Magnetic Polymer Research Articles

Molecular dynamics simulations of microscopic structural transition and macroscopic mechanical properties of magnetic gels.

Magnetic gels with embedded micro-/nano-sized magnetic particles in cross-linked polymer networks can be actuated by external magnetic fields, with changes in their internal microscopic structures and macroscopic mechanical properties. We investigate the responses of such magnetic gels to an external magnetic field, by means of coarse-grained molecular dynamics simulations. We find that the dynamics of magnetic particles are determined by the interplay of magnetic dipole-dipole interactions, polymer elasticity, and thermal fluctuations. The corresponding microscopic structures formed by the magnetic particles, such as elongated chains, can be controlled by the external magnetic field. Furthermore, the magnetic gels can exhibit reinforced macroscopic mechanical properties, where the elastic modulus increases algebraically with the magnetic moments of the particles in the form of ∝(m-mc)2 when magnetic chains are formed. This simulation work can not only serve as a tool for studying the microscopic and the macroscopic responses of the magnetic gels, but also facilitate future fabrications and practical controls of magnetic composites with desired physical properties.

Development of Magnetic Porous Polymer Composite for Magnetic Solid Phase Extraction of Three Fluoroquinolones in Milk.

In this study, a magnetic porous polymer composite with both hydrophilic and hydrophobic groups was synthesized for magnetic solid phase extraction (MSPE) of milk substrates. Optimization was conducted on various parameters, including adsorption dose, solution pH, adsorption time, and some elution conditions. Coupled with a high-performance liquid chromatography fluorescence detector, a novel MSPE method for determination of norfloxacin (NFX), ciprofloxacin (CIP), and enrofloxacin (ENR) in milk was developed based on magnetic metal organic framework polystyrene polymer (Fe3O4@MOF@PLS) as adsorbent. The Fe3O4@MOF@PLS exhibited significantly improved adsorption performance compared to MOF and PLS. Under optimized experimental conditions, the method exhibited good linearity for the three fluoroquinolones (FQs) in the range of 0.5-1000 μg/kg, with limit of detections (LODs) ranging from 0.21 to 1.33 μg/kg, and limit of quantitations (LOQs) from 0.71 to 4.42 μg/kg. The relative standard deviation (RSD) for the three FQs were 3.4-8.8%. The recoveries of three FQs in milk samples ranged from 84.2% to 106.2%. This method was successfully applied to the detection of three FQs in 20 types of milk, demonstrating its simplicity, speed, and effectiveness in analyte enrichment and separation. The method presented advantages in adsorbent dosage, adsorption time, LODs, and LOQs, making it valuable for the analysis and detection of FQs in milk.

Fabrication of Novel Carbon-based Polymers by On-surface Cycloaromatization of Isopropyl Substituents

Surface-catalyzed reactions have been employed for the synthesis of carbon nanomaterials featuring precisely defined atomic structures. A recent breakthrough involves the gold surface-catalyzed [3 + 3] cycloaromatization of isopropyl-substituted arenes, allowing for on-surface synthesis of novel carbon-based polymers[1-3]. In this process, the surface plays a crucial role in activating the isopropyl substituents, facilitating the formation of phenylene rings through intermolecular coupling. For instance, such investigations might open new avenues in the field of carbon magnetism, which has gained an increased attention in view of the recent progress made in the synthesis and characterization of open-shell polycyclic aromatic hydrocarbons[2]. Under this scenario, the comprehensive fabrication of magnetic polymers emerges as a highly appealing field of research.Here, we introduce exemplary approaches toward the bottom-up fabrication of different carbon-based polymers homocoupled via surface-catalyzed [3 + 3] cycloaromatization of isopropyl substituents studied on Au(111) under ultra-high vacuum (UHV) conditions. The chemical structures of the polymers have been clearly elucidated by non-contact atomic force microscopy (nc-AFM). Scanning tunneling spectroscopy (STS), complemented by computational investigations reveals their ground state. Our approach can be a highly relevant step towards the on-surface synthesis of covalently linked 1D organic polymers with prospects in sensing, catalysis and nanoscale spintronic devices.

Fast Determination of Eleven Food Additives in River Water Using C18 Functionalized Magnetic Organic Polymer Nanocomposite Followed by High-Performance Liquid Chromatography.

A novel magnetic nanomaterial with Fe3O4 as the core, PS-DVB as the shell layer, and the surface modified with C18 (C18-PS-DVB-Fe3O4) had been synthesized by seeded emulsion polymerization. C18-PS-DVB-Fe3O4 retains the advantages of the chemical stability, large porosity, and uniform morphology of organic polymers and has the magnetic properties of Fe3O4. A simple, flexible, and efficient magnetic dispersive solid phase extraction (Mag-dSPE) method for the extraction of preservatives, sweeteners, and colorants in river water was established. C18-PS-DVB-Fe3O4 was used as an adsorbent for Mag-dSPE and was coupled with high-performance liquid chromatography (HPLC) to detect 11 food additives: acesulfame, amaranth, benzoic acid, tartrazine, saccharin sodium, sorbic acid, dehydroacetic acid, sunset yellow, allura red, brilliant blue, and erythrosine. Under the optimum extraction conditions, combined with ChromCoreTMAQC18 (5 μm, 4.6 × 250 mm), 20 mmol/L ammonium acetate aqueous solution and methanol were used as mobile phases, and the detection wavelengths were 240 nm and 410 nm. The limits of detection (LODs) of 11 food additives were 0.6-3.1 μg/L with satisfactory recoveries ranging from 86.53% to 106.32%. And the material could be reused for five cycles without much sacrifice of extraction efficiency. The proposed method has been used to determine food additives in river water samples, and results demonstrate the applicability of the proposed C18-PS-DVB-Fe3O4 Mag-dSPE coupled with the HPLC method to environment monitoring analysis.

Core-shell magnetic covalent organic polymer nanocomposites as an adsorbent for the extraction of flavonoids.

A novel 3D magnetic nanocompositematerialbased on covalent organic polymers was successfully synthesized and utilized as an efficient sorbent for magnetic solid-phase extraction. It exhibited a regular core-shell structure, large specific surface area, superior stability, and paramagnetism. To evaluate its extraction efficiency, six flavonoids were tested, demonstrating maximum adsorption capacities ranging from 90 to 218mg/g. Additionally, the material exhibited remarkable reusability and mechanical stability, maintaining its original state over eight cycles with consistent recovery. An analytical strategy combining magnetic solid-phase extraction with high performance liquid chromatography and tandem mass spectrometry was developed for the determination of flavonoids in orange, honey, soybean, and Dioscorea bulbifera L. samples. The low limits of detection (0.01-0.1ng/mL) and limits ofquantification (0.05-0.5ng/mL), as well as satisfactory recovery (80.4-114.8%), were obtained. The linear range started from the limits of quantification to 500ng/mL with R2 ≥ 0.9929. These results suggest that the prepared adsorbent possesses excellent adsorption capabilities for flavonoids, highlighting its significant potential for detecting these compounds in complex sample matrices.

Recent Advances in Synthesising and Applying Magnetic Ion-Imprinted Polymers to Detect, Pre-Concentrate, and Remove Heavy Metals in Various Matrices

Magnetic ion-imprinted polymers (MIIPs) are an innovative material that combines the selectivity of ion imprinting with the ease of separation provided by magnetic properties. Recent advancements in MIIPs have shown that they have higher selectivity coefficients compared to non-imprinted materials. The synthesis of MIIPs involves creating specific recognition sites for target ions in magnetic nanomaterials. Various nanomaterials, such as graphene oxide, carbon nanotubes, and silica, have been incorporated into the IIPs to improve their analytical performance for different environmental applications, including metal extraction, monitoring, detection, and quantification. This review stresses the need to develop new monomers with a high affinity for the target analyte and to find supporting materials with groups that facilitate the effective removal of the target analyte. It also explores the influence of experimental parameters on metal determination.

Innovation in Methods for Incorporating Magnetite into Biocellulose for Electromagnetic Interference Shielding Effectiveness Applications

Materials with magnetic properties are essential in various electric sector technologies. However, the generation of pollutants is of concern, increasing the interest in developing new sustainable, low-cost magnetic materials. These materials have notable applications in protecting against electromagnetic interference (EMI), which can lead to health problems as well as environmental pollution. Therefore, the aims of the present study were to produce a sustainable magnetic polymer using different methods of magnetite incorporation, investigate its magnetic properties, and determine its EMI shielding potential. The magnetic BC materials were obtained via in situ and ex situ magnetic incorporation in processed BC membranes and BC hydrogels. Analyses were carried out using XRD, FTIR, SEM, and VSM, and tests were performed to assess electromagnetic interference shielding effectiveness (EMI SE). The results revealed that the magnetite incorporation method influences the final size of nanoparticles, the arrangement among BC fibers, and the magnetic properties. Materials produced from processed BC had a higher percentage of incorporated magnetite and greater magnetic saturation, whereas those containing nanoparticles with a larger diameter had a stronger coercive field. Although samples did not have high EMI SE, magnetite increased the wave reflection and absorption of the material. This biomaterial can drive important innovations in the energy sector, particularly in efficient and ecological electrical infrastructure.

Synthesis and self-assembly of high grafting density core-shell bottlebrush polymer with amphiphilic side chain

Self-assembly of bottlebrush polymers are widely studied in photonic bandgap materials, biomedical materials and nanomaterial with different structures. In this work, high grafting density bottlebrush polymer with amphiphilic QPDMA[FeCl4]-b-PS side chains grafting on every carbon atom of the backbone are prepared via grafting from approach. The para-isocyanobenzoate monomer modified with chain transfer agent (CTA) is designed and synthesized to prepared polymer backbones with CTA grafting on each atoms. The core-shell bottlebrush block copolymer is prepared by sequential reversible addition-fragmentation chain transfer polymerization of dimethylaminoethyl methacrylate and styrene. The inner core follows quaternization and ion exchange to form water soluble QPDMA[FeCl4] magnetic block. The resulting core-shell bottlebrush magnetic polymer (PCN-g-[QPDMA[FeCl4]-b-PS]) self-assembles into nanowires with magnetic QPDMA[FeCl4] as core and PS as corona in the shell selected solvent dichloromethane, the length of nanowires increases with self-assembly time. While it self-assembles into nanoparticle clusters in core selected aqueous solution. And, the thermal and magnetic properties are affected by the self-assembly morphology. Especially, the as prepared PCN-g-[QPDMA[FeCl4]-b-PS] and the nanoparticles cluster self-assembly are paramagnetic, but the nanowire self-assembly is superparamagnetic.

Analyzing trade-off issues in synthesis of magnetic polymer compounds through theoretical investigation

Incorporating magnetic species, magnetic functional groups or additives, into polymer hosts is an effective method for synthesizing magnetic polymers. Polymers can gain magnetic moments not solely through magnetic coupling but also via the induction of Coulombic excitation. Attachment of the magnetic side-groups to the polymer backbone increases orbital localization in repeat units. This will bring two competing effects. The orbital localization will increase the intra-site Coulomb interaction, which increases magnetic moments in repeat units. Oppositely, the orbital localization also increases the energy splitting between orbitals on the polymer backbone and on side-groups, suppressing thus the magnetic moments of repeat units. However, a preference for low-spin states in the polymer units emerges when a substantial split in orbital energy occurs due to a strong coupling, consequently suppressing the magnetic moment. On the contrary, a minimal split in orbital energy within the polymer units can readily induce a high-spin state and generate a magnetic moment. However, in such cases, the Coulomb interaction triggered by the interconnected magnetic moieties might be too weak to produce a magnetic moment in the polymer. To explore this trade-off, we have proposed a theoretical two-level model aimed at elucidating the decision-making process of experimentalists during the synthesis of magnetic polymers. We also found that the dimerization of the polymer backbone together with the phonon dependence of spin–spin interaction between near-neighbor repeat units increases magnetic moments. As the magnetic responses arising from Coulombic interactions in polymers are intricately linked to carrier density, properties of the magnetic polymers acting as an active layer of a field-effect transistor can be tuned by the gate field, which controls the charge carrier density in the transistor transport channel.

Development of magnetic nanocomposite hydrogels for removal of pesticide from water

Using magnetic and biodegradable polymers for removal of soluble pesticides can reduce environmental and human health damage caused by their presence in rivers, streams, and lakes. In this study, we develop and characterize the crystallinity and thermal properties of novel magnetic hydrogels based on polysaccharides, zeolites, and magnetite (Fe3O4) magnetic nanoparticles (MNs) functionalized with 3-aminopropyltriethoxysilane (Fe3O4@NH2), supported in poly(methacrylic acid)-co-polyacrylamide networks. The potential of the hydrogel for herbicide removal, specifically paraquat, is also investigated. The Fourier-transform infrared spectroscopy, X-ray diffraction analysis, thermogravimetric, kinetic, and swelling degree analysis results demonstrate that MNs do not affect the physicochemical properties and pesticide sorption. However, minor changes, such as the peak at 2θ = 35.57º representing the (311) plane of Fe3O4, confirmed the incorporation of MNs into the polymer matrix. The increase in pH caused an increase in the swelling degree from 1.2 to 10.0 w.w−1, indicating an increase both the pore size, and possibly, in the removal properties. The adsorption results of paraquat through ultraviolet–visible spectroscopy measurements show a small difference in absorptive capacity (qeq) between pure hydrogel (12.95 mg.g−1) and hydrogel with 2.0 % functionalized Fe3O4 NPs (12.99 mg.g−1). Overall, incorporating Fe3O4 NPs in the hydrogel matrix yields materials with promising characteristics and while offering easier, safer removal from the environment.

Magnetic surface-imprinted polymer microspheres coupled with HPLC-MS/MS for sensitive detection of amphetamine-type drugs in water

Magnetic surface imprinted polymer microspheres (Fe3O4@MIPs) were successfully synthesized via Pickering emulsion polymerization, utilizing N-Methylphenethylamine as a surrogate template for amphetamine-type drugs. Fe3O4@MIPs not only possessed excellent dispersibility and enough magnetic properties in aqueous solutions, but also displayed good selectivity towards six amphetamines, with an imprinting factor ranging from 1.8 to 2.6. The adsorption kinetics closely aligned with the pseudo-second-order model, and the adsorption efficiency exceeds 80 % for each amphetamine at equilibrium. Fe3O4@MIPs were then employed as the efficient adsorbents for the extraction of amphetamine drugs. Extraction parameters, including sample pH, the mass of adsorbent, and the type and volume of eluting solvent, were carefully optimized. In combination with the high performance liquid chromatography tandem triple quadrupole mass spectrometry (HPLC-MS/MS), a selective magnetic solid-phase extraction (MISPE) method utilizing Fe3O4@MIPs was developed for the detection of six amphetamines in water samples. The limits of detection and limits of quantitation were determined to be 5.2∼23 ng L−1 and 17∼77 ng L−1, respectively. Recoveries for the six target drugs from lake water and sewage samples fell within the range of 87.2∼110 %. Additionally, the MISPE-HPLC-MS/MS method exhibited excellent repeatability, with a precision below 8.5 % at two spiking levels. The prepared Fe3O4@MIPs possessed the advantages of high selectivity, straightforward preparation, facile separation and good reusability, and was highly suitable for the efficient extraction of amphetamine-type substances in complex environmental water.

4D Printing of Magneto‐Thermo‐Responsive PLA/PMMA/Fe3O4 Nanocomposites with Superior Shape Memory and Remote Actuation

AbstractThis study presents the development and 4D printing of magnetic shape memory polymers (MSMPs) utilizing a composite of polylactic acid (PLA), polymethyl methacrylate (PMMA), and Fe3O4 nanoparticles. The dynamic mechanical analysis reveals that the integration of Fe3O4 maintains the broad thermal transition without significantly affecting α‐relaxation time, indicating high compatibility and homogeneous distribution of the nanoparticles within the polymer matrix. Field emission scanning electron microscopy further confirms the high compatibility of PLA and PMMA phases as well as uniform dispersion of Fe3O4 nanoparticles, essential for the effective transfer of heat during the shape memory process. Significantly, the incorporation of magnetic nanoparticles enables remote actuation capabilities, presenting a substantial advancement for biomedical applications. 4D‐printed MSMP nanocomposites exhibit exceptional mechanical properties and rapid, efficient shape memory responses under both inductive and direct heating stimuli, achieving 100% shape fixity and 100% recovery within ≈85 s. They are proposed as promising candidates for biomedical implants, specifically for minimally invasive implantation of bone scaffolds, due to their rapid remote actuation, biocompatibility, and mechanical robustness. This research not only demonstrates the 4D printability of high‐performance MSMPs but also introduces new possibilities for the application of MSMPs in regenerative medicine.

Numerical study of electroconductive non-Newtonian hybrid nanofluid flow from a stretching rotating disk with a Cattaneo–Christov heat flux model

Motivated by emerging technologies in smart functional nanopolymeric coating systems in pharmaceutical and robotics applications, the convective heat transfer characteristics in swirl coating with a magnetic hybrid power-law rheological nanofluid polymer on a radially stretching rotating disk are examined theoretically. An axial magnetic field is imposed. Copper (Cu) and aluminium alloy (AA7075) nanoparticles with sodium alginate (C6H9NaO7) as a base fluid are considered, and a hybrid volume fraction model is deployed. A non-Fourier (Cattaneo–Christov) heat flux model is deployed to inspire thermal relaxation impacts absent in the classical Fourier heat conduction formulation. Through similarity proxies and the Von Karman transformations, the partial derivative systems of equations with associated boundary constraints are reduced to a system of derivative boundary value problems, which is solved numerically via the weighted residual method with an integral Galerkin scheme, executed in the MAPLE symbolic software. Validation with special cases from articles is captured. The computations revealed that radial, tangential and axial velocity are depleted, whereas temperature is enhanced with increasing magnetic parameter ( M). High thermal transfers are obtained for the hybrid nanofluid relative to the AA7075 alloy nanofluid. A strong increment in temperature is also produced with a greater thermal relaxation effect.

Observation of the photonic Hall effect and photonic magnetoresistance in random lasers

Modulation of scattering in random lasers (RLs) by magnetic fields has attracted much attention due to its rich physical insights. We fabricate magnetic gain polymer optical fiber to generate RLs. From macroscopic experimental phenomena, with the increase of the magnetic field strength, the magnetic transverse photocurrent exists in disordered multiple scattering of RLs and the emission intensity of RLs decreases, which is the experimental observation of photonic Hall effect (PHE) and photonic magnetoresistance (PMR) in RLs. At the microscopic level, based on the field dependence theory of magnetic disorder in scattered nanoparticles and the replica symmetry breaking theory, the magnetic-induced transverse diffusion of photons reduces the scattering disorder, and then decreases the intensity fluctuation disorder of RLs. Our work establishes a connection between the above two effects and RLs, visualizes the influence of magnetic field on RL scattering at the microscopic level, which is crucial for the design of RLs.

Carboxyl-Assisted Coordination-Driven Self-Assembly for the Preparation of Magnetic Polymer Composite Microspheres

Carboxyl-Assisted Coordination-Driven Self-Assembly for the Preparation of Magnetic Polymer Composite Microspheres

Magnetic smart polymer gel with directional plugging for conformance control in oil reservoirs

Polymer gel technology has been proven to be one of the most effective methods for conformance control and enhanced oil recovery. However, to effectively gel highly permeable layers, precise placement of the gelant within the formation is required. Herein, to make the most use of polymer gel in conformance control, a novel magnetic smart polymer gel consisting of polyacrylamide and Fe3O4@polyethylenimine, is designed and prepared as a conformance fluid to achieve directional plugging in target reservoirs. To deeper understanding of the properties of Fe3O4@polyethylenimine and smart gel, as well as how they are formed and function, the microstructure of these materials was characterized through various techniques, including analysis of their crystal and chemical structures, micromorphology, and cross-linking mechanism, et al. The rheological tests suggest that the system has good viscosity and elasticity, and the gel strength can reach 105,463 mPa⋅s after aging 30 days at 120 °C. Furthermore, the controlled manipulation indicated that smart gel can move quickly and repeatedly to a designated location under a magnetic field. Additionally, the influence of the magnetic generator on the intelligent plugging performance of the smart gel system is also explored. It has been found that magnetic plugging can extend the effective lifespan of smart gel. Finally, the conformance control performance of the smart gel system is revealed by the parallel cores flow experiment. This work presents a novel smart gel system designed for directional plugging, to enhance conformance control in high-temperature oil reservoirs.

Magnetic quaternary ammonium polymer bearing porous agarose for selective extraction of Aristolochic acids in the plasma

Aristolochic acids (AAs) naturally occurring in the herbal genus Aristolochia are associated with a high risk of kidney failure, multiple tumors and cancers. However, approaches with high selectivity and rapidity for measuring AAs in biological samples are still inadequate. Inspired by the mechanism of AAs-induced nephrotoxicity, we designed a hybrid magnetic polymer-porous agarose (denoted as MNs@SiO2M@DNV-A), mimicking the effect of basic and aromatic residues of organic anion transporter 1 (OAT1) for efficient enriching aristolochic acid I (AA I) and aristolochic acid II (AA II) in the plasma. The monomers of vinylbenzyl trimethylammonium chloride (VBTAC), N-vinyl-2-pyrrolidinone (NVP) and divinylbenzene (DVB) were employed to construct the polymer layer, which provided a selective adsorption for AAs by multiple interactions. The porous agarose shell contributed to remove interfering proteins in the plasma samples. A magnetic solid-phase extraction (MSPE) based on the proposed composite enhanced the selectivity toward AA I and AA II in the plasma samples. In combination of HPLC analysis, the proposed method was proved to be applicable to fast and specific quantification of AAs in blood samples, which was characterized by a good linearity, high sensitivity, acceptable recovery, excellent repeatability and satisfactory reusability.

Design and research on sequentially controlled magnetic-driven actuators with high stiffness by changing local EGaIn structural density

Magnetic-driven actuators (MDAs) are attracting increasing attention due to fast response and harmless interaction with humans. However, due to their low stiffness and difficulties in sequential magnetic control, MDAs are difficult to complete high-load tasks, and overcoming these obstacles can enable them to be exploited for a wide range of novel applications. In this work, sequentially controlled MDAs (SC-MDAs) with high stiffness were prepared by embedding a polydimethylsiloxane/liquid metal (PDMS/EGaIn) heating layer between magnetic memory polymer (MSMP) films. The variation of EGaIn structural density between different regions leads to temperature discrepancies, resulting in selective activation of specific regions for sequence control. The modulus of the optimized MSMP film at room temperature is 2.21 GPa, which exceeds that of other materials (about 1 MPa) by three orders of magnitude, demonstrating a substantial increase in stiffness. When the content of NdFeB is adjusted to 80 wt%, driving performance is adjusted by optimizing the length-thickness ratio of SC-MDAs. Each claw of the mechanical gripper exhibits a remarkable increase in load capacity, being able to carry 54 times its own weight, which is significantly higher compared to actuators made from other materials (about its weight). A hand-like actuator realizes the sequential control deformation by combining “fingers” with different heating properties.

Polymer composites with magnetically active Eu-substituted NiZn ferrite fillers

In this research, the influence of Eu substitution on structural, quasi-static as well as dynamic (electro)magnetic properties of nickel zinc ferrites has been studied. The correlation of increasing europium content in the substituted NiZn ferrite filler with constant concentration (60 vol%) and the frequency dispersion of the complex permeability in magnetically active composite samples has been explored as well. Eu-substituted nickel-zinc ferrites with chemical composition Ni0.3Zn0.7EuxFe2-xO4, where x changes from 0.00 to 0.10 (step 0.02) ions per formula unit (i./f.u.), have been selected for their high initial permeability and in general good other magnetic parameters. On contrary, non-substituted ferrite of this composition exhibits undesirably low Curie temperature inconvenient for the use of these materials even at room temperatures. Therefore, Eu has been selected as a substituent for its known ability to increase the Curie temperature of prepared ferrites. The ferrites have been synthesized by means of the conventional solid state reaction method including double sintering at the temperatures of 950 °C and 1200 °C and used as magnetically active fillers incorporated into the magnetic polymer composites. Polyvinylchloride (PVC) has been used as the polymeric matrix. In spite of substituent amount x being the only parameter changing intentionally, the behavior of both the ferrite filler (deterministic until the creation of the second, non-magnetic, phase above x = 0.04) and the ferrite/PVC composites is quite hard to explain, and validate quantitatively, on the basis of simple theoretical assumptions. Nevertheless, the experiments confirmed positive effect of europium on the increase of Curie temperature. Also, the peak frequency of the imaginary component of the complex permeability has been found to be very sensitive to x, thus offering an effective tool for tuning the high-frequency properties of the composites useable for various applications, especially the shielding of microwave electromagnetic fields.

Analysis of 15 bile acids in human plasma based on C18 functionalized magnetic organic polymer nanocomposite coupled with liquid chromatography-tandem mass spectrometry

Because of the “enterohepatic circulation” of bile acid, liver damage can be reflected by monitoring the content of bile acid in the serum of the organism. To monitor the concentration of 15 bile acids in plasma samples, a new technique of PRiME (process, ruggedness, improvement, matrix effect, ease of use) pass-through cleanup procedure combined with high performance liquid chromatography-tandem quadrupole mass spectrometry (HPLC-MS/MS) was developed. The sorbent used in the PRiME pass-through cleanup procedure is a new type of magnetic organic resin composite nano-material modified by C18 (C18-PS-DVB-GMA-Fe3O4), which has high cleanup efficiency of plasma samples. It also shows good performance in the separation and analysis of 15 kinds of bile acids. Under the optimal conditions, the results show higher cleanup efficiency of C18-PS-DVB-GMA-Fe3O4 with recoveries in the range of 82.1–115 %. The limit of quantitative (LOQs) of 15 bile acids were in the range of 0.033 µg/L-0.19 µg/L, and the RSD values of 15 bile acids were in the range of 3.00–11.9 %. Validation results on linearity, specificity, accuracy and precision, as well as on the application to analysis of 15 bile acids in 100 human plasma samples demonstrate the applicability to clinical studies.