“Functional integration” is to integrate two or multiple systems or mechanisms that are independent with each other and to realize the two or multiple functions using only one actuation system. Maximization of engineering applications of actuation systems could be achieved through the use of the “functional integration” concept-based structural design. In this article, an integrated semi-active seat suspension, mainly composed of a switching mechanism, a transmission amplification mechanism, and a damping force- or torque-controllable rotary magnetorheological (MR) damper working in pure shear mode, for both longitudinal and vertical vibration attenuation, is proposed, designed, and fabricated. The switching mechanism employs the parallelogram frames as a motion guide which keeps the seat moving longitudinally and vertically. Both longitudinal and vertical motions are transformed into a reciprocating rotary motion that is transmitted to the rotary MR damper after an amplification by a gear mechanism. The torque generated by the MR damper can be tuned by adapting the applied current in real time, and hence, effective two-dimensional vibration control of the seat could be realized. The mathematical model of the semi-active seat suspension system is established, and vibration isolation performance of the system is simulated and analyzed. Based on the established experimental test rig, the prototype of the semi-active seat suspension system is tested, and the results of the mathematical model and the experimental test are compared.