Magnesium-aluminum Layered Double Hydroxide Research Articles

Effect of modified MgAl-LDH coating on corrosion resistance and friction properties of aluminum alloy

The in-situ growing approach was utilized in this article to construct the magnesium–aluminum layered double hydroxide (MgAl-LDH) film on the surface of a 1060 aluminum anodized film. To improve the corrosion resistance and friction qualities of aluminum alloy, the MgAl-LDH coating was treated using stearic acid (SA) and thiourea (TU). The aluminum substrate and anodized aluminum film layer corroded to varying degrees after 24 h of immersion in 3.5% (mass) NaCl solution, while the modified hydrotalcite film layer continued to exhibit the same microscopic morphology even after being immersed for 7 d. The results show that the synergistic action of thiourea and stearic acid can effectively improve the corrosion resistance of the MgAl-LDH substrate. The tribological testing reveals that the hydrotalcite film layer and the modified film layer lowered the friction coefficient of the anodized aluminum surface substantially. The results of the simulations and experiments demonstrate that SA forms the dense LDH-TU interlayer film layer by exchanging NO3– ions between TU layers on the one hand and the LDH-SA film layer by adsorption on the surface of LDH on the other. Together, these two processes create LDH-TU-SA, which can significantly increase the substrate's corrosion resistance. This synergistically modified superhydrophobic and retardant hydrotalcite film layer offers a novel approach to the investigation of wear reduction and corrosion protection on the surface of aluminum and its alloys.

Intercalation and separation of isomeric nitrophenols using the anionic clay, Mg2Al(OH)6(CO3)0.5·nH2O and the structurally related layered hydroxy salt, Ni3Zn2(OH)8(CH3COO)2·mH2O

Intercalative sorption of isomeric nitrophenolates (NP) was investigated in two different layered hydroxide materials - anionic clay, magnesium aluminium layered double hydroxide (MgAl-LDH) through reconstructive mechanism and the structurally related layered hydroxy salt, Ni3Zn2(OH)8(CH3COO)2·mH2O (NiZn-LHS) through ion-exchange. Intercalation of NP isomers was confirmed by powder X-ray diffraction and infrared spectroscopy. The NP uptake by the layered hydroxide materials was quantified by high performance liquid chromatography. Both the layered hydroxide materials exhibit selective intercalation from the nitrophenolate mixtures. The order of preference is 4-NP > > 2-NP > 3-NP in MgAl-LDH and 4-NP > 2-NP > > 3-NP in NiZn-LHS. The bias in intercalation could be attributed to (1) the concentration of the phenolate ions influenced by the pKa of the isomer and (2) extent of H-bonding of the nitro group of the isomer with the hydroxide slabs. The 4-isomer with lower pKa and better H-bonding with the adjacent hydroxide slabs is preferentially intercalated. The anionic clays can be used to sorb out nitrophenols as well as separate them from their mixtures.

Efficient and Superstable Mineralization of Toxic Cd2+ Ions through Defect Engineering in Layered Double Hydroxide Nanosheets

Water and soil pollution caused by toxic cadmium ions (Cd2+) is a serious threat to animals, plants, and human health. Discovering low-cost mineralizers which can efficiently and stably immobilize Cd2+ ions is therefore imperative for wastewater treatment and soil remediation. In this work, we report the successful development of a novel mineralizer for Cd2+ ion capture. A magnesium–aluminum layered double hydroxide (MgAl-LDH) with a monolayer structure (MgAl-mono) was first prepared and then calcined at 350 °C for 4 h to produce a defective MgAl-mono-350. MgAl-mono-350 offered a very high Cd2+ removal capacity (1385.5 mg/g at 25 °C) and the ability to reduce the concentration of Cd2+ in aqueous solution from 100 ppm to less than 50 ppb in 15 min (meeting the discharge standard of industrial wastewater). Detailed characterization and computational studies revealed that MgAl-mono-350 possessed abundant oxygen defects, thereby enabling superstable mineralization of Cd2+ via isomorphous substitution process,and the Cd2+ ions are immobilized in the generated CdAl-LDH structure. MgAl-mono-350 also offered outstanding selectivity for Cd2+ ions over other common ions. This work demonstrates the potential of defect-engineered LDH materials for the selective removal of heavy metals from polluted water.

Intercalation and Separation of Isomeric Nitrophenols Using the Anionic Clays, Magnesium Aluminium Layered Double Hydroxide and Nickel Zinc Layered Hydroxy Salt

Intercalation and Separation of Isomeric Nitrophenols Using the Anionic Clays, Magnesium Aluminium Layered Double Hydroxide and Nickel Zinc Layered Hydroxy Salt

Enhanced Bactericidal Effect of Calcinated Mg-Fe Layered Double Hydroxide Films Driven by the Fenton Reaction.

Osteogenic and antibacterial abilities are the permanent pursuit of titanium (Ti)-based orthopedic implants. However, it is difficult to strike the right balance between these two properties. It has been proved that an appropriate alkaline microenvironment formed by Ti modified by magnesium-aluminum layered double hydroxides (Mg-Al LDHs) could achieve the selective killing of bacteria and promote osteogenesis. However, the existence of Al induces biosafety concerns. In this study, iron (Fe), an essential trace element in the human body, was used to substitute Al, and a calcinated Mg-Fe LDH film was constructed on Ti. The results showed that a proper local alkaline environment created by the constructed film could enhance the antibacterial and osteogenic properties of the material. In addition, the introduction of Fe promoted the Fenton reaction and could produce reactive oxygen species in the infection environment, which might further strengthen the in vivo bactericidal effect.

Synthesis and selenate removal of magnesium–aluminum-layered double hydroxide particle using magnesium oxide

Synthesis and selenate removal of magnesium–aluminum-layered double hydroxide particle using magnesium oxide

Design and fabrication of enhanced corrosion-resistant LDH-Zn-G/Ni dual-layer structural coatings on magnesium alloys

A particular dual-layer structure of reinforced anti-corrosion magnesium aluminum-layered double hydroxide - Zn-G/Ni coating (LDH-ZGN), grown in situ the magnesium aluminum-layered double hydroxide coating (LDH) on the surface of the magnesium alloy, and a Zn-G/Ni composite coating was deposited on the LDH coating by low-pressure cold gas spraying (LPCGS). The LDH-ZGN was characterized by XRD, XPS, SEM, EDS, etc. The coating's corrosion protection and enhancement effect were explored through the electrochemical test of polarization curve, EIS, and coating immersion test. LDH-ZGN exhibited excellent corrosion resistance, mainly attributed to the synergy between reduced graphene oxide (rGO) and magnesium aluminum-layered double hydroxides (MgAl-LDH) and the enhancement effect of the coating under the particular dual-layer structure. • Build a dual-layer structural coating on the surface of the Mg alloy. • The cooperation of MgAl-LDH and rGO improves corrosion resistance. • rGO and Ni synergistically enhance the protective effect of the LDH-ZGN coating.

Enhanced Corrosion and Wear Resistance of LA43M Magnesium-Lithium Alloy with Magnesium-Aluminum Layered Double Hydroxide Coating

Enhanced Corrosion and Wear Resistance of LA43M Magnesium-Lithium Alloy with Magnesium-Aluminum Layered Double Hydroxide Coating

Poly(L-lactic acid)/poly(ethylene oxide) based composite electrospun fibers loaded with magnesium-aluminum layered double hydroxide nanoparticles

Two types of MgAl layered double hydroxide nanoparticles, MgAl LDH, at Mg:Al ratio of 2:1 and 3:1were prepared and used as inorganic fillers to improve the mechanical properties of poly(lactic acid)/poly(ethylene oxide) (PLA/PEO) electrospun composite fibers. Their detailed structural characterization was performed using X-ray diffraction (XRD) and transmission electron spectroscopy (TEM) techniques. Spectroscopic, thermal, mechanical, and morphological properties of the electrospun composite fibers, and cell proliferation on their surface, were examined. XRD and TEM analyses showed that the LDH nanoparticles were 50 nm in size and the Mg:Al ratio did not affect the average spacing between crystal layers. Fourier transform infrared (FTIR) and thermal analyses (TA) revealed the compatibility of the filler and the polymer matrix. The nanoparticles considerably improved the mechanical properties of the electrospun mats. The tensile strength and elongation at break values of the composite samples increased from 0.22 MPA to 0.40 MPa and 12.2 % to 45.66 %, respectively, resulting from the interaction between LDH and the polymer matrix. Scanning electron microscopy (SEM) and MTT analyses demonstrated that the electrospun composite fibers supported the SaOS-2 cells attachment and proliferation on the fiber surfaces, along with their suitable cytocompatibility.

Novel Magnetic Molecularly Imprinted Polymer (MMIP) Based on a Magnesium-Aluminum Layered Double Hydroxide for the Selective Dispersive Micro-Solid-Phase Extraction (SPE) of Fenitrothion with Analysis by Ion Mobility Spectrometry

A novel magnetic molecularly imprinted polymer (MMIP) based on magnesium-aluminum layered double hydroxide was synthesized and employed for the selective dispersive micro-solid phase extraction of fenitrothion prior to its determination using ion mobility spectrometry. The characterization of the prepared MMIP was performed using x-ray diffraction spectroscopy, Fourier transform infrared spectroscopy, thermal gravimetric analysis, vibrating sample magnetometry, and field emission scanning electron microscopy (FE-SEM). The adsorption capacity of magnetic layered double hydroxide modified with molecularly imprinted polymer (mag-LDH@MIP) was 24.0 mg g−1. The factors affecting extraction efficiency were optimized. Using the optimized conditions, the developed method provided favorable linearity (5.0–200.0 μg L−1), a low limit of detection (1.1 μg L−1), and a high preconcentration factor (67). The values for the intra- and inter-day relative standard deviation (n = 5) for fenitrothion were 3.3 and 4.5%, respectively. This developed method was successfully employed to determine trace quantities of fenitrothion in food and water.

Adsorption of Chromate Ions by Layered Double Hydroxide-Bentonite Nanocomposite for Groundwater Remediation.

Herein, magnesium/aluminum-layered double hydroxide (MgAl-LDH) and bentonite (BT) nanocomposites (LDH–BT) were prepared by co-precipitation (CP), exfoliation–reassembly (ER), and simple solid-phase hybridization (SP). The prepared LDH–BT nanocomposites were preliminarily characterized by using powder X-ray diffractometry, scanning electron microscopy, and zeta-potentiometry. The chromate adsorption efficacies of the pristine materials (LDH and bentonite) and the as-prepared nanocomposites were investigated. Among the composites, the LDH–BT_SP was found to exhibit the highest chromate removal efficiency of 65.7%. The effect of varying the LDH amount in the LDH–BT composite was further investigated, and a positive relationship between the LDH ratio and chromate removal efficiency was identified. The chromate adsorption by the LDH–BT_SP was performed under various concentrations (isotherm) and contact times (kinetic). The results of the isotherm experiments were well fitted with the Langmuir and Freundlich isotherm model and demonstrate multilayer chromate adsorption by the heterogeneous LDH–BT_SP, with a homogenous distribution of LDH nanoparticles. The mobility of the as-prepared LDH–BT_SP was investigated on a silica sand-filled column to demonstrate that the mobility of the bentonite is dramatically decreased after hybridization with LDH. Furthermore, when the LDH–BT_SP was injected into a box container filled with silica sand to simulate subsurface soil conditions, the chromate removal efficacy was around 43% in 170 min. Thus, it was confirmed that the LDH–BT prepared by solid-phase hybridization is a practical clay-based nanocomposite for in situ soil and groundwater remediation.

Insights into the Design and Electrocatalytic Activity of Magnesium Aluminum Layered Double Hydroxides: Application to Nonenzymatic Catechol Sensor.

The design of an efficient electrocatalyst for effective trace level determinations of noxious synthetic and or biological compounds is the unceasingly noteworthy conceptual approach for rapid technology. In this work, we designed a magnesium-aluminum layered double hydroxides (Mg-Al LDHs) nanocatalyst and applied it to the electrocatalytic determination of an extremely carcinogenic catechol sensor. A coprecipitation method was employed for synthesizing the nanocatalyst, and the structure, porous nature, and morphology were confirmed by X-ray diffraction, Fourier transform infrared spectroscopy, N2 adsorption-desorption isotherm, field emission-scanning electron microscopy, and transmission electron microscopy. The elemental composition was observed by energy dispersive X-ray analysis. The electrochemical studies were investigated with the help of cyclic voltammetry and differential pulse voltammetry techniques. The Mg-Al LDHs-based electrocatalyst was used to detect catechol by electrochemical measurements with different parameters. The proposed catechol sensor shows a wide dynamic range (0.007-200 μM) with a lower level of detection (2.3 nm) and sensitivity (3.57 μA μM-1 cm-2). The excellent sensor performance is attributed to the high surface area, fast electron transfer, more active sites, and excellent flexibility. This study depicts the proposed sensor as probable to practical in a scientific investigation. In addition, the modified electrode showed greater selectivity and was used in the detection of fatal contaminants in instant treatment strategies. Moreover, the Mg-Al LDHs confirmed auspicious real sample scrutiny with noteworthy retrieval outcomes in lake water samples which exposed improved consequences.

Enhanced Corrosion Resistance of Layered Double Hydroxide Films on Mg Alloy: The Key Role of Cationic Surfactant.

In this study, dense anticorrosion magnesium–aluminum layered double hydroxide (MgAl-LDH) films were prepared for the first time by introducing a cationic surfactant tetradecyltrimethyl ammonium bromide (TTAB) in the process of in situ hydrothermal synthesis of Mg-Al LDH films on an AZ31 magnesium alloy. Results of XRD, FTIR, and SEM confirmed that TTAB forms the MgAl-LDH-TTAB, although TTAB cannot enter into LDH layers, and MgAl-LDH-TTAB powders are much smaller and more homogenous than MgAl-CO32−-LDH powders. Results of SEM, EDS, mapping, and XPS confirmed that TTAB forms the MgAl-LDH-TTAB films and endows LDH films with denser structure, which provides films with better shielding efficiency. Results of potentiodynamic polarization curves (PDP) and electrochemical impedance spectroscopy (EIS) confirmed that MgAl-LDH-TTABx g films have better corrosion resistance than an MgAl-CO32−-LDH film. The corrosion current density (icorr) of the MgAl-LDH-TTAB0.35 g film in 3.5 wt.% NaCl solution was reduced to 1.09 × 10−8 A.cm−2 and the |Z|f = 0.05 Hz value was increased to 4.48 × 105 Ω·cm2. Moreover, the increasing concentration of TTAB in MgAl-LDH-TTABx g (x = 0.025, 0.05, 0.1, 0.2 and 0.35) provided denser outer layer LDH films and thereby increased the corrosion resistance of the AZ31 Mg alloy. Additionally, the |Z|f = 0.05 Hz values of the MgAl-LDH-TTAB0.35 g film still remained at 105 Ω·cm2 after being immersed in 3.5 wt.% NaCl solution for 168 h, implying the good long-term corrosion resistance of MgAl-LDH-TTABx g films. Therefore, introducing cationic surfactant in the process of in situ hydrothermal synthesis can be seen as a novel approach to creating efficient anticorrosion LDH films for Mg alloys.

Synthesis and characterisation of layered double hydroxides with varying divalent metal cations: Mg2+, Zn2+, Ca2+

This study aims to investigate the physicochemical properties of layered double hydroxides (LDH) with different divalent metal (M2+) cations. A series of nitrate-based LDH materials was synthesised by using aluminium (Al3+) as a trivalent cation (M3+) with varying M2+ cations such as magnesium (Mg2+), zinc (Zn2+), and calcium (Ca2+) ions to prepare magnesium–aluminium-layered double hydroxide (MgAl-LDH), zinc–aluminium-layered double hydroxide (ZnAl-LDH), and calcium–aluminium-layered double hydroxide (CaAl-LDH), respectively. MgAl-LDH and ZnAl-LDH were synthesised by the co-precipitation method, whereas CaAl-LDH was prepared by the hydrothermal method. The samples were characterised by powder X-ray diffraction (PXRD), Fourier transform infrared spectra (FTIR), thermogravimetric and differential thermogravimetric analysis (TGA/DTG), field emission scanning electron microscope (FESEM), and accelerated surface area and porosity (ASAP) analysis. The PXRD patterns show that MgAl-LDH (9.8 Å) had the greatest interlayer spacing, followed by ZnAl-LDH (8.9 Å), and CaAl-LDH (8.7 Å). The FTIR spectra clearly confirms the presence of nitrate ions in the LDH structure. Two-step degradation behaviour of the samples was observed in the TGA curve. The LDHs exhibit Type IV isotherms and hexagonal structures were observed on the FESEM images.

Cobalt nanoparticle supported on layered double hydroxide: Effect of nanoparticle size on catalytic hydrogen production by NaBH4 hydrolysis

Catalytic hydrolysis of sodium borohydride (NaBH4) is a promising method to provide clean hydrogen (H2) energy for portable devices. Therefore, designing a non-noble metal catalyst that performs well in this hydrolysis is essential. Cobalt-nanoparticles (Co-NPs) supported on magnesium-aluminium layered double hydroxide (LDH) with various mean diameter were synthesized by changing concentration of cobalt-citrate anion (Co-citrate) precursor used for ion exchange with the LDH host. Then the Co-citrate intercalated LDHs were reduced with NaBH4 to form Co-NPs. Evidence of successful intercalation was shown by X-ray diffraction (XRD) and Fourier-Transform Infrared spectroscopy (FT-IR). Transmission Electron Microscope (TEM) and Scanning TEM (STEM) observations revealed that Co-NPs were in metallic state and their mean diameter increased with the concentration of Co-citrate solution. Nitrogen physisorption isotherms showed that the surface structure of LDHs transformed from non-porous to mesoporous after chemical reduction, which indicated that the Co-NPs were formed in the interlayer of LDHs. Catalytic hydrolysis of NaBH4 at 25 °C clarified that the catalyst synthesized from 6 mM Co-citrate solution showed the highest H2 generation rate of 4520 ± 251 mL min−1·gCo−1, indicating the catalyst had the optimum size of Co-NP. This activity could be considered relatively higher compared to unsupported cobalt and many other supported cobalt-base catalysts previously reported. It was also clearly shown that size of Co-NPs supported on LDH could be a significant parameter as it allowed better accessibility of reactants to the active catalyst surface to obtain maximum activity. For this optimum catalyst, the activation energy was evaluated to be 56.9 kJ mol−1. Although the catalyst was able to achieve almost the same conversion when the catalyst was repeatedly tested five times under the same condition, the catalytic activity decreased gradually. Overall, it could be revealed that Co-NPs supported on LDHs have a huge potential to be used for H2 energy production.

A nanohybrid layered double hydroxide as an effective carrier for delivery and application of the phytohormone indole acetic acid

The increasing need for agricultural production on the one hand, and requirements for greener and more sustainable agricultural practices on the other, have led to a growing demand for efficient and eco-friendly materials for the delivery of agrochemicals. Here we describe, the use of layered double hydroxide (LDH) particles as a carrier for a plant hormone. Magnesium–aluminum LDH intercalated with indole-3-acetic acid (IAA) was synthesized by co-precipitation method, characterized, and examined for real-life applications. Scanning electron microscopy revealed that both pristine and IAA-intercalated LDH particles exhibit hexagonal platelet morphology. X-ray diffraction showed a hydrotalcite-like structure and, together with Fourier transform infrared spectroscopy, verified the efficacious intercalation of IAA anions. The intercalation protected the IAA from enzymatic degradation and allowed its sustained release, as demonstrated by enzymatic stability and release tests, correspondingly. In-vivo assay revealed that intercalation inside LDH significantly increases the biological activity of IAA in promoting adventitious root development in plant cuttings. Results demonstrate the applicability of LDH as an advanced, effective, and sustainable carrier that overcomes the practical limitations of agrochemicals and significantly enhances their efficiency.

Facile Synthesis of Nanosized Magnesium-Aluminium Layered Double Hydroxides

We report facile methods of preparing nanosized hydrotalcite-like compounds, the layered double hydroxides (LDH), with ordinary chemistry laboratory settings to educate the young scientists from high schools to undergraduate university level fostering their research interest in preparing these nanomaterials of practical importance. Coprecipitation and urea hydrolysis methods have been recommended as facile routes of preparing the magnesium-aluminum layered double hydroxides (Mg-Al LDHs). The LDH thus prepared were characterized by Fourier transform infrared (FTIR) spectroscopic and powder X-ray diffraction (XRD) techniques. The observed weakening of some FTIR peaks and XRD planes shifting concerning standard JCPDS 89-5434 data implied the slight structural variation of the compounds and the presence of impurities. The average grain diameter of LDH particles was found in the range of 20 to 60 nm.

Layered double hydroxide supported cobalt nanocluster: size control and the effect in catalytic hydrogen generation

Synthesizing metal nanoclusters with diameters smaller than 5nm is challenging, but desirable because of the high ratio of surface area to interior atom. However, in this report it was achieved by utilizing magnesium-aluminium layered double hydroxide (Mg/Al-LDH) as a host for cobalt citrate anion precursor, which was later reduced into cobalt nanoclusters (Co-NC). Size of the Co-NC was controlled by changing the concentration of cobalt-citrate (Co-citrate) precursor during anion exchange. XRD and FTIR showed that Co-citrate precursor was successfully intercalated on the LDH while nitrogen adsorption/desorption isotherms confirmed that mesopores in the sample were formed after chemical reduction. Furthermore, TEM/STEM observations confirmed the formation of Co-NC. It was also verified that reducing the concentration of Co-citrate from 4mM to 0.5mM resulted in a reduction in the size of Co-NC from 4.4 to 1.3 nm. However, catalytic hydrogen generation from sodium borohydride (NaBH4) hydrolysis experiment indicated that catalytic activity decreased as the size of Co-NC decreases. This is mainly attributed to the limitation in mass transport within the interlamellar space of the smaller cluster LDH compared to the bigger one. Overall, Co-NC-LDH is a promising catalyst for NaBH4 hydrolysis. However, an optimum Co-NC size is critical for enhanced catalytic activity.

Biodegradation of Poly (Butylene Succinate) (PBS)/Stearate Modified Magnesium-Aluminium Layered Double Hydroxide Composites under Marine Conditions Prepared via Melt Compounding.

In the present work, polybutylene succinate (PBS)/stearate modified magnesium-aluminium layered double hydroxide (St-Mg-Al LDH) composites were prepared via melt processing and the effect of different loadings of St-Mg-Al LDH on the degradation behaviour of PBS under marine conditions was investigated. The morphological, mechanical and thermal characteristics of the composites were studied using different characterisation techniques. Optical imaging and scanning electron microscopy revealed that the incorporation of St-Mg-Al LDH accelerates the degradation of PBS along with the activity of microorganisms adhered to the composite films. PBS/St-Mg-Al LDH composites are found to have lower thermal degradation temperatures than those of pure PBS. The decrease in thermal stability is correlated with the degradation of PBS due to the catalytic action Mg and Al present in LDH. Tensile and DMA analysis revealed that the addition of St-Mg-Al LDH did not have a significant impact on the mechanical properties of PBS.

Release of a liver anticancer drug, sorafenib from its PVA/LDH- and PEG/LDH-coated iron oxide nanoparticles for drug delivery applications

The use of nanocarriers composed of polyethylene glycol- and polyvinyl alcohol-coated vesicles encapsulating active molecules in place of conventional chemotherapy drugs can reduce many of the chemotherapy-associated challenges because of the increased drug concentration at the diseased area in the body. The present study investigated the structure and magnetic properties of iron oxide nanoparticles in the presence of polyvinyl alcohol and polyethylene glycol as the basic surface coating agents. We used superparamagnetic iron oxide nanoparticles (FNPs) as the core and studied their effectiveness when two polymers, namely polyvinyl alcohol (PVA) and polyethylene glycol (PEG), were used as the coating agents together with magnesium–aluminum-layered double hydroxide (MLDH) as the nanocarrier. In addition, the anticancer drug sorafenib (SO), was loaded on MLDH and coated onto the surface of the nanoparticles, to best exploit this nano-drug delivery system for biomedical applications. Samples were prepared by the co-precipitation method, and the resulting formation of the nanoparticles was confirmed by X-ray, FTIR, TEM, SEM, DLS, HPLC, UV–Vis, TGA and VSM. The X-ray diffraction results indicated that all the as-synthesized samples contained highly crystalline and pure Fe3O4. Transmission electron microscopy analysis showed that the shape of FPEGSO-MLDH nanoparticles was generally spherical, with a mean diameter of 17 nm, compared to 19 nm for FPVASO-MLDH. Fourier transform infrared spectroscopy confirmed the presence of nanocarriers with polymer-coating on the surface of iron oxide nanoparticles and the existence of loaded active drug consisting of sorafenib. Thermogravimetric analyses demonstrated the thermal stability of the nanoparticles, which displayed enhanced anticancer effect after coating. Vibrating sample magnetometer (VSM) curves of both produced samples showed superparamagnetic behavior with the high saturation magnetization of 57 emu/g for FPEGSO-MLDH and 49 emu/g for FPVASO-MLDH. The scanning electron microscopy (SEM) images showed a narrow size distribution of both final samples. The SO drug loading and the release behavior from FPEGSO-MLDH and FPVASO-MLDH were assessed by ultraviolet–visible spectroscopy. This evaluation showed around 85% drug release within 72 h, while 74% of sorafenib was released in phosphate buffer solution at pH 4.8. The release profiles of sorafenib from the two designed samples were found to be sustained according to pseudo-second-order kinetics. The cytotoxicity studies confirmed the anti-cancer activity of the coated nanoparticles loaded with SO against liver cancer cells, HepG2. Conversely, the drug delivery system was less toxic than the pure drug towards fibroblast-type 3T3 cells.