Types Of Magnetic Nanoparticles Research Articles

EHPnet: NARSAD: The Mental Health Research Association

Vol. 115, No. 8 EnvironewsOpen AccessEHPnet: NARSAD: The Mental Health Research Association Erin E. Dooley Erin E. Dooley Search for more papers by this author Published:1 August 2007https://doi.org/10.1289/ehp.115-a403Cited by:9AboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InReddit In the early 1980s, three leading national mental health groups came together to form the American Schizophrenia Association. Since that time the organization has evolved in both name and scope; it is now known as NARSAD: The Mental Health Research Association to reflect its current focus on a wide range of mental disorders. NARSAD works not only to fund research to prevent, diagnose, and treat psychiatric diseases, but also to educate the public about these conditions. Visitors can find information on these initiatives and more at http://www.narsad.org/.The Diseases and Conditions section of the NARSAD site is divided into six main sections: schizophrenia, depression, bipolar disorder, anxiety, childhood disorders, and other disorders. Each section offers a brief overview of the illness on which it focuses and a summary of symptoms and treatments. Insight into NARSAD’s research into the illness is also available. In addition, feature stories on related topics are provided, as is information for people recently diagnosed with the illness, including resources for learning about the illness they have been diagnosed with and the medications they have been prescribed.The Research Center portion of the NARSAD site provides information for potential grant recipients on how to apply for funding, provides a list of grantees, and notifies visitors of NARSAD grant deadlines. A section of project summaries gives visitors a look at the work NARSAD supports. Among other projects are a twin study to tease out the nongenetic family background contributions to depression and a mouse study of how changes in maternal behavior associated with a genetic modification may be passed to offspring that do not possess the modification.FiguresReferencesRelatedDetailsCited by Surah S, Sirohi S, Nain R and Kumar G (2018) Antimicrobial activity of TiO2 nanostructures synthesized by hydrothermal method INTERNATIONAL CONFERENCE ON STRUCTURAL ANALYSIS OF ADVANCED MATERIALS: ICSAAM 2017, 10.1063/1.5024188, , (030038) Ge G, Wu H, Xiong F, Zhang Y, Guo Z, Bian Z, Xu J, Gu C, Gu N, Chen X and Yang D (2013) The cytotoxicity evaluation of magnetic iron oxide nanoparticles on human aortic endothelial cells, Nanoscale Research Letters, 10.1186/1556-276X-8-215, 8:1, (215), . Saptarshi S, Duschl A and Lopata A (2013) Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle, Journal of Nanobiotechnology, 10.1186/1477-3155-11-26, 11:1, (26), . Osmond-McLeod M, Osmond R, Oytam Y, McCall M, Feltis B, Mackay-Sim A, Wood S and Cook A (2013) Surface coatings of ZnO nanoparticles mitigate differentially a host of transcriptional, protein and signalling responses in primary human olfactory cells, Particle and Fibre Toxicology, 10.1186/1743-8977-10-54, 10:1, (54), . Sriram M, Kalishwaralal K, Barathmanikanth S and Gurunathani S (2012) Size-based cytotoxicity of silver nanoparticles in bovine retinal endothelial cells, Nanoscience Methods, 10.1080/17458080.2010.547878, 1:1, (56-77), Online publication date: 1-Jan-2012. Raemy D, Grass R, Stark W, Schumacher C, Clift M, Gehr P and Rothen-Rutishauser B (2012) Effects of flame made zinc oxide particles in human lung cells - a comparison of aerosol and suspension exposures, Particle and Fibre Toxicology, 10.1186/1743-8977-9-33, 9:1, (33), . Dua P, Chaudhari K, Lee C, Chaudhari N, Hong S, Yu J, Kim S and Lee D (2011) Evaluation of Toxicity and Gene Expression Changes Triggered by Oxide Nanoparticles, Bulletin of the Korean Chemical Society, 10.5012/bkcs.2011.32.6.2051, 32:6, (2051-2057), Online publication date: 20-Jun-2011. Kai W, Xiaojun X, Ximing P, Zhenqing H and Qiqing Z (2011) Cytotoxic effects and the mechanism of three types of magnetic nanoparticles on human hepatoma BEL-7402 cells, Nanoscale Research Letters, 10.1186/1556-276X-6-480, 6:1, (480), . Kim Y, Fazlollahi F, Kennedy I, Yacobi N, Hamm-Alvarez S, Borok Z, Kim K and Crandall E (2010) Alveolar Epithelial Cell Injury Due to Zinc Oxide Nanoparticle Exposure, American Journal of Respiratory and Critical Care Medicine, 10.1164/rccm.201002-0185OC, 182:11, (1398-1409), Online publication date: 1-Dec-2010. Vol. 115, No. 8 August 2007Metrics About Article Metrics Publication History Originally published1 August 2007Published in print1 August 2007 Financial disclosuresPDF download License information EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. Note to readers with disabilities EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. 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Surface modification of magnetic nanoparticles with oleylamine and gum Arabic

Magnetic nanoparticles (MNP) were synthesized under acidic conditions in the presence of oleylamine (OLA) and gum Arabic (GA) to study the influence of surface modification on MNP characteristics and cellular level bioactivity. Highly dispersed MNPs were formed from acidic solutions of ferric and ferrous chloride in the absence and presence of OLA. The MNP synthesized in the presence of GA formed large particle aggregates that exhibited rapid coagulation. The three types of MNP were characterized via thermogravimetric analysis (TGA), and dynamic and electrophoretic light scattering to determine particle size and zeta potential. Cytotoxicity and cell interactions were assessed for each of the three MNP samples using L929 fibroblast cells. OLA modified MNPs exhibited the highest level of cytotoxity. Approximately 27% of L929 fibroblast cells died after exposure to OLA modified MNP in comparison to 10% cell death for untreated, GA treated, and control cells. Cells that were exposed to MNPs could be translated in magnetic fields. The OLA and untreated MNPs could be detected in the cell cytoplasm while the GA-modified MNP clusters were located at the cell membrane based on light microscopy.

In vitro characterization of movement, heating and visualization of magnetic nanoparticlesfor biomedical applications

Magnetic nanoparticles can be used for a variety of biomedical applications. They can beused in the targeted delivery of therapeutic agents in vivo, in the hyperthermic treatmentof cancers, in magnetic resonance (MR) imaging as contrast agents and in the biomagneticseparations of biomolecules. In this study, a characterization of the movement and heatingof three different types of magnetic nanoparticles in physiological systems in vitro is madein a known external magnetic field and alternating field respectively. Infra-red (IR) imagingand MR imaging were used to visualize these nanoparticles in vitro. A strongdependence on the size and the suspending medium is observed on the movementand heating of these nanoparticles. First, two of the particles (mean diameterd = 10 nm, uncoatedFe3O4 andd = 2.8 µm, polystyrenecoated Fe3O4+γ-Fe2O3) did not move while only a dextran coated nanoparticle(d = 50 nm, γ-Fe2O3) moved in type 1 collagen used as an in vitro model system. It is also observed that the timetaken by a collection of these nanoparticles to move even a smaller distance (5 mm) in collagen(∼100 min) isalmost ten times higher when compared to the time taken to move twice the distance (10 mm) in glycerol(∼10 min) under the same external field. Second, the amount of temperature rise increases withthe concentration of nanoparticles regardless of the microenvironments in the heatingstudies. However, the amount of heating in collagen (maximum change in temperatureΔTmax∼9 °C at1.9 mg Fe ml−1 and19 °C at3.7 mg Fe ml−1) is significantly lessthan that in water (ΔTmax∼15 °C at 1.9 mg Fe ml−1 and33 °C at3.7 mg Fe ml−1) andglycerol (ΔTmax∼13.5 °C at 1.9 mg Fe ml−1 and 30 °C at 3.7 mg Fe ml−1). Further, IR imaging provides at least a ten times improvement in therange of imaging magnetic nanoparticles, whereby a concentration of(0–4 mg Fe ml−1) could bevisualizedas compared to (0–0.4 mg Fe ml−1) by MR imaging. Based on these in vitro studies, important issues and parameters thatrequire further understanding and characterization of these nanoparticles in vivo arediscussed.

Selective Heating of Multiple Nanoparticles

ABSTRACTA method for heating multiple types of magnetic nanoparticles independently is described. This technique exploits tuning of the size and material dependent properties of magnetic field heating of nanoparticles to allow independent heating by application of the field at different frequencies. Magnetic field heating experiments as a function of field frequency show that there is potential for this technique in vitro.

Mobilization off lead by propolis and DMSA therapy in rats

We synthesized a novel magnetic nanoparticle coated with sulfonated complex (HSO3-CS-DMSA) of meso-2, 3-dimercaptosuccinic acid (DMSA) and chitosan (CS) to improve conjugation of catecholamines (CAs) on nanoparticles. HSO3[email protected] exhibited the highest CAs’ conjugation efficiency among three types of magnetic nanoparticles. CAs’ conjugation efficiency was increased in order of MNPs, [email protected] and HSO3[email protected] CAs’ conjugation efficiency at pH 7 depended on zeta potential of magnetic nanoparticles and catecholamines were partly desorbed after being washed with acidic solutions. These results showed that the electrostatic interaction between the negatively charged nanoparticles and positively charged amino groups of catecholamines might play an important role in CAs’ conjugation on magnetic nanoparticles.