Machine Learning For Diagnosis Research Articles

Application of predictive model based on CT radiomics and machine learning in diagnosis for occult locally advanced esophageal squamous cell carcinoma before treatment: A two-center study

PurposeDevelopment and validation of a radiomics model for predicting occult locally advanced esophageal squamous cell carcinoma (LA-ESCC) on computed tomography (CT) radiomic features before implementation of treatment. MethodsThe study retrospectively collected 574 patients with esophageal squamous cell carcinoma (ESCC) from two medical centers, which were divided into three cohorts for training, internal and external validation. After delineating volume of interest (VOI), radiomics features were extracted and subjected to feature selection using three robust methods. Subsequently, 10 machine learning models were constructed, among which the optimal model was utilized to establish a radiomics signature. Furthermore, a predictive nomogram incorporating both clinical and radiomics signatures was developed. The performance of these models was evaluated through receiver operating characteristic curves, calibration curves, decision curve analysis as well as measures including accuracy, sensitivity, and specificity. ResultsA total of 19 radiomics features were selected. The multilayer perceptron (MLP), which was found to be optimal, achieved an AUC of 0.919, 0.864 and 0.882 in the training, internal and external validation cohorts, respectively. Similarly, MLP showed good accuracy in distinguish occult LA-ESCC in subgroup of cT1–2N0M0 diagnosed by clinicians with 0.803 and 0.789 in two validation cohorts respectively. By incorporating the radiomics signature with clinical signature, a predictive nomogram demonstrated superior prediction performance with an AUC of 0.877 and accuracy of 0.85 in external validation cohort. ConclusionThe radiomics and machine learning model can offers improved accuracy in prediction of occult LA-ESCC, providing valuable assistance to clinicians when choosing treatment plans.

Machine Learning in Diagnosis and Prognosis of Lung Cancer by PET-CT.

As a disease with high morbidity and high mortality, lung cancer has seriously harmed people's health. Therefore, early diagnosis and treatment are more important. PET/CT is usually used to obtain the early diagnosis, staging, and curative effect evaluation of tumors, especially lung cancer, due to the heterogeneity of tumors and the differences in artificial image interpretation and other reasons, it also fails to entirely reflect the real situation of tumors. Artificial intelligence (AI) has been applied to all aspects of life. Machine learning (ML) is one of the important ways to realize AI. With the help of the ML method used by PET/CT imaging technology, there are many studies in the diagnosis and treatment of lung cancer. This article summarizes the application progress of ML based on PET/CT in lung cancer, in order to better serve the clinical. In this study, we searched PubMed using machine learning, lung cancer, and PET/CT as keywords to find relevant articles in the past 5 years or more. We found that PET/CT-based ML approaches have achieved significant results in the detection, delineation, classification of pathology, molecular subtyping, staging, and response assessment with survival and prognosis of lung cancer, which can provide clinicians a powerful tool to support and assist in critical daily clinical decisions. However, ML has some shortcomings such as slightly poor repeatability and reliability.

Magnifying Networks for Histopathological Images with Billions of Pixels.

Amongst the other benefits conferred by the shift from traditional to digital pathology is the potential to use machine learning for diagnosis, prognosis, and personalization. A major challenge in the realization of this potential emerges from the extremely large size of digitized images, which are often in excess of 100,000 × 100,000 pixels. In this paper, we tackle this challenge head-on by diverging from the existing approaches in the literature-which rely on the splitting of the original images into small patches-and introducing magnifying networks (MagNets). By using an attention mechanism, MagNets identify the regions of the gigapixel image that benefit from an analysis on a finer scale. This process is repeated, resulting in an attention-driven coarse-to-fine analysis of only a small portion of the information contained in the original whole-slide images. Importantly, this is achieved using minimal ground truth annotation, namely, using only global, slide-level labels. The results from our tests on the publicly available Camelyon16 and Camelyon17 datasets demonstrate the effectiveness of MagNets-as well as the proposed optimization framework-in the task of whole-slide image classification. Importantly, MagNets process at least five times fewer patches from each whole-slide image than any of the existing end-to-end approaches.

Revolutionizing Healthcare by Unleashing the Power of Machine Learning in Diagnosis and Treatment

Revolutionizing Healthcare by Unleashing the Power of Machine Learning in Diagnosis and Treatment

Image processing and machine learning for diagnosis and screening of craniosynostosis in children

Objectivecraniosynostosis (CSO) is a congenital disorder resulting from early closure of cranial sutures in newborns, while could cause significant cosmetic and neurodevelopmental problems. As a standard method, different craniometric indices are measured directly from child head or from their 3D CT scan of skull for diagnosis or in post-operative follow-up period. We propose a novel telehealth-compatible deep learning neural network-based method for identifying different craniometric indices in non-syndromic CSO patients 2D photographic data. Methods624 pre-operative and post-operative top-down cranial digital images of 145 craniosynostotic infants (59 sagittal, 55 metopic and 31 unicoronal synostosis) who had surgery at Mofid Children’s Hospital, Tehran, Iran were used in a deep learning neural network algorithm. Head boundary was defined by a faster region-based convolutional neural network (Faster R-CNN) and then different cranial indices (cranial index (CI), cranial vault asymmetry index (CVAI), anterior-posterior width ratio (APWR), anterior-midline width ratio (AMWR) and left–right height ratio (LRHR)) were calculated from segmented images. Accuracy, sensitivity and specificity were calculated for software versus specialist data association between cranial indices were evaluated with inter-class correlation coefficients. ResultsThe head border was segmented in the proposed images with accuracy of 88.67 ± 1.94 in comparison with standard hand made procedure with a sensitivity of 86.91 ± 3.75 and specificity of 88.60 ± 4.81. Among calculated cranial indices, significant decrease in CI value is most useful for diagnosis of sagittal synostosis (CIsagittal = 71.97 ± 4.33), significant increase in CVAI value and significant decrease in LRHR value is most appropriate for unicoronal suture synostosis diagnosis (CVAIunicoronal=6.79±3.80 and LRHRunicoronal = 0.91 ± 0.05) and significant decrease in APWR and AMWR values could be indicator of metopic synostosis (AMWRmetopic= 0.77 ± 0.04 and APWRmatopic = 0.83 ± 0.05). ConclusionDeep learning neural network algorithms could have high levels of capability in calculating cranial indices from routine 2D digital images of non-syndromic craniosynostotic children and act as a substitute for optical scanner or 3D CT-based craniometrics. This method could act as a corner stone for developing a software for a mobile platform that that would allow for screening by tele-medicine or in a primary care setting.

Bio-medical imaging (X-ray, CT, ultrasound, ECG), genome sequences applications of deep neural network and machine learning in diagnosis, detection, classification, and segmentation of COVID-19: a Meta-analysis & systematic review.

This review investigates how Deep Machine Learning (DML) has dealt with the Covid-19 epidemic and provides recommendations for future Covid-19 research. Despite the fact that vaccines for this epidemic have been developed, DL methods have proven to be a valuable asset in radiologists' arsenals for the automated assessment of Covid-19. This detailed review debates the techniques and applications developed for Covid-19 findings using DL systems. It also provides insights into notable datasets used to train neural networks, data partitioning, and various performance measurement metrics. The PRISMA taxonomy has been formed based on pretrained(45 systems) and hybrid/custom(17 systems) models with radiography modalities. A total of 62 systems with respect to X-ray(32), CT(19), ultrasound(7), ECG(2), and genome sequence(2) based modalities as taxonomy are selected from the studied articles. We originate by valuing the present phase of DL and conclude with significant limitations. The restrictions contain incomprehensibility, simplification measures, learning from incomplete labeled data, and data secrecy. Moreover, DML can be utilized to detect and classify Covid-19 from other COPD illnesses. The proposed literature review has found many DL-based systems to fight against Covid19. We expect this article will assist in speeding up the procedure of DL for Covid-19 researchers, including medical, radiology technicians, and data engineers.

A narrative review on machine learning in diagnosis and prognosis prediction for tongue squamous cell carcinoma.

Tongue squamous cell carcinoma (TSCC) is the most common subtype of oral cavity squamous cell carcinoma (OCSCC), and it also has the worst prognosis. It is crucial to find an effective way to solve the challenges in diagnosis and prognosis prediction for TSCC. Machine learning (ML) has been widely used in medical research and has shown good performance. It can be used for feature extraction, feature selection, model construction, etc. Radiomics and deep learning (DL), the new components of ML, have also been utilized to explore the relationship between image features and diseases. The current study aimed to highlight the importance of ML as a potential method for addressing the challenges in diagnosis and prognosis prediction of TSCC by reviewing studies on ML in TSCC. The studies on ML in TSCC in PubMed, Scopus, Web of Science, and China National Knowledge Infrastructure published between the dates of inception of these databases and April 30, 2022, were reviewed. ML (including radiomics and DL) which was used in diagnosis and prognosis prediction for TSCC, has shown promising performance. Despite its limitations, ML is still a potential approach that can help to deal with the challenges in diagnosis and prognosis prediction for TSCC. Nevertheless, more efforts are needed to enhance the usefulness of ML in this field.

The Use of Artificial Intelligence in Orthopedics: Applications and Limitations of Machine Learning in Diagnosis and Prediction

Over the last several years, the impact of Artificial Intelligence on the world and on society has been undeniable. More specifically, a subfield, known as Machine Learning (ML), is driving innovation in a vast variety of fields as it denotes the ability of a machine to identify relationships between data without explicit criteria, emulating a human-like type of learning. Over the last decade, research efforts have also been focused on orthopedics in order to provide help and assistance to surgeons and clinicians in their daily tasks. The purpose of this paper is to serve as a guide by presenting the most recent research and achievements in orthopedics concerning these new technologies, by exposing the main concepts and limitations of different applications, and tackling the main problems concerning both the field and the technology itself. The main ML techniques will be introduced and qualitatively explored, by considering the indexes that better identify the performance of the models; then, the main two applications will be addressed: diagnosis and prediction. Finally, a discussion about the limitations of the studies and technologies will be proposed.

Design a Workflow for the Application of Machine Learning in Diagnosis of Cancer Metastasis

Benign tumors can turn into malignant tumors if they are metastatic. Pathological analysis of cancer tissue is the major method for the diagnosis of cancer malignancy and has been widely used for decades. The analysis is based on the specific features of the malignant tissues with metastatic cancer cells. Nevertheless, the diagnosis fully relies on experts’ efforts, which is a time-consuming process. Also, the decision based on experts’ experiences could be empirical. In this mini review work, we introduced the definition and the diagnosis of cancer malignancy and pointed out the disadvantages of the traditional diagnosis. To improve the efficiency and accuracy of the diagnosis, we proposed a novel workflow for the diagnosis of cancer malignancy. In this workflow, we integrated the in vitro primary cancer cell culture and the machine learning algorithms. After training with big data that consists of images with known features of malignancy status, the machine learning algorithms can recognize the cancer malignancy to perform the diagnosis for cancer patients.

Machine Learning for Diagnosis of Alzheimer’s Disease and Early Stages

According to the WHO, approximately 50 million people worldwide have dementia and there are nearly 10 million new cases every year. Alzheimer’s disease is the most common form of dementia and may contribute to 60–70% of cases. It has been proved that early diagnosis is key to promoting early and optimal management. However, the early stage of dementia is often overlooked and patients are typically diagnosed when the disease progresses to a more advanced stage. The objective of this contribution is to predict Alzheimer’s early stages, not only dementia itself. To carry out this objective, different types of SVM and CNN machine learning classifiers will be used, as well as two different feature selection algorithms: PCA and mRMR. The different experiments and their performance are compared when classifying patients from MRI images. The newness of the experiments conducted in this research includes the wide range of stages that we aim to predict, the processing of all the available information simultaneously and the Segmentation routine implemented in SPM12 for preprocessing. We will make use of multiple slices and consider different parts of the brain to give a more accurate response. Overall, excellent results have been obtained, reaching a maximum F1 score of 0.9979 from the SVM and PCA classifier.

Applications of Artificial Intelligence and Machine Learning in Diagnosis and Prognosis of COVID-19 infection: A systematic review

Introduction: Our aim in this study was to summarize information on the use of intelligent models for predicting and diagnosing the Coronavirus disease 2019 (COVID-19) to help early and timely diagnosis of the disease.Material and Methods: A systematic literature search included articles published until 20 April 2020 in PubMed, Web of Science, IEEE, ProQuest, Scopus, bioRxiv, and medRxiv databases. The search strategy consisted of two groups of keywords: A) Novel coronavirus, B) Machine learning. Two reviewers independently assessed original papers to determine eligibility for inclusion in this review. Studies were critically reviewed for risk of bias using prediction model risk of bias assessment tool.Results: We gathered 1650 articles through database searches. After the full-text assessment 31 articles were included. Neural networks and deep neural network variants were the most popular machine learning type. Of the five models that authors claimed were externally validated, we considered external validation only for four of them. Area under the curve (AUC) in internal validation of prognostic models varied from .94 to .97. AUC in diagnostic models varied from 0.84 to 0.99, and AUC in external validation of diagnostic models varied from 0.73 to 0.94. Our analysis finds all but two studies have a high risk of bias due to various reasons like a low number of participants and lack of external validation.Conclusion: Diagnostic and prognostic models for COVID-19 show good to excellent discriminative performance. However, these models are at high risk of bias because of various reasons like a low number of participants and lack of external validation. Future studies should address these concerns. Sharing data and experiences for the development, validation, and updating of COVID-19 related prediction models is needed.

An increasing number of convolutional neural networks for fracture recognition and classification in orthopaedics

AimsThe number of convolutional neural networks (CNN) available for fracture detection and classification is rapidly increasing. External validation of a CNN on a temporally separate (separated by time) or geographically separate (separated by location) dataset is crucial to assess generalizability of the CNN before application to clinical practice in other institutions. We aimed to answer the following questions: are current CNNs for fracture recognition externally valid?; which methods are applied for external validation (EV)?; and, what are reported performances of the EV sets compared to the internal validation (IV) sets of these CNNs?MethodsThe PubMed and Embase databases were systematically searched from January 2010 to October 2020 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The type of EV, characteristics of the external dataset, and diagnostic performance characteristics on the IV and EV datasets were collected and compared. Quality assessment was conducted using a seven-item checklist based on a modified Methodologic Index for NOn-Randomized Studies instrument (MINORS).ResultsOut of 1,349 studies, 36 reported development of a CNN for fracture detection and/or classification. Of these, only four (11%) reported a form of EV. One study used temporal EV, one conducted both temporal and geographical EV, and two used geographical EV. When comparing the CNN’s performance on the IV set versus the EV set, the following were found: AUCs of 0.967 (IV) versus 0.975 (EV), 0.976 (IV) versus 0.985 to 0.992 (EV), 0.93 to 0.96 (IV) versus 0.80 to 0.89 (EV), and F1-scores of 0.856 to 0.863 (IV) versus 0.757 to 0.840 (EV).ConclusionThe number of externally validated CNNs in orthopaedic trauma for fracture recognition is still scarce. This greatly limits the potential for transfer of these CNNs from the developing institute to another hospital to achieve similar diagnostic performance. We recommend the use of geographical EV and statements such as the Consolidated Standards of Reporting Trials–Artificial Intelligence (CONSORT-AI), the Standard Protocol Items: Recommendations for Interventional Trials–Artificial Intelligence (SPIRIT-AI) and the Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis–Machine Learning (TRIPOD-ML) to critically appraise performance of CNNs and improve methodological rigor, quality of future models, and facilitate eventual implementation in clinical practice.Cite this article: Bone Jt Open 2021;2(10):879–885.

Robust vibration-based faults diagnosis machine learning model for rotating machines to enhance plant reliability

Plant availability and reliability can be improved through a robust condition monitoring and fault diagnosis model to predict the current status (healthy or faulty) of any machines and critical assets. The model can then predict the exact fault for the faulty asset so that remedial maintenance can be carried out in a planned plant outage. Nowadays, the artificial intelligence (AI)-based machine learning (ML) model seems to be current trend to meet these requirements. Hence, the paper is also proposing such vibration-based faults diagnosis ML model through an experimental rotating rig. Here, the 2-Steps approach is used with the ML model to easy the industrial operation and maintenance process. The Step-1 provides the information about the asset health status such as healthy or faulty. The Step-2 then identifies the exact nature of fault to aid the decision making for the fault rectification and maintenance activities to avoid the risk of failure and enhance the reliability.

Machine learning in diagnosis and disability prediction of multiple sclerosis using optical coherence tomography

BackgroundMultiple sclerosis (MS) is a neurodegenerative disease that affects the central nervous system, especially the brain, spinal cord, and optic nerve. Diagnosis of this disease is a very complex process and generally requires a lot of time. In addition, treatments are applied without any information on the disability course in each MS patient. For these two reasons, the objective of this study was to improve the MS diagnosis and predict the long-term course of disability in MS patients based on clinical data and retinal nerve fiber layer (RNFL) thickness, measured by optical coherence tomography (OCT). Material and methodsA total of 104 healthy controls and 108 MS patients, 82 of whom had a 10-year follow-up, were enrolled. Classification algorithms such as multiple linear regression (MLR), support vector machines (SVM), decision tree (DT), k-nearest neighbours (k-NN), Naïve Bayes (NB), ensemble classifier (EC) and long short-term memory (LSTM) recurrent neural network were tested to develop two predictive models: MS diagnosis model and MS disability course prediction model. ResultsFor MS diagnosis, the best result was obtained using EC (accuracy: 87.7%; sensitivity: 87.0%; specificity: 88.5%; precision: 88.7%; AUC: 0.8775). In line with this good performance, the accuracy was 85.4% using k-NN and 84.4% using SVM. And, for long-term prediction of MS disability course, LSTM recurrent neural network was the most appropriate classifier (accuracy: 81.7%; sensitivity: 81.1%; specificity: 82.2%; precision: 78.9%; AUC: 0.8165). The use of MLR, SVM and k-NN also showed a good performance (AUC ≥ 0.8). ConclusionsThis study demonstrated that machine learning techniques, using clinical and OCT data, can help establish an early diagnosis and predict the course of MS. This advance could help clinicians select more specific treatments for each MS patient. Therefore, our findings underscore the potential of RNFL thickness as a reliable MS biomarker.

Software-Based Testing Kit Using Machine Learning for Diagnosis and Predictive Analytics of COVID-19 Patients

Nowadays, the global community is being affected with COVID-19 disease and integrated infections, which are becoming a menace to the whole world. Research is going on to find out the solution, and still, no particular vaccination or solution has been achieved. This research work is focusing on the analytics of dataset extracted, which has assorted attributes, and these attributes are processed in the machine learning algorithm so that the prime factor can be recognized. In this research manuscript, the usage of COVID-19 dataset is done and trained using supervised learning approach of artificial neural network (ANN) on Levenberg-Marquardt (LM) algorithm so that the predictions of the test patients can be done on the key attributes of age, gender, location, and related parameters. The selection of LM-based implementation with ANN is done as it is the faster approach compared to other functions in neural networks.

Machine learning in diagnosis of coronary artery disease.

Machine learning in diagnosis of coronary artery disease.

Machine learning for diagnosis and monitoring of sleep apnea

This paper contains a review and analysis of applications of modern ma-chine learning approaches to solve sleep apnea severity level detection by localization of apnea episodes and prediction of the subsequent apnea episodes. We demonstrate that signals provided by cheap wearable devices can be used to solve typical tasks of sleep apnea detection. We review major publicly available datasets that can be used for training respective deep learning models, and we analyze the usage options of these datasets. In particular, we prove that deep learning could improve the accuracy of sleep apnea classification, sleep apnea localization, and sleep apnea prediction, especially using more complex models with multimodal data from several sensors.

Applying Artificial Intelligence for Diagnostic Classification of Korean Autism Spectrum Disorder.

ObjectiveThe primary objective of this study was to predict subgroups of autism spectrum disorder (ASD) based on the Diagnostic Statistical Manual for Mental Disorders-IV Text Revision (DSM-IV-TR) by machine learning (ML). The secondary objective was to set up a ranking of Autism Diagnostic Interview-Revised (ADI-R) diagnostic algorithm items based on ML, and to confirm whether ML can sufficiently predict the diagnosis with these minimum items. MethodsIn the first experiment, a multiclass decision forest algorithm was applied, and the diagnostic algorithm score value of 1,269 Korean ADI-R test data was used for prediction. In the second experiment, we used 539 Korean ADI-R case data (over 48 months with verbal language) to apply mutual information to rank items used in the ADI diagnostic algorithm. ResultsIn the first experiment, the results of predicting in the case of pervasive developmental disorder not otherwise specified as “ASD” were almost three times higher than predicting it as “No diagnosis.” In the second experiment, the top 10 ranking items of ADI-R were mainly related to the quality abnormality of communication. ConclusionIn conclusion, we verified the applicability of ML in diagnosis and found that the application of artificial intelligence for rapid diagnosis or screening of ASD patients may be useful.

Robust Feature Engineering for Parkinson Disease Diagnosis: New Machine Learning Techniques

Background Parkinson disease (PD) is a common neurodegenerative disorder that affects between 7 and 10 million people worldwide. No objective test for PD currently exists, and studies suggest misdiagnosis rates of up to 34%. Machine learning (ML) presents an opportunity to improve diagnosis; however, the size and nature of data sets make it difficult to generalize the performance of ML models to real-world applications. Objective This study aims to consolidate prior work and introduce new techniques in feature engineering and ML for diagnosis based on vowel phonation. Additional features and ML techniques were introduced, showing major performance improvements on the large mPower vocal phonation data set. Methods We used 1600 randomly selected /aa/ phonation samples from the entire data set to derive rules for filtering out faulty samples from the data set. The application of these rules, along with a joint age-gender balancing filter, results in a data set of 511 PD patients and 511 controls. We calculated features on a 1.5-second window of audio, beginning at the 1-second mark, for a support vector machine. This was evaluated with 10-fold cross-validation (CV), with stratification for balancing the number of patients and controls for each CV fold. Results We showed that the features used in prior literature do not perform well when extrapolated to the much larger mPower data set. Owing to the natural variation in speech, the separation of patients and controls is not as simple as previously believed. We presented significant performance improvements using additional novel features (with 88.6% certainty, derived from a Bayesian correlated t test) in separating patients and controls, with accuracy exceeding 58%. Conclusions The results are promising, showing the potential for ML in detecting symptoms imperceptible to a neurologist.

Machine learning for classification and prediction of brain diseases: recent advances and upcoming challenges

Machine learning is an artificial intelligence technique that allows computers to perform a task without being explicitly programmed. Machine learning can be used to assist diagnosis and prognosis of brain disorders. Although the earliest articles date from more than ten years ago, research increases at a very fast pace. Recent works using machine learning for diagnosis have moved from classification of a given disease versus controls to differential diagnosis. Intense research has been devoted to the prediction of the future patient state. Although a lot of earlier works focused on neuroimaging as data source, the current trend is on the integration of multimodal data. In terms of targeted diseases, dementia remains dominant but approaches have been developed for a wide variety of neurological and psychiatric diseases. Machine learning is extremely promising for assisting diagnosis and prognosis in brain disorders. Nevertheless, we argue that key challenges remain to be addressed by the community for bringing these tools in clinical routine: good practices regarding validation and reproducible research need to be more widely adopted; extensive generalization studies are required; interpretable models are needed to overcome the limitations of black-box approaches.