Lagenaria siceraria (Bottle gourd) class Magnoliopsida family Cucurbitaceae is an excellent fruit in the nature consisting of all the essential constituents that are necessary for normal and good health of human beings. Lagenaria siceraria is official in Ayurvedic Pharmacopoeia. Traditionally, Lagenaria siceraria fruits had been used as a general tonic, cardiotonic, and cardioprotective drug. In addition, it had also been used as aphrodisiac, diuretic, antidote to certain poisons, scorpion stings, and alternative purgative. Lagenaria siceraria is also used to relieve pain, ulcers and fever. Scientific researches have shown that Lagenaria siceraria possesses anthelmintic, antibacterial, antifungal, immunomodulatory, anti-allergic, analgesic, anti-inflammatory, antioxidant, free radical scavenging, cytotoxic, antihyperlipidemic antidiabetic, hepatoprotective, anxiolytic and memory enhancing properties. In this review article we have tried to provide a detailed survey of the literature on the scientific researches of pharmacognostical, phytochemical and pharmacological properties of this wonderful herbal drug.