Machine Learning Classifiers Research Articles

Machine Learning Methods for Precision Dosing in Anticancer Drug Therapy: A Scoping Review.

In the last decade, various Machine Learning techniques have been proposed aiming to individualise the dose of anticancer drugs mostly based on a presumed drug effect or measured effect biomarkers. The aim of this scoping review was to comprehensively summarise the research status on the use of Machine Learning for precision dosing in anticancer drug therapy. This scoping review was conducted in accordance with the interim guidance by Cochrane and the Joanna Briggs Institute. We systematically searched the databases Medline (via PubMed), Embase and the Cochrane Library for research articles and reviews including results published after 2016. Results were reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) checklist. A total of 17 relevant studies was identified. In 12 of the included studies, Reinforcement Learning methods were used, including Classical, Deep, Double Deep and Conservative Q-Learning and Fuzzy Reinforcement Learning. Furthermore, classical Machine Learning methods were compared in terms of their performance and an artificial intelligence platform based on parabolic equations was used to guide dosing prospectively and retrospectively, albeit only in a limited number of patients. Due to the significantly different algorithm structures, a meaningful comparison between the various Machine Learning approaches was not possible. Overall, this review emphasises the clinical relevance of Machine Learning methods for anticancer drug dose optimisation, as many algorithms have shown promising results enabling model-free predictions with the potential to maximise efficacy and minimise toxicity when compared to standard protocols.

Quantum tangent kernel

The quantum kernel method is one of the key approaches to quantum machine learning, which has the advantage of not requiring optimization and its theoretical simplicity. By virtue of these properties, several experimental demonstrations and discussions of the potential advantages have been developed so far. However, as is the case in classical machine learning, not all quantum machine learning models could be regarded as kernel methods. In this work, we explore a quantum machine learning model with a deep parametrized quantum circuit and aim to go beyond the conventional quantum kernel method. In this case, the expressive power and performance are expected to be enhanced, while the training process might be a bottleneck because of the barren plateaus. Moreover, the high computational cost of gradient-based optimization and the large search space of the gradient-free optimization directly make the training intractable. However, we find that parameters of a deep enough quantum circuit do not move much from their initial values during training, allowing for a first-order expansion with respect to the parameters. This behavior is similar to that of the neural tangent kernel in classical machine learning, and such a quantum machine learning with deep variational quantum circuits can be described by another emergent kernel, the . We show that the proposed quantum tangent kernel has the potential to outperform the conventional quantum kernel method by performing a classification task on an ansatz-generated dataset. This work provides a different direction beyond the conventional quantum kernel method and explores the potential power of quantum machine learning with deep parametrized quantum circuits. Published by the American Physical Society 2024

Integrating electro-mechanical impedance data with machine learning for damage detection and classification of blended concrete systems

In recent years, the assessment of structural integrity and durability of concrete systems has significantly advanced with the integration of novel sensing technologies and data-driven techniques. This study introduces an innovative approach that utilizes electro-mechanical impedance (EMI) data acquired through embedded piezo sensors (EPS) to monitor and analyze the condition of blended concrete systems. Moreover, the study involves blended concrete specimens are subjected to controlled damage scenarios under mechanical loadings to establish EPS as an early warning sensor for detecting damage in these systems. Furthermore, the extent of damage under these loadings is comprehensively evaluated using statistical indices and an equivalent stiffness parameter. Additionally, the study focuses on the application of machine learning (ML) algorithms to interpret EMI data for efficient damage classification. ML models, such as decision trees (DT), random forests (RF), k-nearest neighbors (KNN), support vector machines (SVM), and naive Bayes (NB) are trained to identify patterns correlating with different types and extents of structural damage. Among them, the RF classifier exhibits the highest accuracy of 0.91, followed by DT, KNN, SVM, and NB with accuracies of 0.88, 0.86, 0.68, and 0.17 respectively. The integration of EMI data with ML approaches demonstrates significant potential to revolutionize predictive maintenance strategies, enabling precise classification of structural damage and providing critical insights for engineers and stakeholders to proactively address issues, thereby significantly enhancing the safety, durability, and lifespan of concrete infrastructure. This study not only extends the current understanding of EMI data applications but also opens new paths for automated and real-time structural health monitoring.

Optimal groundwater depth and irrigation amount can mitigate secondary salinization in water-saving irrigated areas in arid regions

Secondary salinization poses a significant threat to the sustainable development of water-saving irrigation districts. This study aims to explore the spatial and temporal variations in soil salinity and the factors influencing these changes in water-saving irrigation areas in the inland arid regions of Northwest China. The Manas River Irrigation District was selected as the study area. A grid measuring 10 km × 14 km grid was designed to determine the latitude and longitude coordinates of the grid centers, resulting in 66 sample points. Soil samples were collected from these points in 2013, 2014, 2020, and 2021 from the 0100 cm layer to obtain salinity data. Based on existing research and practical conditions in water-saving irrigation areas, 11 factors influencing soil salinity changes were identified, including irrigation area and irrigation amount. Classical statistical methods and interpretable machine learning techniques were employed to analyze the distribution characteristics of soil salinity and the influencing factors. This analysis proposes effective solutions to mitigate potential secondary salinization in irrigation areas. The results revealed that soil salinity in the irrigation area belonged to moderate variation (Cv = 46.74 %51.80 %). The horizontal direction of the irrigation area shows higher salt content in the upstream and downstream areas, and a gradual decrease in variability with increasing depth characterizes the vertical direction. From 2013–2021, soil salinization in the irrigation area gradually decreased. In 2013 and 2014, the area was predominantly covered by mild saline-alkali soil, accounting for 75.1 % and 76.6 % of the total area, respectively. However, in 2020 and 2021, non-saline soils became dominant, covering 60.9 % and 66.5 % of the total irrigation area, respectively. In order of importance, the factors affecting the spatial and temporal evolution of soil salinity are groundwater depth, annual water surface evaporation, water-saving irrigation area, underground water diversion amount, mineralization of groundwater, irrigation amount, surface water diversion amount, and annual rainfall. In the oasis irrigation area, maintaining a groundwater depth of 4.06.0 m and an irrigation amount of 55006000 m3 ha−1 can alleviate the problem of secondary salinization that may result from large-scale development of water-saving irrigation. The findings of this study provide a basis for the prevention and control of soil salinization in water-saving irrigation areas and the development and management of saline land in oasis areas.

A comparative analysis of classical and machine learning methods for forecasting TB/HIV co-infection

TB/HIV coinfection poses a complex public health challenge. Accurate forecasting of future trends is essential for efficient resource allocation and intervention strategy development. This study compares classical statistical and machine learning models to predict TB/HIV coinfection cases stratified by gender and the general populations. We analyzed time series data using exponential smoothing and ARIMA to establish the baseline trend and seasonality. Subsequently, machine learning models (SVR, XGBoost, LSTM, CNN, GRU, CNN-GRU, and CNN-LSTM) were employed to capture the complex dynamics and inherent non-linearities of TB/HIV coinfection data. Performance metrics (MSE, MAE, sMAPE) and the Diebold-Mariano test were used to evaluate the model performance. Results revealed that Deep Learning models, particularly Bidirectional LSTM and CNN-LSTM, significantly outperformed classical methods. This demonstrates the effectiveness of Deep Learning for modeling TB/HIV coinfection time series and generating more accurate forecasts.

Inertial methods for split common fixed point problems: application to binary classification in machine learning

Inertial methods for split common fixed point problems: application to binary classification in machine learning

Causal estimation of maternal-offspring gut commensal bacterial associations under livestock grazing management conditions

The maternal gut bacteriome influences the microbiota and physiological functions of her offspring, but the flow of microbiota transfer under livestock grazing management has not been fully elucidated. Here, maternal-offspring associations of the gut bacteriome were investigated in Japanese black cattle of different genetic backgrounds as a livestock animal model, especially under open environmental conditions. Statistical analysis of faecal bacterial diversity revealed significant differences between dams and their calves before and after weaning (at 90 days of age). Furthermore, machine learning classification, factor analysis, and causal inference estimates that the faecal bacterial composition of dams has a weaker effect on calves in the preweaning period and a more pronounced effect on those in the postweaning period. Minimally, the genera Allobaculum, Bifidobacterium, Blautia, Bulleidia, CF231, Clostridium, Collinsella, Coprococcus, Faecalibacterium, Methanobrevibacter, Lactobacillus, Sharpea, and Streptococcus in dams are highly linked to the faecal bacteria of postweaning calves. In terms of the metabolisms of faecal short-chain fatty acids, the genera Bifidobacterium and Faecalibacterium were associated with dams and postweaning calves. These computational observations highlight a nongenetic causal link from dam to pre- and postweaning calves regarding the potential shaping of the gut bacteriome, although the association appears to be discontinuous.

X-ray AGNs with SRG/eROSITA: multiwavelength observations reveal merger triggering and post-coalescence circumnuclear blowout

ABSTRACT Major mergers between galaxies are predicted to fuel their central supermassive black holes (SMBHs), particularly after coalescence. However, determining the prevalence of active galactic nuclei (AGNs) in mergers remains a challenge, because AGN diagnostics are sensitive to details of the central structure (e.g. nuclear gas clouds, geometry, and orientation of a dusty torus) that are partly decoupled from SMBH accretion. X-rays, expected to be ubiquitous among accreting systems, are detectable through non-Compton-thick screens of obscuring material, and thus offer the potential for a more complete assessment of AGNs in mergers. But extant statistical X-ray studies of AGNs in mergers have been limited by either sparse, heterogeneous, or shallow on-sky coverage. We use new X-ray observations from the first SRG/eROSITA all-sky data release to characterize the incidence, luminosity, and observability of AGNs in mergers. Combining machine learning and visual classification, we identify 923 post-mergers in Dark Energy Camera Legacy Survey (DECaLS) imaging and select 4565 interacting galaxy pairs (with separations <120 kpc and mass ratios within 1:10) from the Sloan Digital Sky Survey. We find that galaxies with X-ray AGNs are 2.0$\pm$0.24 times as likely to be identified as post-mergers compared to non-AGN controls, and that post-mergers are 1.8$\pm$0.1 times as likely to host an X-ray AGN as non-interacting controls. A multiwavelength census of X-ray, optical, and mid-IR-selected AGNs suggests a picture wherein the underlying AGN fraction increases during pair-phase interactions, that galaxy pairs within ~20 kpc become heavily obscured, and that the obscuration often clears post-coalescence.

Product differentiation of Sarawak premium rice using MOS gas sensors: comparison between transient and frequency response

In Malaysia, rice, ranked as the third most crucial crop, faces challenges due to domestic consumption outpacing production, resulting in increased instances of rice adulteration. This underscores the imperative of maintaining integrity and quality standards across the entire supply chain. This study uses an electronic nose, comprising four metal oxide semiconductor (MOS) gas sensors, and employing temperature modulation, Principal Component Analysis (PCA) and supervised machine learning (classification models) to distinguish rice varieties such as Bario, Bajong, Borneo Fragrant, Biris, and Jasmine. The study evaluated 30 classifiers based on their classification and validation accuracy. Sensor data was first extracted from the transient response of sensors output voltage, yielding a 12-dimension dataset with response times of 30 s, 50 s, and 95 s. Classification models trained from this dataset achieved classification (training) accuracy of up to 100% and validation accuracy of up to 96%, where the best performing models are subspace discriminant and kernel naïve bayes classifiers. An attempt was also made to analyze the sensor data frequency response for rice classification. Comparison between the prediction results in the transient and frequency domains showed that transient response is better suited for the classification of rice.

Positive and unlabelled machine learning reveals new fast radio burst repeater candidates

ABSTRACT Fast radio bursts (FRBs) are astronomical radio transients of unknown origin. A minority of FRBs have been observed to originate from repeating sources, and it is unknown which apparent one-off bursts are hidden repeaters. Recent studies increasingly suggest that there are intrinsic physical differences between repeating and non-repeating FRBs. Previous research has used machine learning classification techniques to identify apparent non-repeaters with repeater characteristics, whose sky positions would be ideal targets for future observation campaigns. However, these methods have not sufficiently accounted for the positive and unlabelled (PU) nature of the data, wherein true labels are only available for repeaters. Modified techniques that do not inadvertently learn properties of hidden repeaters as characteristic of non-repeaters are likely to identify additional repeater candidates with greater accuracy. We present in this paper the first known attempt at applying PU-specific machine learning techniques to study FRBs. We train an ensemble of five PU-specific classifiers on the available data and use them to identify 66 repeater candidates in burst data from the CHIME/FRB collaboration, 18 of which were not identified with the use of machine learning classifiers in past research. Our results additionally support repeaters and non-repeaters having intrinsically different physical properties, particularly spectral index, frequency width, and burst width. This work additionally opens new possibilities to study repeating and non-repeating FRBs using the framework of PU learning.

Identifying neuroimaging biomarkers in major depressive disorder using machine learning algorithms and functional near-infrared spectroscopy (fNIRS) during verbal fluency task

One of the most prevalent psychiatric disorders is major depressive disorder (MDD), which increases the probability of suicidal ideation or untimely demise. Abnormal frontal hemodynamic changes detected by functional near-infrared spectroscopy (fNIRS) during verbal fluency task (VFT) have the potential to be used as an objective indicator for assessing clinical symptoms. However, comprehensive quantitative and objective assessment instruments for individuals who exhibit symptoms suggestive of depression remain undeveloped. Drawing from a total of 467 samples in a large-scale dataset comprising 289 MDD patients and 178 healthy controls, fNIRS measurements were obtained throughout the VFT. To identify unique MDD biomarkers, this research introduced a data representation approach for extracting spatiotemporal features from fNIRS signals, which were subsequently utilized as potential predictors. Machine learning classifiers (e.g., Gradient Boosted Decision Trees (GBDT) and Multilayer Perceptron) were implemented to assess the ability to predict selected features. The mean and standard deviation of the cross-validation indicated that the GBDT model, when combined with the 180-feature pattern, distinguishes patients with MDD from healthy controls in the most effective manner. The accuracy of correct classification for the test set was 0.829 ± 0.053, with an AUC of 0.895 (95 % CI: 0.864–0.925) and a sensitivity of 0.914 ± 0.051. Channels that made the most important contribution to the identification of MDD were identified using Shapley Additive Explanations method, located in the frontopolar area and the dorsolateral prefrontal cortex, as well as pars triangularis Broca's area. Assessment of abnormal prefrontal activity during the VFT in MDD serves as an objectively measurable biomarker that could be utilized to evaluate cognitive deficits and facilitate early screening for MDD. The model suggested in this research could be applied to large-scale case-control fNIRS datasets to detect unique characteristics of MDD and offer clinicians an objective biomarker-based analytical instrument to assist in the evaluation of suspicious cases.

A simple classification and clustering of poverty in rural areas using machine learning

This study aimed to determine the socio-economic poverty status of those living in rural areas using data surveys obtained from household expenditure and income. Machine learning-based classification and clustering models were proven to provide an overview of efforts to determine similarities in poverty characteristics. Efforts to address poverty classification and clustering typically involve comprehensive strategies that aim to improve socio-economic conditions in the affected areas. This research focuses on the combined application of machine learning classification and clustering techniques to analyze poverty. It aims to investigate whether the integration of classification and clustering algorithms can enhance the accuracy of poverty analysis by identifying distinct poverty classes or clusters based on multidimensional indicators. The results showed the superiority of machine learning in mapping poverty in rural areas; therefore, it can be adopted in the private sector and government domains. It is important to have access to relevant and reliable data to apply these machine learning techniques effectively. Data sources may include household surveys, census data, administrative records, satellite imagery, and other socioeconomic indicators. Machine learning classification and clustering analyses are used as a decision support tool to gain an understanding of poverty data from each village. These strategies are also used to describe the profile of poverty clusters in the community in terms of significant socio-economic indicators present in the data. Village clusters based on an analysis of existing poverty indicators are grouped into high, moderate, and low poverty levels. Machine learning can be a valuable tool for analyzing and understanding poverty by classifying individuals or households into different poverty categories and identifying patterns and clusters of poverty. These insights can inform targeted interventions, policy decisions, and resource allocation for poverty reduction programs.

Predicting Prenatal Depression and Assessing Model Bias Using Machine Learning Models

BackgroundPerinatal depression is one of the most common medical complications during pregnancy and postpartum period, affecting 10% to 20% of pregnant individuals, with higher rates among Black and Latina women who are also less likely to be diagnosed and treated. Machine learning (ML) models based on electronic medical records (EMRs) have effectively predicted postpartum depression in middle-class White women but have rarely included sufficient proportions of racial/ethnic minorities, which has contributed to biases in ML models. Our goal is to determine whether ML models could predict depression in early pregnancy in racial/ethnic minority women by leveraging EMR data. MethodsWe extracted EMRs from a large U.S. urban hospital serving mostly low-income Black and Hispanic women (n = 5875). Depressive symptom severity was assessed using the Patient Health Questionnaire-9 self-report questionnaire. We investigated multiple ML classifiers using Shapley additive explanations for model interpretation and determined prediction bias with 4 metrics: disparate impact, equal opportunity difference, and equalized odds (standard deviations of true positives and false positives). ResultsAlthough the best-performing ML model's (elastic net) performance was low (area under the receiver operating characteristic curve = 0.61), we identified known perinatal depression risk factors such as unplanned pregnancy and being single and underexplored factors such as self-reported pain, lower prenatal vitamin intake, asthma, carrying a male fetus, and lower platelet levels. Despite the sample comprising mostly low-income minority women (54% Black, 27% Latina), the model performed worse for these communities (area under the receiver operating characteristic curve: 57% Black, 59% Latina women vs. 64% White women). ConclusionsEMR-based ML models could moderately predict early pregnancy depression but exhibited biased performance against low-income minority women.

Identifying COVID-19 survivors living with post-traumatic stress disorder through machine learning on Twitter

The COVID-19 pandemic has disrupted people’s lives and caused significant economic damage around the world, but its impact on people’s mental health has not been paid due attention by the research community. According to anecdotal data, the pandemic has raised serious concerns related to mental health among the masses. However, no systematic investigations have been conducted previously on mental health monitoring and, in particular, detection of post-traumatic stress disorder (PTSD). The goal of this study is to use classical machine learning approaches to classify tweets into COVID-PTSD positive or negative categories. To this end, we employed various Machine Learning (ML) classifiers, to segregate the psychotic difficulties with the user’s PTSD in the context of COVID-19, including Random Forest Support Vector Machine, Naïve Bayes, and K-Nearest Neighbor. ML models are trained and tested using various combinations of feature selection strategies to get the best possible combination. Based on our experimentation on real-world dataset, we demonstrate our model’s effectiveness to perform classification with an accuracy of 83.29% using Support Vector Machine as classifier and unigram as a feature pattern.

Predicting non-chemotherapy drug-induced agranulocytosis toxicity through ensemble machine learning approaches.

Agranulocytosis, induced by non-chemotherapy drugs, is a serious medical condition that presents a formidable challenge in predictive toxicology due to its idiosyncratic nature and complex mechanisms. In this study, we assembled a dataset of 759 compounds and applied a rigorous feature selection process prior to employing ensemble machine learning classifiers to forecast non-chemotherapy drug-induced agranulocytosis (NCDIA) toxicity. The balanced bagging classifier combined with a gradient boosting decision tree (BBC + GBDT), utilizing the combined descriptor set of DS and RDKit comprising 237 features, emerged as the top-performing model, with an external validation AUC of 0.9164, ACC of 83.55%, and MCC of 0.6095. The model's predictive reliability was further substantiated by an applicability domain analysis. Feature importance, assessed through permutation importance within the BBC + GBDT model, highlighted key molecular properties that significantly influence NCDIA toxicity. Additionally, 16 structural alerts identified by SARpy software further revealed potential molecular signatures associated with toxicity, enriching our understanding of the underlying mechanisms. We also applied the constructed models to assess the NCDIA toxicity of novel drugs approved by FDA. This study advances predictive toxicology by providing a framework to assess and mitigate agranulocytosis risks, ensuring the safety of pharmaceutical development and facilitating post-market surveillance of new drugs.

C-reactive protein (CRP) evaluation in human urine using optical sensor supported by machine learning

The rapid and sensitive indicator of inflammation in the human body is C-Reactive Protein (CRP). Determination of CRP level is important in medical diagnostics because, depending on that factor, it may indicate, e.g., the occurrence of inflammation of various origins, oncological, cardiovascular, bacterial or viral events. In this study, we describe an interferometric sensor able to detect the CRP level for distinguishing between no-inflammation and inflammation states. The measurement head was made of a single mode optical fiber with a microsphere structure created at the tip. Its surface has been biofunctionalized for specific CRP bonding. Standardized CRP solutions were measured in the range of 1.9 µg/L to 333 mg/L and classified in the initial phase of the study. The real samples obtained from hospitalized patients with diagnosed Urinary Tract Infection or Urosepsis were then investigated. 27 machine learning classifiers were tested for labeling the phantom samples as normal or high CRP levels. With the use of the ExtraTreesClassifier we obtained an accuracy of 95% for the validation dataset. The results of real samples classification showed up to 100% accuracy for the validation dataset using XGB classifier.

Exploring transformer models for sentiment classification: A comparison of BERT, RoBERTa, ALBERT, DistilBERT, and XLNet

AbstractTransfer learning models have proven superior to classical machine learning approaches in various text classification tasks, such as sentiment analysis, question answering, news categorization, and natural language inference. Recently, these models have shown exceptional results in natural language understanding (NLU). Advanced attention‐based language models like BERT and XLNet excel at handling complex tasks across diverse contexts. However, they encounter difficulties when applied to specific domains. Platforms like Facebook, characterized by continually evolving casual and sophisticated language, demand meticulous context analysis even from human users. The literature has proposed numerous solutions using statistical and machine learning techniques to predict the sentiment (positive or negative) of online customer reviews, but most of them rely on various business, review, and reviewer features, which leads to generalizability issues. Furthermore, there have been very few studies investigating the effectiveness of state‐of‐the‐art pre‐trained language models for sentiment classification in reviews. Therefore, this study aims to assess the effectiveness of BERT, RoBERTa, ALBERT, DistilBERT, and XLNet in sentiment classification using the Yelp reviews dataset. The models were fine‐tuned, and the results obtained with the same hyperparameters are as follows: 98.30 for RoBERTa, 98.20 for XLNet, 97.40 for BERT, 97.20 for ALBERT, and 96.00 for DistilBERT.

Ensemble of Deep Learning Architectures with Machine Learning for Pneumonia Classification Using Chest X-rays.

Pneumonia is a severe health concern, particularly for vulnerable groups, needing early and correct classification for optimal treatment. This study addresses the use of deep learning combined with machine learning classifiers (DLxMLCs) for pneumonia classification from chest X-ray (CXR) images. We deployed modified VGG19, ResNet50V2, and DenseNet121 models for feature extraction, followed by five machine learning classifiers (logistic regression, support vector machine, decision tree, random forest, artificial neural network). The approach we suggested displayed remarkable accuracy, with VGG19 and DenseNet121 models obtaining 99.98% accuracy when combined with random forest or decision tree classifiers. ResNet50V2 achieved 99.25% accuracy with random forest. These results illustrate the advantages of merging deep learning models with machine learning classifiers in boosting the speedy and accurate identification of pneumonia. The study underlines the potential of DLxMLC systems in enhancing diagnostic accuracy and efficiency. By integrating these models into clinical practice, healthcare practitioners could greatly boost patient care and results. Future research should focus on refining these models and exploring their application to other medical imaging tasks, as well as including explainability methodologies to better understand their decision-making processes and build trust in their clinical use. This technique promises promising breakthroughs in medical imaging and patient management.

Arabic dialect identification in social media: A hybrid model with transformer models and BiLSTM

Arabic Dialect Identification (ADI) is a challenging task in natural language processing applications due to its diversity and regional variations. Despite previous efforts, this task is still difficult. Therefore, this study aims to use transformers to address the issue of ADI on social media. A combination of two hybrid models is proposed in this study: one that combines Bidirectional Long Short-Term Memory (BiLSTM) with CAMeLBERT, and the second model that combines the BiLSTM model with AlBERT. In addition, a novel dataset comprising 121,289 user-generated comments from various social media network platforms and four major Arabic dialects (Egyptian, Jordanian, Gulf and Yemeni) was introduced. Several experiments have been conducted using conventional Machine Learning Classifiers (MLCs) and Deep Learning Models (DLMs) as baselines to measure the performance and effectiveness of the proposed models. In addition, binary classification is performed between two dialects to determine which are closest to each other. The performance of the model is measured using common metrics such as precision, recall, F-score and F-measure. Experiment results demonstrate the superior efficiency of the proposed hybrid models in ADI, CAMeLBERT with BiLSTM and ALBERT with BiLSTM, which both recorded an accuracy of 87.67 % and 86.51 %, respectively.

Application of Machine Learning in Identifying Premature Aging

Previously pathological ageing is known to be mainly associated with the development of cardiovascular disease, which is caused by a combination of socioeconomic, metabolic, behavioural, and environmental risk factors. These include sex differences, age, high blood pressure, obesity, low physical activity, smoking, heavy alcohol consumption, high cholesterol and glucose levels, and diabetes mellitus. All processes occurring in the human body are reflected in biochemical and immunological analyses, which may be markers of early cardiovascular aging. The authors investigated correlations between social factors such as education, work, gender, family life, disability, physical activity, smoking and alcohol, and clinical findings such as coronary heart disease (CHD), postinfarct cardiosclerosis (PICS), chronic heart failure (CHF), diabetes mellitus (DM), body mass index (BMI), glucose levels, total cholesterol (TC) and blood pressure (BP) in older individuals. The authors implemented the basic model using R programming language, RStudio version 2023.09.0+463 on a device running MacBook Air M1, 8 GB RAM to identify the association between clinical data and social life. Also, two mathematical models (1)-(3) were proposed to calculate the correlation in combination with traditional machine learning classifiers between clinical data (biomarkers) and the social life of a patient in the age group of 60-74 years, 75-89 years and 90 and above.