The problems of food shortages through population growth, depletion of minerals, raw materials, mineral and energy resources, climate change, environmental pollution, etc. are solved by the bioeconomy, the narrative of which is the use of natural resources on a renewable basis in achieving sustainable development goals. Ukraine has significant knowledge, agro-industrial, forest, land and water potential for the introduction of biotechnology and sustainable bioeconomy, which includesthe production, exploitation and use of biological resources, processes and systems to provide products, processes and services across all economic sectors. The purpose of the article is to determine the directions of bioeconomy development taking into account the global and macroeconomic crisis caused by military actions on the territory of Ukraine. The research methodology involves the use of general scientific and specific methods used in economics, ecology and biotechnology, and is based on an interdisciplinary approach. The scientific novelty of the obtained results is to determine the directions of development of Ukrainian bioeconomy based on the use of biotechnology in food, agricultural, medical, pharmaceutical, industrial, environmental sphere, green energy, water management and forestry. Conclusions. The study found that Ukraine can create a sustainable, innovative, resource-efficient economy integrated into the world, which combines food security with the sustainable use of renewable energy sources and resources for industry. Biomass can replace fossil fuel products, and residues and waste, agricultural and forestry raw materials can be used to ensure environmentally friendly production. In the post-war period, the bioeconomy should be a priority to support Ukrainian economic recovery, as a sustainable bioeconomy returns resources to the real sector, creates jobs, promotes environmental production and consumption, and makes optimal use of limited resources on a circular basis. Keywords: bioeconomy, sustainable bioeconomy, biotechnology, biomass, postwar economic recovery