Blast-induced traumatic brain injury (TBI) is currently an important and very “hot” research topic because it has been acknowledged to be a significant source of morbidity and disability during the wars in Iraq and Afghanistan, among blast victims. A total of 545 academic articles about blast TBI research have been published since 1946, of which 82% (447 articles) have been published since 2003, and 57% (312 articles) were published from 2010 to 2013. A number of experimental models are currently implemented to investigate the mechanisms of blast-induced TBI in rodents and larger animals such as rabbits and swine. As the fundamental shock wave generator, shock tubes (either compressed air-driven or detonation-driven) are generally employed in these experimental models. The compressed air-driven shock tube is a horizontally mounted, circular steel tube, in which a gas at low pressure (the driven gas) and a gas at high pressure (the driver gas) are separated using diaphragms (such as polyester Mylar membrane). After the diaphragm suddenly ruptures at predetermined pressure thresholds (e.g., 126–147 kPa), shock waves are generated and propagate through the low pressure section (the driven section) toward the mouth of the shock tube. The detonation-driven shock tube is a cylindrical metal tube that is closed at one end. The blast, causing the shock waves, is generated by detonation of an explosive charge in the closed end of the tube. Both compressed air-driven and detonation-driven shock tubes can produce blast shock waves to induce blast injuries in animals. However, because of their designs and structures, both shock tubes are not able to generate the Friedlander wave (an ideal form of a primary blast wave) that occurs when a powerful explosive detonates in a free field, without nearby surfaces that can interact with the wave. A series of complex shock waves are then generated following the lead shock wave (the original shock front), including reflected shock waves, a Mach stem, an unsteady turbulent jet, and rarefaction waves. These waves can cause sudden compression or rarefaction effects upon any object encountered in their motion path, and transfer kinetic energy to the object. Therefore, if an experimental animal is placed inside the shock tube, these complex pressure waves will cause more severe and complex injuries that are rarely observed in blast victims, thus leading to false-positive results in the studies of blast TBI mechanism.