Mahkota Dewa Research Articles

Counseling on processed herbal plants to reduce blood pressure for the elderly in Wonolelo Hamlet, Bandongan, Magelang

Hypertension is defined as blood pressure with a systolic (TDS) of 140 mm Hg or a diastolic (TDD) of 90 mm Hg. One strategy for preventing hypertension is to check blood pressure once a week and to educate people about herbal plants that can help lower blood pressure. The rise in instances of hypertension in Indonesia is attributable to a lack of public understanding about hypertension screening and treatment. The purpose of this program is to raise public awareness of herbal medicines that can be used to lower blood pressure in Wonolelo Hamlet, Bandongan District, Magelang Regency, as well as promote community skills in developing new herbal preparations to lower blood pressure. The service is provided utilizing the Participatory Rural Appraisal (PRA) method, which incorporates the community in the entire process. This practice has a good impact on the community, since it increases community knowledge and inventiveness about herbal plants, as well as the use of family medicinal herbs like celery, fruit and tree of mahkota dewa.

THE ACTIVITY OF GEL EXTRACT MAHKOTA DEWA FRUITS [(Phaleria macrocarpa (Scheff.) Boerl] THROUGH TYROSINASE ENZYME INHIBITOR

Mahkota dewa fruit [(Phaleria macrocarpa (Scheff.) Boerl] contains benzophenone derivatives which have sun protection activity and flavonoid compounds which can act as tyrosinase inhibitors. This study aimed to determine the tyrosinase inhibitor activity of 70% ethanol extract of Mahkota Dewa fruit and gel extract of Mahkota Dewa fruits with variations in concentrations of 1.25% (F1), 2.5% (F2), and 5% (F3). Assay of tyrosinase inhibitor activity against ethanol extract of Mahkota Dewa fruit and ethanol extract was done with various concentrations (31.25, 62.5, 125, 250, and 500 µg/ml), using a positive control of Kojic acid and L-DOPA as a substrate. Absorbance measurement was carried out using UV-vis microplate reader with a wavelength of 480 nm. The results showed that the ethanolic extract Mahkota Dewa had an IC50 value of 6668.06 µg/ml while kojic acid as a positive control possessed an IC50 value of 4.22 µg/ml. Gel preparation of the ethanol extract has inhibitor activity of the enzyme tyrosinase represent moderate values of the IC50each, i.e., F1 (1.25%) amounted to 285.03 µg/ml, F2 (2.5%) amounted to 373.25µg/ml, and F3 (5%) of 397.40 µg/ml. The tyrosinase inhibitor activity of the 70% ethanol extract of Mahkota Dewa fruit was lower with a relative potency of 5.167 x 10-3 times compared to that of kojic acid.

The use of herbal medicines in patients with type-2 diabetes mellitus in Indonesia

In Indonesia, the use of herbal medicine as an alternative medicine is increasing. Herbal remedies are used as complementary medicine and self-medication. Diabetes mellitus requires treatment over the long term. This may contribute to the medication adherence problem. Consequently, many patients seek alternative treatments, such as herbal medications. The purpose of this study was to determine the use and type of herbal medicines among diabetic patients in Indonesia. A cross-sectional study with 190 respondents selected at random from multiple cities in Indonesia. A questionnaire was used to determine the most frequently used herbal medicine, the demographic profile of the patients, the health services, and the level of patient satisfaction with the use of herbal medicines. The participants were predominantly female (62.7%), housewives (39.5%), aged between 40 and 65 (84.5%), high school graduates (74.7%), and had low to moderate incomes (74.7%). The use of herbal medicine was 22%, and the combination of herbal medicine and prescription medication was 6%. Bitter leaves (10%), mangosteen peel (8.9%), insulin leaves (7.9%), mahkota dewa herbs (6.3%), and bitter melon are used as herbal or traditional medicines (4.7%). In terms of satisfaction, 28.7%, 40.9%, and 14.4% of respondents were quite satisfied, satisfied, and very satisfied with the use of herbal medicines, respectively. Herbal remedies are commonly used in alternative diabetes treatments. Bitter leaves are the most frequently used herb, with over half of respondents expressing satisfaction with the benefits of herbal medicine.

Strategi Pemasaran Serbuk Jamu Instan UMKM Tiga Dara di Masa Pandemi Covid 19

Empowerment of Micro, Small and Medium Enterprises (MSME), requires model empowerment, which includes increasing existing MSME to be more advanced in order to be able to compete tightly in free market competition. Since ancient times, empon empon has been proven to have medicinal properties as herbal medicine, which is not only used as a medicine but also as a beauty treatment. One of the MSME that processes empon-empon into instant herbal medicine is Tiga Dara MSME which is located at Jalan Urip Sumoharjo No. 45 East Ungaran Subdistrict, Semarang Regency. Instant herbal powders produced by UD Tiga Dara include instant powders of Ginger, Turmeric, Temulawak, Mahkota Dewa, Kencur etc. The importance of maintaining body immunity during the COVID-19 pandemic is closely related to the availability of instant herbal powder products with empon-empon raw materials, especially ginger. During this pandemic, the demand for instant herbal medicine powder has increased, but Tiga Dara MSME still have limitations in the sales system. The method used in this community service is in the form of training and mentoring MSME in making web and social media as a means of marketing instant herbal powder products. This service aims to assist MSME in marketing their products in order to improve the economy of Tiga Dara MSME. With the existence of the Web and social media as one of the media for product marketing, it is hoped that it can increase sales from MSME and can improve the community's economy so that it can achieve community welfare.

Evaluation of Gastroprotective Effect from Phaleria macrocarpa Fruits Extract on Gastric Ulcer in Male Wistar Rats

Abstract
 
 BACKGROUND: The long-term use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) triggers gastric mucosal damage and causes ulcers. Meanwhile, studies showed that God's crown fruit (Phaleria macrocarpa) contains secondary metabolites of flavonoids and tannins that can protect the gastric mucosa.
 AIM: This study aims to determine the gastroprotective effect of P. macrocarpa ethanolic extracts against gastric ulcers in rats induced with acetosal and ethanol. The extracts were obtained by maceration method using 96% ethanol as solvent.
 METHODS: The male rats used were divided into 7 groups for each test with ethanol and acetosal induction. Each group consisted of 5 rats, namely normal control, induction, carrier, positive control (sucralfate 360 mg/kg BW and omeprazole 3.6 mg/kg BW), and extract doses 100, 200, and 400 mg/kg body weight. All groups were given treatment for 7 days except normal and induction controls. On day 6, rats were fasted for 36 hours and induced with acetosal/ethanol. In ethanol induction, the animal was sacrificed after 10 hours of immersion while in acetosal, the animal was sacrificed 6 hours later. The stomach section was taken for macroscopic, microscopic parameters and gastric acid secretion examination.
 RESULTS: The results of phytochemical screening showed that the extract contained flavonoids, tannins, saponins, alkaloids, and glycosides. In acetosal-induced ulcers, the administration of one dose of the extract reduced the number and score of ulcers, repair epithelial cells, increase pH, and total gastric acidity. Furthermore, the percentage of ulcer inhibition at the extract dose of 400 mg/kg BW was 91.91±3.74% in ethanol induction, and 59±13.08% in acetosal.
 CONCLUSION: The ethanolic extract of P. macrocarpa has a gastroprotective effect on acetosal-induced gastric ulcer rats.
 
 Keywords: Phaleria macrocarpa, Mahkota Dewa fruit, gastroprotective, gastric ulcers, extract

Pembuatan dan Karakterisasi Teh Herbal Penurun Gula Darah dari Buah Mahkota Dewa dan Bunga Telang

This study was conducted to compare the saponin contents and understand the characterization of herbal teas from the Mahkota Dewa fruit and the Telang flower for reducing blood glucose. The method of processing the of the Mahkota Dewa fruit and the flower of the telang into herbal teas is by gradually drying in the oven at a temperature of 110°C for 30 minutes and 70°C for 1 hour, then did size reduction and put into tea bags weighing 2.5 g per bag for 100 ml of water. The results showed that Mahkota Dewa tea had a higher saponin content of 14.4% and a water content of 6.5% more than the Telang flower with a saponin content of 5.6% and a moisture content of 5%. The results of the hedonic test analysis with ANOVA showed that there was a significant difference between the two herbal teas in terms of color but there was no significant difference in terms of taste and aroma. In general, the Mahkota Dewa fruit tea and Telang flower tea were accepted by the panelists on a scale of 3-5 (neutral-very like). For 7 days, the pH of the steeping of Mahkota Dewa tea and Telang flower tea increased from pH 6 to 9. The results of the life test of Mahkota Dewa fruit tea and Telang flower tea can be kept for three days at cold temperatures (10°C–4°C) and one day for room temperature (20°C-25 °C).

Meat bone ratio (MBR) potongan komersial karkas ayam Broiler dengan nanoenkapsulasi ekstrak buah Mahkota Dewa

The objective of this study was to determine the effect of supplementation nanoencapsulation of Mahkota Dewa fruit extract (NEMD) against the meat bone ratio (MBR) of the commercial part of the broiler chicken carcass. The research material was used 200 male broiler chickens aged eight days who were rearing in open house cages. The treatments consisted of drinking water without feed additives (P0; negative control), drinking water + tetracycline antibiotics (P1; positive control), drinking water + 2.5% Mahkota Dewa fruit extract (P2), drinking water + 2.5 % NEMD (P3), and drinking water + 5.0 % NEMD (P4). Parameters observed were slaughter weight, carcass weight, and MBR of the commercial part of the broiler chicken carcass. The data obtained were analyzed using a completely randomized design (CRD). Data with significant results were further tested using orthogonal contrast (P-Value < 0.05). The results showed that the use of NEMD up to 5% in drinking water did not have a significant effect on the MBR of the commercial part of the broiler chicken carcass. The 5% NEMD has not been able to work optimally to increase the MBR of the commercial part of the broiler chicken carcass.

Https://theijmed.com/index.php?journal=theijmed&page=issue&op=view&path%5B%5D=24

Background: Nasopharyngeal cancer (NPC) is a malignant tumor located in the nasopharynx, which can be treated by Cisplatin, a chemotherapy that has a side effect of increasing the production of Reactive Oxygen Species (ROS) that can damage the liver. We aim to determine the effect of giving Mahkota Dewa ( Phaleria macrocarpa ) as an antioxidant on liver function of NPC patients receiving Cisplatin chemotherapy. Subjects and Method: Forty subjects of stage III and IV Nasopharyngeal Carcinoma patients were divided into treatment and control groups. Subjects will be tested for SGOT SGPT before cisplatin chemotherapy. The treatment group was given Phaleria macrocarpa capsules 300 mg/24 hours for 5 weeks since a week before chemotherapy. The control group was given placebo capsules/24 hours for 5 weeks since a week before chemotherapy. The patients received two series of cisplatin chemotherapy with an interval of 3 weeks, then a second blood sample was taken 1 week after the second series of cisplatin chemotherapy. Results: There was a significant difference in SGOT levels in the post-treatment group of Phaleria macrocarpa and control, as well as the difference in the pre- and post- treatment group between the Phaleria macrocarpa and control groups. Also, there was a significant difference in SGPT levels in the pre- and post- treatment in the Phaleria macrocarpa and control groups. Conclusion: The administration of Phaleria macrocarpa has an effect on decreasing the levels of SGOT and SGPT in NPC patients receiving Cisplatin chemotherapy therapy Keywords: Phaleria macrocarpa , SGOT, SGPT, Nasopharyngeal Carcinoma, Cisplatin Correspondence: Adi Januar Akbar. ENT Department of Diponegoro University. Prof. Sudarto Street No. 13, Tembalang, Tembalang Sub-district, Semarang City, Central Java, 50275. Email: diaz17akbarsaleh­@gmail.com. +628161455179. Indonesian Journal of Medicine (2022), 07(01): 1-8 https://doi.org/10.26911/theijmed.2022.07.01.01

Larvicidal Activity and Histopathological Midgut Alteration of Aedes Aegypti Larvae Induced by Methanol Extract Mahkota Dewa fruit (Phaleria Macrocarpa (Scheff). Boerl)

Aedes aegypti is the main vector of DHF in Indonesia. The use of synthetic insecticide results in vector resistance. Mahkota Dewa fruits (Phaleria macrocarpa (Scheff) Boerl) contain flavonoids, saponins, and tannins. Thus, it has the potential as a natural larvicide against Ae. aegypti larvae. The objective of the study was to determine the effectiveness of methanol extract Mahkota Dewa fruit. This research was experimental, used methanol extract Mahkota Dewa fruit at concentration 0.1%, 0.15%, 0.20%, 0.25% and 0.30%, then added 25 larvae each concentration and repeated 3 times. After 24 and 48 hours of exposure, the mortality of larva was counted and then calculated LC50 and anterior midgut histopathology. LC50 values 0,554% (0,391-11,397) and anterior midgut histopathology shows epithelial damage. Mahkota Dewa fruits with methanol extract have activity as larvicide larvae instar III-IV Ae. aegypti.

The Effect of Mahkota Dewa (Phaleria macrocarpa) Leaf Extract on the Mucin 1 Expression in Mice Colonic Epithelial Cells Induced by Dextran Sodium Sulfate (DSS)

The Effect of Mahkota Dewa (Phaleria macrocarpa) Leaf Extract on the Mucin 1 Expression in Mice Colonic Epithelial Cells Induced by Dextran Sodium Sulfate (DSS)

THE EFFECT OF GIVING BOILED WATER OF MAHKOTA DEWA FRUIT ON URIC ACID LEVELS IN MENOPAUSAL WOMEN

Menopause is a normal change that occurs in a woman's life when her menstrual period stops. The average age reaches 48-60 years. A woman has reached menopause if she has not had her periods for 12 consecutive months, and there are no other reasons for the changes that occur during menopause. The number of follicles experiencing atresia is increasing, until one day there are no longer enough follicles, the production of estrogen decreases and menstruation does not occur again which ends with menopause. The purpose of this study was to determine the effect of giving boiled water of Mahkota Dewa fruit on uric acid levels in menopausal women at the Tamalanrea Jaya Public Health Center Makassar. This research is quantitative with a pre-experimental design using the One Group Prettest-Posttest Design. The population in this study were 57 respondents with a sample of 20 respondents. In this study using the Paired Sample T Test. The results showed that the average level of uric acid before and after being given boiled water from the crown of the god was 4,000, Std. Deviation 6.459, S.td Error Mean 2.103 with 95% CI = 1.785-12,215 with p value = 0.000. The conclusion of this study is that there is an effect of giving boiled water of the crown of the gods on uric acid levels in postmenopausal women at the Tamalanrea Jaya Health Center Makassar. It is recommended to the Tamalanrea Jaya Makassar Public Health Center to be used as a reference for further researchers about the benefits of boiled water from the crown of the god on uric acid levels in postmenopausal women.

Local Wisdom of the Rantau Panjang Community, Simpang Hilir District, Kayong Utara Regency in Utilizing Medicinal Plants

Medicinal plants for modern society today are still one of the alternative options in healthcare treatment. This condition is due to the local culture, tradition, and wisdom of a group of people that are still solid and thick. This study aims to analyze the types of medicinal plants used by the community in Rantau Panjang, Simpang Hilir District, North Kayong Regency. This research uses the survey method by conducting interviews with the community and identifying medicinal plants in the field. A sampling of the people who became respondents was done with a purposive sampling technique. The total number of respondents is 333 people distributed in several sub-village, namely Sepakat Jaya 71 people, Tembok Baru 65 people, Ampera 37 people, Makmur 61 people, Sinar Palung 25 people, Kebal Manuk 12 people, Sinar Selatan 35 people and Siput Lestari 27 people. The data obtained were analyzed for Use Value (UV) and Fidelity Level (FL). The village community of Rantau Panjang utilizes 69 types of medicinal plants, with the predominant plant family is Zingiberaceae. The highest use of plant parts is leaves (37.68%), the most common method of processing is boiled (57.97%), and the most extensive way of use is drunk as much as (60.86%). The plants with the highest UV values are turmeric (Curcuma longa L) (0.42), red liyak (Zingiber officinale Linn) (0.34), white turmeric (Curcuma zedoaria L) (0.28), and betel (Piper betle L) (0.22). The types of plants have the highest FL value (100), namely simpur, ketumbar, sawo, leban, pulai, jantung pisang, bunga raya, alalang, durian, nipah, kopi, selo daging, keladi, paku ikan, pegage, kumis kucing, mahkota dewa, belange, belimbing pelunjuk, asam jawa, andong, limau sambal, jambu biji, lidah buaya, pinang, leban, mentimun, daun salam, mentimun, manggis, bajakah, cempedak, pandan wangi, pasak bumi, tebu merah, jengkol, cengkodok, anggrek dan ketepeng.

NARRATIVE REVIEW TANAMAN YANG BERPOTENSI SEBAGAI IMMUNOMODULATOR

COVID-19 (Coronavirus Disease-2019) is an infectious disease caused by the acute respiratory syndrome SARS-CoV-2. Currently, the COVID-19 disease outbreak is experienced by various countries around the world, including Indonesia. In overcoming it, there are several ways of deterrence that can be done, such as by increasing the body's immunity. During the COVID-19 pandemic, maintaining immunity is something that needs to be considered. In addition to vitamins, herbal plants that have the potential as immunomodulators can also be consumed. Therefore, through efforts to improve theimmune system, this review aims to obtain plants that have the potential as immunomodulators to enhance the immune system during the COVID-19 pandemic. The research method in the review used journals available online at Google Scholar with Sinta or Garuda accredited journals. The main focus of this review is herbal plants that have a role as an immunomodulator that can improve the body's immune system. The journals used are journals published in 2011-2021 with inclusion criteria, namely using Indonesian or English about plants that have the potential as immunomodulators, then the journalsobtained are analyzed. The results obtained were 30 types of plants that have potential as immune system enhancers including Dayak Onion Tubers, Papaya Leaves, Kecombrang Fruits, Pineapple Fruits, Kesambi, Soursop Leaves, Purslane, Garlic, Dates, Celery Leaves, Andaliman, Mahkota Dewa Fruit. , Moringa, Meniran, Noni Fruit, Gotu Kola, Sambiloto, Kiseureuh, Javanese Chili, Tempuyung Leaves, Basil Leaves, Ceplukan, Seaweed, Neem Leaves, Red Betel Leaf, Salam Leaves, Guava, Turmeric, Lime and Red Ginger Rhizome with compounds that act as flavonoids, alkaloids, saponins, triterpenoids,xeronin, tannins, quersentin, -tocopherol, lycopene, catechins, diterpenoids, deoxyandrographolide, andrographolide, epicatechin isothiocyanate and curcumin.
 Keywords: COVID-19, Potency of Immumodulator Plants, Flavonoids

The influence of Gum Arabic on the physicochemical and antimicrobial activity of the microencapsulated Mahkota Dewa (Phaleria macrocarpa) leaves

Mahkota Dewa (Phaleria macrocarpa) also known as God's Crown has been historically used as an indispensable alternative herbal medicine. Microencapsulation is a process whereby tiny particles or droplets are engulfed or enclosed in a coating matrix to produce small capsules. Generally, without microencapsulation, powders are fragile materials that could easily interfere with other components that are difficult to dissolve in water, lose their beneficial properties and decrease shelf life. It is hoped that the microencapsulation would increase the consistency of the powder during storage and maintain its beneficial properties. The goal of this research is to investigate the physicochemical and antimicrobial activity of Mahkota Dewa leaves encapsulated in different concentrations of gum Arabic (GA) and to determine the form of antioxidant and their role and properties. Mahkota Dewa leaves powders were microencapsulated in 0%, 2%, 4%, 6%, 8% and 10% gum Arabic using an ultrasonic spray dryer at 90οC. The microencapsulated Mahkota Dewa leaves (MMDL) samples were subjected to physicochemical and antimicrobial activity. The results showed that the 6% GA MMDL exhibited the highest yield (3.91%) while 0% GA was the lowest yield (1.64%). The highest total phenolic and flavonoid content was exhibited by 2% GA. The highest DPPH inhibition was depicted in 0% GA which indicates the highest antioxidant activity (54.9±0.01%) and is significantly (p<0.05) different from other samples. The highest inhibition was exhibited in 0% GA in the TBA method and FTC analysis. The encapsulated powders were identified to have weak antimicrobial activity against Bacillus cereus, Escherichia coli, Staphylococcus aureus, Salmonella and Listeria monocytogenes. The powders produced have an irregularly spherical structure and smooth surface with some dented spots on the surface. The different concentration of gum Arabic resulted in different antioxidant activity, flavonoid content and antimicrobial activity of MMDL.

Preparation of Dye-Sensitized Solar Cell (DSSC) Using TiO2 and Mahkota Dewa Fruit (Phaleria Macrocarpa (Scheff) Boerl.) Extract

A dye sensitized solar cell (DSSC) is a low-cost solar cell with attractive features. DSCC contains of photoelectrode, dye, electrolyte, and counter electrode with photoelectrochemical system. The aim of this research is to determine the percent efficiency produced by DSSC from the Mahkota Dewa extract. This was carried out in various stages, namely sample preparation and extraction, DSSC assembly, TiO2 characterization using Scanning Electron Microscopy (SEM), and testing its current and voltage. The results showed that the maximum wavelength of the Mahkota Dewa extract dye test using a UV-Vis spectrophotometer was 554 nm with an absorbance of 0.163, which was believed to be the wavelength of flavonoid and anthocyanin compounds. Based on the characterization results, surface morphology was spherical and agglomerated. However, after being soaked in the dye, the surface morphology of the TiO2 layer did not appear spherical on the surface that was expected to have been covered by the dye. The measurement using sunlight sources showed that the maximum current and voltage of DSSC with a concentration of 30% w/v was 21.8x10-4A and 58.86 V with an efficiency of 22.43x10-3 %. In addition, there was a 0.482% decrease in DSSC efficiency based on the storage time which lasted for a period of 6 days.

The Effect of the Mahkota Dewa (Phaleria macrocarpa) on the Density of Collagen Incision Wounds

Wounds are a disorder in the continuity of the skin or mucosal epithelial layer, which is a result of physical or thermal damage The research purpose was to analyze effect of mahkota dewa (Phaleria macrocarpa) on the density of collagen incision wound of white rats (Rattus norvegicus). This research has used post test only control group design. The sample were 30 male rats that grouped into control (K1, K2, K3) and treatment (P1, P2, P3) groups. The control group was given 1%CMC, while the treatment group was given oral extract of mahkota dewa at a dose of 22.5 mg/kg bw. The data was analyzed by Kruskall Wallis test. The results showed that there were a significant difference of collagen density between control and treatment group. The mahkota dewa fruits extract increased the macrophage activity. Thus, the macrophage activity could increase the Transforming Growth Factor – ß (TGF-ß) secretion. The TGF-ß could stimulate fibroblast prolipheration. In addition, collagen synthesis could increased. Based on the results, Mahkota dewa (Phaleria macrocarpa) extract could increase the collagen density of incision wound of white rats (Rattus norvegicus).

Restraining effect of P. macrocarpa methanol extract on ROS generation in SK-N-SH cell

Phaleria macrocarpa, is widely known as Mahkota dewa is a herb which is used in medical treatments and found in Malaysia & Indonesia. Extract of P. Macrocarpa contains a chemical composition which is useful in anti-cancerous, anti-fungus, anti-oxidation, anti-diabetic treatments. Reactive oxygen species (ROS) production in mammalian cell is responsible for many cell function, absence of detoxification for removal of this radical, affects cell functions and may produce abnormalities and diseases. Several nervous abnormalities were found be to the effect of ROS generation. Currently there are no effective medicinal options for its treatment. This study focuses on the effect of P. Macrocarpa leaf extract on the restraining reactive oxygen. Methods: P. Macrocarpa leaf extract contains 80% methyl alcohol. Methylthiazolyldiphenyl-tetrazolium bromide (MTT) is used for cytotoxicity analysis and restraining reactive oxygen is studied using 2′,7′-Dichlorofluorescin diacetate in SK-N-SH cell model. Result: ROS Restraining performance of leaf extract is analysed between the group that treated only with crude extract, group treated with extract with Hydrogen peroxide and group treated only with Hydrogen peroxide. HPLC methods shows that Vitexin & iso-vitexin, this bioactive compound were present in the crude extract at retention time 20.98 & 22.94 for Vitexin & iso-vitexin respectively. Conclusion: Anti-oxidation & low toxic characteristic of P. Macrocarpa extract concludes it to be beneficial for its usage as herbal supplement/medicine.

Uji Stabilitas Formula Optimum Masker Gel Peel Off Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl)


 
 
 
 Mahkota Dewa fruit (Phaleria macrocarpa (Scheff.) Boerl was effective as an anti-acne agent and an optimization formula of Mahkota Dewa fruit extractpeel off gel mask has been carried out but the stability test has not been carried out. This study aims to determine the stability of the optimum formula of Mahkota Dewa fruit extract (Phaleria macrocarpa (Scheff.) Boerl)peel off gel mask. The fruit simplicia of Mahkota Dewa was extracted by soxhletation with 70% ethanol. The thick extract is made into a peel off gel mask with 13.09%PVA and 2.97% HPMC. Stability tests were carried out in 3 cycles using the freeze and thaw method. The evaluations carried out included organoleptic, homogeneity, pH, viscosity, dispersibility, adhesion and drying time. Analyzed data by One Way Anova followed by the LSD (Least Significance Difference) test. The results showed that the peel off gel mask optimization formula stable in storage for 3 cycles which overall meet the requirements of physical properties. The preparation was brown with rose aroma, thick, homogeneous with a pH value of 6 ± 0 and a viscosity value of 400 ± 0. The results of the drying time and spreadability test showed no difference in all cycles. Although the results of the adhesion test showed a significant difference, it was still within the range of good adhesion values.
 
 
 

UJI DAYA HAMBAT EKSTRAK ETANOL DAUN MAHKOTA DEWA (Phaleria macrocarpa Boerl.,) TERHADAP Klebsiella pneumonia.

Mahkota Dewa (Phaleria macrocarpa Boerl) is a medical plant of the Thymelaeaceae family originating from Indonesia, precisely from Papua. Phaleria macrocarpa Boerl the deity has been known in various treatments such as diabetes, cancer, liver, dysentery, allergic diabetes, eczema, or gout and others (Ratna & Wiwi, 2014). The purpose of this study is to find out whether extract ethanolic 96% of Phaleria macrocarpa Boerl can inhibit the growth of K. pneumoniae, and to know what concentration of extract ethanolic 96% of Phaleria macrocarpa goodnes to inhibit K. pneumoniae. The method used is the Kirby Bauer Method. With the average inhibition zone concentrations is 100%, 80%, 60%, 40%, 20% respectively 17.41mm, 15.37mm, 12.60mm, 11.10mm, 6.43mm.

Effect of encapsulation agents on antioxidant activity and moisture content of spray dried powder from Mahkota Dewa fruit extract

Mahkota Dewa is rich in bioactive compounds including mangiferin, saponin and polyphenols. This work aims to investigate the encapsulation of Mahkota Dewa by spray drying using different types of encapsulation agent. A subcritical water extraction process was used to extract the bioactive compounds from dried Mahkota Dewa prior to spray drying process. The encapsulation agents used were maltodextrin (MT), arabic gum (AG) and mixture of arabic gum-maltodextrin (AG-MT). The spray drying conditions namely inlet dry air temperatures, dry air flow rate and inlet feed flowrate were 200°C, 3.7 m/s and 485 mL/h, respectively. The spray dried powder samples were evaluated for antioxidant activity and moisture content and compared with those without encapsulation agent. A high value of antioxidant activity and low moisture content were observed for samples with encapsulation agents. Result suggested the maltodextrin produced particles with the lowest moisture content (4.84 %) and highest antioxidant activity (94.22%), thus can be recommended as the most suitable encapsulation agent in this work.