YBa2Cu3O7−δ grain boundary bi-epitaxial Josepshon junctions (JJs) allow a very clear demonstration of Josephson current variation with the misorientation angle, consistent with the d-wave symmetry of the superconducting order parameter in cuprate, high temperature superconductors. Our bi-epitaxial junctions show a strong suppression of the first harmonic, I1 sin o, of the current phase relation when tunneling from a lobe into a node of the superconducting gap function. In these configurations, the contribution of the second harmonic, I2 sin 2o, becomes of the same magnitude as the first one, giving rise to a characteristic two-well Josephson potential as a function of phase o instead of the usual single well. This characteristic intrinsic property has suggested proposals of a new class of qu-bit named “quiet” because of the existence a spontaneously degenerate fundamental state without the need of applying an external field. Our experiments probe the macroscopic quantum properties in a d-wave Josephson junction by measuring macroscopic quantum tunneling and energy level quantization. The switching current out of the zero voltage state is measured as a function of temperature down to 20 mK. The temperature variation of the width of an ensemble of switching events goes over from one, which is characteristic of a thermal activation of phase fluctuations to a temperature independent width which is a token of quantum tunneling of the phase. The transition regime is affected by the two-well potential in a 45∘ misorientation junction as the second harmonic term gives rise to additional thermal transitions. The difference between quantized energy levels in the harmonic potential was determined by microwave spectroscopy. From the broadening of energy levels, it was possible to extract a Q-value of about 40 for the phase oscillations. The relatively high Q indicates quantum coherence over a sizeable time in d-wave junctions and gives hopes for a realization of a “quiet” high-Tc qu-bit. The contributions of V. L. Ginzburg to several different fields of physics are impressive and long standing. In superconductivity the Ginzburg–Landau theory, for instance, still represents a very powerful approach to model a huge number of different physical systems. High Temperature Superconductors (HTS) have strongly influenced research of the last 20 years and their d-wave order parameter symmetry represents one of the most intriguing features from both the fundamental point of view and some types of innovative long-term applications.