Magnitude Of Shear Stress Research Articles

Characterization of the competing role of surface-contact and shear stress on platelet activation in the setting of blood contacting devices.

Supraphysiological shear stress and surface-contact are recognized as driving mechanisms of platelet activation (PA) in blood contacting devices (BCDs). However, the competing role of these mechanisms in triggering thrombogenic events is poorly understood. Here, we characterized the dynamics of PA in response to the combined effect of shear stress and material exposure. Human platelets were stimulated with different levels of shear stress (500, 750, 1000 dynes/cm2) over a range of exposure times (10, 20, and 30 min) within capillary tubes made of various polymeric materials. Polyethylene (PE), polytetrafluoroethylene (PTFE), ethylene tetrafluoroethylene (ETFE), and polyether ether ketone (PEEK), used for BCDs fabrication, were investigated as compared to glass and thromboresistant Sigma™-coated glass. PA was quantified using the Platelet Activity State assay. Our results indicate that mechanical stimulation and polymer surface-contact both significantly contribute to PA. Notably, the contribution of the mechanical stimulus ranges between +36% and +43%, while that associated with polymer surface-contact ranges from +48% to +59%, depending on the exposure time. In more detail, our results indicate that: (i) PA increases with increasing shear stress magnitude; (ii) PA has a non-linear, time-dependent relationship to exposure time; (iii) PA is largely influenced by biomaterials, with PE and PEEK having respectively the lowest and highest prothrombotic potential; (iv) the effects of polymer surface-contact and shear stress are not correlated and can be studied separately. Our results suggest the importance of incorporating the evaluation of platelet activation driven by the combined effect of shear stress and polymer surface-contact for the comprehensive assessment, and eventually minimization, of BCDs thrombogenic potential.

Evaluating cell viability heterogeneity based on information fusion of multiple adhesion strengths.

Cell viability evaluation is significantly meaningful for cellular assays. Some cells with weak viability are easily killed in the detection of anticancer drugs, while others with strong viability survive and proliferate, ultimately leading to the treatment failure or the inaccuracy of biological assays. Accurately evaluating cell viability heterogeneity still remains difficult. This article proposed a multiphysical property information fusion method for evaluating cell viability heterogeneity based on polynomial regression in a single-channel integrated microfluidic chip. In this method, adhesion strengths τN , that are defined as the magnitude of shear stress needed to detach (100 - N) % of cell population, were extracted as the independent variables of polynomial regression model by calculating the nonlinear fitting of the impedance-response curves for shear stress (cell detachment assay). Besides, by calculating the nonlinear fitting of the drug dose-response curves for cancer cells (IC50 assay), the half-maximal inhibitory concentration (IC50 ) was extracted as the dependent variables of polynomial regression model. The results show that the mean relative error of our fusion method averagely reduces by 6.04% and 62.79% compared with the multiple linear regression method and the cell counting method. Moreover, a simplified theoretical model used to describe the quantitative relationship between cell viability and its adhesion strengths was built to provide a theoretical basis for our fusion method.

Investigation of abrasive wear in contact load-dominated slurry flows using a Toroid Wear Tester

Friction loss in slurry pipelines transporting coarse (settling) particles are governed by two mechanisms: Coulombic and kinematic friction. The Coulombic (sliding bed) friction component produces a highly abrasive condition that results in significant wear at the pipe invert and produces asymmetric thinning of the pipe wall. In this paper, an experimental investigation was carried out to study abrasive wear under Coulombic friction-dominated slurry flow conditions. Experiments were conducted in a laboratory-scale apparatus known as the Toroid Wear Tester (TWT) using narrowly-sized coarse particles (0.125–4 mm) suspended in three different carrier fluids (μf: 1–5.12 mPas, ρf: 998–1103 kg/m3). The friction loss attributable to the presence of the coarse particles was obtained from torque measurements made during each test. Visualization experiments were used to establish contact load-dominated (sliding bed) slurry flow conditions based on the ratio of flow velocity to the particle terminal settling velocity i.e. V/v∞. Abrasive wear experiments were then conducted with the TWT operating under full contact load conditions. It was found that the measured wear rates correlated with the magnitude of the Coulombic shear stress. The most important outcome of this study is the demonstrated potential to predict actual slurry pipeline wear rates from TWT experiments.

Evolution of wall flow structure and measurement of shear stress issuing from supersonic jet with extended shelf

This paper reports an experimental study on the supersonic jet surface flow structure visualization and shear stress field measurement issuing from a rectangular nozzle with extended shelf. The evolution of the near-field surface flow structures with an increased Nozzle Pressure Ratio (NPR) is successfully captured by the surface oil flow, infrared detection technology, and the Shear-Sensitive Liquid Crystal Coating (SSLCC) technique. Results reveal that under smaller NPR, the wall flow structure is similar to that of a jet without the extended shelf i.e., clean jets, and this is caused by insufficient effect on the boundary layer. However, at higher amplitudes of NPR, there exists a significant effect of the boundary layer, as a near triangular separation forms on the trailing edge of the Mach stem due to the adverse pressure gradient, which is visualized for the very first time in this paper. Furthermore, the vector field of shear stress is measured quantitatively by SSLCC technique. Results shows that the magnitude of shear stress heightened with NPR increasing, and the directions of shear stress changes across the shock wave and expansion fans. In addition, surface streamlines measured by SSLCC is significantly consistent with the streamlines visualized using the oil flow technique.

Visualization of separation and reattachment in an incident shock-induced interaction

An experimental study is conducted on the qualitative visualization of the flow field in separation and reattachment flows induced by an incident shock interaction by several techniques including shear-sensitive liquid crystal coating (SSLCC), oil flow, schlieren, and numerical simulation. The incident shock wave is generated by a wedge in a Mach 2.7 duct flow, where the strength of the interaction is varied from weak to moderate by changing the angle of attack α of the wedge from 8° and 10° to 12°. The stagnation pressure upstream was set to approximately 607.9 kPa. The SSLCC technique was used to visualize the surface flow characteristics and analyze the surface shear stress fields induced by the initial incident shock wave over the bottom wall and sidewall experimentally which resolution is 3500 × 200 pixels, and the numerical simulation was also performed as the supplement for a clearer understanding to the flow field. As a result, surface shear stress over the bottom wall was visualized qualitatively by SSLCC images, and flow features such as separation/reattachment and the variations of position/size of separation bubble with wedge angle were successfully distinguished. Furthermore, analysis of shear stress trend over the bottom wall by a hue value curve indicated that the relative magnitude of shear stress increased significantly downstream of the separation bubble compared with that upstream. The variation trend of shear stress was consistent with the numerical simulation results, and the error of separation position was less than 2 mm. Finally, the three-dimensional schematic of incident shock-induced interaction has been achieved by qualitative summary by multiple techniques, including SSLCC, oil flow, schlieren, and numerical simulation.

Shear strength properties of hybrid (hinoki cypress and Japanese cedar) cross-laminated timber

In this study, the out-of-plane shear strength of hybrid cross-laminated timber (CLT) with outer layers of hinoki (hinoki cypress, Chamaecyparis obtusa) and inner layers of sugi (Japanese cedar, Cryptomeria japonica) is investigated for four different layer configurations. To investigate the influence from rolling shear properties of cross layers on the shear strength of CLT, stress analysis was conducted using the shear analogy method. The nominal shear strength, the maximum shear force divided by the cross-section of CLT, was in the 1.0–2.1 MPa range. Using the shear analogy method, the rolling shear modulus in the cross layer was determined as 72.9 MPa, which was comparable with the value obtained for laminae in previous study as well as the value confirmed by strain measurements in the present study. The magnitude of rolling shear stress in the cross layer was 0.9–1.1 times the average shear stress, which was negatively correlated with the nominal shear strength. From the regression line between the nominal shear strength and the magnitude of the shear stress in the cross layer, the mean shear strength of the cross layer was estimated to be 1.33 MPa.

Hemodynamic Assessment of Hollow-Fiber Membrane Oxygenators Using Computational Fluid Dynamics in Heterogeneous Membrane Models.

Extracorporeal membrane oxygenation (ECMO) has been used clinically for more than 40 years as a bridge to transplantation, with hollow-fiber membrane (HFM) oxygenators gaining in popularity due to their high gas transfer and low flow resistance. In spite of the technological advances in ECMO devices, the inevitable contact of the perfused blood with the polymer hollow-fiber gas-exchange membrane, and the subsequent thrombus formation, limits their clinical usage to only 2-4 weeks. In addition, the inhomogeneous flow in the device can further enhance thrombus formation and limit gas-transport efficiency. Endothelialization of the blood contacting surfaces of ECMO devices offers a potential solution to their inherent thrombogenicity. However, abnormal shear stresses and inhomogeneous blood flow might affect the function and activation status of the seeded endothelial cells (ECs). In this study, the blood flow through two HFM oxygenators, including the commercially available iLA® MiniLung Petite Novalung (Xenios AG, Germany) and an experimental one for the rat animal model, was modeled using computational fluid dynamics (CFD), with a view to assessing the magnitude and distribution of the wall shear stress (WSS) on the hollow fibers and flow fields in the oxygenators. This work demonstrated significant inhomogeneity in the flow dynamics of both oxygenators, with regions of high hollow-fiber WSS and regions of stagnant flow, implying a variable flow-induced stimulation on seeded ECs and possible EC activation and damage in a biohybrid oxygenator setting.

Aluminum beam reinforced by externally bonded composite materials

A recently popular method for retrofitting reinforced structure beams is to bond composite plates to their tensile faces. An important failure mode of such plated beams is the debonding of the composite plates from the base material of the beam due to high level of stress concentration in the adhesive at the ends of the composite plate. This paper, shows and presents in more detail a closed-form rigorous solution for interfacial stress in cantilever aluminum beams strengthened with bonded composite (sika wrap) plates and subjected to a uniformly distributed load. The results show that there exists a high concentration of both shear and normal stress at the ends of the laminate, which might result in premature failure of the strengthening scheme at these locations. A parametric study has been conducted to investigate the sensitivity of interface behavior to parameters such as laminate and adhesive stiffness, the thickness of the laminate; the effect on plate length of the strengthened cantilever beam region, the effect of adhesive (modules, thickness) and the effect of loading and geometry for the cantilever beam; where all were found to have a marked effect on the magnitude of maximum shear and normal stress in the composite member. The theoretical predictions are compared with other existing solutions. Finally, this research is helpful for the understanding on mechanical behaviour of the interface and design of the composite-aluminum hybrid structures.

The impact of hemodynamic factors in a coronary main artery to detect the atherosclerotic severity: Single and multiple sequential stenosis cases

A conventional invasive catheterization procedure is currently used to detect atherosclerotic severity in coronary arteries. However, it is still challenging to measure multiple consecutive stenoses (MCS) in coronary main arteries, a severe condition, by using the invasive method. In this paper, we report important hemodynamic properties such as wall shear stress (WSS) and velocity magnitude (VM) across different luminal areas of coronary stenosis in patient-based right coronary artery models of MCS using pulsatile heart flow simulations. The hemodynamic factors in coronary blood flow simulations of different degrees of stenosis indicated a relationship between the proximal moderate stenosis and distal severe stenosis models. The results show the physical effects of different hemodynamic factors including VM, mean arterial pressure difference, WSS, and virtual fractional flow reserve (vFFR), which allow for predicting the physiological computation in the MCS artery severity conditions. This study identifies the fundamental physics of coronary plaque with MCS and indicates the impact of these factors on vFFR measurements. These findings provide insights into and improvement of the pathophysiological assessment of MCS. The results reveal hemodynamic properties, which can be used to diagnose coronary irregularities using a visualization method.

Computational fluid dynamics of the right atrium: Assessment of modelling criteria for the evaluation of dialysis catheters.

Central venous catheters are widely used in haemodialysis therapy, having to respect design requirements for appropriate performance. These are placed within the right atrium (RA); however, there is no prior computational study assessing different catheter designs while mimicking their native environment. Here, a computational fluid dynamics model of the RA, based on realistic geometry and transient physiological boundary conditions, was developed and validated. Symmetric, split and step catheter designs were virtually placed in the RA and their performance was evaluated by: assessing their interaction with the RA haemodynamic environment through prediction of flow vorticity and wall shear stress (WSS) magnitudes (1); and quantifying recirculation and tip shear stress (2). Haemodynamic predictions from our RA model showed good agreement with the literature. Catheter placement in the RA increased average vorticity, which could indicate alterations of normal blood flow, and altered WSS magnitudes and distribution, which could indicate changes in tissue mechanical properties. All designs had recirculation and elevated shear stress values, which can induce platelet activation and subsequently thrombosis. The symmetric design, however, had the lowest associated values (best performance), while step design catheters working in reverse mode were associated with worsened performance. Different tip placements also impacted on catheter performance. Our findings suggest that using a realistically anatomical RA model to study catheter performance and interaction with the haemodynamic environment is crucial, and that care needs to be given to correct tip placement within the RA for improved recirculation percentages and diminished shear stress values.

Development and Application of Endothelial Cells Derived From Pluripotent Stem Cells in Microphysiological Systems Models.

The vascular endothelium is present in all organs and blood vessels, facilitates the exchange of nutrients and waste throughout different organ systems in the body, and sets the tone for healthy vessel function. Mechanosensitive in nature, the endothelium responds to the magnitude and temporal waveform of shear stress in the vessels. Endothelial dysfunction can lead to atherosclerosis and other diseases. Modeling endothelial function and dysfunction in organ systems in vitro, such as the blood–brain barrier and tissue-engineered blood vessels, requires sourcing endothelial cells (ECs) for these biomedical engineering applications. It can be difficult to source primary, easily renewable ECs that possess the function or dysfunction in question. In contrast, human pluripotent stem cells (hPSCs) can be sourced from donors of interest and renewed almost indefinitely. In this review, we highlight how knowledge of vascular EC development in vivo is used to differentiate induced pluripotent stem cells (iPSC) into ECs. We then describe how iPSC-derived ECs are being used currently in in vitro models of organ function and disease and in vivo applications.

Experimental analysis of multi-horizontal submerged jets energy dissipater

ABSTRACT The use of a stilling basin with multiple horizontal submerged jets emerging from two layers has been suggested for use as an energy dissipation structure in hydropower stations. In this study, laboratory velocity measurement is performed to analyze the three-dimensional flow structure of submerged jets and to evaluate the effect of the downstream submergence on the flow field. The results indicate that the Reynolds shear stress and vorticity magnitudes increase with increasing jet submergence. Further, it was found that submergence increase leads to a decrease of 2.2% in maximum bed (floor) shear stress and 7.2% in side-walls shear stress. The Reynolds shear stress quadrant decomposition is also performed for all (H = 0) and high magnitude (H = 2) bursting events, which indicate that the turbulence events of outward and inward interactions made dominant contributions to the total Reynolds stress. Turbulent kinetic energy is also analysed to obtain a better characterization of the flow field.

Exploring the Relationships Between Hemodynamic Stresses in the Carotid Arteries.

Background: Atherosclerosis manifests as a focal disease, often affecting areas with complex hemodynamics such as the carotid bifurcation. The magnitude and regularity of the hemodynamic shear stresses acting on the vessel wall are thought to generate risk patterns unique to each patient and play a role in the pathogenesis of atherosclerosis. The involvement of different expressions of shear stress in the pathogenesis of carotid atherosclerosis highlights the need to characterize and compare the differential impact of the various expressions of shear stress in the atherosclerotic carotid bifurcation. Therefore, the aim of this study is to characterize and compare hemodynamic wall shear stresses (WSS) in the carotid arteries of subjects with asymptomatic atherosclerotic plaques. Shear stresses were also compared against vessel diameter and bifurcation angle to examine the relationships with the geometry of the carotid bifurcation.Methods: 4D Flow MRI and contrast-enhanced MRA data were acquired for 245 subjects with atherosclerotic plaques of at least 2.7 mm in conjunction with the Swedish CArdioPulmonary bioImage Study (SCAPIS). Following automatic segmentation and geometric analysis, time-resolved WSS and near-wall turbulent kinetic energy (nwTKE) were derived from the 4D Flow data. Whole-cycle parameters including time-averaged WSS and nwTKE, and the oscillatory shear index (OSI) were calculated. Pairwise Spearman rank-correlation analyses were used to investigate relationships among the hemodynamic as well as geometric parameters.Results: One hundred and seventy nine subjects were successfully segmented using automated tools and subsequently geometric and hemodynamic analyses were performed. Temporally resolved WSS and nwTKE were strongly correlated, ρ = 0.64. Cycle-averaged WSS and nwTKE were moderately correlated, ρ = 0.57. Cycle-average nwTKE was weakly correlated to OSI (ρ = −0.273), revealing that nwTKE provides information about disturbed flow on the vessel wall that OSI does not. In this cohort, there was large inter-individual variation for both WSS and nwTKE. Both WSS and nwTKE varied most within the external carotid artery. WSS, nwTKE, and OSI were weakly correlated to vessel diameter and bifurcation angle.Conclusion: The turbulent and mean component of WSS were examined together in vivo for the first time, and a strong correlation was found between them. nwTKE presents the opportunity to quantify turbulent wall stresses in vivo and gain insight into the effects of disturbed flow on the vessel wall. Neither vessel diameter nor bifurcation angle were found to be strongly correlated to the turbulent or mean component of WSS in this cohort.

Quantification of Oscillatory Shear Stress from Reciprocating CSF Motion on 4D Flow Imaging.

Oscillatory shear stress could not be directly measured in consideration of direction, although cerebrospinal fluid has repetitive movements synchronized with heartbeat. Our aim was to evaluate the important of oscillatory shear stress in the cerebral aqueduct and foramen magnum in idiopathic normal pressure hydrocephalus by comparing it with wall shear stress and the oscillatory shear index in patients with idiopathic normal pressure hydrocephalus. By means of the 4D flow application, oscillatory shear stress, wall shear stress, and the oscillatory shear index were measured in 41 patients with idiopathic normal pressure hydrocephalus, 23 with co-occurrence of idiopathic normal pressure hydrocephalus and Alzheimer-type dementia, and 9 age-matched controls. These shear stress parameters at the cerebral aqueduct were compared with apertures and stroke volumes at the foramen of Magendie and cerebral aqueduct. Two wall shear stress magnitude peaks during a heartbeat were changed to periodic oscillation by converting oscillatory shear stress. The mean oscillatory shear stress amplitude and time-averaged wall shear stress values at the dorsal and ventral regions of the cerebral aqueduct in the idiopathic normal pressure hydrocephalus groups were significantly higher than those in controls. Furthermore, those at the ventral region of the cerebral aqueduct in the idiopathic normal pressure hydrocephalus group were also significantly higher than those in the co-occurrence of idiopathic normal pressure hydrocephalus with Alzheimer-type dementia group. The oscillatory shear stress amplitude at the dorsal region of the cerebral aqueduct was significantly associated with foramen of Magendie diameters, whereas it was strongly associated with the stroke volume at the upper end of the cerebral aqueduct rather than that at the foramen of Magendie. Oscillatory shear stress, which reflects wall shear stress vector changes better than the conventional wall shear stress magnitude and the oscillatory shear index, can be directly measured on 4D flow MR imaging. Oscillatory shear stress at the cerebral aqueduct was considerably higher in patients with idiopathic normal pressure hydrocephalus.

Analysis of Burnett Stresses and Entropy Generation for Pressure-Driven Plane Poiseuille Flow

Abstract In this paper, we undertake an analytical study of stresses (augmented and Onsager–Burnett) and entropy generation for the plane Poiseuille flow problem, and their variation with Knudsen number. The gas flow is assumed to be 2D laminar, fully developed, compressible, and isothermal; these assumptions make the problem amenable to analytical treatment. The variation of stresses and entropy generation has been analyzed over a large range of Knudsen number. The magnitude of stresses and entropy generation at a particular position in the channel has been considered. It is found that the augmented and OBurnett normal stresses are of opposite signs to the corresponding Navier–Stokes stresses, while the magnitude of the net normal stress increases with Knudsen number. The magnitude of the augmented Burnett shear stress is insignificant as compared to the augmented Burnett normal stresses. A close match between the augmented and OBurnett normal stresses has been found at low Knudsen number. However, an opposite variation has been observed between the augmented and Onsager shear stresses at high Knudsen number. A good comparison of the normalized mass flow rate with the reported value in the literature helps to validate our analysis. A minimum in the variation of normalized entropy generation against the Knudsen number (Kn) is observed at Kn close to unity, and is being reported for the first time. The magnitude of net entropy generation from the summation of Navier–Stokes and augmented Burnett stresses is found to be positive, even in the transition regime of gas flow. Further, an appearance of minimum or maximum in normalized net shear stress versus Knudsen number, depending upon the lateral position in the microchannel, has also been observed. Altogether, this analysis supports the validity of the Navier–Stokes equation with modified constitutive expression, even for higher Knudsen numbers. Moreover, the significant terms of Burnett stress are pointed out by the analysis, which can help in developing reduced-order model for these equations.

Shear Stress and RBC-NOS Serine1177 Phosphorylation in Humans: A Dose Response.

Red blood cells (RBC) express a nitric oxide synthase isoform (RBC-NOS) that appears dependent on shear stress for Serine1177 phosphorylation. Whether this protein is equally activated by varied shears in the physiological range is less described. Here, we explored RBC-NOS Serine1177 phosphorylation in response to shear stress levels reflective of in vivo conditions. Whole blood samples were exposed to specific magnitudes of shear stress (0.5, 1.5, 4.5, 13.5 Pa) for discrete exposure times (1, 10, 30 min). Thereafter, RBC-NOS Serine1177 phosphorylation was measured utilising immunofluorescence labelling. Shear stress exposure at 0.5, 1.5, and 13.5 Pa significantly increased RBC-NOS Serine1177 phosphorylation following 1 min (p < 0.0001); exposure to 4.5 Pa had no effect after 1 min. RBC-NOS Serine1177 phosphorylation was significantly increased following 10 min at each magnitude of shear stress (0.5, 1.5, 13.5 Pa, p < 0.0001; 4.5 Pa, p = 0.0042). Shear stress exposure for 30 min significantly increased RBC-NOS Serine1177 phosphorylation at 0.5 Pa and 13.5 Pa (p < 0.0001). We found that RBC-NOS phosphorylation via shear stress is non-linear and differs for a given magnitude and duration of exposure. This study provides a new understanding of the discrete relation between RBC-NOS and shear stress.

A revisit of the electro-diffusional theory for the wall shear stress measurement

This article intends to revisit the electro-diffusional theory for the wall shear stress measurement from mass transfer probes of rectangular shape by considering the existence of two components of the wall shear rate (i.e., axial and transversal). General analytical formulas for the effective transfer length and the dimensionless mass transport coefficient were derived as a function of two parameters: a dimensionless angle of the flow direction, relative to the leading edge of the probe, and the aspect ratio between the width and the length of the strip probe. The correctness of the analytical relations for arbitrary flow direction and the aspect ratio was confirmed by numerical solutions of the transport equation in the convective-diffusive regime. It has also been proved that the differences between the Lévêque solution and the general analytical formula exhibit a significant deviation for a specific range of parameters. In the case of the three-dimensional boundary layers, in addition to the magnitude of the wall shear stress, the direction of the fluid flow in the vicinity of the probe’s surface is of paramount importance. Accordingly, a measurement methodology is proposed using two strip probes with different aspect ratios. The resulting equations required to quantify the magnitude of the wall shear rate vector and the dimensionless angle are also derived.

Lymph Node Subcapsular Sinus Microenvironment-On-A-ChipModeling Shear Flow Relevant to Lymphatic Metastasis and Immune Cell Homing.

SummaryA lymph node sinus-on-a-chip adhesion microfluidic platform that recapitulates the hydrodynamic microenvironment of the lymph node subcapsular sinus was engineered. This device was used to interrogate the effects of lymph node remodeling on cellular adhesion in fluid flow relevant to lymphatic metastasis. Wall shear stress levels analytically estimated and modeled after quiescent and diseased/inflamed lymph nodes were experimentally recapitulated using a flow-based microfluidic perfusion system to assess the effects of physiological flow fields on human metastatic cancer cell adhesion. Results suggest that both altered fluid flow profiles and presentation of adhesive ligands, which are predicted to manifest within the lymph node subcapsular sinus as a result of inflammation-induced remodeling, and the presence of lymph-borne monocytic cells may synergistically contribute to the dynamic extent of cell adhesion in flow relevant to lymph node invasion by cancer and monocytic immune cells during lymphatic metastasis.

Boundary Layer Analysis Adjacent to Moving Heated Plate Inside Electrically Conducting Fluid with Heat Source/Sink

Newtonian steady state flow of fluids with electrical conduction properties was examined adjacent to a moving heated vertical plate subjected to a magnetic field and a heat source/sink. The impact of magnetic parameter, Prandtl number, permeability coefficient, heat source/sink volumetric rate and temperature difference between heated plate and ambient temperature. A reduced system of ODEs was created via group similarity method. The solution led to some important results. Increasing permeability coefficient of the plate material resulted in a significant increase in flow velocity and a slight increase in heat flux but the magnitude of shear stress and temperature distribution decreased. Moreover, increasing the magnetic parameter, M, led to a significant decrease in velocity and a decrease in heat flux, whereas shear stress and temperature distribution increased. Furthermore, increasing Prandtl number, Pr, reduced the velocity significantly and the heat flux slightly. On the other hand, the magnitude of shear stress and temperature distribution increased. In case of using heat source, the increase in its energy rate decreased the heat flux with no significant effect on shear stress. Finally, the increment of temperature difference led to noticeable increase in velocity and a slight increase in heat flux, whereas the shear stress decreased.

Hemodynamic impacts of hematocrit level by two-way coupled FSI in the left coronary bifurcation.

Cardiovascular disease is now under the influence of several factors that encourage researchers to investigate the flow of these vessels. Oscillation influences the blood circulation in the volume of red blood cells (RBC) strongly. Therefore, in this study, its effects have been considered on hemodynamic parameters in the elastic wall and coronary bifurcation. In this study, a 3D geometry of non-Newtonian and pulsatile blood circulation is considered in the left coronary artery bifurcation. The Casson model with various hematocrits is analyzed in elastic and rigid walls. The wall shear stress (WSS) cannot show the stenosis artery alone, therefore, the oscillatory shear index (OSI) is represented as a hemodynamic parameter of WSS individually of time. The results are determined using two-way fluid-structure interaction (FSI) coupling method using an arbitrary Lagrangian-Eulerian method. The most prominent difference in velocity happened in the bifurcation and at hematocrit 30 with yield stress 6.59E-04 Pa. The backflow and vortex flow in the LCx branch grown with increasing shear rates. The likelihood of plaque generation at the ending of the LM branch is observed in hematocrits 10 and 20, while the WSS magnitude is normal in the hematocrit 60 with the greatest yield stress in the bifurcation. The shear stress among the rigid and elastic models is the highest at the ending of the LM branch. The wall shear stress magnitude among the models decreased at most of 24.49% by dividing the flow. Time-independent results for models showed that there is the highest value of OSI at the bifurcation, which then quickly dropped.