The growth and structural analysis of topological semimetal (TSM) PdTe2 were carried out in this study. The self-flux method was employed to grow the single crystals which were structurally characterized by XRD, SEM and EDAX, while the vibrational modes were observed by Raman spectroscopy. Further, the transport properties of the grown crystal are also investigated, which show the presence of the weak anti-localization effect. The low-field (≈1 Tesla) magnetoconductivity is studied by Hikami–Larkin–Nagaoka (HLN) model, and the physical parameters are extracted. Further, a quadratic term and a linear term in applied field were added in HLN model, which are accounted for quantum and classical contributions in conduction mechanism. The modified HLN model was used to study magneto-conductivity in entire field range and at temperature from 2 to 100 K. This study not only confirmed the growth of single crystal PdTe2, but also verified the presence of topological surface states (TSS) through the HLN analysis of magneto-transport measurements.