The phenomenon of heat transfer is prevalent in industries and has an extensive range of applications. However, mostly the discussion of heat transfer problems is limited to the study of the first law of thermodynamics, which deals with energy conservation. It is just restricted to the quantity of energy, not to its quality; i.e., there is no difference between the work (high‐grade energy) and the heat (low‐grade energy). A measurement of the degree of randomness of energy in a system is known as entropy. It is unavailable for doing useful work because work takes place only from ordered molecular motion. Even though many boundary layer models exist in the literature to investigate the flow and heat transfer of various fluids along a stretching surface, they have not yet been used at their maximum ability. The main motive of the current research is to discuss entropy generation or its minimization during heat transfer. This work presents an entropy generation analysis for the transient three‐dimensional stagnation point flow of a hydromagnetic Casson fluid flowing over a stretching surface in the existence of Hall current, viscous dissipation, and nonlinear radiation. The physical configuration of the present work is described in terms of partial differential equations (PDEs) of nonlinear nature. Furthermore, these PDEs are converted into ordinary differential equations by using some relevant similarity transformations. An efficient numerical method named as the spectral quasilinearization method (SQLM) is used to solve this model. The expression of the Bejan number and volumetric entropy generation rate is also computed. A parametric analysis, including the essential physical parameters, is performed to examine the influences of distinct flow parameters on the velocity profile, temperature profile, Bejan number, entropy generation number, and the coefficients of skin friction and the Nusselt number. In order to further insight into the emerging physical quantities of engineering interest, multiple quadratic regression models are used to estimate the coefficients of skin friction and heat transfer.