Aim: To estimate the levels of serum 25OH vitamin D3 in patients with cirrhosis. To assess relation of vitamin D3 deficiency to the severity of liver impairment as evidenced by Child-Turcotte-Pugh (CTP) score and Model for Endstage Liver Disease (MELD) score. Methods: The study was conducted in 50 patients admitted to our Liver Unit between June 2013 and May 2014 for the treatment of cirrhosis compensated or decompensated. Diagnosis of cirrhosis was established by clinical, laboratory parameters, and ultrasonographic findings. Results: A total of 55 patients enrolled in the study and 50 completed the study. There were 47 men (94%) and 3 women (6%) and the mean patient age was 41 years (range: 18–70 years). The main cause of admission in the series was ascites in 42 (82%) patients, hepatic encephalopathy in 32 (64%) patients, variceal bleeding in 12 (24%) patients, and HRS in 10 (20%) patients. The cause of cirrhosis was alcoholism in 44 cases and hepatitis B virus in 6 patients. The mean Child-Pugh score was 8.5. Vitamin D was low in all 50 patients (<30 ng/ml). Insufficiency (10–30 ng/ml) was present in 31 (62%) patients and deficiency <10 ng/ml was seen in 19 (38%) patients. All CTP A patients had insufficiency whereas CTP B has both insufficiency and deficiency. CTP C had deficiency. Patients MELD score <15 has insufficiency. A MELD ≥25 correlated with deficiency. Conclusion: Vitamin D deficiency is very important with various roles in human physiology. Patients with cirrhosis have a deficiency of this vitamin. In our study the severity of deficiency correlates with the severity of cirrhosis.