnetic switch with a simple and low power loss control circuit and an independent control coil from the main coil. Analytical studies thoroughly elucidate the performance and advantages of this proposed magnetic switch, substantiated by Finite Element Method simulations and experimental prototype outcomes.

Development of main concept and core lexicon checklists for the original and modern Cookie Theft stimuli

ABSTRACT Purpose To improve the utility of the cookie theft stimuli by reporting normative control data on both original and modern cookie theft pictures for clinically feasible discourse analysis measures. Method Forty-five transcripts of original cookie theft descriptions by healthy controls were retrieved from the AphasiaBank database and 50 transcripts of modern cookie theft descriptions were contributed by Berube and colleagues. Following the procedure used by Richardson & Dalton (2016), checklists of main concepts produced by at least 33% of participants in each task were identified. Similarly, the Dalton & Richardson (2016) procedure was used to create core lexicon lists, defined as any lemma that was produced by 50% or more of the sample. Descriptive statistics are reported to support the appropriateness of the samples for use as normative data. Results Nine and 14 main concepts were identified for the original and modern cookie theft stimuli, respectively. Six main concepts appeared in both checklists, with unique concepts for each stimulus as well. The average main concept composite score for the original cookie theft was 17.4 (SD = 3.8) with scores ranging from 10/27 to 26/27. For modern cookie theft the average main concept composite score was 28 (SD = 7.6) with scores ranging from 12/42 to 40/42. Twenty-six and 42 lemmas exceeded the 50% cut-off and were identified for the original cookie theft and the modern cookie theft stimuli, respectively. Nineteen core lexicon items were shared across both lists and there were also unique items for each. Twelve function words and 14 content words were identified for the original cookie theft stimulus and participants produced on average 9 (SD = 1.7) function and 11 (SD = 1.8) content words. Twenty function words and 22 content words were identified for the modern cookie theft picture and participants produced on average 15 (SD = 3.3) function and 16 (SD = 3.1) content words. Conclusions The modern cookie theft stimulus elicited more main concepts and core lexicon items compared to the original cookie theft stimulus, which can be attributed to the instructions used with the modern stimulus and the new characters and actions. MCA and Corlex analyses are sensitive functional measures that can be clinically utilized to assess communication ability across clinical populations.

Hydrophobic Clusters Regulate Surface Hydration Dynamics of Bacillus subtilis Lipase A.

The surface hydration diffusivity of Bacillus subtilis Lipase A (BSLA) has been characterized by low-field Overhauser dynamic nuclear polarization (ODNP) relaxometry using a series of spin-labeled constructs. Sites for spin-label incorporation were previously designed via an atomistic computational approach that screened for surface exposure, reflective of the surface hydration comparable to other proteins studied by this method, as well as minimal impact on protein function, dynamics, and structure of BSLA by excluding any surface site that participated in greater than 30% occupancy of a hydrogen bonding network within BSLA. Experimental ODNP relaxometry coupling factor results verify the overall surface hydration behavior for these BSLA spin-labeled sites similar to other globular proteins. Here, by plotting the ODNP parameters of relative diffusive water versus the relative bound water, we introduce an effective "phase-space" analysis, which provides a facile visual comparison of the ODNP parameters of various biomolecular systems studied to date. We find notable differences when comparing BSLA to other systems, as well as when comparing different clusters on the surface of BSLA. Specifically, we find a grouping of sites that correspond to the spin-label surface location within the two main hydrophobic core clusters of the branched aliphatic amino acids isoleucine, leucine, and valine cores observed in the BSLA crystal structure. The results imply that hydrophobic clustering may dictate local surface hydration properties, perhaps through modulation of protein conformations and samplings of the unfolded states, providing insights into how the dynamics of the hydration shell is coupled to protein motion and fluctuations.

Exploring Acori Tatarinowii Rhizoma and Polygalae Radix in Alzheimer's: Network pharmacology and molecular docking analysis.

Explore Acori Tatarinowii Rhizoma (ATR) and Polygalae Radix (PR) mechanisms in Alzheimer's disease (AD) treatment through network pharmacology. ATR-PR was investigated in the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, Batman, and Traditional Chinese Medicines Integrated Database (TCMID) to gather information on its chemical components and target proteins. Target genes associated with AD were retrieved from the GeneCards and National Center for Biotechnology Information (NCBI) databases. The integration of these datasets with potential targets facilitated the construction of an AD and ATR-PR protein-protein interaction (PPI) network using the STRING database. The resulting network identified the core active ingredients and main targets of ATR-PR in AD treatment. Cluster analysis of the PPI network was performed using Cytoscape 3.7.1. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted using the Metascape database. Molecular docking simulations revealed potential interactions between the main active ingredients and core targets. Our analysis identified 8 putative components and 455 targets of ATR-PR. We systematically searched for 1306 genes associated with AD, conducted Venn diagram analysis resulting in 156 common targets, and constructed a PPI network with 57 key targets. GO functional analysis highlighted the primary biological processes associated with oxidative stress. KEGG pathway enrichment analysis revealed the involvement of 64 signaling pathways, with the PI3K/Akt signaling pathway playing a key role. Molecular docking analysis indicated a high affinity between the potential targets of ATR-PR and the main compounds of AD. This study sheds light on the complex network of interactions involving ATR-PR in the context of AD. The identified targets, pathways, and interactions provide a foundation for understanding the potential therapeutic mechanisms. The involvement of oxidative stress-related processes and the crucial role of the PI3K/Akt signaling pathway suggest avenues for targeted therapeutic interventions in Alzheimer's disease treatment. Our proposition of the combined use of ATR-PR has emerged as a potential treatment strategy for AD, supported by a network pharmacology approach. This framework provides a robust foundation for future clinical applications and experimental research in the pursuit of effective Alzheimer's disease treatments.

MeerKAT and ALMA view of the AGAL045.804−0.356 clump

Abstract This study presents a detailed analysis of the GAL045.804−0.356 massive star-forming clump. A high-angular resolution and sensitivity observations were conducted using MeerKAT at 1.28 GHz and ALMA interferometer at 1.3 mm. Two distinct centimetre radio continuum emissions (source A and source B) were identified within the clump. A comprehensive investigation was carried out on source A, the G45.804−0.355 star-forming region (SFR) due to its association with Extended Green Object (EGO), 6.7 GHz methanol maser and the spatial coincidence with the peak of the dust continuum emission at 870 μm. The ALMA observations revealed seven dense dust condensations (MM1 to MM7) in source A. The brightest (Sν ∼ 87 mJy) and massive main dense core, MM1, was co-located with the 6.7 GHz methanol maser. Explorations into the kinematics revealed gas motions characterised by a velocity gradient across the MM1 core. Furthermore, molecular line emission showed the presence of an extended arm-like structure, with a physical size of 0.25 pc × 0.18 pc (∼ 50000 au × 30000 au) at a distance of 7.3 kpc. Amongst these arms, two arms were prominently identified in both the dust continuum and some of the molecular lines. A blue-shifted absorption P-Cygni profile was seen in the H2CO line spectrum. The findings of this study are both intriguing and new, utilising data from MeerKAT and ALMA to investigate the characteristics of the AGAL45 clump. The evidence of spiral arms, the compact nature of the EGO and &amp;lt; 2 km s−1 velocity gradient are all indicative of G45.804−0.355 being oriented face-on.

Microbiological status of donor human milk – A single center study from Poland

Human milk is considered the most suitable source of nutrition for infants. Donor human milk from human milk banks (HMB) is recommended as the best alternative for infants whose mothers' own milk is unavailable. Microbiological screening of milk donated to HMB is important to ensure the quality and safety of the pasteurised human milk. This article describes the microbiological status of human milk donated to the Regional Human Milk Bank in Toruń, Poland. Statistical data regarding the microbiological analysis of milk from 292 donors were collected in the years 2013–2021. Total of 538 milk samples were tested. Only in 6% of human milk samples the bacteria level was above the required standard and/or the milk had potentially pathogenic bacteria. The main core of donors’ breastmilk bacteria represents the skin microbiota, and the composition of the microbiota is strictly related to the surrounding environment. The most abundant genera detected in milk samples were the Staphylococcus group. Prolonged hospitalisation of infants' mothers and/or offsprings is associated with potentially pathogenic bacteria colonization in milk. The use of the modern identification method MALDI-TOF resulted in more accurate results compared to the biochemical methods. Our analysis indicates that most of the tested milk samples (94%), both expressing at home and in hospital environments, meet the criteria for admission to the human milk bank.Effective techniques for identifying microorganisms ensure that donor milk from human milk banks meets the guidelines set for these units.

Narrative and Space: Reconstruction of Heritage Network for South Guangdong Ancient Post Road

The ancient post road in Southern Guangdong is a channel of communication inside and outside Lingnan in different historical periods. It is also known as a corridor of population migration, a channel of commodity exchange and an ancient road of civilization and culture. In view of the limitations of focusing on space while ignoring narrative in the previous research of ancient post road, the analysis method of narrative spatial structure was introduced herein. Based on the four main functions of the ancient post road in Southern Guangdong, including postal exchange, military war, commerce and trade, and official travel, the holistic and systematic narrative space study of the ancient post road in Southern Guangdong was carried out in order to construct a relatively complete narrative space structure of the heritage corridor network. Research showed that the four functional narrative points all rely on corridors. Its spatial structure took Guangzhou as the main core, with Leizhou and Yangjiang in western Guangdong and Chaozhou in eastern Guangdong as the sub-core. A waterway-based land as the auxiliary network system was formed; The post road shifted from the original military function to the economic function, experienced the internal communication with the Central Plains to the coastal areas, and then to the world through the Maritime Silk Road. It became the epitome of the historical development process of Lingnan region. The narrative spatial structure analysis method can deeply explore the historical characteristics and cultural connotation of the heritage corridor, and promote the overall cognition of the post road. The analysis results have certain guiding significance for the construction and protection of the heritage corridor network of the ancient post road in Southern Guangdong. It can also provide a reference for other scholars to carry out the research on similar heritage corridors.